Protein
Dimethyladenosine transferase 2, mitochondrial
Organism
Drosophila melanogaster
Function
Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA. Also regulates mitochondrial DNA copy number. Stimulates transcription independently of the methyltransferase activity.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
Sequence
MLPLRCSWSFARANYSTKKELVTRYSGDFPEKLLNRKQKVPTHMYIANSEAAARINQYLEPHFQSSGCDTVMELNSGAGYFTRHLLDRESQFRRIILLESMDHFMPKIQELHTLYPERVKVRQGDFVNLWKLVYMDKMDGGSRVADLLSDVPQKAFTDDINMLVFGAVGSYPFFKHLINSLIFQTSLFNLGRCEMILAMPPPIYIHLTCNNEIGYLIYRSTSVLFQILFEHKFIAKVPREDFLPQQMAYSPTKSSKLGKVQSINPEYLYLVKFTPRRNLHELCQSQDLPALWFFIKQNYVSRRNRIIPNLEKWVPGCGPRLIINPKSSESVTPIYPDELPKKLPQYSCQSTTMSTRNYYPGINIYTQFGDLLPSQILTLFSQFRQWPEYGESSFLASLENALLKLETANDEPNLEDGVTLPEEDDAEADEIIEEESPVPATTPVKRRRKASS