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nth

Gene
nth
Protein
Endonuclease III
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
344 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
40.568 kDa
Sequence
MELIEILLKKLNKNAVVTEIAKDKDPFKVLISTIISARTKDEVTEEVSKKLFKEIKDVDDLLNIDEEKLADLIYPAGFYKNKAKNLKKLAKILKENYNGKVPDSLEELLKLPGVGRKTANLVITLAFNKDGICVDTHVHRICNRWEIVDTETPEETEFELRKKLPKKYWKVINNLLVVFGREICSSKSKCDKCFKEIKEKCPYYEKIKHFENILKKFNFRKVSKNKIPNEKGTYILKIRLKEGKKIKFGKTERFFKKGYYFYIGSAFGNSMNLKNRIERHLKDDKKMHWHIDYLLKYGKIEEIYITNERVECEVANEFIKKFDFVENFGCSDCKCKSHLFYLKP

Gene
nth
Protein
Endonuclease III
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
245 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
27.03 kDa
Sequence
MPGRWSAETRLALVRRARRMNRALAQAFPHVYCELDFTTPLELAVATILSAQSTDKRVNLTTPALFARYRTARDYAQADRTELESLIRPTGFYRNKAASLIGLGQALVERFGGEVPATMDKLVTLPGVGRKTANVILGNAFGIPGITVDTHFGRLVRRWRWTTAEDPVKVEQAVGELIERKEWTLLSHRVIFHGRRVCHARRPACGVCVLAKDCPSFGLGPTEPLLAAPLVQGPETDHLLALAGL

Gene
nth
Protein
Endonuclease III
Organism
Mycobacterium leprae (strain TN)
Length
245 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
27.194 kDa
Sequence
MARRWSGETRLGLVRRARRMNRALAQAFPHVYCELDFTSPLELTVATILSAQSTDKRVNLTTPAVFARYRSALDYMQADRAELENFIRPTGFFRNKAASLIRLGQALVERFDGEVPSTMVDLFTLPGVGRKTANVILGNAFGIPGITVDTHFGRLVRRWRWTAEEDPVKVEHAVGELIERDQWTLLSHRVIFHGRRVCHARKPACGVCVLAKDCPSFGLGPTEPLLAAPLVQGPEAGHLLALAGL

Gene
nth
Protein
Endonuclease III
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
245 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
27.03 kDa
Sequence
MPGRWSAETRLALVRRARRMNRALAQAFPHVYCELDFTTPLELAVATILSAQSTDKRVNLTTPALFARYRTARDYAQADRTELESLIRPTGFYRNKAASLIGLGQALVERFGGEVPATMDKLVTLPGVGRKTANVILGNAFGIPGITVDTHFGRLVRRWRWTTAEDPVKVEQAVGELIERKEWTLLSHRVIFHGRRVCHARRPACGVCVLAKDCPSFGLGPTEPLLAAPLVQGPETDHLLALAGL

Gene
nth
Protein
Endonuclease III
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
245 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. Has a preference for oxidized pyrimidines, such as thymine glycol (prefers 5S isomers) 5,6-dihydrouracil:G, 5-hydroxyuracil:G, 5-hydroxycytosine:G and urea:A. Cleaves ssDNA containing an AP site.
Similarity
Belongs to the Nth/MutY family.
Mass
27.03 kDa
Sequence
MPGRWSAETRLALVRRARRMNRALAQAFPHVYCELDFTTPLELAVATILSAQSTDKRVNLTTPALFARYRTARDYAQADRTELESLIRPTGFYRNKAASLIGLGQALVERFGGEVPATMDKLVTLPGVGRKTANVILGNAFGIPGITVDTHFGRLVRRWRWTTAEDPVKVEQAVGELIERKEWTLLSHRVIFHGRRVCHARRPACGVCVLAKDCPSFGLGPTEPLLAAPLVQGPETDHLLALAGL

Gene
nth
Protein
Endonuclease III
Organism
Bacillus subtilis (strain 168)
Length
219 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
25 kDa
Sequence
MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCTDALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYGGEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLEVEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVKR

Gene
nth
Protein
Endonuclease III
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
219 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
24.377 kDa
Sequence
MSSLLRKMASKKQRATEILLILKKLYPGATCSLDYQTPVQLLVATILSAQCTDERVNKVTPALFQRYPDANALAYGDRQEIEELIHSTGFFRNKAKNIQGACRKIVEEFDGEVPQRMEELLTLPGVARKTANVVLAHAFGILAGVTVDTHVKRLSQRLGLTKATDPIRIERDLMKLIPQPDWENFSIHIIYHGRAVCAARKPLCGECQLAHLCPSAQAS

Gene
nth
Protein
Endonuclease III
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Length
215 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
24.645 kDa
Sequence
MEIKKLNHKNRYKILKMFSNIYINFKTGLVFTSNFELLISVMLSAQTTDRMVNKTTQRLFGIANTPSGFISIGLHAIRENIRKLGLYNKKSSNILRTCEILLKRYGGKVPNNREDLESLPGVGRKTANVILNVIFKKKTIAVDTHVFRLCNRIGFAKGTTVLTVEKKLLNIVPEKFKLNFHAWFIMHGRYICTSRVPKCSKCIISSLCEFKDKNI

Gene
nth
Protein
Endonuclease III
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Length
213 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
24.928 kDa
Sequence
MIEELAREIVKRFPRNHKETDPFRVLISTVLSQRTRDENTEKASKKLFEVYRTPQELAKAKPEDLYDLIKESGMYRQKAERIVEISRILVEKYGGRVPDSLEELLKLPGVGRKTANIVLWVGFKKPALAVDTHVHRISNRLGWVKTRTPEETEEALKKLLPEDLWGPINGSMVEFGRRICKPQNPLCEECFLKNHCEFYRRRGKGEVRNRTER

Gene
nth
Protein
Endonuclease III
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)
Length
213 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
24.134 kDa
Sequence
MQAQIVNKIFEIFSKNNPSPKTELIYKNDFTLLVAVMLSAQATDISVNLATKSLFETYDTTEKILELGEDGLKKYIKSIGLFNSKAKNIIALCKILISNYQSSVPNDFKELIKLPGVGRKTANVVLNCLFGMPTMAVDTHVFRVAKRIGLARGNSPEIVEKELLQIINEKWLTHAHHWLILHGRYICKARKPDCDICPIKEYCEYYNSPIISK

Gene
nth
Protein
Endonuclease III
Organism
Rickettsia prowazekii (strain Madrid E)
Length
212 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
24.174 kDa
Sequence
MQAQIMNKIFEIFSKNNPKPQTELIYKNDFTLLVAVILSARATDISVNLATKHLFETYNTPEKFLELGEEGLKKYIKSIGLFNSKAKNIIALCQILIKNYQTSIPNNFKELVKLPGVGRKTANVVLNCLFAMPTMAVDTHVFRVSKRIGLAKGNTAAIVEKELLQIIDEKWLTYAHHWLILHGRYICKARKPGCNICPIKEYCEYYINTFSS

Gene
nth
Protein
Endonuclease III
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Length
212 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
24.079 kDa
Sequence
MQAQIVNKIFEIFSKNNPKPQTALIYKNDFTLLVAVILSARATDISVNLVTKHLFETYNTPEKILALGEEGLKKYIKSIGLFNSKAKNIIASCQILIKNYQASIPNDFKELVKLPGVGRKTANVVLNCLFAMPTMAVDTHVFRVSKRIGLAKGNTTVIVEKELLQIIDEKWLTHAHHWLVLHGRYICKARKPSCRICHIKEYCEYYINTFAS

Gene
nth
Protein
Endonuclease III
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
211 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
23.562 kDa
Sequence
MNKAKRLEILTRLRENNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAENIIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVEEKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEKVDI

Gene
nth
Protein
Endonuclease III
Organism
Escherichia coli (strain K12)
Length
211 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
23.562 kDa
Sequence
MNKAKRLEILTRLRENNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAENIIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVEEKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEKVDI

Gene
nth
Protein
Endonuclease III
Organism
Treponema pallidum (strain Nichols)
Length
211 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
23.419 kDa
Sequence
MRLLDSKGVHAVFEQLHAANPQPQGELHWRNTFTLLVAVLLSAQATDKSVNKATAALFDVADTPQAMLALGEERLCSYIRTINLYPTKARRIIALSAELIERFAAQVPCDAHALESLPGVGHKTANVVLNMGFGIPTIAVDTHILRTAPRIGLSSGRTPRAVERDLLVVTPREFRMHAHHWILLHGRYTCTARRPRCTECCLRDLCCKNNI

Gene
nth
Protein
Endonuclease III
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
211 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
23.715 kDa
Sequence
MNKTKRIEILTRLREQNPHPTTELQYNSPFELLIAVILSAQATDKGVNKATEKLFPVANTPQAILDLGLDGLKSYIKTIGLFNSKAENIIKTCRDLIEKHNGEVPENREALEALAGVGRKTANVVLNTAFGHPTIAVDTHIFRVCNRTNFAAGKDVVKVEEKLLKVVPNEFKVDVHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEKVEF

Gene
nth
Protein
Endonuclease III
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
Length
210 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
24.388 kDa
Sequence
MNKKKRYEILSILSRNNPEPKIELFFSSDFELLLSVILSAQSTDFIVNKTTKILFKIANTPETIFLLGLERLKNYIKDIGLYNTKALNIIRTSFIILTKYNSIVPNNRIELESLPGVGRKTANIILNILFKKKTIAVDTHVFRVCNRTNFAKGKNVKIVEEKLIKVVPSIFKLNFHSWFILHGRYICTARKIKCNICLIFKLCEFKQKIF

Gene
nth
Protein
Endonuclease III
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Length
210 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
23.702 kDa
Sequence
MQAQIVNKIFEIFSKNNPNPKTELIYKNDFTLLVAVILSAQATDISVNLATKSLFATYDTPEKILELGEEGLKKYIKSIGLFNSKAKNIIALCKILISNYQASVPNDFKALIKLPGVGRKTANVVLNCLFGMPTMAVDTHVFRVANRIGLAKGDTPEIVENELLQIIDTKWLTHAHHWLILHGRYICKARKPDCDICPIKEYCDYYFNLK

Gene
nth
Protein
Endonuclease III
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Length
209 amino acids
Function
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Similarity
Belongs to the Nth/MutY family.
Mass
24.074 kDa
Sequence
MNKKKRFEILSLFYKKNSNPKIELVFSSDFELLLSVILSAKSTDVMVNKITGTLFQIANTPQSILKLGFNKLRHYIKSIGLYNTKSLNIINSAYLIKTKYNNKVPSNRTELESLPGVGRKTANIILNVLFNKNTIAVDTHVFRVANRTGFAKGKNVIEVEKKMIKIVPSIFKKYVHFWFVLHGRYVCTARQLKCKTCFIEKLCEFDKKK