Protein
Crossover junction endonuclease mus-81
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the XPF family.
Sequence
MAGDTGANPLFLGWVKEWWDTAREHNTKGAPTYKKAYNSLKACPLTFQHPSELQVLNGFGPTISQRLTDRLKQYCEENGLPMPKHPKRKRTLELESALAAAGAVQDEQPPPPKRARTARPYVPKLNSGAYALLMALSELGPKEFMDKTTLIAKAQPYSEHSFTVPTMANKSYTAWDSMKTLEQKELVWLRGLPSKRYSLTDEGWEVVKRMKEAQNLVDGVAGSANTSRNAIASGSGTSNPNRSENVNPNRQDSGVKRESRYTPLDLKPFVTTTATPERPLQPKPHTANSEYSIIIDSDDEDPKYDEEDRKPIIRDTTNRDYIDLVADGDSVPDESNLPHFTPIRLAPGSFTVELVLDTREVQAKNNRDHIQEELSKLGVRPVMRSLELGDVLWIAKCKQPGWLNRLGAEGDEVVLDYIVERKRLDDLIGSIKDGRFREQKYRLKRSGMKNVVYIIENYNIDMDIRRQYQDAMDTAMASIQVVNGYFLKKTDTIAESIRYLAAVTYMLKEIYESKPLFVIPTQVLTAKNYLPLVKHLREKEPSRGYYISYPAFASLVSKSEMMTLKDVFIKMLMCIRRLSGEKAIEIQKVWKTPYQLVKAFEACGSDENGKKKQKVLVMSMLSHLVDRRNVDKGLSERIADVWGFL