MRE11

Double-strand break repair protein MRE11

731 amino acids

Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity).

Belongs to the MRE11/RAD32 family.

80.647 kDa

MSDYEEDTRPPPNIETADPEDTIKILLATDNHIGYLERDPIRGQDSINTFREILQLAVKNEVDFILLAGDLFHENKPSRDCLYQTLALLREYTLGDKPIQVELLSDPDEGKAAGFSFPAINYEDPNFNISIPVFSIHGNHDDPQGPGVNGALCALDVLSVSGLLNYMGKFDLPTSDADAATTGIAVRPVLLRKGSTKLGMYGVGNVKDQRMHFELRSNRVRMYMPKDKDEWFNILLVHQNRVKHGPQEYVPEGMFDDSVDLVVWGHEHDCRIIPEPVAGKNYYITQPGSSVATSLADGEAIEKHVALLEIKGKEFQLTPIPLRTVRPFVISEVVLEDAAEEEGLDVNDQMEITKYLKQKVNDLIDQAQALWEERNARSIEAGDEEIPPMLPLVRLKVDTTNVTQTSNPIRFGQEFQGRVANPRDLLVFHRSKKAGKRGAGKVDIDQPELSIDDPDLTVSEKLAKVRVKTLVREYLAAQELQLLGENGMSDAIQMFVEKDDIHAIQTHVNKSLKTMLKNIKSDEVDEDDLDDLLAKAKQRQEEEYLEATRAGESAKGKGKAKATDDDGGAASDDSMLMDIDTGGGATFNMSDDDDDDEPPPPPKRRAATSRATTTKKAPAKAPAKKATTTTARGRGKKAAPPSSDDEVIELDDDEDEISEEEVVAKPVKRTSRAAVLSQSQAPAKKAPAKKKTPARQTQTQLSFAPAGRSSRAAASKARSKMVFDDDDDDDD

MRE11

Double-strand break repair protein MRE11

720 amino acids

Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity).

Belongs to the MRE11/RAD32 family.

80.291 kDa

MSREDFSDTLRVLVATDCHLGYMEKDEIRRHDSFKAFEEICSIAEEKQVDFLLLGGDLFHENKPSRTTLVKAIEILRRHCLNDKPVQFQVVSDQTVNFQNAFGQVNYEDPHFNVGLPVFSIHGNHDDPAGVDNLSAIDILSACNLVNYFGKMVLGGSGVGQITLYPILMKKGSTTVALYGLGNIRDERLNRMFQTPHAVQWMRPEVQEGCDVSDWFNILVLHQNRVKSNPKNAISEHFLPRFLDFIVWGHEHECLIDPQEVSGMGFHITQPGSSVATSLIDGESKPKHVLLLEIKGNQYRPTKIPLTSVRPFEYTEIVLKDESDIDPNDQNSILEHLDKVVRNLIEKASKKAVNRSEIKLPLVRIKVDYSGFMTINPQRFGQKYVGKVANPQDILIFSKASKKGRSEANIDDSERLRPEELNQQNIEALVAESNLKMEILPVNDLDVALHNFVNKDDKLAFYSCVQYNLQETRGKLAKDSDAKKFEEDDLILKVGECLEERLKDRSTRPTGSSQFLSTGLTSENLTKGSSGIANASFSDDEDTTQMSGLAPPTRGRRGSSTANTTRGRAKAPTRGRGRGKASSAMKQTTLDSSLGFRQSQRSASAAASAAFKSASTIGEDDVDSPSSEEVEPEDFNKPDSSSEDDESTKGKGRKRPATTKRGRGRGSGTSKRGRKNESSSSLNRLLSSKDDDEDEDDEDREKKLNKSQPRVTRNYGALRR

mre11

Double-strand break repair protein MRE11

711 amino acids

Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.

Belongs to the MRE11/RAD32 family.

81.131 kDa

MSSSSSSLDDEDTFKILVATDIHLGFMEKDAVRGNDSFVAFDEILRLAQDNEVDFLLLGGDLFHDNKPSRRTLHICLEQLRKYCMGDRPIEFEVLSDQSVNFGYSKFPWVNYQDNNLNISLPVFSVHGNHDDPTGADALCALDILSSAGLVNHFGRATSVEKIDISPVLLQKGHSKIALYGLGSIPDERLYRMFVNKQVMMLRPREDESSWFNLFVIHQNRSKHGPTNYIPEQFLDEFLDLVIWGHEHECKIAPTRNEQQLFYVSQPGSSVATSLSPGEAEKKHVGLLRIKGKKMNMQKIPLQTVRQFFIEDLVLSDYPDIFNPDNPRVTQEIETFCIEKVEAMLDTAERERLGNPRQPDKPLIRLRVDYTGGFEPFNTLRFSQKFVDRTANPKDIIHFFRHKEQKDKKDSITINFGKIDSKPLLEGTTLRVEDLVKEYFKTAEKNVQLSLLTERGMGEAVQEFVDKEEKDALEELVKFQLEKTQRFLKERHIDAEEEKIDEEVRKFRETRKTNTNEEDEEVREAIQRARTHRSQAPDVEMSDEDDDALLRKVSLSDDEDVRASMPARGRGRGRARGGRGQSTTTRGTSRRGRGSASADQPSSGRATKATGKNMSILDAFKPSSRQPTARNVAKKTYSEDIEDDDSDLEEVSFTPSSVIESRRTSSTSTSYSRKSTQPQSQATKAHFFDDDDDEEDFDPFKKSGPSRRGRR

MRE11

Double-strand break repair protein MRE11

708 amino acids

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). RAD50 may be required to bind DNA ends and hold them in close proximity (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289, PubMed:30612738). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).

Belongs to the MRE11/RAD32 family.

80.593 kDa

MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR

MRE11

Double-strand break repair protein MRE11

707 amino acids

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Belongs to the MRE11/RAD32 family.

80.49 kDa

MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLARGNEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMQKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSRQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRDTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDEEEDVFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR

MRE11

Double-strand break repair protein MRE11

707 amino acids

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Belongs to the MRE11/RAD32 family.

80.49 kDa

MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLARGNEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMQKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSRQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRDTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDEEEDVFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR

Mre11

Double-strand break repair protein MRE11

706 amino acids

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Belongs to the MRE11/RAD32 family.

80.223 kDa

MSPTDPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHENKPSRKTLHSCLELLRKYCMGDRPVQFEVISDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGNTNFIPEQFLDDFIDLVIWGHEHECKIGPIKNEQQLFYVSQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMQKLPLRTVRRFFIEDVVLANHPNLFNPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPGKPLIRLRVDYSGGFEPFNVLRFSQKFVDRVANPKDVIHFFRHREQKGKTGEEINFGMLITKPASEGATLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRNTNEEDDEVREAMSRARALRSQSETSTSAFSAEDLSFDTSEQTANDSDDSLSAVPSRGRGRGRGRRGARGQSSAPRGGSQRGRDTGLEITTRGRSSKATSSTSRNMSIIDAFRSTRQQPSRNVAPKNYSETIEVDDSDEDDIFPTNSRADQRWSGTTSSKRMSQSQTAKGVDFESDEDDDDDPFMSSSCPRRNRR

Mre11

Double-strand break repair protein MRE11

706 amino acids

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Belongs to the MRE11/RAD32 family.

80.122 kDa

MSPTDPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHENKPSRKTLHSCLELLRKYCMGDRPVQFEIISDQSVNFGFSKFPWVNYRDGNLNISIPVFSIHGNHDDPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIGPTRNEQQLFYVSQPGSSVVTALSPGETVKKHVGLLRVKGRKMNMQKLPLRTVRQFFMEDVVLANHPSLFNPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPEKPLIRLRVDYSGGFEPFNVLRFSQKFVDRVANPKDVIHFFRHREQKGKTGEEINFGKLIIKPASEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRNTNEEDDEVREAMSRARALRSQSENAASAFSADDLSFDITEQTADDSDDSQSAVPSRGRGRGRGRRGGRGQSTAPRGGSQRGRDTGLGISTRGRSSKATASTSRNMSIIDAFRSTRQQPSRNVATKNYSETIEVDESDDDDSFPTSSRADQRWSGTAPSKRMSQSQTAKGVDFESDEDDDDDPFMSGSCPRRNRR

Mre11

Double-strand break repair protein MRE11

706 amino acids

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Belongs to the MRE11/RAD32 family.

80.223 kDa

MSPTDPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHENKPSRKTLHSCLELLRKYCMGDRPVQFEVISDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGNTNFIPEQFLDDFIDLVIWGHEHECKIGPIKNEQQLFYVSQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMQKLPLRTVRRFFIEDVVLANHPNLFNPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPGKPLIRLRVDYSGGFEPFNVLRFSQKFVDRVANPKDVIHFFRHREQKGKTGEEINFGMLITKPASEGATLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRNTNEEDDEVREAMSRARALRSQSETSTSAFSAEDLSFDTSEQTANDSDDSLSAVPSRGRGRGRGRRGARGQSSAPRGGSQRGRDTGLEITTRGRSSKATSSTSRNMSIIDAFRSTRQQPSRNVAPKNYSETIEVDDSDEDDIFPTNSRADQRWSGTTSSKRMSQSQTAKGVDFESDEDDDDDPFMSSSCPRRNRR

Mre11

Double-strand break repair protein MRE11

706 amino acids

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Belongs to the MRE11/RAD32 family.

80.122 kDa

MSPTDPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHENKPSRKTLHSCLELLRKYCMGDRPVQFEIISDQSVNFGFSKFPWVNYRDGNLNISIPVFSIHGNHDDPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIGPTRNEQQLFYVSQPGSSVVTALSPGETVKKHVGLLRVKGRKMNMQKLPLRTVRQFFMEDVVLANHPSLFNPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPEKPLIRLRVDYSGGFEPFNVLRFSQKFVDRVANPKDVIHFFRHREQKGKTGEEINFGKLIIKPASEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRNTNEEDDEVREAMSRARALRSQSENAASAFSADDLSFDITEQTADDSDDSQSAVPSRGRGRGRGRRGGRGQSTAPRGGSQRGRDTGLGISTRGRSSKATASTSRNMSIIDAFRSTRQQPSRNVATKNYSETIEVDESDDDDSFPTSSRADQRWSGTAPSKRMSQSQTAKGVDFESDEDDDDDPFMSGSCPRRNRR

MRE11

Double-strand break repair protein MRE11

705 amino acids

Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.

Belongs to the MRE11/RAD32 family.

79.126 kDa

MGDESNTLRVLVATDCHLGYMEKDEIRRFDSFEAFEEICSLAEQNKVDFVLLGGDLFHENKPSRSTLVKTIEILRRYCLNDQPVKFQVVSDQTINFPNRFGQVNYEDPNFNVGLPVFTIHGNHDDPAGVDNLSAIDILSACNLVNYFGKMDLGGSGVGEIAVYPVLVKKGTTFVALYGLGNIRDERLNRMFQTPHAVQWMRPETQDGMSVSDWFNILVLHQNRIKTNPKSAINEHFLPRFLDFIVWGHEHECLIDPQEVPGMGFHITQPGSSVATSLIDGEAKPKHVLLLEIKGNQYRPTKIPLRSVRPFHYAEVVLKDEVDVDPNDQASVLEHLDKIVRNLIKKSSQPTASRPETKLPLIRIKVDYSGFSTINPQRFGQKYVGKVANPQDILIFSKSAKKRQTTGVGNIDDSEKLRPEELNQQTIEALVAENNLKMEILPVDDLDIALHDFVSKDDKMAFYACLQRNLEETRTKLNSEADKFKIEEEDIIVKVGECMQERVKERSLRSKEDSRFTSSSQNLDTGGRSVTAQSNLNSFSDDEDTREMLLGARTTNAGRKASGFTRPSKDATDVAKTGTSRRGRGRGTASMKQTTLNFSQSRSSAAIRSEEVQSSSDEENETNEANEVVESSEPEESPQQTGRKRAAPRGGRGRGRGATAKRGRKADISSIQSMLMSKDDDDDDEDDRPKKPPPRVTRNYGAVRRR

MRE11

Double-strand break repair protein MRE11

705 amino acids

Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.

Belongs to the MRE11/RAD32 family.

79.126 kDa

MGDESNTLRVLVATDCHLGYMEKDEIRRFDSFEAFEEICSLAEQNKVDFVLLGGDLFHENKPSRSTLVKTIEILRRYCLNDQPVKFQVVSDQTINFPNRFGQVNYEDPNFNVGLPVFTIHGNHDDPAGVDNLSAIDILSACNLVNYFGKMDLGGSGVGEIAVYPVLVKKGTTFVALYGLGNIRDERLNRMFQTPHAVQWMRPETQDGMSVSDWFNILVLHQNRIKTNPKSAINEHFLPRFLDFIVWGHEHECLIDPQEVPGMGFHITQPGSSVATSLIDGEAKPKHVLLLEIKGNQYRPTKIPLRSVRPFHYAEVVLKDEVDVDPNDQASVLEHLDKIVRNLIKKSSQPTASRPETKLPLIRIKVDYSGFSTINPQRFGQKYVGKVANPQDILIFSKSAKKRQTTGVGNIDDSEKLRPEELNQQTIEALVAENNLKMEILPVDDLDIALHDFVSKDDKMAFYACLQRNLEETRTKLNSEADKFKIEEEDIIVKVGECMQERVKERSLRSKEDSRFTSSSQNLDTGGRSVTAQSNLNSFSDDEDTREMLLGARTTNAGRKASGFTRPSKDATDVAKTGTSRRGRGRGTASMKQTTLNFSQSRSSAAIRSEEVQSSSDEENETNEANEVVESSEPEESPQQTGRKRAAPRGGRGRGRGATAKRGRKADISSIQSMLMSKDDDDDDEDDRPKKPPPRVTRNYGAVRRR

MRE11

Double-strand break repair protein MRE11

700 amino acids

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).

Belongs to the MRE11/RAD32 family.

80.024 kDa

MSAVSLQDDEDTFKILIATDIHLGYLEKDAVRGNDTFVTFNEILEHAQKNEVDFILLGGDLFHENKPSRKTIHTCLESLRKYCMGDRPVSFEVLSDQAVNFQLSKFPWVNYQDENLNIFMPIFSIHGNHDDPTGVDALCALDILSCAGLLNHFGRSTSVEKIDISPILLRKGRTKIALYGLGAIPDERLYRMFVNKQVTMLRPKEDEDSWFNMFVIHQNRSKHGATNYIPEQFLDDFINLAVWGHEHECKITPAQNEQQHFYVTQPGSSVVTSLSPGEAVKKHIGLLRVKGKKMKMQRIALETVRTFYMEDVVLADHPELFNPDNPKVTQAIQAFCMEKVEMMLDNAERERLGNPRQPQKPLIILRVDYTGGFEPFIVHRFSQKYMDRVANPKDIIHFFRHREQKEKNDNDINFGKLLSRPASEEVTLRVEDLVKQYFQTAEKKVQLSLLTERRMGEAVQEFVDKEEKDAIEELVKFQLEKTQRFLKERHIDAEEEKIDEEVRKFRESRRKNTEEEDEEVREAMTRARAHRSEGVVLDSASSDEGLMDTGMKASGDSDDDIPTTLSRGRGRGRARGARGQNSAARGSSRRGRGNTSQGSSTSSRTYKSVPDKNSSIMDAFRSLKPEPSQSTSKFFSEDIIDDEMDLEESPISLSSKTNQRSSAMSSFSKRGSQSQMSRGVDFESDEDDPFKNTATSRRKK

MRE11

Double-strand break repair protein MRE11

692 amino acids

Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.

Belongs to the MRE11/RAD32 family.

77.65 kDa

MDYPDPDTIRILITTDNHVGYNENDPITGDDSWKTFHEVMMLAKNNNVDMVVQSGDLFHVNKPSKKSLYQVLKTLRLCCMGDKPCELELLSDPSQVFHYDEFTNVNYEDPNFNISIPVFGISGNHDDASGDSLLCPMDILHATGLINHFGKVIESDKIKVVPLLFQKGSTKLALYGLAAVRDERLFRTFKDGGVTFEVPTMREGEWFNLMCVHQNHTGHTNTAFLPEQFLPDFLDMVIWGHEHECIPNLVHNPIKNFDVLQPGSSVATSLCEAEAQPKYVFILDIKYGEAPKMTPIPLETIRTFKMKSISLQDVPHLRPHDKDATSKYLIEQVEEMIRDANEETKQKLADDGEGDMVAELPKPLIRLRVDYSAPSNTQSPIDYQVENPRRFSNRFVGRVANGNNVVQFYKKRSPVTRSKKSGINGTSISDRDVEKLFSESGGELEVQTLVNDLLNKMQLSLLPEVGLNEAVKKFVDKDEKTALKEFISHEISNEVGILSTNEEFLRTDDAEEMKALIKQVKRANSVRPTPPKENDETNFAFNGNGLDSFRSSNREVRTGSPDITQSHVDNESRITHISQAESSKPTSKPKRVRTATKKKIPAFSDSTVISDAENELGDNNDAQDDVDIDENDIIMVSTDEEDASYGLLNGRKTKTKTRPAASTKTASRRGKGRASRTPKTDILGSLLAKKRK

mre11

DNA double-strand break repair protein Mre11

617 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

67.781 kDa

MDREIRILHTADTHLGYRQYHSEVRRQDFFKAFETVIKDAVDMQVDAVVHAGDLFDSRNPTLEDLLETMNVLSRLKVANIPFFGIVGNHESKQSTQWLDLFEEMGLAGRLGKAPKMVGDVAIYGIDSVPKSKIPLFDYSGFEIPESLPENCRKLLVMHQIMQPSPFPDWDCAEVIENLPFKADAVLLGDYHEYEKIKVGESWVTYSGSTERNSASEKEPRSYSIITLSGEGLEISRRTIPTRNFLFITAKVDGEEKPFEQIFSTVNEHLEEIPESVVFLDVSGDSSSVLSFSEIEEYLLSKGALVVKVKDARVKEGIPEEVIKVAFHDPDRAVAEELRRMSLNDGGLIVDEVIRSPDVPRSRVDEETENRLLGLIEAIDFKDPDFMIKIPVSHVSPVDPSSSVSSIESSGSVSPIDSVSTVSPSSPSSSAIIKEPEELKPPGAAEEIENPKPAGVTEFTAAVAAKSETLMPPVRIQRSESLNESLNKIFEKHDVVPESPETAGSIAGSVETAVEDEISKVTPDSGVITAPQSSSPVSFSDNSQTGFSAISPPESIPSPEILKENSEADADEKPVDGKLSEEKPVGVPDKATKTVKQSHRKGKEKSAVPRQYNLGDYL

mre11

DNA double-strand break repair protein Mre11

617 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

67.781 kDa

MDREIRILHTADTHLGYRQYHSEVRRQDFFKAFETVIKDAVDMQVDAVVHAGDLFDSRNPTLEDLLETMNVLSRLKVANIPFFGIVGNHESKQSTQWLDLFEEMGLAGRLGKAPKMVGDVAIYGIDSVPKSKIPLFDYSGFEIPESLPENCRKLLVMHQIMQPSPFPDWDCAEVIENLPFKADAVLLGDYHEYEKIKVGESWVTYSGSTERNSASEKEPRSYSIITLSGEGLEISRRTIPTRNFLFITAKVDGEEKPFEQIFSTVNEHLEEIPESVVFLDVSGDSSSVLSFSEIEEYLLSKGALVVKVKDARVKEGIPEEVIKVAFHDPDRAVAEELRRMSLNDGGLIVDEVIRSPDVPRSRVDEETENRLLGLIEAIDFKDPDFMIKIPVSHVSPVDPSSSVSSIESSGSVSPIDSVSTVSPSSPSSSAIIKEPEELKPPGAAEEIENPKPAGVTEFTAAVAAKSETLMPPVRIQRSESLNESLNKIFEKHDVVPESPETAGSIAGSVETAVEDEISKVTPDSGVITAPQSSSPVSFSDNSQTGFSAISPPESIPSPEILKENSEADADEKPVDGKLSEEKPVGVPDKATKTVKQSHRKGKEKSAVPRQYNLGDYL

mre11

DNA double-strand break repair protein Mre11

614 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

68.374 kDa

MDREIRILHTADTHLGYRQYHSEVRRQDFFKAFETVIQDAVDMQVDAVVHAGDLFDSRNPTLEDLLETMNILSRLKAVDIPFFGIVGNHESKQNTQWLDLFEEMGLAERLGKTPKLVGNTTIYGIDSVPKSKIPLYDYSGFELPDSLPENCKKLLVMHQIVQPFPYADWDCAEVLENLPFKVDAILLGDYHKYEKIKVGEEETWATYSGSTERNSASENEPRSYNIITLSGEGLEISRRTIPTRNFLFITAKIDGEEKPYEQIFSAINEHLEEIPESVVFLDISGNSDSVLSFSEIEEYLLSKGALVSKVKDARIKETLPEEVAKVAFSDPDHAVAEEIRRMSLNDGGLIVDEIIRSPDVVRSRVDEETENRLLRLIETIDFEDPDFRIEIPASPISSTDSIDPVSPINHPVSSADSVSAVSPESSADHVSPDIIENNEKPIPAVEAEKIETLDPAGETEFVAGIAGKTETFRAPVRIKNSESLNEALKKSYEAPDKVREAPDVNPEPPEPLPAFKNIGSPETFGSCETTVSSEVPEKGGERTELEDDAVNKTEKETGKLSGFGVEAGSEKEDADRIEKPAHVPDKAEKPVKQSQRKGKGKSAVPRQYNLGDYL

mre11

DNA double-strand break repair protein Mre11

614 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

68.374 kDa

MDREIRILHTADTHLGYRQYHSEVRRQDFFKAFETVIQDAVDMQVDAVVHAGDLFDSRNPTLEDLLETMNILSRLKAVDIPFFGIVGNHESKQNTQWLDLFEEMGLAERLGKTPKLVGNTTIYGIDSVPKSKIPLYDYSGFELPDSLPENCKKLLVMHQIVQPFPYADWDCAEVLENLPFKVDAILLGDYHKYEKIKVGEEETWATYSGSTERNSASENEPRSYNIITLSGEGLEISRRTIPTRNFLFITAKIDGEEKPYEQIFSAINEHLEEIPESVVFLDISGNSDSVLSFSEIEEYLLSKGALVSKVKDARIKETLPEEVAKVAFSDPDHAVAEEIRRMSLNDGGLIVDEIIRSPDVVRSRVDEETENRLLRLIETIDFEDPDFRIEIPASPISSTDSIDPVSPINHPVSSADSVSAVSPESSADHVSPDIIENNEKPIPAVEAEKIETLDPAGETEFVAGIAGKTETFRAPVRIKNSESLNEALKKSYEAPDKVREAPDVNPEPPEPLPAFKNIGSPETFGSCETTVSSEVPEKGGERTELEDDAVNKTEKETGKLSGFGVEAGSEKEDADRIEKPAHVPDKAEKPVKQSQRKGKGKSAVPRQYNLGDYL

mre11

DNA double-strand break repair protein Mre11

587 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

65.998 kDa

MGSVISAEIFRRYQQYKATGELRRKPVIGIVIEEAPRVLGKEVIERQGNNIYSTIAREGRKFNIGLIAITQLVSLIPRTVLANMNTKIILGNEMAQERAEIIGSASQDLSADNRTIASLDKGEAIVSSIFTKFAVPVKIPLFEEFIESAGLESEDTDDDMIEFYRVGLSMYRFAHLSDCHLGAQKHPDLRELEFEAFRMALDDALQKDVDFMIIAGDLFHSNIPNMETVKRATLELRRVREAGVPIYVNYGSHDYSPSSTSMIDILESAGVIDKVVRPIPGKKLGLEFTVDEKTGAKITGLSGRSRTLEAEYFMKLDREALEAEDGFRIFLFHSAITQFKPVDLADMESVDLNLFPRGFEYYAGGHVHRKGCYIEEGYGPIVYPGTLFGSYAGDLEENARGETRGYYLVEFTDRAREPEFREIRPAEFEYIECDVTGKNSQDAYHQIGREIAGHDVTGKVVMLKIRGELSSGRTSDIDSASIREKLESMGARVVQINRYGLSTREIQKVRVVESDVPRLERRIFREKLAGLDIRNRRLMEEGDSIAVELLRRLENEKAPGENKSEYEKRIIEDAGDVLGLDLGGDGT

mre11

DNA double-strand break repair protein Mre11

587 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

65.998 kDa

MGSVISAEIFRRYQQYKATGELRRKPVIGIVIEEAPRVLGKEVIERQGNNIYSTIAREGRKFNIGLIAITQLVSLIPRTVLANMNTKIILGNEMAQERAEIIGSASQDLSADNRTIASLDKGEAIVSSIFTKFAVPVKIPLFEEFIESAGLESEDTDDDMIEFYRVGLSMYRFAHLSDCHLGAQKHPDLRELEFEAFRMALDDALQKDVDFMIIAGDLFHSNIPNMETVKRATLELRRVREAGVPIYVNYGSHDYSPSSTSMIDILESAGVIDKVVRPIPGKKLGLEFTVDEKTGAKITGLSGRSRTLEAEYFMKLDREALEAEDGFRIFLFHSAITQFKPVDLADMESVDLNLFPRGFEYYAGGHVHRKGCYIEEGYGPIVYPGTLFGSYAGDLEENARGETRGYYLVEFTDRAREPEFREIRPAEFEYIECDVTGKNSQDAYHQIGREIAGHDVTGKVVMLKIRGELSSGRTSDIDSASIREKLESMGARVVQINRYGLSTREIQKVRVVESDVPRLERRIFREKLAGLDIRNRRLMEEGDSIAVELLRRLENEKAPGENKSEYEKRIIEDAGDVLGLDLGGDGT

MRE11

Double-strand break repair protein MRE11

567 amino acids

Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity).

Belongs to the MRE11/RAD32 family.

65.003 kDa

MKILITSDNHLGYRESDPVLLDDSYDTFEEILGIAQRERVDLVLQGGDLFHENRPSRSCLNRTIGLFRRYCIGNERSGLRSNLALNFHDQNIGISIPVVSIHGNHDDPSGISMVSPIDILQSAGLVNYIGKYNLIDRIDVYPLLLEKEYRVAIYGLGHIKDRRLYRMFCEGRIVFHRPEDYDSWYNVLILHQNRIPREKEHFSSDLVEGFFDLIVYGHEHESMVVKGDCLILQPGSTVRTSLCEGERHDKYAYILRIGEECTLEHVKLRSVRPLLLDTLRIEERDNVEEKVENKIRGMIDLGRKKESLFNKEITAIDVDTKRFKCRGDSNEACGAGPVCKGYQLEEKTRIPLVKLKIELCGDEVLDKHRFSAQFKGLVANPSDMLTISRKTRRREEVETQPMAERVEISQILRKILGNVEFGVLSRLGFSESLDEFVKGDSNAFMGMVRKNIEKVVNAVDHSSIVDEDVIKAMKRASREEDRGYEEDHFEPRAALGVLDEMDPGLANKNLRNEYSSRLGGNSEENESKAKKNFNVEDLLGKEYLSKKLRKDKEDSSTDVSFTFSKYL

mre11

DNA double-strand break repair protein Mre11

451 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

50.627 kDa

MRMAHVADVHLGHALMNLRSREEAVMETFERLMEEVRECSVDVLVIAGDLFEHARPKTEALYLAVEKLSELKEDGVEIVATAGNHEIRRRKGAVSPISVLERMGLVRHLYYSERRPERHRYTATFDGVRVTFHGLQYLPKNSFVERAKVIRAKYRPDPEADVNVAIFHQALPGTIPDESEIVEPAYFPEGHDYYAMGHVHVPSREEKIHGSPAPYPGSPEPLTFLEVKDERGAHKRRGFFLVEFDRGGLVEYEFVEVEWSRELSVVEVSGERWEEELRRRVRRGQIVKVVAKDTGASPEEVEKVAIEAGADRCVVELRERRREVEEGDETEGPLDLEGIIREGVKRARAATLTRVDVPDDVVVEVALEILRGVREDNPPDLGDVEGIVAGEPPSEGSEESSEEPEESDGEEVGLEVEEVKVESRGTSSEGMSRAGSKLGSSGRPSLDRWIG

mre11

DNA double-strand break repair protein Mre11

451 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

50.627 kDa

MRMAHVADVHLGHALMNLRSREEAVMETFERLMEEVRECSVDVLVIAGDLFEHARPKTEALYLAVEKLSELKEDGVEIVATAGNHEIRRRKGAVSPISVLERMGLVRHLYYSERRPERHRYTATFDGVRVTFHGLQYLPKNSFVERAKVIRAKYRPDPEADVNVAIFHQALPGTIPDESEIVEPAYFPEGHDYYAMGHVHVPSREEKIHGSPAPYPGSPEPLTFLEVKDERGAHKRRGFFLVEFDRGGLVEYEFVEVEWSRELSVVEVSGERWEEELRRRVRRGQIVKVVAKDTGASPEEVEKVAIEAGADRCVVELRERRREVEEGDETEGPLDLEGIIREGVKRARAATLTRVDVPDDVVVEVALEILRGVREDNPPDLGDVEGIVAGEPPSEGSEESSEEPEESDGEEVGLEVEEVKVESRGTSSEGMSRAGSKLGSSGRPSLDRWIG

mre11

DNA double-strand break repair protein Mre11

443 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

51.178 kDa

MKFAHIADVHLGYEQYNQPWRAEDFAKAFKVIAEKAVESNADFVVIAGDLFHRSLPSPRTIKEAVETLWMFRKENIPVFAVEGNHDKTSRDISAYHLLESLGLLNVLGLRRNPVRGENVESLRIQNVYLVKGVVDDVEILGDRHRSKWQLEKVLPLLKPQSDKSVLVLHQAVKEVVDIDLDMAYELTINDLPEASYYAFGHIHLPKIYEFDGKAIAYPGSVERYDLREASKIVRYRDELVLKDGIRKGFILVKNFRPEFVEIETRELYDVEIEDESVEGLEKKFLEVLGRADKEGIMVAKLKSSDAVDVRRLSEVAAKRVRYAEIRFERILEEIEEVEIKQESEFFTEFELKLLELLRGEMDEDEVYSLVVEHYLSGGALKQEEGAEERVVEEETEKKVEEQFKGDEEADEAERRAEETEKAKSTKKARKPKTLLDFLGVEEE

mre11

DNA double-strand break repair protein Mre11

441 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity (By similarity). In polyploid organisms, the Rad50/Mre11 complex appears to restrain the repair of double-strand breaks by homologous recombination, allowing another pathway to act as the primary mode of repair (PubMed:19593371).

Belongs to the MRE11/RAD32 family.

48.175 kDa

MTRVIHTGDTHLGYQQYHSPERRQDFLDAFERVVADALDGDVDAVVHAGDLYHDRRPELPDLLGTLAALRRLDDAGIPFLAIVGNHESTRGGQWLDLFERLGLATRLGRDPHVVGGVAFYGLDHVPRSRRDELDYQFDPVDADRAVLVAHGLFTPFAHADWETETVLAESNVDFDAVLLGDNHVPDTAELDGTWVTYCGSTERASASERDPRGYNLVEFTPDAVDIRRRTLETRPFAFVEVDLAGDEGIERVRQRVREFDLEDAVVIVELRGEGETVTPAAVESFAVEEGALVARVNDKRDIDDDGDLATDVTFADPDDAVRERVREMGLSSAALDVDETVRASKVADSNVRDEVRERVESLLSDDPDAFVAAERESDAEAEESESVEDAADGEDAAAVEDTAETAAEAATDTDTETTADTDSETAADPAASRDSSLGDFA

mre11

DNA double-strand break repair protein Mre11

426 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair (PubMed:11029422, PubMed:18854158, PubMed:18957200). The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA (PubMed:18957200). Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity (PubMed:11029422, PubMed:18854158, PubMed:18957200).

Belongs to the MRE11/RAD32 family.

49.456 kDa

MKFAHLADIHLGYEQFHKPQREEEFAEAFKNALEIAVQENVDFILIAGDLFHSSRPSPGTLKKAIALLQIPKEHSIPVFAIEGNHDRTQRGPSVLNLLEDFGLVYVIGMRKEKVENEYLTSERLGNGEYLVKGVYKDLEIHGMKYMSSAWFEANKEILKRLFRPTDNAILMLHQGVREVSEARGEDYFEIGLGDLPEGYLYYALGHIHKRYETSYSGSPVVYPGSLERWDFGDYEVRYEWDGIKFKERYGVNKGFYIVEDFKPRFVEIKVRPFIDVKIKGSEEEIRKAIKRLIPLIPKNAYVRLNIGWRKPFDLTEIKELLNVEYLKIDTWRIKERTDEESGKIGLPSDFFTEFELKIIDILGEKDFDDFDYIIKLITEGKVEEEGPLEEAVKKVSEEKGKTVRQKIESIPKKKRGTLDSWLGGAR

mre11

DNA double-strand break repair protein Mre11

426 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair (PubMed:11029422, PubMed:18854158, PubMed:18957200). The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA (PubMed:18957200). Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity (PubMed:11029422, PubMed:18854158, PubMed:18957200).

Belongs to the MRE11/RAD32 family.

49.456 kDa

MKFAHLADIHLGYEQFHKPQREEEFAEAFKNALEIAVQENVDFILIAGDLFHSSRPSPGTLKKAIALLQIPKEHSIPVFAIEGNHDRTQRGPSVLNLLEDFGLVYVIGMRKEKVENEYLTSERLGNGEYLVKGVYKDLEIHGMKYMSSAWFEANKEILKRLFRPTDNAILMLHQGVREVSEARGEDYFEIGLGDLPEGYLYYALGHIHKRYETSYSGSPVVYPGSLERWDFGDYEVRYEWDGIKFKERYGVNKGFYIVEDFKPRFVEIKVRPFIDVKIKGSEEEIRKAIKRLIPLIPKNAYVRLNIGWRKPFDLTEIKELLNVEYLKIDTWRIKERTDEESGKIGLPSDFFTEFELKIIDILGEKDFDDFDYIIKLITEGKVEEEGPLEEAVKKVSEEKGKTVRQKIESIPKKKRGTLDSWLGGAR

mre11

DNA double-strand break repair protein Mre11

415 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

48.079 kDa

MGIKFAHLADVHLGYEQFNRSQRAEEFAKAFEDAIKICVDEKVDFIVIAGDLFNSSRPSPGTIKTAVKILQIPRDNNIPVFAIEGNHDRTQRGPSILHLLEDLGLLYVLGVRDEKVENEYLTSEKTKAGWLVKGMYKDVEIHGMKYMSAAWFEGNIELFKSMFRPEGDAILVLHQGVREITENNYPNYSSELSLSDLPKGYLYYALGHIHKRFELTYDDAPVVYPGSLERWDFGDYSLKLTWNGFQFKEEVGVDKGFYIVEDFKPRFIRINARDFIDVHIKGHSENEIKKAVKLAVPKIPRNSYVRFNIRWKRPVDVDWIKSIVNAEYVRVNPIIIKEERGPDGKDLDVKKFFTELEWKIIELASEKEYEYYLNQIIDLLASEEGKVEAKIDAKREEKKFVRPKNPGDIMAWVKG

mre11

DNA double-strand break repair protein Mre11

415 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

48.079 kDa

MGIKFAHLADVHLGYEQFNRSQRAEEFAKAFEDAIKICVDEKVDFIVIAGDLFNSSRPSPGTIKTAVKILQIPRDNNIPVFAIEGNHDRTQRGPSILHLLEDLGLLYVLGVRDEKVENEYLTSEKTKAGWLVKGMYKDVEIHGMKYMSAAWFEGNIELFKSMFRPEGDAILVLHQGVREITENNYPNYSSELSLSDLPKGYLYYALGHIHKRFELTYDDAPVVYPGSLERWDFGDYSLKLTWNGFQFKEEVGVDKGFYIVEDFKPRFIRINARDFIDVHIKGHSENEIKKAVKLAVPKIPRNSYVRFNIRWKRPVDVDWIKSIVNAEYVRVNPIIIKEERGPDGKDLDVKKFFTELEWKIIELASEKEYEYYLNQIIDLLASEEGKVEAKIDAKREEKKFVRPKNPGDIMAWVKG

mre11

DNA double-strand break repair protein Mre11

413 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

48.043 kDa

MKFAHLADVHLGYEQFNKPQRAEEFANTFKKALEMCVKESVDFIIIAGDLFNSSRPSPGTIKTAIKLLQIPKENNIPVFAIEGNHDRTQRGPSVLHLLEDLGLLYVIGLRQERVENEYLTSERVGNYWLVKGVYDNLEIHGMKYMSSAWFEANLNFFKGIFRPDEDAILVLHQGIRDITEKVFPSYSAELKLSDLPRGYLYYALGHVHKRFETNYGDSPVVYPGSLERWDFGDYAKRLVWNGVTFREEVGSDKGFYIVEDFTPRFVNIKVRDFIDVVIKGDSEREIKKAVKASLPHIPRNSYVRFNIKWRKPFDVEWIKEIVNAEYLRIHTAIIKDEKSMNGESVDIKSFFTEQEWKVIDLASSDEFESYIEKIVDILSGYEKKEEREKKESKIRKFERPKNPGDLTAWLRGG

mre11

DNA double-strand break repair protein Mre11

413 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

48.043 kDa

MKFAHLADVHLGYEQFNKPQRAEEFANTFKKALEMCVKESVDFIIIAGDLFNSSRPSPGTIKTAIKLLQIPKENNIPVFAIEGNHDRTQRGPSVLHLLEDLGLLYVIGLRQERVENEYLTSERVGNYWLVKGVYDNLEIHGMKYMSSAWFEANLNFFKGIFRPDEDAILVLHQGIRDITEKVFPSYSAELKLSDLPRGYLYYALGHVHKRFETNYGDSPVVYPGSLERWDFGDYAKRLVWNGVTFREEVGSDKGFYIVEDFTPRFVNIKVRDFIDVVIKGDSEREIKKAVKASLPHIPRNSYVRFNIKWRKPFDVEWIKEIVNAEYLRIHTAIIKDEKSMNGESVDIKSFFTEQEWKVIDLASSDEFESYIEKIVDILSGYEKKEEREKKESKIRKFERPKNPGDLTAWLRGG

mre11

DNA double-strand break repair protein Mre11

409 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

45.018 kDa

MPKVLHVADVHLGARPYGLEERRDDIFRSFEFVVETALKDRPDAVLIAGDLFDKPKLPLRDVKQAVELVRALTDAGIPVLAAHGEHDTPSVRDETLLSLMEASLDGFKAPLYRSGMRPGDFVVDLGSLKVAVVPFFKVPLEERRRLTLRFLREFDQISRTSSGTLVLLAHMSLDAEMQFDAVASPSDLPSGAKYAALGHLHAPRIRLDAPTPYAYPGVLDPLKVEEINTPGSPLYVDLSGDAPIIEKVKVPRRPQYRIEVDIGDGGSIYNAVNRGLRRVLANVRASREDWLKPLIHVIIKSDKPISKARVIAEARKAAGGADVLLKIHWKIVAGGEHAGTSPGLQGEGPLDLAKIAAEYYKIPLNAASTILHDLAEAAAEKDELRVREILETLATTVSQDTWKRILYMR

mre11

DNA double-strand break repair protein Mre11

387 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

42.685 kDa

MARVIHTGDTHLGYQQYHAPQRRQDFLDAFDAVITDAIDEGVDAVVHAGDLYHDRQPGLRDILDTIALLRPLQDADIPFLAVVGNHEGTRDAQWLDLFETLGLAERLDDSPRVVADTAFYGLDYVPQSKRDDHDYTVADHDADHAALVSHGLFTPFPYANWDLDAVLADATVEFDAVLLGDNHTPDTAQLGDTWVTYCGSTERASASERDPRGYNIVSFSSDATTDVAISRKSLNTREFVFVDADLGPTDGTAFIQERLRERALDDAVVVVTITGDGDTVTPAEIERFGDDRGALLTRVNDRREFDTGDDAPDVDVSFADPDDAVEQRVRDLGLDEPARDVDRIVRDDTLADAAVRERVIQRAEAVLDDDADAADDDGRPTTVEEFQ

mre11

DNA double-strand break repair protein Mre11

387 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

44.979 kDa

MSKTQILHISDTHLGKRQYNLDFREQDVYDTFSQLIDIAIKEHVDGIIHTGDLFDINDPPNKAEIVAIRELKRLKEAGIPFIVIAGDHDSPKKFTAIYPQKILEEFDLIKFLSKPDTPYKLGEITIYGISHVPNVAKERLKELLSRLKPENKKSILLLHQGLKEVLPYEGAWQIQIDDLPKAFSYYALGHFHTRRVFQLDGGRIIEIAGSPDILREEEIEGYEKEGKGATLIDFSGDIPTIQKINIDVRKQYVVTLNTNNLREEIRKLREKYDTNNEKKPIFHIILEGKSIPKNVLMKELQEINNFAPYWRIYKDNTKEKDEKDVKIDLPTDTTIENLIYNYLVKIANFSETEARMIVDIINRADEREYVKEELMKMIGVENDNKKN

mre11

DNA double-strand break repair protein Mre11

387 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

44.979 kDa

MSKTQILHISDTHLGKRQYNLDFREQDVYDTFSQLIDIAIKEHVDGIIHTGDLFDINDPPNKAEIVAIRELKRLKEAGIPFIVIAGDHDSPKKFTAIYPQKILEEFDLIKFLSKPDTPYKLGEITIYGISHVPNVAKERLKELLSRLKPENKKSILLLHQGLKEVLPYEGAWQIQIDDLPKAFSYYALGHFHTRRVFQLDGGRIIEIAGSPDILREEEIEGYEKEGKGATLIDFSGDIPTIQKINIDVRKQYVVTLNTNNLREEIRKLREKYDTNNEKKPIFHIILEGKSIPKNVLMKELQEINNFAPYWRIYKDNTKEKDEKDVKIDLPTDTTIENLIYNYLVKIANFSETEARMIVDIINRADEREYVKEELMKMIGVENDNKKN

mre11

DNA double-strand break repair protein Mre11

382 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity (By similarity). Recruited immediately to chromosomal DNA after gamma irradiation, and remains DNA bound in the course of DNA repair (PubMed:18294364).

Belongs to the MRE11/RAD32 family.

44.157 kDa

MQLLHISDTHLGKRQYNLESREKDVYDTFTQLIDIAINEHVKAVIHTGDLFDVNNPPNRAKLHAIKELKRLKDHNIPFICIAGDHDSPKRKEEIYPQRILEEFNLIKILQKIDNRVKLENVEVYGISHISNVSVNDLKEQLSKVKPETRKSILMLHQGIRTYLPYQGAWQIELSDLPKGFSLYAVGHLHSRRKDYLDGGALIEIAGSPDIMREEEIEDYQKSKKGATLIDMSGDLPSINYINVNIRDQLVLDINVDKIEQSIESVIQKLKENVKNDKKPILHIELEGTVPIRKDVLMTKLQALRDYVEHYRIYKNNIVSIKEENLKTKLKTTYSSLNDIIADYLKGIGYTDEETKIIIDIINEEDEKKVEELLKKFAGVEDK

mre11

DNA double-strand break repair protein Mre11

382 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity (By similarity). Recruited immediately to chromosomal DNA after gamma irradiation, and remains DNA bound in the course of DNA repair (PubMed:18294364).

Belongs to the MRE11/RAD32 family.

44.157 kDa

MQLLHISDTHLGKRQYNLESREKDVYDTFTQLIDIAINEHVKAVIHTGDLFDVNNPPNRAKLHAIKELKRLKDHNIPFICIAGDHDSPKRKEEIYPQRILEEFNLIKILQKIDNRVKLENVEVYGISHISNVSVNDLKEQLSKVKPETRKSILMLHQGIRTYLPYQGAWQIELSDLPKGFSLYAVGHLHSRRKDYLDGGALIEIAGSPDIMREEEIEDYQKSKKGATLIDMSGDLPSINYINVNIRDQLVLDINVDKIEQSIESVIQKLKENVKNDKKPILHIELEGTVPIRKDVLMTKLQALRDYVEHYRIYKNNIVSIKEENLKTKLKTTYSSLNDIIADYLKGIGYTDEETKIIIDIINEEDEKKVEELLKKFAGVEDK

mre11

DNA double-strand break repair protein Mre11

381 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

43.551 kDa

MVQILHISDTHLGKRQYSLVEREKDIYDIFSQLVDIAIKEHVDVIIHSGDLFDVSSPTTNALVMAIKILKRLKDVNIPFLSIPGDHDTPKRKGYLIPHNILSELDLIKILNYEKPYIIKGIEVYGIPHIPTVSKSILVSALSALRPKSSRSILLLHQGVKQILPYDGSWQMELGSLPKGFGYYALGHIHTRWRLTQDDGSVIAIAGSPDIMREEEIEGYEKFGKGAYLIDFSKDLPILSTINITVRPQKVVTINTKNIKKDILTIRDDLIEHNKSENNKPILHIIVEGERMRKDLLYKELLPLNDVALYYRIYKDETTQTVDNLSYTLPRDKGLDKIIIEYLTKYEKFSEDEANLILQMIKNVESDEIVNEILKKLTGVNL

mre11

DNA double-strand break repair protein Mre11

381 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

43.551 kDa

MVQILHISDTHLGKRQYSLVEREKDIYDIFSQLVDIAIKEHVDVIIHSGDLFDVSSPTTNALVMAIKILKRLKDVNIPFLSIPGDHDTPKRKGYLIPHNILSELDLIKILNYEKPYIIKGIEVYGIPHIPTVSKSILVSALSALRPKSSRSILLLHQGVKQILPYDGSWQMELGSLPKGFGYYALGHIHTRWRLTQDDGSVIAIAGSPDIMREEEIEGYEKFGKGAYLIDFSKDLPILSTINITVRPQKVVTINTKNIKKDILTIRDDLIEHNKSENNKPILHIIVEGERMRKDLLYKELLPLNDVALYYRIYKDETTQTVDNLSYTLPRDKGLDKIIIEYLTKYEKFSEDEANLILQMIKNVESDEIVNEILKKLTGVNL

mre11

DNA double-strand break repair protein Mre11

376 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

43.33 kDa

MHFSDTHIGYRSLTLDEREQDFYDAFHEAIDIALENSVDFVIHTGDLFDTWVPGNRAIREFRNAVMKLNARNIPIFVIFGDHDRPRRNGEPAAGIFDFMGVHVLGWDAYEYAVRKFDGEDVLIGGISNMKGYMKTRLKDEYKRSENIEEGYRNRILMSHQAIDPFFVPDQCEAKMDDLPMNFSYIAMGHLHDFMERRIGPLISYAGSTEIKSENEINGYLKQGKGVNIVDISNGEVDLQRIRLKSVRPQIRVESDADNYVHEISEKLSSLRVKDNEKKPLVGLEIHGDISMETVMQDISKFDNAIFSRPKIRKDPKIPNIHTETADLREYFRAYLGDERLADLAMKIMAHSRSKDIDGIMKEIEVLYGDNRQDSPD

mre11

DNA double-strand break repair protein Mre11

376 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

43.33 kDa

MHFSDTHIGYRSLTLDEREQDFYDAFHEAIDIALENSVDFVIHTGDLFDTWVPGNRAIREFRNAVMKLNARNIPIFVIFGDHDRPRRNGEPAAGIFDFMGVHVLGWDAYEYAVRKFDGEDVLIGGISNMKGYMKTRLKDEYKRSENIEEGYRNRILMSHQAIDPFFVPDQCEAKMDDLPMNFSYIAMGHLHDFMERRIGPLISYAGSTEIKSENEINGYLKQGKGVNIVDISNGEVDLQRIRLKSVRPQIRVESDADNYVHEISEKLSSLRVKDNEKKPLVGLEIHGDISMETVMQDISKFDNAIFSRPKIRKDPKIPNIHTETADLREYFRAYLGDERLADLAMKIMAHSRSKDIDGIMKEIEVLYGDNRQDSPD

mre11

DNA double-strand break repair protein Mre11

374 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

42.598 kDa

MVRFLHMSDTHIGAKSLTIEEREQDYYDTFQEAVEIAIDEKVDFIIHSGDLFDTWIPGNRSMKVFRDAMMKLNDRQIPVFYVFGDHDRPRRNSESAAGIFDFLGLHILGRDEFAGIEREFSGMKVFIGGISNMKGYLRNQLKEEYKKAESASTGYKNSILISHQALDPIFIPEQCEAKVNDLPMNYSYIAMGHLHDFVEREIGPLLSYPGSTELKSDREINGLLKMGKGINVIDLDNGVASLHRVKLKKVRYQFKVESDPENYLEEIKSILDKYANAIGEKKPIVNLIINGQISMEEVYEDLKKINGAIFNRPQILKIVDMPNVPSGSSELREYFQAFLKDQKLTDLAMKVFQHTADGDKEAIIREAAGEAIDN

mre11

DNA double-strand break repair protein Mre11

372 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

43.263 kDa

MQFVHMADNHLGYRQYNLDERENDIYESFLECIDKIIEIRPDFVIHSGDLFESPQPPVNAIRCAMEGLLKLKEKNIPIYLIHGNHDIPKSQQKGKPFGLLKKILGNSLLTFGKNKSHVFNNEVFIGGIEYVSQNKIPKTYEDLEKINSDSKNYKKKILLFHQSVNPFIPQSFEMQVTDFPDDFNYIAGGHIHQRALKPINDGNSVFSYAGSTDIMSVSEVKDYKKNGKGFYLGDLSGDFDINSIQKIDVECRNFLIDKKIKNENDYKKTVEELQNLQSEKKKPILYCDIVENLFNSFNDEIANLTLYKRISRIDENLEESLIINESSIEEIFQEYIKNKEMDVNFVYGLYKKLLENDEDSLLYVNDYFKGNY

mre11

DNA double-strand break repair protein Mre11

372 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

43.263 kDa

MQFVHMADNHLGYRQYNLDERENDIYESFLECIDKIIEIRPDFVIHSGDLFESPQPPVNAIRCAMEGLLKLKEKNIPIYLIHGNHDIPKSQQKGKPFGLLKKILGNSLLTFGKNKSHVFNNEVFIGGIEYVSQNKIPKTYEDLEKINSDSKNYKKKILLFHQSVNPFIPQSFEMQVTDFPDDFNYIAGGHIHQRALKPINDGNSVFSYAGSTDIMSVSEVKDYKKNGKGFYLGDLSGDFDINSIQKIDVECRNFLIDKKIKNENDYKKTVEELQNLQSEKKKPILYCDIVENLFNSFNDEIANLTLYKRISRIDENLEESLIINESSIEEIFQEYIKNKEMDVNFVYGLYKKLLENDEDSLLYVNDYFKGNY

mre11

DNA double-strand break repair protein Mre11

366 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

43.132 kDa

MMFVHIADNHLGYRQYNLDDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPVKALRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPLALLKDYVKILDGKDVINVNGEEIFICGTYYHKKSKREEMLDKLKNFESEAKNYKKKILMLHQGINPYIPLDYELEHFDLPKFSYYALGHIHKRILERFNDGILAYSGSTEIIYRNEYEDYKKEGKGFYLVDFSGNDLDISDIEKIDIECREFVEVNIKDKKSFNEAVNKIERCKNKPVVFGKIKREFKPWFDTLKDKILINKAIIVDDEFIDMPDNVDIESLNIKELLVDYANRQGIDGDLVLSLYKALLNNENWKELLDEYYNTKFRG

mre11

DNA double-strand break repair protein Mre11

366 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

43.132 kDa

MMFVHIADNHLGYRQYNLDDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPVKALRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPLALLKDYVKILDGKDVINVNGEEIFICGTYYHKKSKREEMLDKLKNFESEAKNYKKKILMLHQGINPYIPLDYELEHFDLPKFSYYALGHIHKRILERFNDGILAYSGSTEIIYRNEYEDYKKEGKGFYLVDFSGNDLDISDIEKIDIECREFVEVNIKDKKSFNEAVNKIERCKNKPVVFGKIKREFKPWFDTLKDKILINKAIIVDDEFIDMPDNVDIESLNIKELLVDYANRQGIDGDLVLSLYKALLNNENWKELLDEYYNTKFRG

mre11

DNA double-strand break repair protein Mre11

361 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

42.565 kDa

MIAFISDLHLGNIYANKKETEEHSYNALAKIEEKLLEYQPDLVLVGGDIFDKNKVSGKEIGVFIDFINKMNKNNIGVVSISGNHDGKYWLKESFDHAIPYILYKSGINPENGYEYYSFAGIYLKNSRDWKTLSMIEDKYDISIVGFSFYTKDRLPELYEYLSIIDREKSDYILLMHQSLKSLLPQDPAAIDLTIENYKYALFGHMHMKYYKDKIIVTPPPYSISLKEANTEKGFWLIDKKPVFVPIEDSRPFIKMAIDLDNPIEIKPNKNAILILDVYYRESQIDKLNLLKKTLSENFLYVKINPILKETSKIIVKKSENKEEIFKKYLKEDYDFFMELYEKFRDIKDPETIVQYLEFFYR

mre11

DNA double-strand break repair protein Mre11

361 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

Belongs to the MRE11/RAD32 family.

42.565 kDa

MIAFISDLHLGNIYANKKETEEHSYNALAKIEEKLLEYQPDLVLVGGDIFDKNKVSGKEIGVFIDFINKMNKNNIGVVSISGNHDGKYWLKESFDHAIPYILYKSGINPENGYEYYSFAGIYLKNSRDWKTLSMIEDKYDISIVGFSFYTKDRLPELYEYLSIIDREKSDYILLMHQSLKSLLPQDPAAIDLTIENYKYALFGHMHMKYYKDKIIVTPPPYSISLKEANTEKGFWLIDKKPVFVPIEDSRPFIKMAIDLDNPIEIKPNKNAILILDVYYRESQIDKLNLLKKTLSENFLYVKINPILKETSKIIVKKSENKEEIFKKYLKEDYDFFMELYEKFRDIKDPETIVQYLEFFYR