Protein
Low-affinity Na(+)/H(+) antiporter NhaS1
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Function
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Might be able to function at relatively high concentrations of Na(+) ions. Has also Li(+)/H(+) antiport activity under K(+)-rich conditions, but it might not have any physiological relevance.
Similarity
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Sequence
MDTAVNESLSISYNLEQFLIVLSVSLSIATLSKTVPILRKIPYTLLLVIVGMALAFVDVKLINLSPELIMEIFLPPLLFEAAWNLQWRNLKENWFPITLFATLGVVICVVGIAFPLSYWGGMELAIAFLAAAALSATDPVSVIALFKELGASKKLNTLMEGESLFNDGVAVVVFLILVGIPLGTSTFDLSVTLARFVTVIGIGVGCGLVIGFSLSLLTQRFDLPFVEQSLTLVSAYGAYILAENLGGSGVIGVVVVGMVLGNYGSRIGMNPRTRLIVSIFWEFVAFFVNSIIFLLIGDQIGLSSLSDHLNLILIAIAAVVVTRLVSVFGLSLISNKVSDQISSTHITLQEQTVLWWGGLRGSVAIAVALSVPQAIAERQAIIDIVFGVVLFTLLVQGLTTQFVLKGLDLIGDQPQRLEYAELVSRQIALRRVLAELEKTDEFPDINPERLRYKQELVQGQLQSVTDKLKLLLQEYPLLQEVANKKFDQTVLDIEAETYADLIRMGRLEENIMPLLVTLEGENVAEPS