Protein
Structure-specific endonuclease subunit SLX4
Organism
Drosophila melanogaster
Function
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage (By similarity). Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity). Interacts with the structure-specific MEI-9-ERCC1 endonuclease to generate meiotic crossovers.
Similarity
Belongs to the SLX4 family.
Sequence
MDRKTRRANFKNLQPRLTRSTKAAADTLSLSNFFATPENAEEVPSCLADIPVQPDPPAPKIKPIRTSNVFEKPGPKPKKAPKLKASTVSTSSGARRGRGKSKQQPSISNFLRNEQIFAEVTAQHCMADNFSADDIEMALALSKSESEKHGRLRLHDDDDAVVDLLDDEEKSTERIRHKLQKYGFRTAAKEDYKSLAVLPVVASKGGRRGKWANRFTSLTLRNPDVQQKKLEEKVSALLGQEMRGKEPNGEDCCLTPYTVITAALKELRAEGESRILREPSEGPIDDLESYYVTDLFEVSRTPAHHLLKNWAAIQGRDFSPERETQKCRQLRQQHELVYAELERYYGDPQKLEEEVMQELDELEKLVADNMIEDDSVVINIVEAESSSTGSSPSKEPPDKRPKMTMEDKENLQPTTSKASLTVPAQSTRCTSPDLFADSEDEPDIVTTAISNEPEDVRNLSMKVYKNVSISERSSSVAEIEIVSSNDEPSQITTYEVFSSDEVKTVSNATQEKISFDDDFIDLTQEFDMVEFNESKPRTPNLIASSETDSNVDNLNGDTILDFSSQEVSCPISKELYAKYAKVETFPVWNAAAEEEDKIEFSLSMERDLKSSEQSSHQLGILTTPNDTEHSSSFSELNFSRNSLRRSVSLSTDLSFKSPLNWKMNSSAEKRVSPAASPYKQSDASVDLTQNSDDENDAILLSDEEINYSIWKGNKTVKDLDIGDDSSDSCFASPVTKKRAIPQFQTEEDLDAFLMDFSTDGNGSQGSHSPNKSALSKERAEFGILDAAPSQPFSLSELQSHADKEKSSDNEINWAEASFLDAPAKPLSRRSSHKFNELLAKISKPAHNSGDDFDEFDQMVFQSTKEAASSAGETSDMPQGLDLLLKGEIKTTAIPETRAPGNQTPIEPQQVDVDGNVYSVRVCHTPKPDFATLPESEILQQLYKYGIKPLKRKQAVKMLEFIYNQTHPIMKTAAVQDLPARSEPIVRSKSTPVIMERPHSQVAKSTSKTLKAIGTKKDLTFNDATGEELLRFSQSLAPSLCDDFETFVMQTNVTKKTPQPLVPLHIAWHNLICANPQLHESVLTYEPIDLQAVYLHLKHMGHRYDPKDLKTFFDRRCIIFRYELGAPGKQAERHVRRHTKKPSKRK