Protein
Mycosubtilin synthase subunit B
Organism
Bacillus subtilis
Function
This protein is a multifunctional enzyme, able to activate and polymerize the amino acids Tyr, Asn, Gln and Pro as part of the synthesis of mycosubtilin. The Asn and Gln residues are further epimerized to the D-isomer form. The activation sites for these amino acids consist of individual domains.
Similarity
Belongs to the ATP-dependent AMP-binding enzyme family.
Sequence
MSVFKNQVTYWANLFDEEDSLSVIPYFKTAENASLTRVGYQEKSIYRSLSPEVSQRILTMANHSEMATYLILLAGIECLLYKYTDRASTILGIPTVSKQKSSSSTVNTIVLLKNTLSCQSTFKTVFEQLKKAVNDSLKNQNLPFRKIVQHVNVQYDNENIPLIHTVVSLNEIHSLQFKEDIATDTLFHFDLENSEIHLKLIYNGNLYDEDYMDQMVSHLNQLLSVILFQPQAAIHTAEGIPEAVKQQILFDFNDTAADYSGNKTVSQLFEEQAERTPDHVAVKFVNNHMTYRELNEKSNRLARTLRNYGVQADTLVAIMAERSLEMIVSIMAIWKAGGAYVPLDPEYPEERLQYVLNDANADVLVVQRHFKNSLVFDGPMIDLNDETSYHADCSLLSPIAEHSHLAYVIYTSGTTGKPKGVMVEHGGIVNSLQWKKAFFKHSAEDRVLVLYPYVFDAFILNFFGPLISGAALYLLPNEDNKDLFAIQNVLKLERITHFSTSPRLLQAMTEQMNAEDFYHVQHVVVGGEKLEPDTVERLFSLQPQIRINNEYGPTENSVVSTFQPVYSADEQITIGKPVANHQAYILGAHRQIQPIGVPGELYVGGSGVARGYLNQPDLTEEKFVDHLLIPRRKMYKTGDLARWLPDGRIEYLGRIDHQVKIRGYRIELGEVEAALSNLEEVRETTVESREGIDGTKQLYAYYVGEPSLSAGQFREILSRELPDYMIPSYFIHLERIPLTSNGKIDLKALPVADEKTRMENEYIAPQNSIEELLASIWQEVLGTERIGILDNFFDFGGDSIKSIQVSSRLYQSGYKIDMKHLFTYPTIAELSPFVEPVGRMADQGEVKGRTSLTPIQHWFFEQNMPHANHYNQAVMLYSAQGFKETPLRRAIESIAVHHDALRMVFEETPNGYTARIAGTEESKLYQLEVMNCKEDADPAHAVANKANQIQSSMELSQGPLMKLGLFKCADGDHLLIAIHHLVIDGVSWRILLEDFASSYEQAERGQMVRLPQKTDSFPFWAEQLSKYAQETDREQELAYWNELARLELEPLPKDNAVEDSLLKDSGDVTIQWTREETQQLLKQANRAYNTEINDLLLTSLGLAVHRWTGMEEVVVNLEGHGREPVIPDVDITRTVGWFTSQYPVVLKMEAGKELSQRIKTVKEGLRRVPNKGMNYSVIQYLSGRAEADSLQLHPEIRFNYLGQFDQDLQQHALQISPYSTGVSLNENQPRTAVLDLNGMVAEGKLSLSLSYSHKQYERSTMEQFARSLKESLQEIIVHCVNQQQTSLTPSDVLLKDIKIDELEELLDQTRELGEVENIYPLTPMQKGMLFHSLFDSHSGAYFQQTMFELHGDLDIDSFSKSLDDLSKRYEIFRTNFLKGKDQPLQIIFKTKKIGFQFIDLREMDQARQDDRICAYAKEDKLRGFDLAKDVLMRVIVLRTDDTTYRFIWSFHHILMDGWCLPLITKEIFDHYFALLQQKQPEQAAITPYSQYIEWLDRQDAEEAKRYWDQYLEGYEEQTVLLKDSHQAEDEHYFPEKVSCAIDTDLTLKMKQTASKHHVTLNTLLQTAWGILLQKYNRSRDVVFGSVVSGRPSAIPNVETMIGLFINTIPVRIQCEAGTTFAELMKRTQERAVASQTYETYPLYDIQALTTQKQNLITHLMIFENYPVDQYMESIGQHNESPIDISNVKMEEQTNYHLNVTVIPGDVININFEYNAKVYDRESMERVRGHLLQILHQVVADADIRVEQLEMLTEGEKRQLLQNLNDTAAPYPQSTVGQWFEAQSQQIPDQAAVIDGDKQITYRQLNERANRLARTLRARGVQADQPVATISRNSIELVTGILAILKAGGAYVPIDPEYPQDRIQYILEDSKAGIILMPRDVRQQITYEGVVILLDEESSYHEEAFNLEPLSNANHLAYVIYTSGSTGKPKGVLIEHRGLSNYIWWAKEVYVKNEKTNFPLYSSISFDLTVTSIFTPLVTGNTIIVYDGEDKTALLSSIVQDQRVDIIKLTPAHLHVLKAMNIANKIAIRKMIVGGENLSTQLAQSIHEQFDGQIEICNEYGPTETVVGCMLYRYDAVKDRRESVPIGTAAANTSIYVLDEDMKPVPIGVPGEMYISGAGVARGYLNRPELTAEKFVENPFVTGERMYKTGDLAKWLPDGNIEYLGRMDEQVKIRGFRIELGEIETAMLQAEEIKEAVVTAREDVHGLKQLCGYYVSSQPITVSQIREQLSQSLPGYMIPAYFIKLEKMPLTPNGKINQKELPTPDLQLQDRVAYKPPRTQVEQLLVSTWESVLGAEKIGILDNFFDLGGDSIKSIQVSSRLNQLGYKMEIKHLFQYATIAELSPHIEQNVRIPDQDEVKGKVSLTPIQHWFFEQTTTDPHYYNQAVMLYAPQGFSGIAASPNATKAWRAPRCVRMTFQATEHGYEAWNAEITQSELYHLDVINLKTEADPGPAIEAKANQIQSSMQLSNGPLMKAGLFQCADGDHLLIAIHHLIVDGISWRILMEDIVSGYKQAENGQDIQLPYKTDSFRLWAEKLSAYAQSDAIKQEQEYWARIEQTDVKPLPKDFQESHAFSIDSETVTVEWTKEETEQLLKQANRAYNTEINDLLLSSLGLSISHWSGLEQIALHLEGHGREQVIPNMDISRTVGWFTSLFPVVLHIEPGKEISHYIKTAKEELRQIPHKGIGYGVLRYLSGSTTPLPAKMTPEISFNYLGQFDQDIQNQAVQLSSYSCGSDSSGNQIRPYVLNINGMIVNDRLMVTISYSTKQYAKETIDQLSAIIQNNLRTVIEHCVHKEQTELTPSDILLKGMAIDELDQLLIQLPDAGEIENVYPLTPMQKGMLFHSLLDEDSNSYFEQASFDLQGELKIDRFEASLDHLFAKYAVLRTRFYSGWNDIPLQIVYKTQRMKVHFTDLRDIDENQRKDEIASYQSEDKAKGFDLARDPLMRIAIFRIEERKYHLIWSFHHIVMDGWCLPLITKEAFEHYIGLQEGRETDLAYTDPYSKYIEWLDQQDQNAAKRYWREYLEGYKGETRILHKRPQHERKAYAYANEICRFNQKQTRQLQRIANQHHVTLNTLIQTLWGILLQKYSGTGDVVFGSVVSGRPAEISGVEQMIGLFINTIPVRICCDEGSSFVETMKMVQDNALASQSYDTYPLYEIQAQTEQKQNLIDHILIFENYPIGQQVEEGHNAAELNIMNFHMEEHSHYDFNMVVIPGEQLNVHFGYNQNVYEQSEVERISGHFEQLMHQVLEHPNIKVEELELLTQQEKEQLLSRFQAREMQYSREQTIHERFSKQAFRTPDRTAVVFEGESLTYGELNKRANQLAQALRVEGVQAGQLVGIMAERSLEMIIGIFGILKAGGAYLPIDPDSPVERIHYIARDSGINILLTHGELPENLNFSGTCINMKEEQAYHETDINLAVPCQFDQLAYCIYTSGTTGTPKGTPKGTLIEHRQVIHLIEGLRNAVYSAYDGVLHVAMLAPYYFDASVQQIYASLLLGHTLFIVPKEAVSDGEALCQYYRQHRIDVTDGTPAHLKLLVAADDGEGVPLRHLLIGGEALPKTTVTKFIHLFGADRAAPAITNVYGPTETCVDASLFNIEVSADAWTRSQVHIPIGKPLGNNRMYILDSQQKLQPVGVQGELYIAGDGVGRGYLNLPELTNKKFVNDPFVPSGRMYRTGDLARLLPDGNIEFIERVDHQVKIHGFRIELGEIESIMLNIPEIQEAVASVLEDADGEHYICGYYVANKPFPTSQLRDRLTRHLPGYMIPAYFVQMDQMPLTPNGKLNRNLLPEPDGKRYGDTEYVPPRNSTEMKLTKIWQDVLGLEQVGIRDNFFDIGGHSLRATTLIAKIQKQLHVQIPLRNIFQFPTIEQLAQAIMTMEETEYASIPLIEKRPYYPVSSAQKRLYILNHLEGGELSYNMLGLMTVKGELDRDKLQQAFDKLIHRHESLRTGFKMVDGEPVQYVLDHVEFAVESYYAKEDEIDHCISQFVRAFQLEEPPLLRVGLIELQPNHAILMFDMHHIISDGTSMNVLIKEFVRAYQGAELPPLRIQYKDYSVWQTGEARLEQIQKQEDYWLELYSGDIPVLHLPTDYIRPSTRDFTGATLHFTIDEKKSEGLKQLALKTESTLYMVLLASYTLLLSKYSGQEDIVVGSPIAGRPHADLDSIIGMFVNTLAMRNYPAKEKTFSQYLAEVKENALKAYEHQDYPFEALVDQLNIARDLSRNPLFDTMFVLQNTEQEQLGMDGLTFKPYPSKHTMAKFDLTLTAVEEETHIHCTMEYLTTLFKPETVERMMRHFVQLIDAIIEHPEARLASLEMMRSREKNEIWNLFNDTAVIDERMPTTIHQQFEQQAEDTPDRVAILFENQTWTYRQLNERSNQLARVLRNQGVGADRVAAILTERSANMMIGILAILKAGGAFLPIDPELPDERRAYLMEDSGADVLVTCVEHTVPPSFEGSVVLLDDPLVYQGDASNLNLSYAENHLLYVIYTSGTTGKPKGVQLEHKTMLNLLAYEREYTQLRFDRVLQFAAMSFDVCYQEIFSTILSGGTLYIIDNEAKREIRELNEFVKTHRIQTAFLPTAFLKLLASEKQYFEPFAECVDHIITAGEQLIMTNTLREMMMRHQVSLHNHYGPSETHVVTMCTVDPEIHQEMPPIGKPISNTEILILNEAGTLQPIGIVGELCIAGISLARGYHNRESLTHEKFVPHPYDANKRMYKTGDLARYLPDGNIEYAGRMDHQVKIRGYRIELNEVEAALLNIEHVQEAVVLARENTEGQSDLYAYFVAEQALPISQFKEKLAQQIPGYMIPSYLMQLEQMPLTSNGKVNRSALPLPAAGMQTGIDHVAPRTRLEEQLVLIWKEVLKLEQVGVKDNFFDLGGHSLRGMTLVGKIHKQFNKTISLREVFQGPTIEEMAKVIANSETCGPDYIPAVEVKDVYPVSSVQKMVYLSTQIEGGELSYNMPGILTLEGRIDMDRLQTAFHRLIQRHESLRTGFEMIRGEPMQMVKPEVEFTIERYKATAEEVEELFRTFVRPFDLSQAPLLRVGLIELEQEKHIFMFDMHHIVTDGASMNIFIEELIQLYDGKELAPLRIQYKDFTAWQQQAEQKERIKKQEDYWLDVFHEALPSFELPKDFARPQVRSFEGKRYNFVLNESVVQGVKQLEELTGSTTYMILFAAYTILLAKYSGQEDIVVGTPVAGRVHDDLQHIIGMFVNTLAIRTAPAGEKTFKDYVTETKETMLKAYENQEYPFEELVEKLGVQRDLSRNPLFDTMFVLQNTEQTDIEIDSLAVRPYEETHAVAKFDLQLTFEMHQHEIQGSFDYCTKLFKKRTIATLAQDYVMILSAVIQNSSIPLKEIQLSEKVNKKEHFASVIELDF