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metrnl

Gene
METRNL
Protein
Meteorin-like protein
Organism
Homo sapiens
Length
311 amino acids
Function
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).
Similarity
Belongs to the meteorin family.
Mass
34.398 kDa
Sequence
MRGAARAAWGRAGQPWPRPPAPGPPPPPLPLLLLLLAGLLGGAGAQYSSDRCSWKGSGLTHEAHRKEVEQVYLRCAAGAVEWMYPTGALIVNLRPNTFSPARHLTVCIRSFTDSSGANIYLEKTGELRLLVPDGDGRPGRVQCFGLEQGGLFVEATPQQDIGRRTTGFQYELVRRHRASDLHELSAPCRPCSDTEVLLAVCTSDFAVRGSIQQVTHEPERQDSAIHLRVSRLYRQKSRVFEPVPEGDGHWQGRVRTLLECGVRPGHGDFLFTGHMHFGEARLGCAPRFKDFQRMYRDAQERGLNPCEVGTD

Gene
Metrnl
Protein
Meteorin-like protein
Organism
Mus musculus
Length
311 amino acids
Function
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.
Similarity
Belongs to the meteorin family.
Mass
34.53 kDa
Sequence
MRGAVWAARRRAGQQWPRSPGPGPGPPPPPPLLLLLLLLLGGASAQYSSDLCSWKGSGLTREARSKEVEQVYLRCSAGSVEWMYPTGALIVNLRPNTFSPAQNLTVCIKPFRDSSGANIYLEKTGELRLLVRDIRGEPGQVQCFSLEQGGLFVEATPQQDISRRTTGFQYELMSGQRGLDLHVLSAPCRPCSDTEVLLAICTSDFVVRGFIEDVTHVPEQQVSVIYLRVNRLHRQKSRVFQPAPEDSGHWLGHVTTLLQCGVRPGHGEFLFTGHVHFGEAQLGCAPRFSDFQRMYRKAEEMGINPCEINME

Gene
Metrnl
Protein
Meteorin-like protein
Organism
Rattus norvegicus
Length
311 amino acids
Function
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).
Similarity
Belongs to the meteorin family.
Mass
34.468 kDa
Sequence
MRGVVWAARRRAGQQWPRSPGPGPGPPPPPPLLLLLLLLLGGASAQYSSDLCSWKGSGLTREAHSKEVEQVYLRCSAGSVEWMYPTGALIVNLRPNTFSPAQNLTVCIKPFRDSSGANIYLEKTGELRLLVRDVRGEPGQVQCFSLEQGGLFVEATPQQDISRRTTGFQYELMSGQRGLDLHVLSAPCRPCSDTEVLLAICTSDFVVRGFIEDVTHVPEQQVSVIHLRVSRLHRQKSRVFQPAPEDSGHWLGHVTTLLQCGVRPGHGEFLFTGHVHFGEAQLGCAPRFSDFQKMYRKAEERGINPCEINME

Gene
metrnl
Protein
Meteorin-like protein
Organism
Danio rerio
Length
286 amino acids
Function
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance (By similarity).
Similarity
Belongs to the meteorin family.
Mass
31.709 kDa
Sequence
MLSPFLAYLLSVVLLCRIARSQYSSDQCSWRGSGLTHEGHTRGVEQVYLRCAQGFLEWLYPTGAIIVNLRPNTLSPAASLLSVCIKPSKESSGTHIYLDRLGKLRLLLSEGDQAEGKVHCFNIQDGALFIEAVPQRDISRKITAFQYELVNHRPGADPQSLSAPCQPCTDAEVLLAVCTSDFVARGRILGVSEEDEQTSVTVSLSHLYRQKTQVFVSGGGRAKRWTGFVKMSRQCGVKPGDGEFLFTGTVRFGEAWLSCAPRYKDFLRVYQDARQQGTNPCHLETD

Gene
metrnl
Protein
Meteorin-like protein
Organism
Xenopus laevis
Length
286 amino acids
Function
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance (By similarity).
Similarity
Belongs to the meteorin family.
Mass
32.144 kDa
Sequence
MLRRGLLSFFMVILIDRGTSQLYSSDMCNWKGSGLTHEGHTKDVEQVYLRCSEGSVEWLYPTGAMVINLRPNTLTSAYKHLTVCIKPFKDSKGANIYSEKTGELKLVVPDGENNPHKVYCFGLDRGGLYIEATPQQDISRKITGFQYELISQRTLSDLHTVSDPCRPCSDTEVLLAVCISDFVVKGTISAVTNDEELQESLINVTVDKLYRQKSKIFLPKDNGGWEGMIRTPLECGVKTGMGSFLFTGRMHFGEPRLGCTPRYKDFKRIYLEAKKQGLNPCEISTD