Protein
Aminodeoxyfutalosine synthase
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Function
Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.
Similarity
Belongs to the radical SAM superfamily. MqnE family.
Sequence
MDAGLKRELEQKVRSGERLTREDGIALYESDDLAWLGGLAHEVRTRKNGDVVHFNVNRHLNMTNVCTASCAYCSFQRKPGEKDAYTMRIEEAVKLAKAMEGENLTELHIVNGLHPNLPWRYYPRSLRELKAALPEVSLKAFTATEIHHFETISGMSASDILDELIDAGLESLTGGGAEIFDWEVRQHIVDHRTHWEDWSRIHRLAHEKGLKTPCTMLYGHIEEPRHRVDHVLRLRELQDETGGFQVFIPLRYQHDFVDMKDGKVRNRLQARTQMATGAEALKTFAVSRLLFDNVPHVKVFWVMHGVQTAQLALQHGADDMDGSVVEYKITHDADDFGTPNKLTREDLLDLIRDAGFRPVERNTRYEILREYEGPDPARRESPQPMRV