Function
Efflux pump; part of the gene cluster that mediates the biosynthesis of monakolin K, also known as lovastatin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:18578535, PubMed:19968298).
Sequence
MASHQSEKEKPQSCTTEVQVSHVTGLKLGLVVTSVTLVVFLMLLDMSIIVTAIPHITAQFHSLGDVGWYGSAYLLSSCALQPLAGKLYTLLTLKYTFLAFLGVFEVGSALCGAARCSTMLIVGRAVAGMGGSGLTNGAITILASAAPKQQQPLLIGIMMGLSQIAIVCGPLLGGAFTQHASWRWCFYINLPVGALAAILLLAIHIPKSVPTSDCTMPAPRAVGVRVILSQLDLLGFVLFAAFAVMISLALEWGGSDYMWDSSVIIGLFCGAGISLVVFGFWERYVGNSMAMIPFSVASRRQVWCSCLFLGFFSGALLTFSYYLPIYFQAVKDVSPTMSGVYMLPGIGGQIVMAIVSGAIIGKTGYYIPWALASGIIVSISAGLVSTFQPHTSIAAWVMYQFMGGFGRGCGMQTPIIAIQHALPPQMSALGISLAMFGQTFGGSLFLTLAKLVFSAGLDAGLREYAPAVSAEAVTAAGATGFRDVVPANLLSQVLLAYCKGIDHTFYLAVGASGATFLFAWGMGQVGLIWWGEERTGFGRDERV