mylipb

E3 ubiquitin-protein ligase MYLIP-B

464 amino acids

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway (By similarity).

52.661 kDa

MLCHITRPDSVVLEVEVDPKANGEDILNKICQKMGIIEVDYFGLQFTGTKGESLWMNLRNRICQEVDCVSPCRLRLRVKFFVEPHLILQEQTRHLFLMHVKEEIIKGSLRLDAEQAIELCALLAQAEFGDYKQNTAKYCYSQIYGQDPSHDTINTISLKHKSLEGVSQASAEYQALQLVSSLTYYGVEWHFARDSEGQQLLIGVGQEGLFVCKSDFTPIERLMYPVIQMATQSGRNVYVTITKDNGDSVVLLFKFVSPSAANGLYRAITEIHAFYRCDTVMSTVKMQYSRDFKGHLASLFLNESIDLGKRYIFDIQRTSKEVYDRTRRALFNAGVSVNGRGISRSLLRQTKVDREERMCVDCRETHVLKEKLQRLQEALTCALCCEQEISAAFCPCGHMFCCYNCASQLQCCPVCRSEVDRVQHVYLPTCASLLGLAEAKTTNSVLRRTGISEDCANKENARQM