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mrsA

Gene
mrsA
Protein
2-ketoarginine methyltransferase
Organism
Pseudomonas syringae pv. syringae
Length
350 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase involved in the formation of 3-methylarginine (MeArg), a potent antibiotic against the closely related soybean pathogen P.syringae pv. glycinea. Transfers the methyl group from S-adenosyl-L-methionine into 5-guanidino-2-oxopentanoate acid to yield 5-guanidino-3-methyl-2-oxopentanoate5-guanidino-3-methyl-2-oxopentanoate, a precursor of MeArg.
Mass
38.734 kDa
Sequence
MNLLDSIKSENTGFETTLIKGIEPIRQFVLAISIYHLFDTKLFSLLIKHEVASPEVACNELGMEKEKLLGLFRYLKNEGILLETIDGFSLSKEGHALAPFEGWYVMLVGGYATTFLQMGERLQEGAGWATRDATKVGVGSCGISHFDAIPLTRSLMAQAPGTCTKLLDLGCGNGRYLAEFCKALPQIQAWGAEPDRGGFEEAVDLIEKEGLSHRVHISHSGAVEFLDSDFDFEPDFIVLGFVLHEILGQAGRPAVVNFLKKIVHRFPAINLIIIEVDNQFDNAGAMRHGLALAYYNPYYLLHCFTNQLLVQDADWLDIFAEAGLSLVTRETTSDQVDSTGLEIGYLLRRA

Gene
mrsA
Protein
Peptide methionine sulfoxide reductase MsrA
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Length
165 amino acids
Function
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Similarity
Belongs to the MsrA Met sulfoxide reductase family.
Mass
18.896 kDa
Sequence
MKNIVLGGGCFWCVEAVFERLKGVINTEVGYSGGKPNPSYESVCNGDGNIEVVKINYDEKQISLLEILTLFFKIHDPTSIDKQGGDIGIQYRSIIFYENEEDKILAQNFIEEQQKIFSKKIVTKISRLQTYYKAENYHQHYFINNPDQGYCQAVIAPKLQKIQSD

Gene
mrsA
Protein
Lantibiotic mersacidin
Organism
Bacillus sp. (strain HIL-Y85/54728)
Length
68 amino acids
Function
Kills a number of Gram-positive bacteria. Acts at the level of cell wall biosynthesis by interfering with bacterial peptidoglycan biosynthesis. Specifically inhibits the conversion of the lipid II intermediate into polymeric nascent glycan strands by transglycosylation. May interact with the peptidoglycan precursor rather than with the enzyme.
Similarity
Belongs to the type B lantibiotic family.
Mass
7.228 kDa
Sequence
MSQEAIIRSWKDPFSRENSTQNPAGNPFSELKEAQMDKLVGAGDMEAACTFTLPGGGGVCTLTSECIC