Protein
Dynein heavy chain, cytoplasmic
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Function
Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae.
Similarity
Belongs to the dynein heavy chain family.
Sequence
MEVASSGVPDGAPTAISQGPLVDADAVVEYLADVLRVTLGALRSELENAGSLLSKTKYSETAQRCLRFASESQVALYVQKDLVASDHTNGTADSEEPPAEYVYTLSAEISSSSTTVASVAFIKRPAAIDPSLPISSQIQVMNLPGPAALNNTQAQQGTSLSPYEILHLLVHHGLSPYFEANTRNQDGAAKAKTDSEVKTGVPGTKKKFAELELGLLHLQQNVEIPALNLPLHEVVQAALVEAEKRGVKPSVDLIDSTLLESSAFINSIQNNVNAWIKSIQTITKMSRDADSGSAAQEINFWLSMETALEGIENQLRGDGVQLTMDILRHAKRYQATLSFVADTGLREATDLVQKYNQLMRDFPLDELLSATSLQKVRESLVLIFNHLNKKLKICPYPIKRALALVEAISGDLDSQIHSLLNGRTIMHLDYREFRTLMKTAGSIWRTWDDNLKEFTNVARESTRRRNEKFIPIKINARHDKTQERLKYINTFRVNHEQLQRTIANVLGPKSYSAEDAAAGAAADGAVIVEEIGDVDAVEEVAQAYAALKSVDVLDVSPTGTQNWITAEIAYNERTSRVENSIIARLRDRLATAKNANEMFRVFSKFNALLVRPKIRGAIGEYQTQLIDNVKQDISALHERFKQQYGHSEAHAMAQLRDLPPVSGAIVWARQIERQLDGYMRKVEDVLGEDWHLHTEGQKLQAESNLFRKKLDTRPVFETWLHDVQRRRITISGRLFNIIRNRAAGNTLELAVNFDAQIIALFKEIRNLIWLNFQVPHAVSNISKEAKRVYPYAISLMESVRTLLQTNRSILSMTDVAILLNGYMNDAQSMIVRGIPLRWESFVHSYELHVKQAALVNGALDSVIPSRGESKHVQFVREFAASAAVLQHKTAVLASINDTIQKAIHELKTCPYEFSAFKQRLDAIQAAVDKLNLENYVNLGFWVHNLNQKIEGILSERLHKAIREWMNSFQESQSGQPMQKVNGNGDTDTTAYNIEFPGLTHEISMRNQVLHLDPPLQYARATWFSHFDNWLGIICNLEKIKSSRYQISIEVQKVQLSESCFADLPQHCTNELILVYSAIETRLKEVSEYVDKWLQFQSLWDLQSEQVYDILGDDLSQWLQLLQEIRKSRATFDTSEVSRSFGNIKIDYEQVQTRVNAKYDQWQHEILLKFGSKLGNRMREVHSEIATARHDLEGKSLDSASTAHAVAFITSVQQCKRKAKVWEPEVDLFRQGQATLVRQRYQFPSDWLHVENVDGEWAALNELLGRKGKIVEEQTEALRAKIAAEDKVINDKITEAIAQWNEEKPVSGTIPPEEASRSLSMFQTRLESLQSEFEMVSKAKEALDLPPSAESSLPAILEEVQDFMSVWAALSTIWRSLNDLRDTLWTSIQPRKLRQSIDGLIKMTKEMPSRMRQYAAFEHIQNVLKQLLKVNPLLSDMKSEAVRERHWLKIYKALKPGMRFSLVSLTLGDVWDLQLAASETVIRNIIAQAQGEMALEEFLKSVRETWQNYSLDLVNYQNKCRLIRGFDDLFAKCSENLNSLQAMRHSPYYKEFEEDASSWEDKLNRVHVLFDVWIDVQRQWVYLEGVFTGNADIKHLLPLESSRFQNINSEFFAVMKKVYKSPFVLDVLAINGVQKSLERLAELLNKIQKALGEYLERERVSFPRFYFVGDEDLLEIIGNSNDIFRVAKHFKKMFAGLSGVLMDDDNNIVGFTSKEGEEVRLKKEVNLVKTPRINDWLTALESNMKLTLAELLAEAIEQFEPIYNSAEVDRTAFDDFIANYPAQIVVLASQVVWTNEVQKSLENSGTTLPTLYDAQVRILELLAVTVLGDLDPISRKKCEHLITEFVHQRDTISKLIASNATSATHYLWLLQMRYVYQADGDFLQRLYVHMANAKLNYGFEYLGVPERLVRTPLTDRCFLTLTQALCQRLGGSPYGPAGTGKTESVKALGLQLGRFTLVFCCDDTFDFQAMGRIFLGICQVGAWGCFDEFNRLEERILSAVSQQIQNIQIGLRNKETDEKSQIDLVGRRLTVNMNTGIFITMNPGYAGRSNLPDNLKKLFRSVAMSKPDKELIAEVMLFSQGFKQAKRLSQQTVPFFDHCSTRLSKQAHYDFGLRALKSVLVSSGGLKRARIANSDGDLGPDEIVEPQIIVQSLRETIAPKLVREDVATMLQIQEQDFAGVEYVPANYEALTAAIREIAREQHFVDSEMWITKILQLYQIQSIHHGVMMVGKSGSGKSSAWKILLQALQRIEGVEGVSHIIDSKVMSKEALYGSLDSTTREWTDGLFTGILRKIVDNLRGEDTKRHWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLNLPPNVRIMFEVESLKYATLATVSRCGMVWFNEDTVTPSMIITNYVESLKTKTFEDLDDDSVPSGQSAVKTQDCQDMLSTILSQLLQTDELVHKSLGEAKKYNHIMEFTEIRALNTLFSLLNKACRNILEYNIQHVDFPLEYEQIESYISKKLLLALVWSFTGDCPLGDRKSFGEFVSGLTTIDLPIETNSSIIDFDVTLPKGTWSSWQSQVPTIDVNTHSITQTDVVIPTVDTVRHEDVLYSWLAEHKPLLLCGPPGSGKTMTLFAALRKLPNMEVVGLNFSSATTPDLLIKTFEQYCEYKKTLSGVVMSPNQIGRWLVIFCDEINLPAPDKYGTQRAISFLRQLVEQNGFWRTSDKTWVSLDRIQFVGACNPPTDAGRTPLAERFLRHSPLVMVDYPGEISLNQIYGTFNSAILKILPLLRGYSESLTKAMVQFYLESQQRFTPKIQPHYVYSPRELTRWVRGVYEAIKPLESLSVEGLVRIWAHEALRLFQDRLVTEEERAWTADAVRRIALEHFPTIDQEAALKGPILFSNWLSRNYVPVEQEQLRDFVKARLKTFCEEEVDVPLVLFNDVLEHALRIDRVFRQPQGHLILIGVSGSGKTTLSRFVAWMNGLKVFQIKVHGKYSSEDFDDDLRSVLRRAGCKGEKICFIMDESNVLDSGFLERMNTLLANAEVPGLFEGDEFSSLMTACKEGAQRQGLILDSQEELYKWFTQQIVKNLHVVFTMNPPEEGLSSKAATSPALFNRCVLNWMGDWSDQALFQVGSELTQSVDLDKPGFVAPDSIPVAYRELSLPASHRDTVINAMVYIHHSLQRFNQRLQKQQGKTTYLTPRHYLDFVAQYVKLFNEKREDLEEQQRHLNVGLEKLRDTVEKVSDLRGSLAQKKMQLEKKDAEANEKLQRMVADQREAEQRKAVSLEVQAALEKQEKEVALRKDVVLHDLARAEPAVLEAQKSVSNIKRQHLTEVRSMGNPPAGVRLALEAVCTLLGHKVDSWKTIQGIVRRDDFIASIVNYDNEKQMTKNHRLKMQNEFFSKEDFTYERVNRASKACGPLVQWVEAQVNYSAILDRVGPLRDEVGQLEEQALQTKAEAQAIENTINDLESSIATYKSEYAALISETQAIKAEMERVQFKVDRSVRLLDSLSSERTRWEEGSKSFETQISTLIGDVLIAAAFLAYAGFYDQQFRKAMTEDWVQHLVQSGISLKPHNPITEYLSNADERLAWQAHSLPVDDLSTENAIFLKRYNRYPLIIDPSGRVTEFLQKESSDRKLTVTSFLDDSFVKQLESALRFGNPILIQDAEHLDPILNHVLNKEYQKTGGRVLIQLGKQEIDFSPSFKLFLSTRDPSATFAPDVCSRTTFVNFTITQSSLQIQSLNEVLKSERDDVDRRRSDLVKAQGEFNVHLRQLEKRLLQALNESHGNILDDDNVIETLETLKKEAAEISRKMAETEGVMTEVEEITQRYSIIARSCSAVFAVLEQLHHINHFYQFSLQYFTDIFESVLHGNPHLENSGLRKMEDYQQRIQIILRDLFVTTYQRTSLGVIQKDRITLAMLLAQAAPYPMDKSIIDTILDESVEGTDLSANPEAKVQVMSAFGNMSLFKAHLPSVTAEQWDQFLGEELAENFVPKVWDENTSELDKLLRSLLLVKLCRMDRFVPAAERFIVAVFGRELYEGSTDLKDIVGQVTATAPISLSSSPGFDASYKVDALVERTHATCANIAMGSNEGLESADKAISNAASAGTWVLVKNVHLAPSWLQSLEKRLASLKPHKDFRLFLSMESSPKIPVNLIRASRVLMYEQPAGVRANMKDSLSSLSTRASKAPVEKARVYLLLCFLHAVVQERLRYAPSLGWKGFWEFNDSDYECSANIIDHWVDVVAQGRSNVAPQKLPWDMIRTLITEMYGGKVDDSDDFQQLERLVHSFLTPATFEADYKLVEGVENDECLILPGETGLPAFVEWVNKLPEREPPTYLGLPANAEKLLLVGHGKKMISDLARITSLLDEGEQLMIDA