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nodal3-a

Gene
nodal3-a
Protein
Nodal homolog 3-A
Organism
Xenopus laevis
Length
401 amino acids
Function
Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer region. Acts with wnt11 to induce Spemann organizer cells and induce axis formation. The unprocessed protein antagonizes bmp-signaling.
Similarity
Belongs to the TGF-beta family.
Mass
46.301 kDa
Sequence
MAFLNLFFCLVFISPLMAMPPVLQGRKSISPDSILKDTSTDIGAREFQGRKFPNFMMQLYQNIIRGRDNDLSNLEHPTLQESDTVQSFIAKSYTTVGNRWTLFFDMSSISRSNELKLAELRICLPSFRKSHSVTVDIYHTNDGKEKLFMGSFKTKLSSALDSDCKVFNLTILLQNFLTRGKRLIKDEYIQAKGLHLKDLEKSATEKDTENVDTMKQHQYHVSDFAAERIMLVVFAKEQSHAKPDPPSLGQKLFPSKYGIDDNANKVNGFRRLRRNKKEKTQIHVSTVPPKPIEEIKPECKKVDMFVDFQKIGWGSWIIYPKAYNAYRCESTCAVPQNETENATNHSYIKSLLPLSDMERKECPSCVPMKMMSMSMLYYENEDFILRHHEEMIVEECGFKDM

Gene
nodal3-A
Protein
Nodal homolog 3-A
Organism
Xenopus tropicalis
Length
401 amino acids
Function
Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer region. Acts with wnt11 to induce Spemann organizer cells and induce axis formation (By similarity). The unprocessed protein antagonizes bmp-signaling.
Similarity
Belongs to the TGF-beta family.
Mass
45.802 kDa
Sequence
MAFLSLFLCLVFSSPLMAMPPALQGRKAISPASILKGPSTDNGARDFHGRKFPHFMMQLYQNIISRRDKDLSNLEHPTLQESDTVQSFIAKSYTTVGNHWTLFFDMSSISTSNELKLAELRICLPSFGKSHSVTVEIYHTKDTKEKLFMGSFKTKISSALDADCKVFNLTMVLHNYLIRGKRLIKDEYIQAKGLLLRDLEKSAAEKGAENVDTLKQDKYHVSDFAAERIILVVFAKERSQAKPDPPSLGKQLFPLKYGMADNANKVNGFRRLRRNKKEKTRIDVGTTPPKPVEEIKPKCRKVDMFVDFQKIGWGSWIVYPKAYNAYRCESACAVPLNETDDATNYSYIKSLLPLSDTERRECPSCVPVKMRSMSMLYYENEDFVLRHHEEMIVEECGFKDI