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metI

Gene
metI
Protein
Cystathionine gamma-synthase/O-acetylhomoserine (thiol)-lyase
Organism
Bacillus subtilis (strain 168)
Length
373 amino acids
Function
Catalyzes the formation of L-cystathionine from O-acetyl-L-homoserine and L-cysteine. Cannot use O-succinyl-L-homoserine as substrate. Also exhibits O-acetylhomoserine thiolyase activity, catalyzing the synthesis of L-homocysteine from O-acetyl-L-homoserine and sulfide.
Similarity
Belongs to the trans-sulfuration enzymes family.
Mass
41.705 kDa
Sequence
MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGFDYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGGTYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIARITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLGEEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLYPGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIANGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE

Gene
metI
Protein
Probable D-methionine transport system permease protein MetI
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Length
225 amino acids
Function
Part of the binding-protein-dependent transport system for D-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Similarity
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
Mass
23.762 kDa
Sequence
MSFNTIAQWFALNSDLLLTATWQTLYMVAIAGAVGFALGIPLGVILHTTKKEGLLENLPLNRALGAVVNIGRSVPFLVLMVAIIPVTKLIVGTFIGTTAAIVPLTIGAIPFVARLIESALLEVPTGLVEAAQSMGATPLQIIRKVLLPEALPTILNSVTITLVTLVSYSAMAGTVGGGGLGDVAIRYGFHRYDITIMAVTVVMLIVLVQIIQSIGDALVRRVDHR

Gene
metI
Protein
D-methionine transport system permease protein MetI
Organism
Escherichia coli O157:H7
Length
217 amino acids
Function
Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Similarity
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
Mass
23.242 kDa
Sequence
MSEPMMWLLVRGVWETLAMTFVSGFFGFVVGLPVGVLLYVTRPGQIIANAKLYRTVSAIVNIFRSIPFIILLVWMIPFTRVIVGTSIGLQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQIGYQYGYIGYNATVMNTVLVLLVILVYLIQFAGDRIVRAVTRK

Gene
metI
Protein
D-methionine transport system permease protein MetI
Organism
Escherichia coli (strain K12)
Length
217 amino acids
Function
(Microbial infection) Probably transports the toxic C-terminal region of CdiA from E.coli strain MHI813 across the inner membrane to the cytoplasm, where CdiA has a toxic effect. Toxin transport is strain-specific, mutations in this gene do not confer resistance to several other tested CdiA toxins.
Similarity
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
Mass
23.256 kDa
Sequence
MSEPMMWLLVRGVWETLAMTFVSGFFGFVIGLPVGVLLYVTRPGQIIANAKLYRTVSAIVNIFRSIPFIILLVWMIPFTRVIVGTSIGLQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQIGYQYGYIGYNATVMNTVLVLLVILVYLIQFAGDRIVRAVTRK

Gene
metI
Protein
Probable D-methionine transport system permease protein MetI
Organism
Pasteurella multocida (strain Pm70)
Length
217 amino acids
Function
Part of the binding-protein-dependent transport system for D-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Similarity
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
Mass
23.382 kDa
Sequence
MTPRIWELVGLSTLETLYMGFIATLFAIVIGLPIGLLAFLTGKGEILENRRANQVLNVIINIGRSVPFIILLIILLPFTRLVVGTTLGTTAAIVPLSVSAIPFFARLTANALLEIPSGLTEAAKSMGATNWQIVTKYYLPESIPILINGITLTLVALIGYSAMAGAVGGGGLGNLAITYGEHRNMIYVKWIATIIIVLIVMLSQKLGDHLAERFDHR

Gene
metI
Protein
D-methionine transport system permease protein MetI
Organism
Salmonella typhi
Length
217 amino acids
Function
Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Similarity
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
Mass
23.231 kDa
Sequence
MSEAMMWLLVRGVWETLAMTFVSGFFGFVIGLPVGVLLYVTRPGQIMENARLYRSLSAVVNIFRSIPFIILLVWMIPFTRIIVGTSIGLQAAIVPLTVGAAPFIARIVENALLEIPAGLIEASRAMGATPLQIVRKILLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQIGYQYGYIGYNATVMNTVLVLLVVLVYLIQLSGDRIVRAVTHK

Gene
metI
Protein
D-methionine transport system permease protein MetI
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
217 amino acids
Function
Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Similarity
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
Mass
23.249 kDa
Sequence
MSEAMMWLLVRGVWETLAMTFVSGFFGFVIGLPVGVLLYVTRPGQIMENARLYRSLSAVVNIFRSIPFIILLVWMIPFTRIIVGTSIGLQAAIVPLTVGAAPFIARMVENALLEIPAGLIEASRAMGATPLQIVRKILLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQIGYQYGYIGYNATVMNTVLVLLVVLVYLIQLSGDRIVRAVTHK

Gene
metI
Protein
D-methionine transport system permease protein MetI
Organism
Yersinia pestis
Length
217 amino acids
Function
Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity).
Similarity
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
Mass
23.218 kDa
Sequence
MSEAMMWLMARGVWETLMMTFVSGFFGFVLGLPVGVLLYVTRPGQIIANNKIYRTLSGVVNIFRSIPFIILLVWMIPFTRMIVGTSIGLQAAIVPLTVGAAPFIARMVENALLEIPSGLVEAARAMGATPMQIIKKVLLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQIGYQYGYIGYNATVMNTVLVLLVILVYLIQLSGDRIVKAVTHK

Gene
metI
Protein
Probable D-methionine transport system permease protein MetI
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
213 amino acids
Function
Part of the binding-protein-dependent transport system for D-methionine. Probably responsible for the translocation of the substrate across the membrane.
Similarity
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
Mass
22.935 kDa
Sequence
MWGVVATATYETVYISFASTLLAVLVGVPVGIWTFLTGKNEILQNNRTHFVLNTIINIGRSIPFIILLLILLPVTRFIVGTVLGTTAAIIPLSICAMPFVARLTANALMEIPNGLTEAAQAMGATKWQIVRKFYLSEALPTLINGVTLTLVTLVGYSAMAGTQGGGGLGSLAINYGRIRNMPYVTWVATIIIVLFVMISQKLGDTLAKKVDHR