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mazF7

Gene
mazF7
Protein
Probable endoribonuclease MazF7
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
136 amino acids
Function
Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE7 (PubMed:19016878, PubMed:20011113). Probably an endoribonuclease (By similarity).
Similarity
Belongs to the PemK/MazF family.
Mass
14.235 kDa
Sequence
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGVRAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP