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mtbP

Gene
MTBP
Protein
Mdm2-binding protein
Organism
Homo sapiens
Length
904 amino acids
Function
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
Similarity
Belongs to the MTBP family.
Mass
102.193 kDa
Sequence
MDRYLLLVIWGEGKFPSAASREAEHGPEVSSGEGTENQPDFTAANVYHLLKRSISASINPEDSTFPACSVGGIPGSKKWFFAVQAIYGFYQFCSSDWQEIHFDTEKDKIEDVLQTNIEECLGAVECFEEEDSNSRESLSLADLYEEAAENLHQLSDKLPAPGRAMVDIILLLSDKDPPKLKDYLPTVGALKHLREWYSAKITIAGNHCEINCQKIAEYLSANVVSLEDLRNVIDSKELWRGKIQIWERKFGFEISFPEFCLKGVTLKNFSTSNLNTDFLAKKIIPSKDKNILPKVFHYYGPALEFVQMIKLSDLPSCYMSDIEFELGLTNSTKQNSVLLLEQISSLCSKVGALFVLPCTISNILIPPPNQLSSRKWKEYIAKKPKTISVPDVEVKGECSSYYLLLQGNGNRRCKATLIHSANQINGSFALNLIHGKMKTKTEEAKLSFPFDLLSLPHFSGEQIVQREKQLANVQVLALEECLKRRKLAKQPETVSVAELKSLLVLTRKHFLDYFDAVIPKMILRKMDKIKTFNILNDFSPVEPNSSSLMETNPLEWPERHVLQNLETFEKTKQKMRTGSLPHSSEQLLGHKEGPRDSITLLDAKELLKYFTSDGLPIGDLQPLPIQKGEKTFVLTPELSPGKLQVLPFEKASVCHYHGIEYCLDDRKALERDGGFSELQSRLIRYETQTTCTRESFPVPTVLSPLPSPVVSSDPGSVPDGEVLQNELRTEVSRLKRRSKDLNCLYPRKRLVKSESSESLLSQTTGNSNHYHHHVTSRKPQTERSLPVTCPLVPIPSCETPKLATKTSSGQKSMHESKTSRQIKESRSQKHTRILKEVVTETLKKHSITETHECFTACSQRLFEISKFYLKDLKTSRGLFEEMKKTANNNAVQVIDWVLEKTSKK

Gene
Mtbp
Protein
Mdm2-binding protein
Organism
Mus musculus
Length
894 amino acids
Function
May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells.
Similarity
Belongs to the MTBP family.
Mass
100.314 kDa
Sequence
MDRYLLLVTWREGKFRSVAGGEIEPGTEATSLESTDKQPDLTATNIYHLLKRSISDSIHPDDSTFPACSVGGTPHSRKWFFAVQAICGFYQFCSSDWQEIHFDAEKDKIEDVLQANIEECQSAVECFEEDDSNSRESLPLADLYEESAENLHQLSDKLPAPGRAMIDIILLPSDKDPPKLKECLPIVGALKHLKEWHSAKVIIAGSYCEINCQKIAEYLSASVVPLEEFRNAIDPRELWRGEIQMRERKFGFEISFPEFCLKGVTPTNVSAYNLNTCFLAKKIASSKVFHYYGPALEFVQMIKLSDLPSCYMSDIEFELEVTGHCTRQNSMLLLEQISSLCGKVGALFVLPCTVSNVLIPPPSQLASRKWKEYMAKKPKTISVPDVAVKGEFSGYHLLLQGMGKRKCRATLLHSASQINGSFALSVIHGKMKTKAGEARPSFPFDFSSLPRFSEEQVLQREKQLASFQVLALKECLKRRKAANQPEAFSADELKSLLALTRERFLGHFDVLPTEAALAQTDTVKAAGVVNDDGTVEPYSSSLMETNPLEWPERHVLQNLETSEKAKQKMRTGSLPRSSEQLLGHKEGPRDSLTLLDAKELLKYFTSDGLPVGDLQPLHIQRGEKPFVLTPELSPGKLQVLPFEKASECHYHGIEYCLDDQKALERDGGFSELQSRLIRYETQTTCTRDSFPVPTVLSPLPSPAVLSEPQSVPEGEALQGELRTEVSGLKRRSKDPSCLYPQKRLTRSESSDCLPSQASCNSNHHHHTGKPRKPQAERCVSGLPLPGREASKDTSKTSSGQKRAHESKSSKQMKESRSQKHTRMLKEVVKDTLKRHHITEAHESFTACSQRLFDISKFYLKDLKTSRGLFEEMKKTANNNVVQVIEWVVEKMSKK

Gene
mtbp
Protein
Mdm2-binding protein
Organism
Xenopus tropicalis
Length
867 amino acids
Function
May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity).
Similarity
Belongs to the MTBP family.
Mass
97.059 kDa
Sequence
MERFVLCIHWERRAESGAEQHRVPQGLAYAQDIYTQLKEYSTKYTSTFPACSLTGNPGTRKWFFALQSLYGSFQFCSSDWDDLCPAVTTEDNEEPVQTALDECLEALQFPDGEDDNSRDSISQTNLFEEAAELLHQLSDKLPAPGRALVDVLLFTPEAPKLKDCLSAIGAIKHLKEWHSAKITIVSKDCKGWQKIAKFLSANVVESACPKELIDSHELWRGNIEISERKFTSEVEFPEFCLRSVSDDKFPYFEHNGDDKNKAVLLPEVFHYYGTSLEYVQMVALSEIPSYFVSDSVFELSITRNALQGKSKLMLDQLCSLTDKVGAIFMLSCNVCSLPNPPALQRSSKKWREYMSRKPKDIKVPGVELKGEYCSYYFLIQGKGSGFCKATLLHSASQISGAASLVLLHQRLNNYQPGNMAEGTSEILDSVPHFRGEQIAVRERILARAQALAVNEYLKRHEALPHPSVSHVNNLRTLLAVTRERVIGDCESRLDGVSYKNLQNITVSTPTVSESEAMISNPADWPERNVLQNLENFEKVKQRLRASILSSSAEQLLGRKDGLKEGMTLLDAKELLKYFTPQGIAVGELQPLQVQRGDNAFLLTPKLTPKKLKGLPFEKAAECHYHGLEYCLDNRKALDRDVAFSELQSRLIRYETQTTCTRECCPVPFALSPLPSPAVLSEPGSVPDGESIQTELRGEPLLLKRRSRDLDGLYASKRLAKSGSSDSLVSLASEGSGHQPPTRATRLRPERAASSTSAVQPPSARVQMAPSVPAQSKQSTHPDLEQKESRSQKHNRMLKEVVSKTLQKYGIGVEHPCYAACNQRLFDISKFFLKDLKTSRGLLDEMKKAASNNAKQVIQWELDKLKKK

Gene
mtbp
Protein
Mdm2-binding protein
Organism
Xenopus laevis
Length
860 amino acids
Function
May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity).
Similarity
Belongs to the MTBP family.
Mass
96.308 kDa
Sequence
MERFVLCIHWERRAEQQQPVPQGLVYAQDIYTQLKEYSTNCTSTFPACSLTGNPGIRKWFFALQSLYGFSQFCSSDWEDLCPAVTTDDSEEPVQTALDECLDALQFPDGEDDNSRDSISQTNLFEEAAELLHQLSDKLPAPGRALVDVLLFPSEAPKLKDCLSAIGAIKHLKEWHTAKITIVSKDCKGWQKIGKFLSANVVVSDCPRQLIDPQELWRGTIEIKERKFTSEVEFPEFCLRSVSDDKVPYFENNGDDKNKTVLSEVFHYYGASLEYVQMVALSEIPSYFVSDSVFELSITRNGLQGKSKLMLDQLCSLTEKVGAIFMLPCNVCSLPNPPALQRSSKKWREYMSRKPKDIKVPGVELKGEYCSYYFLIQGKGSGLCKATLLHSASQISGAASLLLLHQRLNNNHPVNMAESTSDILDSLPHFNGEQIALREQILARAQVLAVKEYLKRQEAQPHASVSQSNNLGRLLALTREHVIGDCESRLDSVSYKNMQNITVSTPAFPESEAMISNPADWPERNVLQNLENFEKIKQRLRASILSGSAEQLLGRKDGLKEGMTLLDAKELLKYFTPQGLAVGELQPLQVQRGDNAFLVTPKLTPRKLKGLPFEKAAECHYHGLEYCLDNRKALDRDVAFSELQSRLIRYETQTTCTRECCPIPFALSPIPSPAVLSEPGSVPDGESIQTELRGDPLRLKRRSKDIEGLYPSKRLAKSGSSDSLVSLASEGSGHQQPTRLRTERTASSVSGAQPSSTRVRTAPSVPAQSKPSSHLELEQKESRSQKHNRMLKEVVSKTLQKHSIGVEHPCYAACNQRLFEISKFFLKDLKTSRGLLDEMKKAASNNAKQVIQWELDKLKKN

Gene
mtbP
Protein
Phi-3T prophage-derived modification methylase Phi3TI
Organism
Bacillus subtilis (strain 168)
Length
443 amino acids
Function
This enzyme methylates the first cytosine within the sequences GGCC and GCNGC.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Mass
50.51 kDa
Sequence
MSKLRVMSLFSGIGAFEAALRNIGVDYELIGFSEIDKYAIKSYCAIHNVSETLNVGDISKAKKDNIPYFDLLTSGFPCPTFSVAGGRDGMEYKCSNCSHEHLITYEDYKKGVKCPKCEAVSKAKDERGTLFFETALLAEEKKPKFVILENVKGLINSGNGQVLRIISETMNNIGYRIDLELLNSKFFNVPQNRERVYIIGIREDLVENEQWVVGQKRNDVLSKGKKRLQEINIKSFNFKWPLQDTVTKRLREILEDFVDEKYYLNEEKTKKLVEQLGTAPLQKQEVREPLMVGHVDLKGHDAIKRVYSPEGLSPTLTTMGGGHREPKIAEKQKEVRAVLTPEREEKRQNGRRFKENGEPAFTVNTIDRHGVAIGEYPKYKIRKLSPLECWRLQAFDDEDFEKAFAAGISNSQLYKQAGNSITVSVLESIFQELIHTYVNKESE

Gene
mtbP
Protein
Modification methylase Phi3TI
Organism
Bacillus phage phi3T
Length
443 amino acids
Function
This enzyme methylates the first cytosine within the sequences GGCC and GCNGC.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Mass
50.51 kDa
Sequence
MSKLRVMSLFSGIGAFEAALRNIGVDYELIGFSEIDKYAIKSYCAIHNVSETLNVGDISKAKKDNIPYFDLLTSGFPCPTFSVAGGRDGMEYKCSNCSHEHLITYEDYKKGVKCPKCEAVSKAKDERGTLFFETALLAEEKKPKFVILENVKGLINSGNGQVLRIISETMNNIGYRIDLELLNSKFFNVPQNRERVYIIGIREDLVENEQWVVGQKRNDVLSKGKKRLQEINIKSFNFKWPLQDTVTKRLREILEDFVDEKYYLNEEKTKKLVEQLGTAPLQKQEVREPLMVGHVDLKGHDAIKRVYSPEGLSPTLTTMGGGHREPKIAEKQKEVRAVLTPEREEKRQNGRRFKENGEPAFTVNTIDRHGVAIGEYPKYKIRKLSPLECWRLQAFDDEDFEKAFAAGISNSQLYKQAGNSITVSVLESIFQELIHTYVNKESE