mios

Gene

mios

Protein

GATOR complex protein MIOS

Organism

Dictyostelium discoideum

Length

1119 amino acids

Function

As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.

Similarity

Belongs to the WD repeat mio family.

Mass

126.106 kDa

Sequence

MSQSSTRKRLIQWSPHNKSSFIVGSNDLRLYNFKFKDKNEKKNENNINNSNQYNQNNQQQQQQQIQQQQQQQQQQQQQQQQQQQQQQQQQQQQHDIYSPKSITSKYMETYNFDIEYPPDDWVPQEKKTISLMSVNSDVQLMKCMAWCPDESDTNLIACGLTSGRAILTSFSSVNRILKELVPKHTRSCNAISWNPIYTNQLAVGLDKVRGDSSTLIWDINYLQSTTLNNHLHKNNNNYISKLQQQQNNIDQPYIISQISDNSFSTSTDYTDTIYQPISEFTQSEATLALAWLPNNPSCLLVGTGSKWLKLYDIRDVNSSQSVMAHQKSVNGVCVDPFDFNRIATMSEDSHIKVWDLRNLDDPLIIVNSNCKSIQQIDWCPTRSGVLASVGKDKSSIKLWDIKAPIEFSKSPKLESTTLSTGGGGSGSNTSNNLNKRSTSNNNNSQDPINTISKPTKIHHSSDVVSSFSWHPTNECRMLTVSYSGVIDVVSLNENIPISWSPHGGICFSFGNNVLEGPTKGETLEPNILNYKNLINDGRYEKDISSKIKERAIFGYSANVEENINLANKINDENINFLWKWIQKVPIQIQNFKRESSLISTPSISTTTPGGPITPSATTKTIINNNNNNNNNKNINNNINNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNEYNGIYNILIEKDISTVESSNGFVIYKSPNRNLCLSICGWGFNQSLPLENILSRLEKSGEYERAAAIAVFHLDIKRAILVVTNATYNIHPVTQTNHHGHLMRQDREFSLKLLSIALAGFDGSSTSNNNNNNNNNNNNIWKETCKSTAKSFINPYLKTCLEFLASNSDSKDIYSIIEDSRINLDDKIAFSCKYLDYQDLIHFVERNTIRVIECGNLKGVLLTGLTGRGVDLLSNYIDRTCDIQTAVLAISLVVPKFFRDKRVSKWSSIYSDLLDQWELWHERAILDIQTRISGIDQPPTPQIFAKCGFCQNSFAFESISASSIVGRNASSKPNFKAKVPFCPHCKQSLPRCCLCLLPLNCMVPTPEFKKSNTTIGSGGGSIASSGGINNSGSINNPNDSQLWSNGSEPFEDWFTWCQTCRHGGHSQHILDWFKDHSICPVTSCDCRCSQL

Protein

GATOR complex protein MIOS: mios

Gene

mios

Protein

GATOR complex protein MIOS

Organism

Dictyostelium discoideum

Length

1119 amino acids

Function

As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.

Similarity

Belongs to the WD repeat mio family.

Mass

126.106 kDa

Sequence

Protein

GATOR complex protein MIOS: mios

Gene

mios

Protein

GATOR complex protein MIOS

Organism

Danio rerio

Length

876 amino acids

Function

As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.

Similarity

Belongs to the WD repeat mio family.

Mass

98.182 kDa

Sequence

MSSGYKPDILWSPHHADRYVICDTELSLYRIGPSGSSETKAGALQLSEETAATLLAINSDTPFMKCVAWYPKHEPECLLAVGHTNGRVVLTSLGQSHNSKSKDLAGKEFVPKHARQCNTLAWNPVDSNWLAAGLDKHRADFSVLIWDISSKFSPEAVPAEKVRLSGDADSGLLVTKPLYELGQNDACLSLCWLPRDHQKLLLAGMHRNLAIFDLRNTSQKTFVNTKAIQGVTVDPHFQDRVASYFEGQVAIWDLRKFEKPVFTLNEQPKPLTKVAWCPTRMGLLATLTRDSNIIRLYDMQHTPMPFGDEVEPTIMERGVQPCSESIISSFAWHPSAQNRMVVVSPSRVMNDFTLFERISLAWSSTTSLMWACGRHLYECAEDSGQAAEAEKDIATKMRERAQSRYGHDTVQVWRNHVLAGGDDPQLRSLWYTLHFMKQYTENVEQKQQSNKQSLIYSGIKNIVKSSSGTTETRRCWSGSDRQTDVPRFHSEERSLALQLCGWISQGPDTDVEPFLKSLEQEGEWERAAAVALFNLDIRRAIQILNKGASSEKGDLNLNVVAMALSGYTDEKNSLWREMCSSLRLQLKKPYLCIMFAFLTSEPGAYDGVLYESRVAVRDRVAFACMFLNDAQLPRYIDKLTNEMKEAGNLEGILLTGLTKDGVDLMESYVDRTGDVQTASFCMLKGSPGEVLKDPRVQCWIENYRNLLDAWRFWHKRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSCSAMPHQGRGFSQYGVSGSPTKSKVTSCPGCRKPLPRCALCLMNMGTPVSSCPGTGKADEKADLTRDKKLAQFNNWFTWCHNCRHGGHAGHMLSWFRDHSECPVSACTCKCMQLDTTGNLVPSDSV

Protein

GATOR complex protein MIOS: mios

Gene

mios

Protein

GATOR complex protein MIOS

Organism

Danio rerio

Length

876 amino acids

Function

As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.

Similarity

Belongs to the WD repeat mio family.

Mass

98.182 kDa

Sequence

Protein

GATOR complex protein MIOS: mios

Gene

MIOS

Protein

GATOR complex protein MIOS

Organism

Homo sapiens

Length

875 amino acids

Function

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).

Similarity

Belongs to the WD repeat mio family.

Mass

98.584 kDa

Sequence

MSGTKPDILWAPHHVDRFVVCDSELSLYHVESTVNSELKAGSLRLSEDSAATLLSINSDTPYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLAWNPLDSNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVKLSAGETETTLLVTKPLYELGQNDACLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQKMFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSVQPCDNYIASFAWHPTSQNRMIVVTPNRTMSDFTVFERISLAWSPITSLMWACGRHLYECTEEENDNSLEKDIATKMRLRALSRYGLDTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEDMDQKSPGNKGSLVYAGIKSIVKSSLGMVESSRHNWSGLDKQSDIQNLNEERILALQLCGWIKKGTDVDVGPFLNSLVQEGEWERAAAVALFNLDIRRAIQILNEGASSEKGDLNLNVVAMALSGYTDEKNSLWREMCSTLRLQLNNPYLCVMFAFLTSETGSYDGVLYENKVAVRDRVAFACKFLSDTQLNRYIEKLTNEMKEAGNLEGILLTGLTKDGVDLMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLDAWRFWHKRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSCSAVPHQGRGFSQYGVSGSPTKSKVTSCPGCRKPLPRCALCLINMGTPVSSCPGGTKSDEKVDLSKDKKLAQFNNWFTWCHNCRHGGHAGHMLSWFRDHAECPVSACTCKCMQLDTTGNLVPAETVQP

Protein

GATOR complex protein MIOS: MIOS

Gene

Mios

Protein

GATOR complex protein MIOS

Organism

Mus musculus

Length

875 amino acids

Function

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.

Similarity

Belongs to the WD repeat mio family.

Mass

98.335 kDa

Sequence

MSGTKPDILWAPHQVDRFVVCDSELSLYHVESAVNSELKAGSLRLSEDSAATLLSINSDTPYMKCVAWYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLAWNPLDSNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVRLSAGEAETTLLVTKPLYELGQNDASLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQKMFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSVQPCDNYIASFAWHPTSQNRMIVVTPNRTMSDFTVFERISLAWSPITSLMWACGRHLYECAEEESDNSLEKDIATKMRLRALSRYGLDTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEDNDQKSPGNKGSLVYAGIKSIVKSSLGMVESSRHNWSGLDKQTDIQNLNEERILALQLCGWIKKGTDVDVGPFLNSLVQEGEWERAAAVALFNLDIRRAIQILNEGASSEKGDLNLNVVAMALSGYTDEKNSLWREMCSTLRLQLNNPYLCVMFAFLTSEAGAYDGVLYENKVAVRDRVAFACKFLGDAQLNKYIEKLTNEMKEAGNLEGILLTGLTKDGVDLMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLDAWRFWHKRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSCSSVPHQGRGFSQYGVSGSPTKSKVTSCPGCRKPLPRCALCLINMGTPVSSCPGGSKSDEKVDLSKDKKLAQFNNWFTWCHNCRHGGHAGHMLSWFRDHAECPVSACTCKCMQLDTTGNLVPAETVQP

Protein

GATOR complex protein MIOS: Mios

Gene

MIOS

Protein

GATOR complex protein MIOS

Organism

Pongo abelii

Length

875 amino acids

Function

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.

Similarity

Belongs to the WD repeat mio family.

Mass

98.401 kDa

Sequence

MSGTKPDILWAPHQVDRFVVCDSELSLYHVESTVNSELKAGSLRLSEDSAATLLSINSDTPYMKCVACYLNYDPECLLAVGQANGRVVLTSLGQDHNSKFKDLIGKEFVPKHARQCNTLAWNPLDNNWLAAGLDKHRADFSVLIWDICSKYTPDIVPMEKVKLSAGETETTLLVTKPLYELGQNDACLSLCWLPRDQKLLLAGMHRNLAIFDLRNTSQKMFVNTKAVQGVTVDPYFHDRVASFYEGQVAIWDLRKFEKPVLTLTEQPKPLTKVAWCPTRTGLLATLTRDSNIIRLYDMQHTPTPIGDETEPTIIERSVQPCDNYIASFAWHPTSQNRMIVVTPNRTMSDFTVFERISLAWSPITSLMWACGRHLYECTEEENDNSLEKDIATKMRLRALSRYGLDTEQVWRNHILAGNEDPQLKSLWYTLHFMKQYTEDMDQKSPGNKGSLVYAGIKSIVKSSLGMVESSRHNWSGLDKQSDIQNLNEERILALQLCGWIKKGTDVDVGPFLNSLVQEGERERAAAVALFNLDIRRAIQILNEGASSEKGDLNLNVVAMALSGYTGEKNSLWREMCSTLRLQLNNPYLCVMFAFLTSETGSYDGVLYENKVAVRDRVAFACKFLSDTQLNRYIEKLTNEMKEAGNLEGILLTGLTKDGVDLMESYVDRTGDVQTASYCMLQGSPLDVLKDERVQYWIENYRNLLDAWRFWHKRAEFDIHRSKLDPSSKPLAQVFVSCNFCGKSISYSCSAVPHQGRGFSQYGVSGSPTKSKVTSCPGCRKPLPRCALCLINTGTPVSSCPGGTKSDEKVDLSKDKKLAQFNNWFTWCHNCRHGGHAGHMLSWFRDHAECPVSACTCKCMQLDTTGNLVPAETVQP

Protein

GATOR complex protein MIOS: MIOS

Gene

MIOS

Protein

GATOR complex protein MIOS

Organism

Homo sapiens

Length

875 amino acids

Function

Similarity

Belongs to the WD repeat mio family.

Mass

98.584 kDa

Sequence

Protein

GATOR complex protein MIOS: MIOS

Gene

Mios

Protein

GATOR complex protein MIOS

Organism

Mus musculus

Length

875 amino acids

Function

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.

Similarity

Belongs to the WD repeat mio family.

Mass

98.335 kDa

Sequence

Protein

GATOR complex protein MIOS: Mios

Gene

MIOS

Protein

GATOR complex protein MIOS

Organism

Pongo abelii

Length

875 amino acids

Function

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.

Similarity

Belongs to the WD repeat mio family.

Mass

98.401 kDa

Sequence

Protein

GATOR complex protein MIOS: MIOS