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nhej1

Gene
nhej1
Protein
Non-homologous end-joining factor 1
Organism
Danio rerio
Length
309 amino acids
Function
DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination.
Similarity
Belongs to the XLF family.
Mass
34.182 kDa
Sequence
MEAVLSALPWVPVNISGSDLLAKAWFGDSQYRVLLTDLSTVWEEEMSTDDIQSRAQDLNKRLRAPAQAFFSHLCSVARPCFSGLDEDQISAAQAALEQHGESLTVKLKSELAGLPFYWEFRCTTTPVAVVCRQLVRPLLAMTLVLQRQAEDLAALLARKDAEIQDYQENGAVLSRARLQTEPFEVHQYKENFITQILPQMNVTLDSLGFDSELQALYMAVNSGKTGRKRKHSPDSSPAAQENHITDHQHISESTDVGPSLASQEHNNAKESGRSQVANSQQTLPLSSTAGSEDRSTSRAKKKKAVGLFR

Gene
Nhej1
Protein
Non-homologous end-joining factor 1
Organism
Rattus norvegicus
Length
304 amino acids
Function
DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary. Binds DNA in a length-dependent manner.
Similarity
Belongs to the XLF family.
Mass
33.885 kDa
Sequence
MEELEQGLLMQPWAWLQLAENSLLAKASITKHGYALLISDLQQVWHEQVDTLEVSQRAKELNKRLTAPPAAFLHHLDEVLRPLFKDSAHQDAAHPSKATFSCDRGEEVLILRVRSELSGLPFNWHFHCLPASSLLVSQHLICPLMGVSLALHSHVRELAALLRMKDLEIQAYQESGAVLSRGRLKTEPFEENSFLEQFMVEKLPEACAVGDGRPFAMNLQSLYVAVTKQQVQARQKHKGSGEPQTSSSTSPQGTDSQLQNQPEQQISPTPTLSEPECEPMAASGPVHRAQLVKAKRKKPRGLFS

Gene
NHEJ1
Protein
Non-homologous end-joining factor 1
Organism
Homo sapiens
Length
299 amino acids
Function
DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17470781). Binds DNA in a length-dependent manner (PubMed:17317666).
Similarity
Belongs to the XLF family.
Mass
33.337 kDa
Sequence
MEELEQGLLMQPWAWLQLAENSLLAKVFITKQGYALLVSDLQQVWHEQVDTSVVSQRAKELNKRLTAPPAAFLCHLDNLLRPLLKDAAHPSEATFSCDCVADALILRVRSELSGLPFYWNFHCMLASPSLVSQHLIRPLMGMSLALQCQVRELATLLHMKDLEIQDYQESGATLIRDRLKTEPFEENSFLEQFMIEKLPEACSIGDGKPFVMNLQDLYMAVTTQEVQVGQKHQGAGDPHTSNSASLQGIDSQCVNQPEQLVSSAPTLSAPEKESTGTSGPLQRPQLSKVKRKKPRGLFS

Gene
Nhej1
Protein
Non-homologous end-joining factor 1
Organism
Mus musculus
Length
295 amino acids
Function
DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary (PubMed:17360556). Binds DNA in a length-dependent manner (By similarity).
Similarity
Belongs to the XLF family.
Mass
32.739 kDa
Sequence
MEELEQDLLLQPWAWLQLAENSLLAKVSITKHGYALLISDLQQVWHEQVDTSVVSQRAKELNKRLTAPPAALLCHLDEALRPLFKDSAHPSKATFSCDRGEEGLILRVQSELSGLPFSWHFHCIPASSSLVSQHLIHPLMGVSLALQSHVRELAALLRMKDLEIQAYQESGAVLSRSRLKTEPFEENSFLEQFMAEKLPEACAVGDGKPFAMSLQSLYVAVTKQQIQARQAHKDSGETQASSSTSPRGTDNQPEEPVSLSSTLSEPEYEPVAASGPMHRARLVKSKRKKPRGLFS