Protein
UV-damage endonuclease
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Endonuclease for the repair of UV-irradiated DNA. Involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway.
Similarity
Belongs to the uve1/UvsE family.
Sequence
MPSRKSKAAALDTPQSESSTFSSTLDSSAPSPARNLRRSGRNILQPSSEKDRDHEKRSGEELAGRMMGKDANGHCLREGKEQEEGVKMAIEGLARMERRLQRATKRQKKQLEEDGIPVPSVVSRFPTAPYHHKSTNAEEREAKEPVLKTHSKDVEREAEIGVDDVVKMEPAATNIIEPEDAQDAAERGAARPPAVNSSYLPLPWKGRLGYACLNTYLRNAKPPIFSSRTCRMASIVDHRHPLQFEDEPEHHLKNKPDKSKEPQDELGHKFVQELGLANARDIVKMLCWNEKYGIRFLRLSSEMFPFASHPVHGYKLAPFASEVLAEAGRVAAELGHRLTTHPGQFTQLGSPRKEVVESAIRDLEYHDELLSLLKLPEQQNRDAVMIIHMGGQFGDKAATLERFKRNYARLSQSCKNRLVLENDDVGWTVHDLLPVCEELNIPMVLDYHHHNICFDPAHLREGTLDISDPKLQERIANTWKRKGIKQKMHYSEPCDGAVTPRDRRKHRPRVMTLPPCPPDMDLMIEAKDKEQAVFELMRTFKLPGFEKINDMVPYDRDDENRPAPPVKAPKKKKGGKRKRTTDEEAAEPEEVDTAADDVKDAPEGPKEVPEEERAMGGPYNRVYWPLGCEEWLKPKKREVKKGKVPEEVEDEGEFDG