Function
Ligand for members of the frizzled family of seven transmembrane receptors. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells (PubMed:9288750, PubMed:9288749, PubMed:16678095, PubMed:25344071). Involved in cleavage axis determination (PubMed:9288750). Binds to receptor tyrosine kinase cam-1 (PubMed:17942487). Together with wnt ligand lin-44, plays a role in controlling vulva precursor cell P7.p lineage orientation during vulva development, probably by acting as a ligand for tyrosine kinase receptor lin-18 (PubMed:15369677). May act redundantly with other Wnt ligands such as cwn-1 and cwn-2 to control seam cell polarity (PubMed:22022276).
Sequence
MHINTPVLLAIIYFLVFAPKSADAWWLLSKTDTSSANSGSSPILCKNVPGLTPQQKRMCHENPNIIKYLISGLRSALHTCEYTFQREAWNCTLTLPGVGTSPLQIASRESAYVYAISAAGVSHSLARACSKGLIDDCGCGETPQGSGSVAVSQASSRSSSDFVWAGCSDNVKFGNTFGRKFVDQYDRQHATEPRSQMNLHNNRVGRRLLVNAMNKECKCHGVSGSCVTKTCWKVMPKFDEFASRLHQKYQLAKLVTNNDQKLTVRSSPSAGSSGRSERFARNMDASSKQMRNELIYLDASPNYCAIDVKDRECGENCPNICCGRGWRTTREIVDEPCHCQFVWCCEVKCKTCKKLVERNYCL