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nscB

Gene
nscB
Protein
Lactamase-like protein nscB
Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)
Length
439 amino acids
Function
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin B, a prenylated anthracenone that probably exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576). The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (By similarity). The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (By similarity). The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (By similarity). The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (By similarity). Neosartoricin B can be converted into two additional compounds neosartoricins C and D (By similarity). Neosartoricin C is a spirocyclic compound that is cyclized through the attack of C3 hydroxyl on C14, followed by dehydration (By similarity). On the other hand, neosartoricin D is a further cyclized compound in which attack of C2 on C14 in neosartoricin C results in the formation of the acetal-containing dioxabicyclo-octanone ring (By similarity). Both of these compounds are novel and possibly represent related metabolites of the gene cluster (By similarity).
Similarity
Belongs to the metallo-beta-lactamase superfamily.
Mass
49.014 kDa
Sequence
MKSRVYVRFDRGFHVICPYQAKLAGSRKNDGAGYISPLALKSPIGLQHDLEDGCRIRSAFGKCIVNSRFLALIDVRKSGFKERGSKEPHGNSFVYWVTYSFLQFFETTMDELPSGRGMGGRLPFNQSFWEEFLSGREGQLPTLPDISHVSKSVIRILGGNPGSMHLQGTNTYLVGTGRSRILIDTAQGLPVWIDCISSFLHTQKIELSYVLLTHWHGDHTGGVPDLIAQNSSLADKIYKNHPDSGQNPITHGQIFSVDGATVRAIFTPGHSVDHMCFLLEEENALFTGDNVLGHGFSVAQDLGRYMDSLRDMASLGCRIGYPAHGAVIENLPGKLEEYIQHREGRERMMLSALTRQRVRGEGLREEGVKCGLTLNEIVMAIYGKLPPEVIEKALAPSLLQVLWKLTEDRMVGFKPGDPLKRQWFALEQRKRNKARGYPS

Gene
nscB
Protein
Lactamase-like protein nscB
Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)
Length
343 amino acids
Function
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin B, a prenylated anthracenone that probably exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576, PubMed:23368997). The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (By similarity). The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (By similarity). The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (By similarity). The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (By similarity). Neosartoricin B can be converted into two additional compounds neosartoricins C and D (By similarity). Neosartoricin C is a spirocyclic compound that is cyclized through the attack of C3 hydroxyl on C14, followed by dehydration (By similarity). On the other hand, neosartoricin D is a further cyclized compound in which attack of C2 on C14 in neosartoricin C results in the formation of the acetal-containing dioxabicyclo-octanone ring (By similarity). Both of these compounds are novel and possibly represent related metabolites of the gene cluster (By similarity).
Similarity
Belongs to the metallo-beta-lactamase superfamily.
Mass
38.096 kDa
Sequence
MGGRMPFNQSFWEEFLMGREGRLPTLPEISHVSKRVVRILGGNPGSMHLQGTNTYLVGTGRSRILIDTAQVKQASFLRLQRAPSQLIHSKKGLPVWISRISSFLRTHNLELSYVLLTHWHGDHTGGVPDLLAHSPSLADKIYKNCPDAGQNPITDGQIFSVNGATVRAVFTPGHSVDHMCFQLEEENALFTGDNVLGHGFSVAQDLGRYMHSLGDMASLGCGIGYPAHGAVIGNLPEKLEEYMKHREGRERMMLSTLTREQAQGEGGRVGETKGGLTLNEIVIAMYGRVPQEVVEKALAPSLLQVLWKLAEDRRVGFKPGDPLKRRWFALDQRKRNRVRGYPS

Gene
nscB
Protein
Lactamase-like protein nscB
Organism
Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97)
Length
331 amino acids
Function
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin B, a prenylated anthracenone that probably exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576). The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (By similarity). The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (By similarity). The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (By similarity). The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (By similarity). Neosartoricin B can be converted into two additional compounds neosartoricins C and D (By similarity). Neosartoricin C is a spirocyclic compound that is cyclized through the attack of C3 hydroxyl on C14, followed by dehydration (By similarity). On the other hand, neosartoricin D is a further cyclized compound in which attack of C2 on C14 in neosartoricin C results in the formation of the acetal-containing dioxabicyclo-octanone ring (By similarity). Both of these compounds are novel and possibly represent related metabolites of the gene cluster (By similarity).
Similarity
Belongs to the metallo-beta-lactamase superfamily.
Mass
36.643 kDa
Sequence
MDQSSSGGSMGGRLPFNQSFWEEFLMGREGHLPALPEISHVSKSVVRILGGNPGSMHLQGTNTYLVGTGRSRILIDTAQGLPVWISRISSFLYTQKIELSYVLLTHWHGDHTGGVPDLISQNSSLSNRIYKNRPDSGQNPITHGQIFSVAGATVRAILTPGHSVDHMCFLLEEENALFTGDNVLGHGFSVAQDLGRYMDSLRDMASLGCRIGYPAHGAVIEKLPGKLEEYIQHREGRERMMLSALTRQRVQGEGVREGGVKCGLTLNEIVMVIYGRLPQEVIEKALAPSLLQVLWKLTEDRMVGFKPGDPLKRQWFALEQKKRNKVRGCPS

Gene
nscB
Protein
Lactamase-like protein nscB
Organism
Trichophyton tonsurans (strain CBS 112818)
Length
331 amino acids
Function
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin B, a prenylated anthracenone that probably exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576, PubMed:23368997). The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (By similarity). The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (By similarity). The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (By similarity). The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (By similarity). Neosartoricin B can be converted into two additional compounds neosartoricins C and D (PubMed:23758576). Neosartoricin C is a spirocyclic compound that is cyclized through the attack of C3 hydroxyl on C14, followed by dehydration (PubMed:23758576). On the other hand, neosartoricin D is a further cyclized compound in which attack of C2 on C14 in neosartoricin C results in the formation of the acetal-containing dioxabicyclo-octanone ring (PubMed:23758576). Both of these compounds are novel and possibly represent related metabolites of the gene cluster (PubMed:23758576).
Similarity
Belongs to the metallo-beta-lactamase superfamily.
Mass
36.643 kDa
Sequence
MDQSSSGGSMGGRLPFNQSFWEEFLMGREGHLPALPEISHVSKSVVRILGGNPGSMHLQGTNTYLVGTGRSRILIDTAQGLPVWISRISSFLYTQKIELSYVLLTHWHGDHTGGVPDLISQNSSLSNRIYKNRPDSGQNPITHGQIFSVAGATVRAILTPGHSVDHMCFLLEEENALFTGDNVLGHGFSVAQDLGRYMDSLRDMASLGCRIGYPAHGAVIEKLPGKLEEYIQHREGRERMMLSALTRQRVQGEGVREGGVKCGLTLNEIVMVIYGRLPQEVIEKALAPSLLQVLWKLTEDRMVGFKPGDPLKRQWFALEQKKRNKVRGCPS

Gene
nscB
Protein
Lactamase-like protein nscB
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
330 amino acids
Function
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin, a prenylated anthracenone that exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576, PubMed:23368997). The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (PubMed:23368997). The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (PubMed:23368997). The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (PubMed:23368997). The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (PubMed:23368997). There is no gene encoding O-acetyltransferase in the nsc gene cluster; thus, the last step of 2-O-acetylation leading to neosartoricin may be catalyzed by an unidentified O-acetyltransferase (PubMed:23368997).
Similarity
Belongs to the metallo-beta-lactamase superfamily.
Mass
36.492 kDa
Sequence
MALRMPFNQAFWEEYLSGQDATLPSLPDTSTLTSRVIRILGGNPGAMHLQGTNTYLVGTGPSRILIDTGQGLPIWLSRIVGVLQSNNISISHILLTHWHGDHTGGVPDLISYNPTLAEHVYKNLPDLGQKPIEDGQIFAVEGATVRAVFTPGHSVDHMCFLLEEENALFTGDNVLGHGFSVAPDLGRYMESLELMAKLGCVIGYPAHGAVIDDLPSKLEEYIRHKEMRVQGILSVLVKERERVEGERGKEGRRKGGMTLHEIARAMFGTVPDEVIDQAMAPFLMQALWKLTEDGKVGFEPGDPVKRKWFAVARRKTRPSIRRQHGSVTSR

Gene
nscB
Protein
Lactamase-like protein nscB
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
328 amino acids
Function
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin, a prenylated anthracenone that exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576, PubMed:23368997). The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (PubMed:23368997). The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (PubMed:23368997). The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (PubMed:23368997). The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (PubMed:23368997). There is no gene encoding O-acetyltransferase in the nsc gene cluster; thus, the last step of 2-O-acetylation leading to neosartoricin may be catalyzed by an unidentified O-acetyltransferase (PubMed:23368997).
Similarity
Belongs to the metallo-beta-lactamase superfamily.
Mass
36.083 kDa
Sequence
MALRMPFNQAFWEEYLSGQDATLPSLPDTSTLSSRVIRILGGNPGAMHLQGTNTYLVGTGPSRILIDTGQGLPIWLSRIVGVLHSNNISISHILLTHWHGDHTGGVPDLISYNPTLGEHVYKNLPDAGQKPIEDGQIFAVEGATVRAVFTPGHSVDHMCFLLEEENALFTGDNVLGHGFSVAPDLGRYMESLELMAGLGCVLGYPAHGAVIGDLPSKLEEYIRHKEMRVQGILSVLVKERERVEGDRGTEGRRKGGMTLHEIARAMFGTVPDEVIDQAMAPFLMQALWKLTEDRKVGFEPGDPVKRKWFAVARRKTKPPRQHGSVARQ

Gene
nscB
Protein
Lactamase-like protein nscB
Organism
Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892)
Length
322 amino acids
Function
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin B, a prenylated anthracenone that probably exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576). The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (By similarity). The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (By similarity). The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (By similarity). The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (By similarity). Neosartoricin B can be converted into two additional compounds neosartoricins C and D (By similarity). Neosartoricin C is a spirocyclic compound that is cyclized through the attack of C3 hydroxyl on C14, followed by dehydration (By similarity). On the other hand, neosartoricin D is a further cyclized compound in which attack of C2 on C14 in neosartoricin C results in the formation of the acetal-containing dioxabicyclo-octanone ring (By similarity). Both of these compounds are novel and possibly represent related metabolites of the gene cluster (By similarity).
Similarity
Belongs to the metallo-beta-lactamase superfamily.
Mass
35.972 kDa
Sequence
MSGRLPFSQSFWEEFLMGREGHLPVLPELSHVSKGVIRILGGNPGSMHLQGTNTYLVGTGRSRILIDTAQGLPAWINRISSFLSTQKIELSYVLLTHWHGDHTGGVPDLIARNSSLANKIYKNQPDSGQSPITHGQIFSVDGATVRAILTPGHSVDHMCFLLEEENALFTGDNVLGHGFSVAQDLGRYMDSLRDMASLGCRIGYPAHGAMIENLPGKLEEYIQHREGRERMMLSALTRHRVRGEGTRDERVKYGLTLNEIVLAVYGRLPQEVIEKALAPSLLQVLWKLTEDRMVGFKPGDPLKRQWFALEQRQRNKVRGCRG

Gene
nscB
Protein
Lactamase-like protein nscB
Organism
Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)
Length
313 amino acids
Function
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin B, a prenylated anthracenone that probably exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576). The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (By similarity). The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (By similarity). The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (By similarity). The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (By similarity). Neosartoricin B can be converted into two additional compounds neosartoricins C and D (By similarity). Neosartoricin C is a spirocyclic compound that is cyclized through the attack of C3 hydroxyl on C14, followed by dehydration (By similarity). On the other hand, neosartoricin D is a further cyclized compound in which attack of C2 on C14 in neosartoricin C results in the formation of the acetal-containing dioxabicyclo-octanone ring (By similarity). Both of these compounds are novel and possibly represent related metabolites of the gene cluster (By similarity).
Similarity
Belongs to the metallo-beta-lactamase superfamily.
Mass
34.66 kDa
Sequence
MGGRLPFNQSFWEEFLMGREGSLPNLPEISHVSKRVVRILGGNPGSMHLQGTNTYLVGTGRSRILIDTAQGLPAWIHRISSFLFTHNIELSYVLLTHWHGDHTGGVPDLIAHNPLLTNKIYKNNPDAGQNTITDGQIFSVNGATVRAVFTPGHSVDHMCFVLEEENALFTGDNVLGHGFSVAQDLGCYMDSLRNMSALACGLGYPAHGAIIENLPGKLDEYIQHREGRERMMLSTLTKELVQGQERRGEGTKGGLTLNEIVISIYGRLPQEVIEKALAPSLLQVLWKLTEDRRVGFKPGDPLKRQWFALISVE

Gene
nscB
Protein
Lactamase-like protein nscB
Organism
Trichophyton verrucosum (strain HKI 0517)
Length
287 amino acids
Function
Lactamase-like protein; part of the gene cluster that mediates the biosynthesis of neosartoricin B, a prenylated anthracenone that probably exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent (PubMed:23758576). The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone (By similarity). The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation (By similarity). The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5 (By similarity). The FAD-dependent monooxygenase nscC is then responsible for the stereospecific hydroxylation at C2 (By similarity). Neosartoricin B can be converted into two additional compounds neosartoricins C and D (By similarity). Neosartoricin C is a spirocyclic compound that is cyclized through the attack of C3 hydroxyl on C14, followed by dehydration (By similarity). On the other hand, neosartoricin D is a further cyclized compound in which attack of C2 on C14 in neosartoricin C results in the formation of the acetal-containing dioxabicyclo-octanone ring (By similarity). Both of these compounds are novel and possibly represent related metabolites of the gene cluster (By similarity).
Similarity
Belongs to the metallo-beta-lactamase superfamily.
Mass
32.255 kDa
Sequence
MHLQGTNTYLVGTGKSRILIDTAQKNCKLANQYQKGLPVWINRISSFLYTHKIELSYVLLTHWHGDHTGGVPDLISRNSSLADKIYKNRPDSGQNPITHGQIFSVDGATVRAIFTPGHSVDHMCFLLEEENALFTGDNVLGHGFSVAQDLGRYMDSLRDMASLGCRIGYPAHGAVIEYLPGKLEEYIQHREGRERMMLSALTRQRVRGEGVREEGVKCGLTLNEIVMAIYGKLPPEVIEKALAPSLLQVLWKLTEDRMVGFKPGDPLKRQWFALEQRKRNKVRGCPS