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mei4

Gene
mei4
Protein
Meiosis-specific transcription factor mei4
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
517 amino acids
Function
Functions as a meiosis-specific transcription factor. Binds to the 5'-GTAAAYA-3' consensus sequence of the promoter of the spo6 gene.
Mass
57.685 kDa
Sequence
MVENQGNVEAHGKPKKVILSLSLKESSKINDSQNVSNVSSKEKCETEALLREENKENLSSDSIRQMIFGDEMAGFVDTGEKPPCSYATLIGLAILQSHNKQLTLSGIYTWIRNTFRYYLNHDGGWQNSIRHNLSLNKAFIKVEKPKGKTLKGHYWTIDPDHMQNFVSVRLHRSHSTDSNSKKRPSSKCHEIKPLTTREIPLARKRSRLNSFNSSTSTSGSSSNVAAEVSNDASQPSNQDSSLNSNIVKPPLPPSNVQSNSSSSENVPKPNAETQEDLPTIDAHESSLYENVNDSRLYEVPACRNMALNTGYSDADPGYLRTSFRSNSHNSLPYSANEEEDVLQADFLVSQQSSMVSSYVSSRDPHSMPYYRREPIPLRPSSRFYEYTRPTYGRTDTSCSAPGAFCSTQINSPSSYINYSKCAPSSPTLSLQKHREHVKSLLYVPDLTPSFDGSDPWNPSSQLLSEPLFDQHSFQSSLDDLMSVTCFRDSPELNHESSGYSSAPLMPSNRAFINDFSL

Gene
MEI4
Protein
Meiosis-specific protein MEI4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
408 amino acids
Function
Required for meiotic induction of recombination, viable spore production and chromosome synapsis. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.
Mass
48.215 kDa
Sequence
MSRGKLEDMEQKETSEVDWIICFALIQSRNPTLWKRALSRKKGDVEDVGALKSEKNLKINPRENSKHIYKWVAPFENGFLNNKSLFAHLEPIYNFLCQNKYKSFEDAVGLKELQSFSKDVSTADINNWFLPRYKILLKILSLKTKEIDFRGLSQVFQTLQILLVSHYSHRIDSDSSFKRTLIDVHVFNFIAKFLFNRILLKKNQNDPKWLQNFYDQGDGKHLCDKVDYKRLCSLHFTLIYSIINIQLIKIKTNQTFEPQILKYVSVLKLIEHILIIIESLIHVLIRFVSKHKLICINRKKAYCRVYLERELSLKKTYLKNFYSVISGVPEKELGGLLKILKIVILSLLETFESIEWQHLKPFLEKFPAHEISLQKKRKYIQAALLITAERNLIARFRLSRWFNETENI

Gene
Mei4
Protein
Meiosis-specific protein MEI4
Organism
Mus musculus
Length
389 amino acids
Function
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:25795304, PubMed:27723721). Probably acts by forming a complex with IHO1/CCDC36 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721).
Similarity
Belongs to the MEI4L family.
Mass
44.471 kDa
Sequence
MDIQPWYLKTSKLALALAIIHSKPADRSSREYTEYLASLVTQKESTWKSKLEALEAEVLQLRQKLLLSRISSGLFKNGPDVLPTLSDQEPTSSENTLTLMDDSGCVLSNEQRNEPAELSQHFVESTDPPLLPLPLEKRPRTTLENPLSSHMQFFQHLLELKKWTESSSLKVYLTHFEKDSSTVSDSVSQLLDALITFYRNPKLPFSSFWTEAVGTLARLASDFNLSNHIFKRCSKKLEEFEKTLLQAILENNSINRFQVQRYVSQSLVTLGSCSLLRKSIISLLLSEVNSFVDDLGAIDQDQGIYDVTRYENIFSLFWILEQVLQQAPQGDRTAHMDHSIPEMQTFLQKHDEVIFRLSDAFPLFAFYLWRLGVLLNSAEMETVKNESLP

Gene
MEI4
Protein
Meiosis-specific protein MEI4
Organism
Homo sapiens
Length
385 amino acids
Function
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis.
Similarity
Belongs to the MEI4L family.
Mass
44.024 kDa
Sequence
MDVQKWYLRTSKLALALAIIRSKPADKSSREYTEHLAMLLSEEQSKWRSKVEILEAEVMQLRQKLLVSRLCSGSFKSGYVSSQLEAQEPKSSESTLTSMEDSGCDLSNEQRTESSDLSQHFVESCTPTHFPPLPLVKRPCAILQNPLSSHMQFLQYLLELKNLTESGNLKRDLTHFEKDSSTVSDSVFQLLDGLITFYRNPKLPFSRFWTEAVGTLASLISDYNLSSHILKKCSKKLEEFEKTLLHAILGNNHINQFQVQHYVSQSLVTLGNCSLLRKSIISLLLSEVNGFADDLGAINQEQASYDVSRYENIFYLFWVLEQLLQKETEEGNTSSIGHDDQEIKKFLQKHDETIFQLSDAFPLFTFYLWRVGILLSSAQIETLRK

Gene
mei4
Protein
Meiosis-specific protein MEI4
Organism
Danio rerio
Length
363 amino acids
Function
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination.
Similarity
Belongs to the MEI4L family.
Mass
41.212 kDa
Sequence
MEGKSASCPEGVVSWYIRTSRLAVALAIIKLRPPGGARQFTESLAERLKRQDESWKSKAEGLHEDLLHLRQELLLTRTLLNTRSSAGQAPGQEIAKVLSQDDTREVNSGTLQTCLPPTPPNSQKVPPKDRQWRQDHRLTKHVQFLQRLSGLRSGFEESLCQDGDVVWDSVVQLLDCVVEDFRQAHTGQPLRHPEQLHNAIQVVAQTLSPGGARQGFPVQHFSRVEDLLKEMVNLLLTNQQLNAFSVQDSLSDCLLALGGNCCITRTPLIQLLMSQIIQLAQQLRDACEKSREEHEHHQVDWVCYQNSFYLFWLLERLAQDTDNRVNQELVVRLETKAFPLADEFSLFSLYMWRIGGLFRAGDS