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msrB1

Gene
MSRB1
Protein
Peptide methionine sulfoxide reductase B1, chloroplastic
Organism
Oryza sativa subsp. japonica
Length
214 amino acids
Function
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Involved in abiotic stress response. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. MSRB family specifically reduces the MetSO R-enantiomer.
Similarity
Belongs to the MsrB Met sulfoxide reductase family.
Mass
23.422 kDa
Sequence
MAMRQYAAATAASSSFRARPRARPSCLPAAALPLAPCCGVAWSRASYRRASVRAMGAASSSSSSSSSSPSPQGQAQAQAQGKPNYSTSLTDEEWRKRLTKDQYYITRQKGTERAFTGEYWNTKTPGIYHCVCCDTPLFESSTKFDSGTGWPSYYQPIGDNVKCKLDMSIIFMPRTEVLCAVCDAHLGHVFDDGPRPTGKRYCINSASLKLKKTQ

Gene
MSRB1
Protein
Peptide methionine sulfoxide reductase B1, chloroplastic
Organism
Arabidopsis thaliana
Length
202 amino acids
Function
Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Specifically reduces the MetSO R-enantiomer. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. May play an essential function in association with MSRB2 in maintaining vegetative growth during environmental constraints, through the preservation of photosynthetic antennae. MSRB1 and MSRB2 account for most of the leaf peptide MSR capacity.
Similarity
Belongs to the MsrB Met sulfoxide reductase family.
Mass
22.607 kDa
Sequence
MASSTRLTIIQSSFVSARTRLNYVSKTNHSGFACRSLSKPRNLSLSVYSMGSSSSSPKPDNVQEAEKNEFASLSENEWKKRLTPEQYYITRQKGTERAFTGEYWNSKTPGVYNCVCCDTPLFDSSTKFDSGTGWPSYYQPIGNNVKTKLDLSIIFMPRQEVVCAVCNAHLGHVFDDGPRPTGKRYCLNSAALKLNALEKTRD

Gene
msrB1
Protein
Peptide methionine sulfoxide reductase MsrB 1
Organism
Rhizobium meliloti (strain 1021)
Length
135 amino acids
Similarity
Belongs to the MsrB Met sulfoxide reductase family.
Mass
15.364 kDa
Sequence
MSENRMPKITKTNEEWRAALTPEQYRVTREHGTERPFTGPFLDNKRHGTYKCVCCGRALFRSDTKFDSGCGWPSYFAPVDPDAIAEYVDRSHLMVRTEIRCADCDAHLGHVFPDGPPPTGLRYCLNGTAMTFEED

Gene
msrB1
Protein
Peptide methionine sulfoxide reductase MsrB 1
Organism
Rhizobium meliloti (strain 1021)
Length
135 amino acids
Similarity
Belongs to the MsrB Met sulfoxide reductase family.
Mass
15.364 kDa
Sequence
MSENRMPKITKTNEEWRAALTPEQYRVTREHGTERPFTGPFLDNKRHGTYKCVCCGRALFRSDTKFDSGCGWPSYFAPVDPDAIAEYVDRSHLMVRTEIRCADCDAHLGHVFPDGPPPTGLRYCLNGTAMTFEED

Gene
MSRB1
Protein
Methionine-R-sulfoxide reductase B1
Organism
Bos taurus
Length
116 amino acids
Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
Similarity
Belongs to the MsrB Met sulfoxide reductase family.
Mass
12.833 kDa
Sequence
MSFCSFFGGEIFQNHFEPGIYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPEHNRPGAIKVSCGRCGNGLGHEFLNDGPKRGQSRFUIFSSSLKFIPKAEETSASQGQ

Gene
MSRB1
Protein
Methionine-R-sulfoxide reductase B1
Organism
Homo sapiens
Length
116 amino acids
Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
Similarity
Belongs to the MsrB Met sulfoxide reductase family.
Mass
12.76 kDa
Sequence
MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPEHNRSEALKVSCGKCGNGLGHEFLNDGPKPGQSRFUIFSSSLKFVPKGKETSASQGH

Gene
Msrb1
Protein
Methionine-R-sulfoxide reductase B1
Organism
Mus musculus
Length
116 amino acids
Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
Similarity
Belongs to the MsrB Met sulfoxide reductase family.
Mass
12.788 kDa
Sequence
MSFCSFFGGEVFQNHFEPGVYVCAKCSYELFSSHSKYAHSSPWPAFTETIHPDSVTKCPEKNRPEALKVSCGKCGNGLGHEFLNDGPKRGQSRFUIFSSSLKFVPKGKEAAASQGH

Gene
MSRB1
Protein
Methionine-R-sulfoxide reductase B1
Organism
Sus scrofa
Length
116 amino acids
Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
Similarity
Belongs to the MsrB Met sulfoxide reductase family.
Mass
12.783 kDa
Sequence
MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSHSKYAHSSPWPAFTETIHADSVAKRPEHNRPGALKVSCGRCGNGLGHEFLNDGPKRGQSRFUIFSSSLKFIPKGQESSPSQGQ

Gene
MSRB1
Protein
Methionine-R-sulfoxide reductase B1
Organism
Pongo abelii
Length
116 amino acids
Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
Similarity
Belongs to the MsrB Met sulfoxide reductase family.
Mass
12.744 kDa
Sequence
MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPEHNRAEALKVSCGKCGNGLGHEFLNDGPKPGQSRFUIFSSSLKFVPKGKETSASQGH

Gene
Msrb1
Protein
Methionine-R-sulfoxide reductase B1
Organism
Rattus norvegicus
Length
116 amino acids
Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
Similarity
Belongs to the MsrB Met sulfoxide reductase family.
Mass
12.797 kDa
Sequence
MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHEDSVAKCPEKNRPEALKVSCGKCGNGLGHEFLNDGPKRGQSRFUIFSSSLKFIPKGKEAPASQGD

Gene
msrb1
Protein
Methionine-R-sulfoxide reductase B1-A
Organism
Danio rerio
Length
110 amino acids
Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (mical1, mical2 or mical3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
Similarity
Belongs to the MsrB Met sulfoxide reductase family.
Mass
12.553 kDa
Sequence
MSFCSFSGGEIYKDHFESGMYVCAQCGYELFSSRSKYEHSSPWPAFTETIHEDSVSKQEERWGAYKVRCGKCGNGLGHEFVNDGPKHGLSRFUIFSSSLKFIPKVKNEQQ