Protein
Nuclear hormone receptor family member nhr-6
Organism
Caenorhabditis elegans
Function
Transcriptional activator that induces gene expression by binding to the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:20506374). Required for proper morphogenesis of the spermatheca and the spermatheca-uterine valve formation (PubMed:18096150, PubMed:25529479). Promotes cell proliferation and differentiation of the spermatheca precursor cells during spermatheca development in larval stage L4 (PubMed:18096150, PubMed:25529479). Might play a role in promoting G1/S phase progression in the spermatheca precursor cell lineage (PubMed:25529479). Also required for the differentiation of the spermatheca-uterine junction core (sujc) cells which are generating the spermatheca-uterine valve (PubMed:18096150).
Similarity
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Sequence
MEQLSIQTDELQDQFSNCSPASVDSSYSSCSSVEDEIEIYTRLVRNEEPLRRDFFREMSKNSSCSSSFDYGEFGPSSSSRKGSKTTDADLDSLFHSLVETSDQVNTVPKPTKTEVESIPEEFEQKPSSSSHRLPSEMNASITHIKSELDPTMQAFQMPHNDLFLATAAPHYNPFALSNDFMPNPLMPSFTSPFYPQHFPVSDSRRGSQGTTSSSNNTGGTPSPHSSSLPTSPPQLQGFLRSFLNPDNLSTPTSFGVPSETALDADKMCAVCNDRAVCLHYGARTCEGCKGFFKRTVQKNSKYTCAGNKTCPIDKRYRSRCQYCRYQKCLEVGMVKEIVRHGSLSGRRGRLSSKTKLARSEDQPSPPLPLLALMGKAIEDHTNMTVVRQFMQPFDETIALRILHGELHATKKLLMAMPQISEIQPADFQILLSRSFFAIMAIRVANRCGNSTDTIMFESGELFSLNAFPACFQQIIRFMVDKARTFSSLVDWEPQAFAAFIALQFLAGNTEHNVLGLTNKPLVDQVQSTIINALKDHCSGSQNKLAKIVRLTQEFDVFHALGLQALDILYPSHQLPEEFMFLINLTRAPLRSTDAPPACGSPVAPSGSSLFNFQMGPAAF