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nuf2-b

Gene
nuf2-b
Protein
Kinetochore protein Nuf2-B
Organism
Xenopus laevis
Length
462 amino acids
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Similarity
Belongs to the NUF2 family.
Mass
54.631 kDa
Sequence
MDKLTFPIFPAADLVNFFRQNILTGTEAKNFNKNDLYPNPKPEMVQKLYMRILQQVFSYGVEQFYMVPMDLDIQYPHLVEGFAPVANILKLMARLLPMCRVYDFHPSDVLNPKGKRTLHLLSGIFNFLQFRTTQREVYMEYCSGYKSALENVRQLQKTNHEAEIKIEKLTTVPPEQQAEFKALSSEIHDLQQIISQEYRAKDVMFQEKIAQRKAEFAEKNKRLNEQKLTIATMKEEQERMKSQIVESPEQRKSKTERMKETVHRLKQARQETSDKCDHYRDRVALAFMWQSDVQGYLKKLQNIDANLEIHRKIHEEIRHIEEQLMNLNLELKSLSNEDAQLKRIILVKKEKLAKVDIKNKKKQEDFNQQKQEILEVCSHIQEKRQVIHGRVAQVLQEIQQTISKKEQLLETTEAGKNKCQEVITDFRAALEKYHDSLQKASERSADRRREKIAELNRRLSRQ