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nep1

Gene
Nep1
Protein
Neprilysin-1
Organism
Drosophila melanogaster
Length
849 amino acids
Function
Metalloendoprotease which functions in fertility and memory formation (PubMed:24395329, PubMed:27629706). Required in the dorsal paired medial neurons and alpha/beta mushroom body neurons for the proper formation of long-term and middle-term memories (PubMed:27629706). Required in males to maximise egg-laying in female mates and is also required in females for their fertility (PubMed:24395329).
Similarity
Belongs to the peptidase M13 family.
Mass
96.534 kDa
Sequence
MSQQHEATAAAAEKPLNNGYLQANAPLEELSATVVSPLLGQQQVQHQAPHQMQQQQQQQQQNKLPTVVFLAPDGSGGVGIQRGNPAQGNPGMVTGTGSHSDWLLKESQQRRRLLVLAIAFTVLGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWSPPADLSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDRRAYHRYMTQVALLLGADPATAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALGPGIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW

Gene
nep1
Protein
Aspartic proteinase nepenthesin-1
Organism
Nepenthes gracilis
Length
437 amino acids
Function
Extracellular proteinase found in the pitcher fluid of carnivorous plants. Digest prey for nitrogen uptake.
Similarity
Belongs to the peptidase A1 family.
Mass
46.357 kDa
Sequence
MASSLYSFLLALSIVYIFVAPTHSTSRTALNHRHEAKVTGFQIMLEHVDSGKNLTKFQLLERAIERGSRRLQRLEAMLNGPSGVETSVYAGDGEYLMNLSIGTPAQPFSAIMDTGSDLIWTQCQPCTQCFNQSTPIFNPQGSSSFSTLPCSSQLCQALSSPTCSNNFCQYTYGYGDGSETQGSMGTETLTFGSVSIPNITFGCGENNQGFGQGNGAGLVGMGRGPLSLPSQLDVTKFSYCMTPIGSSTPSNLLLGSLANSVTAGSPNTTLIQSSQIPTFYYITLNGLSVGSTRLPIDPSAFALNSNNGTGGIIIDSGTTLTYFVNNAYQSVRQEFISQINLPVVNGSSSGFDLCFQTPSDPSNLQIPTFVMHFDGGDLELPSENYFISPSNGLICLAMGSSSQGMSIFGNIQQQNMLVVYDTGNSVVSFASAQCGAS

Gene
nep1
Protein
NEDD8-specific protease 1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
420 amino acids
Function
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as the pcu1, pcu2 and pcu4 cullins and other proteins.
Similarity
Belongs to the peptidase C48 family.
Mass
47.258 kDa
Sequence
MSSSPTVLELFDVCFKQEDVDSLKKPNWFTDVSIDYVDELIEHLWFPSYPNQANEILLLRPSLVFLLAEAAISPEELKVALPKKLMNCKYLFMPINDLDKHAAGSGGSHWSLMVASIPDGQCYYYDSLSNGKTKDCRSALARVSDLFKKKFTIECMPVQQQRNGYDCGAHVCAFTLELVRRLLHSPMPTSSMWNLSTFQPDVTAIREQLSRCLDHIINSLGTRVSGDFDEDFPTGTVFFDLESHLPLLDVALPVLPKSSDSSETSHESSNSNLKKSSESGSTNHHNNHESDKDLHHEGHHHHHHHHHHHHSHDDDPSSPAEKKQNHVPSPSEKIQDHVPSPSEKKQDRVPSPSNNKEDHLPLLSDEKLDKSAIDKIEPTPLPSVHMNSHIAKGELPKFHNSTDNPFLTPPEELVSGDFPF

Gene
NEP1
Protein
Ribosomal RNA small subunit methyltransferase NEP1
Organism
Candida albicans
Length
267 amino acids
Function
S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates the pseudouridine corresponding to position 1189 (Psi1189) in S.cerevisiae 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.
Similarity
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
Mass
29.547 kDa
Sequence
MSELKNGTTEPKKNETTQSDSKSKSTSTNKSSVPPASLVPVQPTALTSRDKTTQRLIVVLSQACLETYKMNSGGPGGDRFALLNCDDHQGLLRKMGRDIAEARPDITHQCLLTLLDSPINKAGRLQVYIQTARGVLIEVNPSVRIPRTFKRFSGLMVQLLHKLSIRSENSKEVLLKVIKNPITDHLPTKCRKVTLSFDAELKRVQDYVTTLDENESICVFVGAMARGKDNFADEFVDEKIGLSDYPLSASVACSKFCHGCEDVWGIY

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Length
232 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA (By similarity).
Similarity
Belongs to the NEP1 family.
Mass
27.169 kDa
Sequence
MSEKKRLHLIIADAELETVPEQILDHPAIVNYAKRRKRKPEKIILDSTYHHAALKQLEDGERRGRPDIVHICLLNALDSILNKEDRLRVYVHTRNDYVIYIKPETRLPRNYNRFIGLMESLFEKGAVPEDLELLRLERKTLQELINEINPDAVFVMHEEGELMIPKNFGKLLDKFKKPAVIIGGFPHGDFRSRVEGVKISLYKEPLMAWTIVNEVIVSYEWEVIKKFSTKFI

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)
Length
230 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
26.375 kDa
Sequence
MNMKEPISIILLESALELVPKELWKHPAVVKNARRRGKKPGETLLDVSLHYHAMKKLKDKEKRGRPDIVHISLLNALESPLNKEGYLRIYIHTYPGHIIFVKPETRIPRNYNRFVGLMEQLLIHGKVPPDSDDPLLYVKTMTISDLLEKINKNGIILLREHGEKEKPENIVKYAVENNYAIGIGGFPHGDYSQEIISISKAEFSIYNKPLTTWITISRVIVGAEHLYNII

Gene
NEP1
Protein
Ribosomal RNA small subunit methyltransferase NEP1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
229 amino acids
Function
S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates the pseudouridine corresponding to position 1189 (Psi1189) in S.cerevisiae 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.
Similarity
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
Mass
25.596 kDa
Sequence
MVEDSKARIGGPNNSSVTKKQEPRLYVVLCEASLETYTSNDHRTSLLNCDDHQGILRKMGRDIAEARPDITHQCLLTLLDSPINKAGLLQVYILTKKNVLIEVNPSVRIPRTFKRFSGLMVQLLHKLSIRSMESSNTHLLRVVKNPVTKYLPADCRKVTLSFDAEVMRPQEYLGDKQSVCVFVGAMARGHDSFADEYVDDKIAISNYPLSASVACSKFCHGAEDAWAII

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Length
229 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
26.88 kDa
Sequence
MEEKKRLHLIIADAELETVPPEILDHPAIVNYAKRRKKRPEKIILDSTYHHAALRQLEDGERRGRPDIVHICLLNALDSILNKEDRLRVYVHTRNDYVIYIKPETRLPRNYNRFIGLMENLFEKGAVPEDLELLRMEKKTLNELIEEINPDVVFIMHEEGELMIPKNFGKLLDKFKKPTVIVGGFPHGDFKSKVDGVKISLYREPLMAWTIVNEVIVSYEWEVIKKFKS

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)
Length
226 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
25.401 kDa
Sequence
MISMLLADSELELVPREIVGYPAVRLNARKRNKSPAKSILDASLHHSAMRALPMGDRRGRPDIVHVFLLVALESVLNRVGQLRVYIHTRNNEMITIDPTTRIPKNYPRFVGLMESLFEKGSVPEREPLIVMQRDRDIGACIGEIPHEKVILLSPKGRRVRLSDYVKECDNALFILGGFPKGEFISDVLSEADDTISIYEESLSVWTVASEILVNYENHVLEASAPS

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Length
224 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
25.238 kDa
Sequence
MKIVFLECSVELVPRSLWSHPQVLKSARRYGIEPGDLLLDKSLHYNAMAELPAKWKRGRPDILHVALLTTTDSPLYNEGLLRIYFQVYDGRLFEVGTGVRVPKNYERFRGLVAQLLKTERVPPGEGEALIRLHSRSLAEFVEREGRFILMWEKGSPTTTTYVAARALSTGLPIGVGCFPRGEFKRSTLRKASEAYSIMGGAPLKTWGVASRIVYALERLKSPFT

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Length
223 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
25.955 kDa
Sequence
MKKRLHLIIADSELELVPESIIDHPAIVNYAKRRKKKPEKIILDSTYHHAALRQLEDGERRGRPDIVHICLLNALDSILNKEDRLRVYVHTRNDEVIYVDPSTRLPRNYNRFIGLMESLFEKKVVPEDLQLLRLEKKTLAELINEISPDAVFIMHENGEFMIPKHFGKLLASFKKPVVIVGGFPHGDFRSKVEGVKISLYREPLMAWTIVNEVIVSYEWEVIK

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Length
222 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
25.939 kDa
Sequence
MLHLVIADAELETIPEEMQADPAIRRFAKKRNKRVDRMILDSNYMHTSIDRYFPNESKRRGRPDIIYLLLEMTQESILNHKNQLRTYVHTRNNQVIRISPITRMPKSYNRFIGLFEDLFEKRIITNNGKELLSMEESSLGDLINSIRRDRTILLHPKGEMRKPSEFISNANILIVIGGFSEGDFISDTSFINERYAIFDQELTIWSVANEMVANYERAVGLT

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Length
222 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
25.904 kDa
Sequence
MLHLIVADSELETIPEEMLDDPGVRRFAKKRNKRVDRMILDSNYMHAFIDKYYPGESKRRGRPDIIYILLEMAQESILNRKNLLRTYIHTRNDFVIKISPITRMPKSYNRFIGLFEDLFEKEIITNNGKTLLSLERMKLDELLESLKKDRTILLHPKGEFKKPSEFISTEDIAAIIGGFSEGDFRSDVSNIPEKYSIFRDELTIWSVGLEIVASYERAIGLL

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Length
221 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
24.339 kDa
Sequence
MILVLAESALELVPKEIWNHPAVLADARRRGKRPGEILLDRARHHPAMRLLADAKRRGRPDIVHQVLLAFQYSLLAKRGLGKAYIHTRDDYVIAVSPEARVPKNYNNFVALIEQLFALGKVPPKGEPLMELYRKDLATLLQELGGVWAVFHESGARKPLSQMGSELLKSVVVVGGFPHGDFQNKWVVEKAAVVYSLGEESLDAAQVICKAVTAAEVAAGLL

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Length
221 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
24.304 kDa
Sequence
MILVLAESALELVPREIWSHPAVVADARRRGKKPGGILLDRSRHHPAMAVLLDSRRRGRPDIVHQALLVFQYSLLAARGLGRMYIHTLGDYVISVDPSTRVPKNYNNFVSLVEQLFATGRVPPEGRPLMEIRRQGLRDLLTELGGRWVVMHEAGLRIPLVQLGKEVLDSVVVIGGFPHGDFNNKWVLEEAAARYSLGEVAMDAAQVACRVVAAAEAAAGLL

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Length
221 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
24.08 kDa
Sequence
MILVLAEAALELVPESLWRHPAIVADARRRGKKPGEILLDRARHHVAMAKLDKAERRGRPDIVHQVLLAFQYSLLNRAGRGRAFVHTVGDYIISVKPETRVPKNYNNFVSLMEQLFKVGRVPPEGEALMEARRGSLAALLEELGGKWVALHEQGRAVSFAELGRAVADAVVVVGGFPHGDFENKWILEGAEAVYKIGNVSLDAAQAVCRAVAAAEAALGLI

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)
Length
221 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
24.891 kDa
Sequence
MIVVLAESALELVPRELWNHPVIQADAKRRGKKPGEILLDRARHHLAMSSLRDASKRGRPDIVHQVLLVFQYSLLNKRGLGRIYIHTQGDYTIYVRWETRIPKNYNNFVSLMEQLYATGRVPPKGEPLIELYKKDLSTLLRELGGRWVVLHESGVKKPFIELGAALLNSVVVIGGFPHGDFTNKWVLEKADAIYKIGDETMDAAQVVYRAITAAEVAAGLL

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta)
Length
221 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
24.355 kDa
Sequence
MILVLAESAIELVPREIWSHPAVASDARRRGKRPGEILLDRARHHPAMAGLEDGARRGRPDIVHQVLLVFQYSLLNRRGLGRVYIHTRGDYIIQVKPQTRIPKNYNNFVSLMEQLYALGRAPPHGDSLMELHRGSLAGLLEQLGGRWVVLHERGARRRFAELGAALLNSVVVVGGFPHGDFSNRWVLEKAEAVYSVGDEPLDAAQAVCRAVAAAEASAGLI

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
Length
220 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
25.073 kDa
Sequence
MLHLIIAEAELELVPESIRDHPAVVNYARRRKKRPEEAILDSTYHHAALKKLPDGDRRGRPDIVHICLLNALESIANKEGFLRVYVHTRNDEVIHIKPETRLPRNYNRFLGLMESLFKKGAVPEGLELLRIEKKPLESLIEDINPDTVFIMHEEGELIRPRSFGEILASHQNPVVVVGGFPHGDFMRPIEGTKVSLYREPLMAWTVVSEVIVNFEAALGL

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Length
220 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
25.184 kDa
Sequence
MLHLIIADSELELVPKELQNHPSIISHAKRRFKKPEEILLDSTYHHTALKSLKDGERRGRPDIVHLCLINALESILNKEGKLRVYVHTRNNEVIYIKPETRLPRNYNRFVGLMESLFKNRVIPKDLALLRIENKTLSEIIGDIGPDAVFIMHENGVLMSPQSFGRKLNEYISPAVIVGGFPHGDFLSVLEGEKISIYKEPLMAWSVVNEVLINYEGSLLW

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Length
219 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
24.974 kDa
Sequence
MKINLILLDSSLELVPKEIASHPAVIRNARKRNKKPEHTILDISLHYHAMKNLPNWRKRGRPDIVHLALLMFLTEKVPIKGEVYIHTIDGKIIYVNSDMRPPKNYNRFIGLAEQLLLHGQVPINDANPLMKILNIKLTDLKSKYKIGVLSEDGKKVKPEELCNLGENWLLGVGAFPHGDFSEEIKGVADEYFSISNYKLETHQVICRIISACLQQLGWP

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Thermococcus onnurineus (strain NA1)
Length
219 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
24.908 kDa
Sequence
MLHLVIADSELELAPKSIVDHPAIVNYAKRRNKKPEEVLLDSTYHHSALKKLEDGERRGRPDIVHVCLLNALESIANKEGKLRVYVHTRNDEVIYIKPETRIPRNYNRFVGLMESLFKNGVVPEGLELLRMEEKSLAELIDEIKPDGVFVMHENGESMKPQEFGKVLAGLQSPLVVVGGFPHGDFRSEIPGKKISLYKAPLMAWTVVNEIIINFEHWVL

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
219 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
25.308 kDa
Sequence
MGSAFVFLEASLELIPQKIRGHPAVRADAIRRGKRPEKILLDDSKHHTAMKSLEFREKRGRPDIVHQCLLLLLDSPLRDFEVYVHTLNGEIIWVNRETRLPRNYNRFVGLMEKLFEERRITAGDTTLIEFKDVGLRDIVRGRDVLLFREKGGRFEFSELLDGDVAVCIGAFPHGDFFEETLRELGEFKEVSLGTESYTSLYVTSRVLCEYERVRAHKVG

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Length
218 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
Similarity
Belongs to the NEP1 family.
Mass
24.933 kDa
Sequence
MHLNIILLEASLELVPKEIVNHPAVIKNAKRRNKKPEDTLLDISLHYHAMKYLENSHKRGRPDILHQALLVILTDPVIKGDIFIHTIQSKIIKVNPNMRPPKNYLRFIGLMEQLLKYGKIPINGDETLMEVTNLTLDNIVNRYDLILLSEKGEKINPEEICKLDEKWLLGIGAFPHGDFSDKILNLAKKIYSISGFPLETQQVLCRIFSACNSILGWP

Gene
nep1
Protein
Ribosomal RNA small subunit methyltransferase Nep1
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
205 amino acids
Function
Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of pseudouridine at position 914 (Psi914) in 16S rRNA. Is not able to methylate uridine at this position.
Similarity
Belongs to the NEP1 family.
Mass
24.082 kDa
Sequence
MTYNIILAKSALELIPEEIKNKIRKSRVYKYDILDSNYHYKAMEKLKDKEMRGRPDIIHISLLNILDSPINHEKKLNIYIHTYDDKVLKINPETRLPRNYFRFLGVMEKVLKGERNHLIKMEEKTLEDLLNEINAKKIAIMTKTGKLTHPKLLKEYDTFIIGGFPYGKLKINKEKVFGDIKEISIYNKGLMAWTVCGIICYSLSF