mazF2

Gene

mazF2

Protein

Endoribonuclease MazF2

Organism

Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

Length

114 amino acids

Function

Toxic component of a type II toxin-antitoxin (TA) system. Acts as an endoribonuclease on single-strand RNA, cleaving between the second and third bases in the sequences CUCCU and UUCCU. Neutralized by coexpression with cognate antitoxin MazE2.

Similarity

Belongs to the PemK/MazF family.

Mass

12.262 kDa

Sequence

MVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTAIVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Protein

Endoribonuclease MazF2: mazF2

Gene

mazF2

Protein

Probable endoribonuclease MazF2

Organism

Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

Length

102 amino acids

Function

Toxic component of a type II toxin-antitoxin (TA) system. Acts as an endoribonuclease. Neutralized by coexpression with cognate antitoxin MazE2.

Similarity

Belongs to the PemK/MazF family.

Mass

11.32 kDa

Sequence

MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRRITRLSPARLHEACQTLRASTGC

Protein

Probable endoribonuclease MazF2: mazF2

Gene

mazF2

Protein

Probable endoribonuclease MazF2

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

102 amino acids

Function

Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli partially inhibits cell growth after one cell generation (PubMed:16611633). Its cognate antitoxin is MazE2. Probably an endoribonuclease (By similarity).

Similarity

Belongs to the PemK/MazF family.

Mass

11.32 kDa

Sequence

MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRRITRLSPARLHEACQTLRASTGC

Protein

Probable endoribonuclease MazF2: mazF2