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mettl1-A

Gene
mettl1-A
Protein
tRNA (guanine-N(7)-)-methyltransferase A
Organism
Xenopus tropicalis
Length
273 amino acids
Function
Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Mass
31.697 kDa
Sequence
MCNTQATPSDPGITVAHPKKRYYRQRAHSNPMADHTFQYPVKPEIMDWSEYYPDYFKPLVPDSAHDDAKDLQERKEQHQVEFADIGCGYGGLLVELSPLFPNTLMLGLEIRVKVSDYVQDRIKSLRASHLGQYQNIACIRSNAMKYIPNFFKKGQLSKMFFLFPDPHFKKTKHKWRIISPTLLAEYAYVLRIGGMVYTITDVEEVHTWMVKHFTEHPLFERVAKEELVNDIVVGKLGTSTEEGKKVQRNKGLNLLAVFRRIENSTFIQRDSQQ