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mutT

Gene
mutT
Protein
Putative 8-oxo-dGTP diphosphatase
Organism
Bacillus subtilis (strain 168)
Length
149 amino acids
Function
May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate (By similarity). Functions, in conjunction with ytkD, to protect vegetatively growing cells from DNA-damaging agents such as H(2)O(2) or t-BHP (t-butylhydroperoxide). The 2 proteins do not however protect spores.
Similarity
Belongs to the Nudix hydrolase family.
Mass
16.398 kDa
Sequence
MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEAAVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSPGRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK

Gene
mutT
Protein
8-oxo-dGTP diphosphatase
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
136 amino acids
Function
Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate (By similarity).
Similarity
Belongs to the Nudix hydrolase family.
Mass
15.648 kDa
Sequence
MDKKIIQVAAGIIRNEFGQIYLTQRLEGQDFAQSLEFPGGKVDAGETPEQALKRELEEEIGIVALNAELYERFQFEYPTKIISFFFYLVNEWIGEPFGREGQEGFWVEQHALDAGQFPPANAKLIHRLLNETHNFI

Gene
mutT
Protein
8-oxo-dGTP diphosphatase
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Length
130 amino acids
Function
Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate (By similarity).
Similarity
Belongs to the Nudix hydrolase family.
Mass
16.09 kDa
Sequence
MKYTNIVIGIIIKKNKIYITKARKKKYVLDLWEFPGGKVKENENLTYSLKRELSEEVGLKILRFRFFRCIKYFYKKIKLYFFLITRWKGRIYSKEGYLYKWIFLDDLKYFNFPSPNSHIIHDLQKMIFFK

Gene
mutT
Protein
8-oxo-dGTP diphosphatase
Organism
Escherichia coli (strain K12)
Length
129 amino acids
Function
Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate.
Similarity
Belongs to the Nudix hydrolase family.
Mass
14.927 kDa
Sequence
MKKLQIAVGIIRNENNEIFITRRAADAHMANKLEFPGGKIEMGETPEQAVVRELQEEVGITPQHFSLFEKLEYEFPDRHITLWFWLVERWEGEPWGKEGQPGEWMSLVGLNADDFPPANEPVIAKLKRL

Gene
mutT
Protein
8-oxo-dGTP diphosphatase
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
Length
124 amino acids
Function
Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate (By similarity).
Similarity
Belongs to the Nudix hydrolase family.
Mass
15.061 kDa
Sequence
MELLSKKKVYITRGKYKKNIWEFPGGKVKKHENIVHALKRELLEEVGIIVLKINFFQYIEYIYPEKKIKLYFFLKKKWKGRPYSIEGYTYLWKRLCHLRALDFPLANHSVINALKKNNILIKFR

Gene
mutT
Protein
8-oxo-dGTP diphosphatase
Organism
Proteus vulgaris
Length
112 amino acids
Function
Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate.
Similarity
Belongs to the Nudix hydrolase family.
Mass
12.774 kDa
Sequence
MMDKKKLHIAAGVICDKHNNVFIAQRPLKSHMGGFWEFPGGKLEDNETPEQALLRELQEEIGIDVTQCTLLDTVAHDFPDRHITLSFFLVTEWKNELTEKKGSCRVGHLLCL