Protein
Metallophosphoesterase 1 homolog
Organism
Caenorhabditis elegans
Function
Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
Similarity
Belongs to the metallophosphoesterase superfamily. MPPE1 family.
Sequence
MIWLKNLRVPILLAIILVVYNEYFIFFIAFSSCQWPCKYGRCSESSVKAFMISDTHLLGKINGHWLDKLKREWQMYQSFWISTWIHSPDVTFFLGDLMDEGKWAGRPVFEAYAERFKKLFGDNEKVITLAGNHDLGFHYAIMPETLEMFKKEFRRGLIDEMKIKKHRFVLINSMAMHGDGCRLCHEAELILEKIKSRNPKNRPIVLQHFPLYRKSDAECDQVDEQHEIDLKEMYREQWDTLSKESSLQIIDSLNPKAVFGGHTHKMCKKKWNKTGNSEYFYEYTVNSFSWRNGDVPAMLLVVIDGDNVLVSSCRLPSEILQIMVYIFGGIGIVILAFILISRRVRIFKRRPSYSLLMYRSQEKCD