Protein
MutS protein homolog 5
Organism
Caenorhabditis elegans
Function
Crucial component in meiotic recombination, functioning at some point after the initiation step of recombination. Plays a role in promoting the crossover outcome of meiotic recombination events. Required for formation of normal meiotic crossover, and crossover and chiasmata generated by artificially made DNA breaks.
Similarity
Belongs to the DNA mismatch repair MutS family.
Sequence
MSTRWRYYNSKRGNGFRGRGRGRGRGTSLTAVALPRDDNFHKGAQDGAYFKDMPMDPEQFRDETVLSLSFAQGMLGAAYYEQSSQLLKIMNDISEDLEFRFLKRLIDDVKPTLIIANRSQDLEFIKFLTTRYDPQEKIYEDGTTEEGTSEDTVPTWDSSLAYSTDETTAEKEEKEEDEDDDDEGLPAKLNKLPNNFFRMSRAIERLKAMAGSHDSSMTEEDKYIIIKMRFDIEAVNMIRSFGALLLFLDETRMGVTDDPLSVTSPIKSIKTFTLGNLVEIDFNTIQALDILPKETENKKTFGQGRSLYQLMDKCRSTVGKKCLRKWFRNPTTDRDDLVSRQKCVHYFKQDWNAEVTAKLSSILGRVKALNSVFQKFQSGTAQLIHWECFVSTVNALVEILNIIRQTPISKEFPVESDLLREVSEIAVIAGSIINFAESKIQGRVTVMNGIDEELDEIRDTYENMPMVLTAIAKQEEARLGLPPYSNVACVYIPLVGFVLSVPRDYGVESQPDMTLLYSTHEDLRVRNATTSRLDDEFGDILMRLIDSQTAIILTLKTRVMKKKRSIIKLLSIASRIDVLISFGLIAAQNGWNCPALVDEPVIEAVELYHPISVLVVKKSFVPNQVSSGRDGIKASIITGPNACGKSVYMKSIGIMVFLSHIGSFVPARHAKIGIVDRIVTRMFTVDSVLDGMSTFAKDVEQVALALRKATGNSLVIIDEFGKGTMTEVGLSLLASVMTYWMNRGADRCPHIFLSSHFHALPNYIPLETNIATFLTFTVLREAGGKIKYLFRMTPGLVDCSFALSVAKEEGIPPPVIGRACRIYKALKAGTLLKEIKAEVSNDNEKQLVEDMDVVLADEDGFMAAVESFVKRKKTSFCESSMRNVSEEIEKERSEASTPASKSRSTITARSNSVLSSRSMASVDQLSVLDALLPKKKKKKVTGSSMESSMSPDPFQEEDEGTEGEEDQISAPVSRPTLPSVQKYASEEEKQQSINSRHSFSTRTAIHIPTPIQMGEAGGVKRPRSTSTSSPGPSASKSVRTEVFKKTPNVKESQVLETPKQLSISSFLEPKFPSSEKDVISRVSERYLQSDPFKTPISDRRSQQSSRHSTPKNRSMNQSLIQSARDTPHETIRSSNEVNPEFFNIFNFPDDSILKSQDTYDPNVTPRSSSRRELRPDVSHSQNSQFGEVFSELGTQFSIFNSQQSFPGNSMGTTNPDCSIFDDFFANSQDGEKKIDSTKTSMPIVNSDNFIFKTPEPRSSEKQRSLLKNKGQASNSSISPSSLILGQLAFGDVDQTPRPRGDNPIEFQYDVVDDDDPIFEEKNCSAPVFEFLKSNDDEEDDEFLKSFLETEGSLHIDTSADETIDRSKRS