Protein
Nucleoid occlusion protein
Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Function
Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage.
Similarity
Belongs to the ParB family.
Sequence
MKHSFSRLFGLGDKEEEAEIAEHDTNKEEIQEIPVGDIIPNRFQPRTIFSEEKIKELAATIHTHGIIQPIVVRKTEREGQYELIAGERRWRAVQTLDWEKVPAIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQSTIANKLRLLKLPEEVQEAILKKEISERHARALIPLKQPDLQVKLLHEVIEKSLNVKQTEDRVVKMLEQDKRKPKPKRKAYSRDARIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQFTIRIPK