Function
Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners (PubMed:9458050, PubMed:11914278, PubMed:19119011, PubMed:18198337, PubMed:19781752). Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes (PubMed:11914278, PubMed:18198337, PubMed:19119011). The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases (PubMed:11914278). Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation and organization (PubMed:19119011, PubMed:15557118). Both the condensin complex I and II play a role in meiotic and mitotic chromosome segregation (PubMed:11914278, PubMed:19119011, PubMed:15557118). Plays a role in robust cytokinesis upon the presence of chromatin obstructions (PubMed:23684975). Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase (PubMed:9458050, PubMed:19119011, PubMed:18198337, PubMed:19781752).
Sequence
MHIKSIHLDGFKSYQKHTDILDFSPTFNAITGYNGSGKSNILDSICFIMGINKLDNIRAKSMHELISHGGTKAIVQVRFDNTDKRCSPFGMEHLDEIVVQRIITAQATGKGCATSYTLNGHAATNGKMQDFFRGVGLNVNNPHFLIMQGRITTVLNMKPEEILGMVEEAAGTKMYDQKKKDAEKTMFLKDAKLKEVDRIFQSSIDPRMVKFREDRKNMVEVTRLKKLKENFSRKYEAFQYFQTCEAVKKSAKEIEDAKKGIEDLGEKFNQLDLDLKNKEDEKKKMEESRDDQHEEAALSAAHLSKQSIMLQKETVKNQLVETINKLKKEGEQINKSLSKDREVLDAKRKEHEDSKAANSKDIQSQSDDEALVTKYRNDLESLTRGTIANDKGEHVSIESEIQSCKSTASQMSSGITAAKKRGERLHNQIKHLEGEKATLSARSKSDIGSADNYQKEVDEINKQLQLLGFNIDADTEKREHAAKLHESITKLKDMDTRLLNSYKDGRYALNYQRPPLHIDKFDEKRDVFGYVAHLIKMKPGCEQFAVAADIALGGVLGNVVVSTQDIARILIDGKAFTSRKTMIPVSENARNASSYNTLPDVKLRRAKEIAEKYNDTVTKMIDLIEYPDFISNTILNAVGQILVVDSLDVAREIAYDEVAKTRMITRRGDDVRTNGIMTGGYNDPGNKPALIALEPMYARRPQIEAQQRELDALNRELQLTEASSQKCRDLNNQLATAMRKLAQVKTNINNSEFGIVVRDLKVHSEEYEKNQAEIEATVKTLKDVEDKIKTLESMKNKDKNSQEKRKKELTALLQKAEQTVAQNKNRGEKARREVMLLQATVEEMEKTIKKDEGIWEQKKKECDELEEKLPNAIAALKDAELEQKAAQAKLNDLKNNQRQISTRLGKIAKECDALIREKAKTKSKREEKEKELTSLQQSEASNRKEARSKLKKFEWLSDEEAHFNKKGGLYDFEGYTVSKGKDEIKELTDKIETLERSCCIQNVSNLDTCEAKVLDIKNKRERITEDFNMLKKTIATLDKKKVDELIRAHESVNKDFGQIFNCLLPDAHASLVPPEGKTVCEGLEVKVSFGGVVKDSLHELSGGQRSLVALSLILAMLKFKPAPLYILDEVDAALDLSHTANIGMMIKTHFHHNQFIIVSLKQGMFSNADVLFQTRFADGHSTCTRLNGGDIAVLCQDKVLQAQALELTDAGKAKKDAAAKKGAQKNDKEPPKKKPIVVDDDDFE