nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus (isolate 1A11)

Length

263 amino acids

Function

Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

30.62 kDa

Sequence

MGGTISMRRSRSTGDLRQRLLRARGETYERLLGEVEDGSSQSLGELDKGLSSLSCEGQKYNQEQYMNTPWRNPAEEREKLAYRKQNMDDIDEEDDDLVGDTVRPKVPLRTMSYKLAIDMSHFIKEKGGLEGIYYSARRHRILDIYLEKEEGIIPDWQDYTSGPGIRYPKTFGWLWKLVPVNVSDEAQEDEEHYLMHPAQTSQWDDPWGEVPAWKFDPTLAYTYEAYVRYPEEFGSKSGLSEEEVRRRLTARGLLNMADKKETR

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus (isolate K78)

Length

263 amino acids

Function

Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

30.245 kDa

Sequence

MGGAISMRRSKPAGDLRQKLLRARGETYGRLLGEVEDGSSQSLGGLGKGLSSRSCEGQKYNQGQYMNTPWRNPAEEKEKLAYRKQNMDDIDEEDDDLVGVSVRPKVPLRAMTYKLAIDMSHFIKEKGGLEGIYYSARRHRILDMYLEKEEGIIPDWQDYTSGPGIRYPKTFGWLWKLVPVNVSDEAQEDERHYLMQPAQTSKWDDPWGEVLAWKFDPTPAYTYEAYVRYPEEFGSKSGLSEEEVRRRLTARGLLNMADKKETR

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus (isolate F236/smH4)

Length

263 amino acids

Function

Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

30.36 kDa

Sequence

MGGAISKKQYKRGGNLRERLLQARGETYGRLWEGLEEGYSQSLGASGKGLSSLSCEPQKYSEGQYMNTPWRNPATERAKLGYRQQNMDDVDDEDDDLIGVSVHPRVPLRAMTYKLAIDMSHFIKEKGGLEGIYYNERRHRILDMYLEKEEGIIPDWQNYTSGPGIRYPMHYGWLWKLVPVDVSDEAQEDETHCLVHPAQTYQWDDPWGEVLAWKFDPELAYSYKAFIKYPEEFGSKSGLSEEEVKRRLTARGLLKMADKKETS

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus (isolate Mm142-83)

Length

262 amino acids

Function

Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

30.287 kDa

Sequence

MGGAISKKRSKPPRDLRQRLLRARGENYGRLFKGVEDGSSQSLGGLDKGLSSLSCEGQKYNQGEYMNTPWRNPAEERKKLPYRKQNIDDIDEEDDDLVGIPVEARVPLRTMSYKLAIDMSHFIKEKGGLEGIYYSARRHRILDIYLEKEEGIIPDWQIHSGPGIRYLKMFGWLWKLIPVNVSDEAQEDEEHYLVHPAQTSQWDDPWGEVLAWKFDPTLAYTYEAYIRYPEEFGSKSGLSEKEVKRRLAARGLLEMADRKETS

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus (isolate PBj14/BCL-3)

Length

261 amino acids

Function

Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

30.088 kDa

Sequence

MGGVTSKKQRRRGGNLYERLLQARGETYGRLWEGLEGEYSQSQDASGKGLSSLSCEPQKYCEGQFMNTPWRNPATERAKLDYRQQNMDDVDSADLVGCPVSPRVPVRIMTYKLAIDMSHFIKEKGGLEGIYYSDRRHKILDLYLEKEEGIIPDWQNYTAGPGIRYPMFFGWLWKLVPVNVSDEAQEDETHYLMHPAQTSQWDDPWGEVLAWKFDPKLAYNYKAFVEHPEEFGSQSGLSKEEVQRRLTARGLLKMADKKKTS

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 2 subtype A (isolate CAM2)

Length

260 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

29.707 kDa

Sequence

MGASGSKKRSRPLQGLQERLLRARAGTCGECYNALEGESLRSQEGSDREQNSLSCEGQRYQQGDFMNTPWRAPAAEGKKNAYRQQNMDDIDSDDDDLVGVPATPRVPLRTMTYKLAVDMSHFIKEKGGLEGLFYSERRHRILDIYLEKEEGIIADWQNYTSGPGVRYPMFFGWLWKLVPVDTSQEGEDTETDTETHCLLHPAQTSRHDDMHGETLVWKFDSMLALKYEAFTRYPEEFGHKSGLPEDEWKAKLKARGIPFS

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 2 subtype A (isolate BEN)

Length

257 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

29.911 kDa

Sequence

MGASGSKKLSKHSRGLRERLLRARGDGYGKQRDASGGEYSQFQEESGREQNSPSCEGQQYQQGEYMNSPWRNPATERQKDLYRQQNMDDVDSDDDDLIGVPVTPRVPRREMTYKLAIDMSHFIKEKGGLQGMFYSRRRHRILDIYLEKEEGIIPDWQNYTHGPGVRYPMYFGWLWKLVSVELSQEAEEDEANCLVHPAQTSRHDDEHGETLVWQFDSMLAYNYKAFTLYPEEFGHKSGLPEKEWKAKLKARGIPYSE

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 2 subtype A (isolate D194)

Length

257 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

29.449 kDa

Sequence

MGASGSKKRSEHSQGLRERLLRARGGGYVKQRNASGGESSQSQEGSGREQKSPSCEGQQYQQGEFMNTPWRTPAAIGQKNSYKQQNMDDVDSDDDDLVGVPVMPRVPLREMTYKLAIDMSHFIKEKGGLEGIFYSRERHRILDLFLEKEEGIIPDWQNYTHGPGTRYPMYFGWLWKLVPVDISQEAEEVETNCLVHPAQTSRYDDEHGETLVWRFDPMLAYSYKAFILHPEEFGHKSGLPEKEWKAKLKARGIPYSE

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 2 subtype A (isolate ROD)

Length

256 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

29.566 kDa

Sequence

MGASGSKKHSRPPRGLQERLLRARAGACGGYWNESGGEYSRFQEGSDREQKSPSCEGRQYQQGDFMNTPWKDPAAEREKNLYRQQNMDDVDSDDDDQVRVSVTPKVPLRPMTHRLAIDMSHLIKTRGGLEGMFYSERRHKILNIYLEKEEGIIADWQNYTHGPGVRYPMFFGWLWKLVPVDVPQEGEDTETHCLVHPAQTSKFDDPHGETLVWEFDPLLAYSYEAFIRYPEEFGHKSGLPEEEWKARLKARGIPFS

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 2 subtype A (isolate SBLISY)

Length

256 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

29.437 kDa

Sequence

MGASGSKKRSRPSRGLQERLLRARGGACGGLWDESEGGYSQFHEGSGREQKLPSCEGQRYQQGDFMNTPWRTPATEKEKESYRQQNMDDVDSDDDDLVGVSDTSRVPLRAMTYRMAVDMSDLIKDKGGLEGMYYSERRHRILDIYLEKEEGIIPDWQNYTHGLGVRYPMFFGWLWKLVPVTVPQEGEDTETLCLMHSAQVSRFDDPHGETLVWKFDPMLAHEYTTFILYPEEFGHKSGMEEDDWKAKLKARGIPFS

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 2 subtype A (isolate Ghana-1)

Length

255 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

29.249 kDa

Sequence

MGASGSKKHSKHSQRLRERLLRAHGGGYVQQCNASGGEYSQSQEGSGKGQKSPSCEGQQYRQGDFMNTPWRTPAIEGQKKLYKQQNMDDIDSSDDDLVGVPVTPRVPLRAMTYKLAVDMSHFIKKRGLDGMFYSRDRHRILDLYLEKEEGIIPDWQNYTHGPGVRYPMCFGWLWKLVPVDVSQEAEDDETNYLTHPAQTSRHDDEHGETLLWRFDPTLAYDYKAFILHPEEFGHKSGLPEKEWKAKLKARGIPYS

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 2 subtype A (isolate ST)

Length

255 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

29.136 kDa

Sequence

MGASGSKKRSEPSRGLRERLLQTPGEASGGHWDKLGGEYLQSQEGSGRGQKSPSCEGRRYQQGDFMNTPWRAPAEGEKGSYKQQNMDDVDSDDDDLVGVPVTPRVPLREMTYRLARDMSHLIKEKGGLEGLYYSDRRRRVLDIYLEKEEGIIGDWQNYTHGPGVRYPKFFGWLWKLVPVDVPQEGDDSETHCLVHPAQTSRFDDPHGETLVWRFDPTLAFSYEAFIRYPEEFGYKSGLPEDEWKARLKARGIPFS

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 2 subtype A (isolate KR)

Length

253 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

28.862 kDa

Sequence

MGASGSKKCSRSLQGLRERLLRARGETCGGQWDGSAGEYLQFQEGSGRGQNLPSCEGQRYQQGDFMNTPWRTPAAGREGTLYKQQNMDDVDADNDNLIGVPVTPRVPLRAMTYKLAVDISHFLNEKGGLDGMYYSERRHRILDIYMEKEEGIIPDWQNYTHGPGVRYPKFFGWLWKLVPVDVPQGEEDHCLLHPAQTSGSDDPHGETLMWRFDPRLAYEYTAFNRYPEEFGYKSGLPEEEWKAKLKARGIPFS

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 2 subtype B (isolate D205)

Length

240 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

27.406 kDa

Sequence

MGSAGSKKRSERQQGLREKLLRVPERPYGRLSGERREQSSRSPGESDKDLNSPSCEGQNARGAEGGGQQDADESDEDDEVGAICKTPIVPLRPMTYKLAVDMSHFIKEQGGLEGMYYSERRHRILDTYFENEEGIVSGWQNYTHGPGIRYPKYFGWLWKLVPVEVPAATREEEETHCLMHPAQISSWDDIHGETLIWQFDSLLAYDYVAFNRFPEEFGYQSGLPEEEWKARLKARGIPTD

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate SC)

Length

239 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

27.412 kDa

Sequence

MGGKWSKRSVVGWPTVRERMRKTEPAADGVGAASRDLEKHGAITSSNTPANNADCAWLEAQEEEEVGFPVRPQVPLRPMTYKAAVDLSHFLKEQGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGIRYPLCFGWCFKLVPVKPEKIEEANEGENNSLLHPMSLHGMEDPEREVLEWRFDNRLAFHHMARDLHPEYYKDCLTSMCLQGTFRWGISREARLGGTGEWRALRCCI

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 2 subtype B (isolate EHO)

Length

238 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

27.004 kDa

Sequence

MGSAGSKKQSKQQPGLRERLLRARRGPRGESSGERQERSLQYPGGSDKGLNSPSCDGQKTLGAEGGGKQDSDEDDEDNEVGVRVRPGVPLRPMTFKLAVDMSHFLKEKGELEGIFYSERRHKILDTYLENEEGIVSGWQNYTHGPGVRYPKFFGWLWKLVPINMIAEPEDEETHCLVHPAQTSAWDDPHEETLVWQFDSLLAYDYVAFSRFPEEFGYQSGMPEKEWKAKLRARGIPTE

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus agm.vervet (isolate AGM155)

Length

230 amino acids

Function

Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

26.528 kDa

Sequence

MGLGSSKPQHKKQLTIWRALHATRHTRYGLLADPLIGQSSTLQEECDKGLRKSLIRKRNGNMTPEGRRLQDGDQWDEWSDEEDEVGFPVRPRVPLRQITYKLAVDFSHFLKEKGGLDGIYYSDRRNKILNLYALNEWGIIDDWNAWSKGPGIRYPRCFGFCFKLVPVALHEEAETCERHCLVHPAQLHEDPDGINHGEILAWKFDPMLAVQYDPSREYFTDLYSTVGTGN

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus agm.vervet (isolate AGM3)

Length

229 amino acids

Function

Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

26.647 kDa

Sequence

MGLGNSKPQHKKQLSLWHALHKTRATRYGLLADPLIGQSSTLQEECDKALKESLIRKRNGKMTPEGRKLQEGDKWDEWSDEEDEVGFPVRPRVPLRQMTYKLAVDFSHFLKEKGGLDGIYYSDRRNQILNLYALNEWGIIDDWNAWSEGPGIRYPRCFGFCFKLVPVDLHEEAETCERHCLVHPAQVREDPDGINHGEVLVWKFDPMLAVQYDPNRKYLTDMHDLGKRK

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus agm.vervet (isolate AGM TYO-1)

Length

229 amino acids

Function

Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

26.655 kDa

Sequence

MGSQNSKPAHKKYSKLWQALHKTHVTRYGLLADPLIGTSSTVQEECDKALRKSLIRKQNGNMTEEERRLQEGDTWEEWSDDEEEVGFPVRPRVPLRQMTYKLAVDFSHFLKEKGGLDGIYYSDRRNKILNLYALNEWGIIDDWNAWSKGPGIRFPKCFGFCFKLVPVDLHEEAQTCERHCLVHPAQMGEDPDGISHGEILVWKFDPMLAIQYDPNREYFTDMHGLVKRK

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 2 subtype B (isolate UC1)

Length

225 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

25.68 kDa

Sequence

MGSAGSKKQSKQQRGLRERLLRTQEEPYGKLSEGQRKQSSRSPGGSDKDLNSPSCEGRNAPRAEGGGQQDTDDSDEDNEVGVYVRPNRPLRSMTYKMAIDMSHFIKEKGGLEGIYYSERRHRILDTYLENEEGIVSGWQNYTYGPGIRYPRTFGWLWKLVPVDIPEEERGAETSCLVHPAQISSWDDIHGETLAWRFDPLLAHDYVAFNRYPEEFGYQSGLPEKE

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus agm.grivet (isolate AGM gr-1)

Length

223 amino acids

Function

Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

25.695 kDa

Sequence

MGSSNSKRQQQGLLKLWRGLRGKPGADWVLLSDPLIGQSSTVQEECGKALKKSWGKGKMTPDGRRLQEGDTFDEWDDDEEEVGFPVQPRVPLRQMTYKLAVDFSHFLKSKGGLDGIYYSERREKILNLYALNEWGIIDDWQAYSPGPGIRYPRVFGFCFKLVPVDLHEEARNCERHCLMHPAQMGEDPDGIDHGEVLVWKFDPKLAVEYRPDMFKDMHEHAKR

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate BRVA)

Length

218 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

25.032 kDa

Sequence

MGGKWSKMAGWSTVRERMRRAEPARERMRRAEPRAEPAADGVGAVSRDLEKHGAITSSNTAATNADCAWLEAQEDEEVGFPVKPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQQRQDILDLWVYHTQGYFPDWQNYTPGPGVRYPLTFGWCFKLVPVEPEKIEEANEGENNSLLHPMSQHGMDDPEREVLQWRFDSRLAFHHMARELHPEYYKNC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF)

Length

216 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

24.567 kDa

Sequence

MGGKWSKHSVPGWSTVRERMRRAEPATDRVRQTEPAAVGVGAVSRDLEKHGAITSSNTAATNADCAWLEAYEDEEVGFPVRPQVPLRPMTYKAAIDLSHFLKEKGGLEGLIYSQKRQDILDLWIYHTQGYFPDWQNYTAGPGVRFPLTFGWCFKLVPVDPEKVEEANEGENNCLLHPMSQHGMDDPEKEVLVWKFDSKLALHHVARELHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535)

Length

215 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

24.501 kDa

Sequence

MGGKWSKSSIVGWPAIRERMRRARPAADRVGTQPAADGVGAVSQDLARHGAVTSSNTSHNNPDCAWLEAQEEEEVGFPVRPQVPLRPMTYKAAFDLGFFLKEKGGLDGLIYSKKRQEILDLWVYHTQGFFPDWQNYTPGPGIRYPLTFGWCYKLVPVDPAEVEETTEGEDNCLLHPINQHGMEDEHREILMWKFDSSLARRHVARELHPDYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate YU-2)

Length

214 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

24.533 kDa

Sequence

MGGKWSKRSMAGWPTVRERMRRAEPAAERMRRAEPAADGVGAVSRDLERHGAITSSNTAATNADCAWLEAQEEEEVGFPVRPQVPLRPMTHKAAMDLSHFLKEKGGLEGLIHSQQRQDILDLWVYHTQGYFPDWQNYTPGGTRWPLTFGWCFKLVPVEPEKIEEANAGENNCLLHPMSQHGMDDPEREGLEWRFDSRLAFHHVARELHPEYYKN

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus (isolate GB1)

Length

214 amino acids

Function

Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

24.259 kDa

Sequence

MGSSQSKKRSEAWVRYSSALRQLVGGPVTPDGYKQIESSQGAEKQSLLRGRAYGTYSEGLDKVQNDPLTKDEKLDLTQQDPEEEEEVGFPVCRQVSLRVPSYKDLIDFSHFIKEKGGLGGIYYSRRREEILDLYAENEWGFEPGWQQYTTGPGTRYPKTFGFLFKLEPVSRAIGDEYAANNHLLHSSQLCPQEDPEGETLMWSGTLILPMTLQH

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group O (isolate ANT70)

Length

213 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

24.1 kDa

Sequence

MGNALRKGKFEGWAAVRERMRRTRTFPESEPCAPGVGQISRELAARGGIPSSHTPQNNAALAFLESHQEEEVGFPVAPQVPLRPMTYKGAFDLSFFLKEKGGLEGLIYSHKRAEILDLWVYNTQGFFPDWQNYTPGPGTRFPLTFGWLFKLVPVSEEEAERLGNTCERANLLHPACAHGFEDTHKEILMWKFDRSLGNTHVAMITHPELFQKD

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group N (isolate YBF30)

Length

212 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

24.348 kDa

Sequence

MGKIWSKSSLVGWPEIRERMRRQTQEPAVEPAVGAGAASQDLANRGAITIRNTRDNNESIAWLEAQEEEEEVGFPVRPQVPLRPITYKQAFDLSFFLKDKGGLEGLVWSRKRQDILDLWMYHTQGILPDWHNYTPGPGIRYPVTFGWCFKLVPLSAEEVEEANEGDNNALLHPICQHGADDDHKEVLVWRFDSSLARRHVARELHPEFYKNC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype D (isolate Z6)

Length

212 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

24.416 kDa

Sequence

MGGRWSKSSIVGWPAIRERIRRTDPRRTDPAADGVGAASRDLEKHGAITSSNTRDTNADCAWLEAQEESEEVGFPVRPQVPLRPMTYKLAVDLSHFLKEKGGLEGLIWSKKRQEILDLWVYNTQGIFPDWQNYTPGPGIRYPLTFGWCFELVPVDPREVEEATEGETNCLLHPVCQHGMEDTEREVLKWRFNSRLAFEHKAREMHPEFYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group O (isolate MVP5180)

Length

211 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.555 kDa

Sequence

MGNAWSKSKFAGWSEVRDRMRRSSSDPQQPCAPGVGAVSRELATRGGISSSHTPQNNAALAFLDSHKDEDVGFPVRPQVPLRPMTFKAAFDLSFFLKEKGGLDGLIYSHKRAEILDLWIYHTQGFFPDWQCYTPGPGPRFPLTFGWLFKLVPVSAEEAERLGNTNEDASLLHPACNHGAEDAHGEILKWQFDRSLGLTHIALQKHPELFPK

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate OYI)

Length

211 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

24.067 kDa

Sequence

MGGKWSKCSMKGWPTIRERMKRAELQPPEPAAEGVGAASRDLEKHGAITSSNTAATNADCAWLEAQEDEEVGFPVRPQVPLRPMTYKGALDLSHFLKEKGGLEGLIYSQKRQDILDLWVYHTQGYFPDWQNYTPGPGIRYPLCFGWCFKLVPMDPDQVEEANEGENNSLLHPISLHGMDDPEKEVLVWKFDSRLAFRHMAREVHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2)

Length

210 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

24.042 kDa

Sequence

MGGKWSKRSMGGWSAIRERMRRAEPRAEPAADGVGAVSRDLEKHGAITSSNTAATNADCAWLEAQEEEEVGFPVRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYHTQGYFPDWQNYTPGPGIRYPLTFGWCFKLVPVEPEKVEEANEGENNSLLHPMSLHGMEDAEKEVLVWRFDSKLAFHHMARELHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype A (isolate MAL)

Length

209 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.645 kDa

Sequence

MGGKWSKSSIVGWPKIRERIRRTPPTETGVGAVSQDAVSQDLDKCGAAASSSPAANNASCEPPEEEEEVGFPVRPQVPLRPMTYKGAFDLSHFLKEKGGLDGLVWSPKRQEILDLWVYHTQGYFPDWQNYTPGPGIRFPLTFGWCFKLVPMSPEEVEEANEGENNCLLHPISQHGMEDAEREVLKWKFDSSLALRHRAREQHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate MN)

Length

208 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.731 kDa

Sequence

MGGKWSKRVTGWPTVRERMRRAEPAELAADGVGAASRDLEKHGALTSSNTAATNADCAWLEAQEEEEVGFPVKPQVPLRPMTYKAALDLSHFLKEKGGLDGLIYSQKRQDILDLWVYHTQGYFPDWQNYTPGPGIRYPLTFGWCFKLVPVEPEKIEEANKGENNCLLHPMSQHGMDDPEREVLVWKSDSHLAFQHYARELHPEYYKNC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3)

Length

208 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.532 kDa

Sequence

MGGKWSKSKMGGWPAVRERMQKAEPAADGVGAASRDLEKHGTITSSNTAANNAACTWLEAQEDEDEEVGFPVRPQVPLRPMTFKAAVDLSHFLKEKGGLDGLVFSQKRQDILDLWVYHTQGYFPDWQNYTPGPGTRYPLTFGWCFKLVPVEPDKVEEATEGENNSLLHPICLHGMDDPEKEVLVWKFDSRLAFHHVAREKHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate SF162)

Length

208 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.685 kDa

Sequence

MGGKWSKRMSGWSAVRERMKRAEPAEPAADGVGAVSRDLEKHGAITSSNTAANNADCAWLEAQEDEDVGFPVRPQVPLRPMTYKAALDLSHFLKEKGGLEGLIYSQKRQDILDLWIHHTQGYFPDWQNYTPGPGIRYPLTFGWCFKLVPVDPDYVEEANAGENNSLLHPMSQHGMDDPEKEVLVWRFDSRLAFHHMARELHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020)

Length

208 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.917 kDa

Sequence

MGGKWSKSSIVGWPAIRERMRRTPPTPPAAEGVGAVSQDLERRGAITSSNTRANNPDLAWLEAQEEDEVGFPVRPQVPLRPMTYKGAVDLSHFLKEKGGLEGLIYSKRRQEILDLWVYHTQGYFPDWQNYTPGPGIRYPLTMGWCFKLVPVDPEEVEKANEGENNCLLHPMSQHGMEDEDKEVLKWEFDSRLALRHIARERHPEYYQD

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220)

Length

207 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.533 kDa

Sequence

MGGTMSKCSPVGWPAIRERIRRAAPAAEGVGAASRDLDKYGALTSSNTPANNPDCAWLEAQEEEEEVGFPVRPQVPLRPMTYKAAFDLSLFLKEKGGLEGLIYSKKRQEILDLWVYNTQGFFPDWQNYTPGPGVRYPLTFGWCFKLVPVDPSEVEEINEGENNCLLHPASLHGMEDEDREVLKWKFDSHLARRHMARELHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype D (isolate NDK)

Length

207 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.748 kDa

Sequence

MGGKWSKSSLVGWPAIRERIRKTDPAADGVGAVSRDLEKHGAITSSNTASTNDTCAWLEAQEESEEVGFPVRPQVPLRPMTYKEAVDLSHFLKEKGGLEGLIWSKKRQEILDLWVYNTQGIFPDWQNYTPGPGIRYPLTFGWCFQLVPVDPQEVEEATEREDNCLLHPMCQQGMEDPERQVLMWRFNSRLALEHKARELHPEFYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype G (isolate SE6165)

Length

207 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.549 kDa

Sequence

MGGKWSKSSIVGWPEVRERIRNTPTAAEGVGAVSQDLDRHGAITSSNTAANNPDCAWLEAQEEDSEVGFPVRPQVPLRPMTFKGAFDLSFFLKEKGGLDGLIYSKKRQEILDLWVYNTQGYFPDWQNYTPGPGTRFPLTFGWCFKLVPMDPAEVEEANKGENNSLLHPICQHGMEDEDREVLVWRFDSSLARRHIARELHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype H (isolate VI991)

Length

207 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.703 kDa

Sequence

MGGKWSKGCISGWPAVRERIRQTEPAAEGVGAVSQDLDRRGAVTINNIASNNADSAWLEAQEEEEEVGFPVRPQVPLRPMTYKGAFDLSHFLKEKGGLEGLIYSKKRQEILDLWVYNTQGYFPDWHNYTPGPGERYPLTFGWCFKLVPVDPQDVEKANEGENNSLLHPMCQHGIEDPEREVLMWKFDSRLALRHRAKELHPEFYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group N (isolate YBF106)

Length

207 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.722 kDa

Sequence

MGKIWSKSSLVGWPEIRERIRRQTPEPAVGVGAVSQDLANRGAITTSNTKDNNQTVAWLEAQEEZEVGFPVRPQVPLRPMTYKAAFDLSFFLKEKGGLEGLVWSRKRQEILDLWVYHTQGFFPDWQNYTPGPGVRYPLCFGWCFKLVPLSEEAVEEANEGDNNALLHPICQHGVDDDHKQVLVWRFDSSLARRHVAKELHPDFYKNC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus (isolate K6W)

Length

207 amino acids

Function

Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes (By similarity).

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.853 kDa

Sequence

MGGAISMRRSKPAGDLRQKLLRARGETYGRLLGEVEDGSSQSLGGLGKDLSSRSCKGQKYNQGQYMNTPWRNPAEEKEKLAYRKQNMDDIDEEDDDLVGVSVRPKVPLRAMTYKLAIDMSHFIKEKGGLEGIYYSARRHRILDMYLEGIIPDWQDYTSGPGIRYPKTFGWLWKLVPVNVSDEAQEDERHYLMQPAQTSKWDDPWERF

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083)

Length

207 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.553 kDa

Sequence

MGGKWSKSSIVGWPQIRERIRQTPVAAEGVGAVSQDLARHGAITSSNTATNNPDCAWLEAQEEDSDVGFPVRPQVPLRPMTYKAAFDLSFFLKEKGGLDGLIYSKRRQDILDLWVYNTQGFFPDWQNYTPGPGTRLPLTFGWCFKLVPMDPAEIEEANKGENISLLHPICQHGMEDEDREVLVWRFNSSLARRHLARELHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype D (isolate ELI)

Length

206 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.613 kDa

Sequence

MGGKWSKSSIVGWPAIRERIRRTNPAADGVGAVSRDLEKHGAITSSNTASTNADCAWLEAQEESDEVGFPVRPQVPLRPMTYKEALDLSHFLKEKGGLEGLIWSKKRQEILDLWVYNTQGIFPDWQNYTPGPGIRYPLTFGWCYELVPVDPQEVEEDTEGETNSLLHPICQHGMEDPERQVLKWRFNSRLAFEHKAREMHPEFYKN

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)

Length

206 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.469 kDa

Sequence

MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate HXB3)

Length

206 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.419 kDa

Sequence

MGGKWSKSSVVGWPAVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAANNAACAWLEAQEEEKVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGIRYPLTFGWRYKLVPVEPEKLEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate LW123)

Length

206 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.414 kDa

Sequence

MGGKWSKSSVIGWPTVRERMRRAEPAADGVGAASQDLEKHGAITSSNTAATNADCAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGIRYPLTFGWCYKLVPVEPEKLEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus (isolate EK505)

Length

206 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.741 kDa

Sequence

MGKVWSKSSLVGWPQVIDRMRRQQDPAEGVGAVSQDLANRGAITIRNTKENNQALAWLEEQKEEAVGFPVCPQVPLRPMTYKEAFDLSFFLREKGGLEGLVWSTKRQEILDLWVYHTQGIFPDWQNYTPGPGVRYPLTFGWCFKLVPLSPEEVEEANQGDNNVLLHPMCQHGMEDPDKEVLVWRFDSSLARVHRARELHPEFYQNC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus (isolate MB66)

Length

206 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.774 kDa

Sequence

MGGKWSKSSLVGWPEVRDRLRRTQTAAEGVGPVSRDLARHGAITSRNTSQTNETLAWLEEVQNEEVGFPVRPQVPLRPMTFKGAFDLSHFLKEKGGLEGLVYSKKRQEILDLWVYHTQGFFPDWQNYTPGPGIRYPLTFGWCFKLVPLEPEEVERANEGDNNILLHPICQHGQEDEAREVLVWTFDSRLALKHRARELHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate PCV12)

Length

206 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.366 kDa

Sequence

MGGKWSKSSVVGWPAVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAANNAACAWLEAQEEEKVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGIRYPLTFGWCYKLVPVEPEKLEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056)

Length

206 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.498 kDa

Sequence

MGGKWSKSRMGGWSTIRERMRRAEPVAEGVGAVSRDLDRRGAVTINNTASTNRDAAWLEAQEDGEEVGFPVRPQVPLRPMTYKGAFDLSHFLKEKGGLDGLIYSKQRQDILDLWVYNTQGYFPDWQNYTPGPGERFPLTFGWCFKLVPVNPQEVEQANEGENNSLLHPMSLHGMEDDGREVLMWKFDSRLALTHLARVKHPEYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025)

Length

206 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.511 kDa

Sequence

MGNKWSKCSTVGRPAIRERMRRAPAAEGVGPASQDSDKYGALTSSSTPANNADCAWLEAQQEEEEVGFPVRPQVPLRPMTYKAVVDLSFFLEEKGGLEGLIYSKKRQDILDLWVYNTQGYFPDWQNYTPGPGVRFPLTFGWCFKLVPVDPREVEEANTGENNSLLHPMSLHGMEDSHREVLQWKFDSLLARRHMARELHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11)

Length

206 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.561 kDa

Sequence

MGGKWSKSSIVGWSTVRERMRKTPPAADGVGAVSQDLDKHGAVTSSNTAFNNPDCAWLEAQEDEDVGFPVRPQVPLRPMTFKGAFDLGFFLKEKGGLDGLIYSKRRQEILDLWVYHTQGFFPDWQNYTPGPGIRYPLTFGWCYKLVPVDPREVEEATEGENNCLLHPVNQHGMEDEHREVLKWKFDSSLARKHVAREMHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate BH10)

Length

206 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.352 kDa

Sequence

MGGKWSKSSVIGWPAVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAANNAACAWLEAQEEEKVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGIRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)

Length

206 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors (PubMed:14990729).

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.342 kDa

Sequence

MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate SF33)

Length

205 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.318 kDa

Sequence

MGGKWSKSKMGWPAVRERMKRAEPAADGVGAASRDLEKHGALTSSNTAATNADCAWLEAQEDEEVGFPVKPQVPLRPMTYKAALDLSHFLKEKGGLEGLVYSQKRQDILDLWIYHTQGYFPDWQNYTPGPGVRFPLTFGWCFKLVPVEPEKVEEANEGENNSLLHPMSLHGMEDPEKEVLVWKFDSHLAFRHMARELHPEYYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype A (isolate U455)

Length

205 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.253 kDa

Sequence

MGGKWSKKSRVEWPEVRKRMRETPAAAKGVGAVSQDLDKYGAVTSSNTSSTNASCAWLEAQEEGDVGFPVRPQVPLRPMTYKAAFDLSFFLKEKGGLDGLIHSQKRQEILDLWVYHTQGFFPDWQNYTPGPGIRYPLTFGWCYKLVPVDPAEVEEATGGENNSLLHPICQHGVDDEEKEVLMWKFDSTLALKHRAYELHPEFYKD

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850)

Length

205 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.356 kDa

Sequence

MGGKWSKSSIVGWPAVGERMRQTPTAAEGVGAVSRDLDRRGAITSSNTRTTNPDLAWLEAQEEEEVGFPVRPQVPVRPMTYKAAVDLSHFLKEKGGLEGLIYSKKRGDTLDLWVYHTQGYFPDWQNYTPGPGIRYPLTLGWCFKLVPVDPEEVEKANEGENNCLLHPMSQHGMEDEDREVLRWKFDSSLALRHIARERHPEFYQD

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype A (isolate Z321)

Length

205 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.306 kDa

Sequence

MGNKWSKGWPAVRERIRQTPPAPPAAEGVGAASQDLAKHGAISSSNTATNNPDCAWLEAQEESEEVGFPVRPQVPLRPMTFKGAFDLSFFLKEKGGLDGLIYSKKRQEILDLWVYHTQGFFPDWHNYTPGPGTRYPLCFGWCFKLVPVDPREVEEANTGENNCLLHPMSQHGMDDDEREVLMWKFDSSLARKHLAREMHPEFYKD

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Simian immunodeficiency virus (isolate CPZ GAB1)

Length

205 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.85 kDa

Sequence

MGTKWSKSSLVGWPEVRRRIREAPTAAEGVGEVSKDLERHGAITSRNTPETNQTLAWLEEMDNEEVGFPVRPQVPTRPMTYKAAFDLSHFLKEKGGLEGLVYSRRRQEILDLWVYHTQGFFPDWQNYTTGPGTRFPLCFGWCFKLVPLTEEQVEQANEGDNNCLLHPICQHGMEDEDKEVLVWRFDSRLALRHIAREQHPEYYKD

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate BH8)

Length

205 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.305 kDa

Sequence

MGGKWSKSSVVGWPAVRERMRRAEPAADGVGAVSRDLEKHGAITSSNTAATNADCAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIHHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPEKEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHMARELHPEYFKNC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype J (isolate SE9173)

Length

204 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.122 kDa

Sequence

MGNKWSKSWPQVRDRMRRAAPAPAADGVGAVSQDLAKHGAITSSNTAATNDDCAWLEAQTEEEVGFPVRPQVPLRPMTYKGAFDLSFFLKEKGGLDGLIYSKKRQEILDLWVHNTQGYFPDWQNYTPGPGTXYPLTFGWCFKLVPVDPSEVEEANEGENNCLLHPACQHGIEDEEREVLKWKFDSSLARRHIARELHPEFYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (strain 89.6)

Length

204 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.382 kDa

Sequence

MGGKWSKRRAEGWQTIRERMRRAEPAEPAADGVGAVSRDLARHGAITSSNTNNADIAWLEAQEEGEVGFPVRPQVPLRPMTYKAAVDLSHFLKEKGGLEGLVHSQKRQDILDLWVYHTQGFFPDWQNYTPGPGIRYPLTFGWCYKLVPVEPDEGENNREDNSLLHPANQHGVEDSERQVLVWRFDSRLAFHHVARELHPEYFKN

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype J (isolate SE9280)

Length

203 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.074 kDa

Sequence

MGNKWSKSWPQVRERMRRAPAPAADGVGAVSQDLAKHGAITSSNTAATNADCAWLEAQTEEEVGFPVKPQIPLRPMTYKGAVDLSFFLKEKGGLDGLIYSKKRQEILDLWVHNTQGYFPDWQNYTPGPGIRYPLTFGWCYKLVPVDPSEVEEANEGENNCLLHPICQHGIEDEEREVLQWKFDSSLARRHIARELHPEFYKDC

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate Lai)

Length

202 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

23.033 kDa

Fragment

single

Sequence

MGGKWSKSSVVGWPAVRERMRRAEPAADGVGAVSRDLEKHGAITSSNTAATNADCAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPEPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTRLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEY

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257)

Length

200 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

22.866 kDa

Sequence

MGGKWSKSSIVGWPAIRERIRAAEGVGAVSQDLDKRGAITNSNTGATNADLAWLEAQEEEVGFPVRPQVPLRPMTYKAALDLSHFLKEKGGLEGLIYSRKRQEILDLWVYHTQGYFPDWQNYTPGPGPRFPLTFGWCFKLVPVDPEEVEKANEGENNCLLHPMSLHGMEDDDKEVLKWQFDSRLALRHIARERHPEYYKD

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255)

Length

200 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

22.946 kDa

Sequence

MGGKWSKSSIVGWPNVRERMRAAEGVGKVSQDLDKHGAITSSNTRATNADLAWLEAQEEEVGFPVRPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIYSKKRQEILDLWVYHTQGYFPDWQNYTPGPGIRYPLTLGWCFKLVPVDPEEIEKANEGENNCLLHPISLHGMEDEDREVLRWKFDSSLALRHVARERHPEFYQD

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 2 subtype A (isolate NIH-Z)

Length

180 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

20.409 kDa

Sequence

MGASGSKKRSKPLQGLQERLLQARGETCGGRCNESGGGYLQSHEGSGREQNSPSCEGQRYQQGDFVNTPWRTPAAEREKELYKQQNMDDVDLDDDDQVGFPVTPRVPLRPMTFKLAVDMSHFIKEKGGLEGLFYSQRRHRILDLYLDKAFTLYPEEFGHNSGLPEKEWKARLKARGIPFS

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34)

Length

97 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

10.592 kDa

Fragment

single

Sequence

MGGRWSKSSIVGWPAIRERIRRTDPAADGVGAVSRDLEKHGAITSSNTRGTNADCAWLEAQEESEEVGFPVRPQVPLRPMTYKGALDLSHFLKEKGG

Protein

Protein Nef: nef

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype B (isolate JH32)

Length

17 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

1.901 kDa

Fragment

single

Sequence

MGGKWSKRSVVGWPAVR

Gene

nef

Protein

Protein Nef

Organism

Human immunodeficiency virus type 1 group M subtype D (isolate Z84)

Length

9 amino acids

Function

Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.

Similarity

Belongs to the lentivirus primate group Nef protein family.

Mass

0.967 kDa

Fragment

single

Sequence

MGGKWSKSS