mptB

Alpha-(1->6)-mannopyranosyltransferase B

602 amino acids

Involved in the initiation of core alpha-(1->6) mannan biosynthesis of lipomannan (LM-A) and multi-mannosylated polymer (LM-B), extending triacylatedphosphatidyl-myo-inositol dimannoside (Ac1PIM2) and mannosylated glycolipid, 1,2-di-O-C16/C18:1-(alpha-D-mannopyranosyl)-(1->4)-(alpha-D-glucopyranosyluronic acid)-(1->3)-glycerol (Man1GlcAGroAc2), respectively. Catalyzes the addition of alpha-(1->6)-mannose residue.

Belongs to the MptA/B family.

64.199 kDa

MFSAPLRRMMRVTKDEQIQPNSNAPENRKWFPRAPRPLRQFLDTLPRIGTAGSRSATLHVEDEQSPLGATLFDVATGASSINDRDTDASGLEPEKIRRFAWLRLIGTMGALMIAFGALGAGALPVVNNPYVDFPGGNFMSRMLQTSSMIVLIGVGFLVLAWVLMAPLVGIPFKRSGNRTASVSLSMLRRTFGAWVAPIMLTAPLFTQDIYSYLAQGSVTAQGMDAYAGGPLELLGPDNHLARSVPFIWAQSPSPYGPVALSIAASISVITNDSIVGGVLAHRIASLLGVVAAGWAITMLARRCRVSEEASFYLGVLNPLLILHLIGGIHNESILLGFLLVGLELGLRGTDRIQTGLWGPAWTYIALSGVLISCAGLVKVTGFIGLGFVGMALARAFHARGHRHVVAIGVAGLVQVAALVITVVVLSVITGISLGWITGQGGAATIRSWMSMTTNIGVISGFIGMNLGLGDHTAAMLVVTRAAGIAVAAAFMVRMLFATYRGHIHAVGGLGVATFVLVILFPVVHPWYMLWAIVPLASWANRLFFQLGVIAYSTAFSFFVLPRGLALPVGTVFSIYFGAALGFSILLLVGWWSLRRNPTFGLH

mptB

Dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase

249 amino acids

Cyclic phosphodiesterase that hydrolyzes the cyclic phosphate of 7,8-dihydroneopterin 2',3'-cyclic phosphate (H2N-cP) and converts it to a mixture of 7,8-dihydroneopterin 2'-phosphate (H2N-2'P) and 7,8-dihydroneopterin 3'-phosphate (H2N-3'P). Is also able to utilize other phosphodiesters as substrates in vitro: hydrolysis of bis-pNPP and pNPPC produces nitrophenyl phosphate, and that of 2',3'-cAMP produces 3'-AMP. ATP, 3',5'-cAMP, GTP, 3',5'-cGMP, and 4',5'-cFMN cannot serve as substrates.

28.523 kDa

MERLIKLAEQIKDEELRKKVIEFLKNPKATHPGIVDTGISVEEAPASINWHHRYEGGLIEHTISVTKIALKMADVLEEVYGVEVNRDYIIAGALLHDIMKPYNYIRKEDGTFDHYDMFNLDHLTLAVAELYKRDFPIEVIKIVASHHGDHSPTRPNSIEAYIVHYADEADSKINDVAVRVCQARSRDLGISEQEIYKAVNPLKVYEVRSREGKLKTIEFLKDILKSIGIISEDEKKDENNESLENKESN