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midn-b

Gene
midn-b
Protein
Midnolin-B
Organism
Xenopus laevis
Length
451 amino acids
Function
Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
Mass
49.213 kDa
Sequence
MEQQPSVPRSCTNVARETPMNLNIQSTTGTRYELSVPLNETVDGLKRRISQRLKVPKERLTLLHRETRLSSGKLQDLGISDGSRLTLLPSVEAGLMSQMSRPEQSVMQALESLTETQVNDFLSGRSPLTLALRVGDHMMFVQLQLAAQQSGGSHLQHRHVITRGADAGAPPQYRTLHTSTSALSHLASCTPGSTPPTTLSPTSSTHCDAPHSSPLTTSVFRSHGEGVSPCAEQVPCSTRGTEGTSSSPSSRSRKPGAIIESFVNHAPGVFSGTFSGTLHPHCQDGAGRPRRDIGTILQILNDLLSATRHYQGMPPSLTTLRCHTQCASQARNAKATSPQSTGPQQTTHPVGHCQAQTRTCKPSGDRLRQTENRATRCKVERLQLLMHQKRLRRKARRDSRAPYHWMPTRKSSRTSSNSSTSSGEGSLEIDFEDSLWKPDVKAELNSEFVVA