manD

Alpha-mannosidase D

1222 amino acids

Belongs to the glycosyl hydrolase 38 family.

141.19 kDa

MESSKFVKIIWVFGIWILVFTFLIIYNNYDYKSTFGINKFEKRSLKTINQINNKENGDDKKLSVFLIPHSHCDGGWLQDYDGYYYNIVQYILSGVVNELNLDKEKKFNWVEIGFFSRWWNDQNEIQKEIVRNLINNKQLSFISGGWVQNDEATATIDDVITQMTQGHQWLKDTLNYTVEYAWQIDPFGYSSSTPTIFSSMGIKGLVINRVSNDVKSYMKSVKEMEFIWKGSESLGEQSQMLVSTLNIHYDYPKHIDPKKDFSLNDRIKGFTKYLNDLSKTRESNILMIPLGDDFRYSNAKTEFSVSKEWVKALQDNKEYYNIKEIKYATLDEYFIALEDSFLRNNKFGKSRKQNVYTETFSDGDDEVSALSLYNKDFFPYSTGNLEYWTGYYTTRPLLKRLIRESSLLQKSSDILYTLAIGENSNNQIDINNLQTLSNQLNENRNTIALVQHHDIVTGTSRSFVLNDNFQRLQKSRISNYNIISNSLEYLLNKSNNKTNNNNNNNNKNNNNNNNNNNNNNNNLKNTNSISTTGSSSSSGSGSSNNNNNTVNKSEPFNFENAIDLSNESNNQYSLVFHNTLGWEVNQHVSFRIKVNKNDNQLLESIQLVEAISNKTIQIQIIPIQDDSNCQSIENNYIVFAIINLPPLGLNTYYLSIANSEDSKSNFTYLSKPKLLKKGNEINFNNNRFKVEFESNGLISKITDKNSNEIKTIEQTFHQYSTKKSGPYIFNVKGGKKHGFLENPDKFIYHDGPLVSQLTMLYGVDDYCNVTSIVVQRIYKNNNEINNSNSKSLITENYIETGYSINGDMNRETTINYKVKDLENDDIFYTDNGLESRKRIYNHDRSVNQNYYPVLGYIKLKETSENNNHQYTVYVDRSVGATSPSDGEMEIMIHRTMDTDDWKGVNWPSKDIGRSDAKLYFNMDLVNNQLQNEKRISLHITNQPIMFVKKHNNQTGYLLKYSPLSNQLPSNIHLQSLLTLKNNTVGLRLFNIHEVDSNTQSTTDTDKSTLFNELEISNFIETGLSFLKLTKNNLIDKFSTRINKKFPIKCGESEYSFINEKPSSIIFSNNGTNNIIDGENKGENNKTIETIQIKPHEIKSFTFNFNFQLDQIIPNNNNNNNKYAINKELNNEYIEQSIENQRYEYDFSFFPIKPTFYDDRGKYNRPNHLALILSLSIGIPAGILIIVIALVVTYKKRKNRKTLTSSNSSSNLIQQEDQTDYSP

manD

D-galactonate dehydratase family member ManD

403 amino acids

Has low dehydratase activity with D-mannonate and D-gluconate, suggesting that these are not physiological substrates and that it has no significant role in the in vivo degradation of these compounds. Has no detectable activity with a panel of 70 other acid sugars (in vitro).

Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.

45.207 kDa

MKIRDAYTIVTCPGRNFVTLKIVTESGTHGIGDATLNGREMAVAAYLDEHVVPALIGRDAGRIEDTWQYLYRGAYWRRGPVTMTAIAAVDMALWDIKAKAAGMPLYQLLGGKSRERVMTYAHCTGQTIEDCLGEVARHVELGYRAVRVQSGVPGIETTYGVAKTPGERYEPADSSLPAEHVWSTEKYLNHAPKLFAAVRERFGDDLHVLHDVHHRLTPIEAARLGKAVEPYHLFWLEDCVPAENQESLRLIREHTTTPLAIGEVFNSIHDCRELIQNQWIDYIRMPLTHGGGITAMRRVADLASLYHVRTGFHGPTDLSPVCLGAAIHFDTWVPNFGIQEHMPHTDETDAVFPHDYRFEDGHFLAGESPGHGVDIDEELAAKYPYERASLPVNRLEDGTLWHW

manD

D-mannonate dehydratase

402 amino acids

Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro).

Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.

45.244 kDa

MKITAARVIITCPGRNFVTLKIETDQGVYGIGDATLNGRELSVVAYLQEHVAPCLIGMDPRRIEDIWQYVYRGAYWRRGPVTMRAIAAVDMALWDIKAKMAGMPLYQLLGGRSRDGIMVYGHANGSDIAETVEAVGHYIDMGYKAIRAQTGVPGIKDAYGVGRGKLYYEPADASLPSVTGWDTRKALNYVPKLFEELRKTYGFDHHLLHDGHHRYTPQEAANLGKMLEPYQLFWLEDCTPAENQEAFRLVRQHTVTPLAVGEIFNTIWDAKDLIQNQLIDYIRATVVGAGGLTHLRRIADLASLYQVRTGCHGATDLSPVTMGCALHFDTWVPNFGIQEYMRHTEETDAVFPHDYWFEKGELFVGETPGHGVDIDEELAAKYPYKPAYLPVARLEDGTMWNW

manD

N-acetylglucosamine-6-phosphate deacetylase

399 amino acids

Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate.

Belongs to the metallo-dependent hydrolases superfamily. NagA family.

43.122 kDa

MESKSHAHCFRAQRVLHGKQWQQDAVVTVDENGTISAIESYDGQRHADAIPLGPVDLMPGLIDSHVHGSQGCDVMDATHDSLNTMSRYFATLGVTAFVATTVTAPVAKIRAALAQVAKSKHDGVDGAEILGAYLEGPYFTEKNKGAHPTQWFRELAVEELEDWISYSDNQLLKVALAPEKTGALDAIRYLDAHGIHVMLGHSDADYEQVKAALAAGAKGIVHCYNGMRGLHHRDPGVVGAGLLHPHCFVEMIADGHHVHPAAIDVAHRCCGSRMTLITDAMRATGMPDGQYTLGEYQVDMKQGVVMTSSGGLAGSTLTLLRGVKNIHRWLNVPIEQAWLMASYTPAESLGIQHQLGSLEVGKYASMVAVSSDFSIEKTWVKGRLVFDAATSPRQEALCI

manD

Mannan endo-1,4-beta-mannosidase D

381 amino acids

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.

Belongs to the glycosyl hydrolase 5 (cellulase A) family.

41.603 kDa

MKHLLSLVCTLGAATLAASAAAEAGSMPSANGLDFVIDGEASYFAGSNAYWLSFLTNNADVDLALDHFAESGLKILRIWGFSDVTAEPSDNKVYFQLHQNGSSTVNTGPNGLERLDYIISGAEKRGIKLVIPLVNYWDDFGGMNAYISAYGGDKPGWYTNDKIQAAYHAYVKAVVSRYVDSPAIFAWELANEPRCSGCDTSIINQWATKTSSFIKSLDPNHMVAMGDEGMGLPGDSNYPYSYYEGNDFALNLAIPDIDFGTLHLYTTDWGVSNNSWGNKWVQDHAAVCKSAGKPCLFEEYGMKGNHCTYELAWQKTALATPGMAADLFWQFGENLSSGQTHNDKYTVYYGSNEWKCVVSDHVAAVAVRRYRLPVGGGQHGP