About Products Protein Database Contact

mer

Gene
Mer
Protein
Moesin/ezrin/radixin homolog 2
Organism
Drosophila melanogaster
Length
635 amino acids
Function
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Mer acts synergistically along with Ex and Kibra to regulate the Hippo signaling pathway.
Mass
74.492 kDa
Sequence
MSPFGSKKNRSLSVRVSTFDSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQRVELHASNNVYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYAVHVQYGPYDYETYKDGMLAGGELLPKGVTDQYQMTPEMWEERIKTWYMDHEPMTRDEVEMEYLKIAQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKKFTIRLVDAKVSNFIFYSQDLHINKMILDLCKGNHDLYMRRRKPDTMEIQQMKAQAKEEKQRRQIERKKFIREKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECKANHFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAETEKLRKELICAKMAEREATARLLEFLNSGRKSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGGAELTTHSSHYLVQGDNSSGISDDFEPKEFILTDNEMEQITNEMERNHLDYLRNSKQVQSQLQTLRSEIAPHKIEENQSNLDILSEAQIKAGENKYSTLKKLKSGSTKARVAFFEEL

Gene
mer
Protein
5,10-methylenetetrahydromethanopterin reductase
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Length
349 amino acids
Function
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
Similarity
Belongs to the mer family.
Mass
37.501 kDa
Sequence
MAEVSFGIELLPDDKPTKIAHLIKVAEDNGFEYAWICDHYNNYSYMGVLTLAAVITSKIKLGPGITNPYTRHPLITASNIATLDWISGGRAIIGMGPGDKATFDKMGLPFPCKIPIWNPEAEDEVGPATAIREVKEVIYQYLEGGPVEYEGKYVKTGTADVNARSIQGSDIPFYMGAQGPIMLKTAGEIADGVLVNASNPKDFEVAVPKIEEGAKEAGRSLDEIDVAAYTCFSIDKDEDKAIEATKIVVAFIVMGSPDVVLERHGIDTEKAEQIAEAIGKGDFGTAIGLVDEDMIEAFSIAGDPDTVVDKIEELLKAGVTQVVVGSPIGPDKEKAIELVGQEVIPHFKE

Gene
mer
Protein
5,10-methylenetetrahydromethanopterin reductase
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
332 amino acids
Function
Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.
Similarity
Belongs to the mer family.
Mass
36.051 kDa
Sequence
MKFGIEFVPDMKYYELEYYVKLAEDSGFDYTWITDHYNNRNVYSMLTILALKTRTIKLGPGVTNPYHISPALTASAIGTINEISGGRAVLGIGAGDKVTFERIGITWEKPLKRMREAVEIIRQLTEGKAVKYDGEIFKFNGAKLGFKPGSIPIYIGAQGPKMLQLAAELGDGVLINASHPKDFEVAKENIDAGLAKAGKSRDAFDTVAYASMSVDKDRDKARNAARIVVAFIVAGSPPTVLERHGLSEDAVNAVREALNNAFTKGDWGGVAKSVTDEMIDIFSISGTPDDVIERINELSKAGVTQVVAGSPIGPDKKKSIQLIGKEIIPKLK

Gene
mer
Protein
5,10-methylenetetrahydromethanopterin reductase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
331 amino acids
Function
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
Similarity
Belongs to the mer family.
Mass
35.353 kDa
Sequence
MKFGIEFVPNEPIQKLCYYVKLAEDNGFEYCWITDHYNNRNVYMALTAIAMNTNKIKLGPGVTNPYVRSPAITASAIATLDELSGGRAVLGIGPGDKATFDALGIEWVKPVTTLKESIEVIRKLLAGERVSYEGKVVKIAGAALAVKPIQKAVPVYMGAQGPKMLETAGMIADGVLINASNPKDFEAAIPLIKKGAEAAGRSMDEIDVAAYACMSVDKNADKAKQAAVPVVAFIAAGSPPVVLERHGIDMEKVEAIRNALKSGNFPEAFKNVDDTMLEAFSIYGTPEDVVEKCKKLAEMGVTQIVAGSPIGPNKETAIKLIGKKVIPALKE

Gene
mer
Protein
5,10-methylenetetrahydromethanopterin reductase
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
328 amino acids
Function
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
Similarity
Belongs to the mer family.
Mass
34.72 kDa
Sequence
MKFGIEFVPSDPALKIAYYAKLSEQQGFDYVWITDHYNNRDVYSTLTVLALNTNSIKIGSGVTNSYTRNPAITASSIASIAEISGGRAVLGLGPGDKATFDAMGIAWEKPLATTKEAIQAIRDFIAGKKVSMDGEMVKFAGAKLAFKAGNVPIYMGAQGPKMLELAGEVADGVLINASHPKDFEVAVEQIRKGAEKVGRDPSEVDVTAYACFSIDKDPAKAINAAKVVVAFIVAGSPDLVLERHGIPVDAKKQIGDAIAKGDFGALMGGLVTPQMIEAFAICGTPEDCMKRIKDLEAIGVTQIVAGSPIGPEKEKAIKLIGKEIIAKM

Gene
mer
Protein
5,10-methylenetetrahydromethanopterin reductase
Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Length
328 amino acids
Function
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
Similarity
Belongs to the mer family.
Mass
34.592 kDa
Sequence
MKFGIEFVPSDPALKIAYYAKLSEQQGFDHVWITDHYNNRDVYSTLTVLALNTNSIKIGPGVTNSYTRNPAITASSIASIAEISGGRAVLGLGPGDKATFDAMGIAWKKPLATTKEAIQAIRDFISGKKVSMDGEMIKFAGAKLAFKAGNIPIYMGAQGPKMLELAGEIADGVLINASHPKDFEVAVEQIKKGAEKAGRDPSEVDVTAYACFSIDKDPVKAVNAAKVVVAFIVAGSPDLVLERHGIPVEAKSQIGAAIAKGDFGALMGGLVTPQMIEAFSICGTPDDCMKRIKDLEAIGVTQIVAGSPIGPAKEKAIKLIGKEIIAKM

Gene
mer
Protein
5,10-methylenetetrahydromethanopterin reductase
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)
Length
328 amino acids
Function
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
Similarity
Belongs to the mer family.
Mass
34.812 kDa
Sequence
MKFGIEFVPADPALKIAYYAKLSEQQGFDYVWITDHYNNRDVYSTLTVLALNTNSIKIGSGVTNSYTRNPAITASSIASIAEISGGRAVLGLGPGDKATFDAMGIAWEKPLATTKEAIQAIRDFIDGKKVSMDGEMVKFAGAKLAFKAGKIPIYMGAQGPKMLELAGEVADGVLINASHPKDFEVAVEQIRKGAEKVGRDPSEVDVTAYACFSIDKDPVKAVNAAKVVVAFIVAGSPDLVLERHGISVEAKKQIGDAIAKGDFGSLMGGLVTPQMIEAFSICGTPEDCMKRIKDLEAIGVTQIVAGSPIGPDKEKAIKLIGKEIIAKM

Gene
mer
Protein
5,10-methylenetetrahydromethanopterin reductase
Organism
Methanolobus tindarius
Length
326 amino acids
Function
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
Similarity
Belongs to the mer family.
Mass
34.043 kDa
Sequence
MTFGIEFVPSDPVLKIAHYAKLAEQQGFDNVWITDHYNNRDVYSTLTVLAMNTNSIKLGTGVTNPYTRNAAITASSIGSLNEISGGRAILGLGPGEQATFDAMGISWEQPLTTTKESIAAIRGFLAGEKVTMDGDMIKFGGAKMAFKAGDVPIYMGAQGPKMLELAGEVSDGVLINASHPKDFEVAVKQIAAGAKKAGRDPKEVDVAAYACFSIDKDAAKAKSAAQIVVAFIVAGSPDMVLERHGIDPAAKADIGGAIAKGDFGALMGGMVTDSMMDAFSICGTPDDCKARINELLDIGVTQIVAGSPIGPNKEKAIKLIGKEIIG

Gene
mer
Protein
5,10-methylenetetrahydromethanopterin reductase
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
321 amino acids
Function
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
Similarity
Belongs to the mer family.
Mass
33.479 kDa
Sequence
MKFGIEFVPNEPIEKIVKLVKLAEDVGFEYAWITDHYNNKNVYETLALIAEGTETIKLGPGVTNPYVRSPAITASAIATLDELSNGRATLGIGPGDKATFDALGIEWVKPVSTIRDAIAMMRTLLAGEKTESGAQLMGVKAVQEKIPIYMGAQGPMMLKTAGEISDGALINASNPKDFEAAVPLIKEGAESAGKSLSDIDVAAYTCCSIDEDSAAAANAAKIVVAFIAAGSPPPVFERHGLPADTGAKFGELLGKGDFGGAIGAVDDALMEAFSVVGTPDEFIPKIEALGEMGVTQYVAGSPIGPDKEKSIKLLGEVIASF

Gene
mer
Protein
5,10-methylenetetrahydromethanopterin reductase
Organism
Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)
Length
321 amino acids
Function
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
Similarity
Belongs to the mer family.
Mass
33.488 kDa
Sequence
MKFGIEFVPNEPIEKIVKLVKLAEDVGFEYAWITDHYNNKNVYETLALIAEGTETIKLGPGVTNPYVRSPAITASAIATLDELSNGRATLGIGPGDKATFDALGIEWVKPVSTIRDAIAMMRTLLAGEKTESGAQLMGVKAVQEKIPIYMGAQGPMMLKTAGEISDGALINASNPKDFEAAVPLIKEGAEAAGKSIADIDVAAYTCCSIDEDAAAAANAAKIVVAFIAAGSPPPVFERHGLPADTGKKFGELLGKGDFGGAIGAVDDALMEAFSVVGTPDEFIPKIEALGEMGVTQYVAGSPIGPDKEKSIKLLGEVIASF