Protein
Homoaconitase, mitochondrial
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Function
Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
Similarity
Belongs to the aconitase/IPM isomerase family.
Sequence
MFRVQRLRMFSTSRALYAGQNMTEKIVQRHAVGLPEGKTVVSGDYVSIKPAHCMSHDNSWPVALKFMGLGASTIKNPRQVVNTLDHDVQNKSEKNLTKYKNIENFAKKHGIDFYPAGRGIGHQIMIEEGYAFPLTMTVASDSHSNTYGGIGALGTPIVRTDAAAIWATGQTWWQIPPVAQVELKGELPAGISGKDIIVALCGVFNQDQVLNHAIEFTGDSLDKIPIDYRLTIANMTTEWGALSGLFPVDNVLLDFYRNRLTKVGNNHPRINEARINELQAKSDSLQADPDAKYAKKLIIDLSTLTHYVSGPNSVKISSTVDDLSKQDIKVNKAYLVSCTNSRLSDLESAANVVCPSGDINQVHKVAEGVEFYIAAASSEVEAEARATGAWQKLLNAGCLPLPAGCGPCIGLGTGLLEEGQVGISATNRNFKGRMGSKDALAYLASPSVVAASAILGKIGSPAEVLGTKDPNFTGVVATVEDAPATSADGKDVADESGASGSVEILEGFPSEISGELVLCDADNINTDGIYPGKYTYQDDVPKETMAKVCMENYDPDFQTKANPGDILISGFNFGTGSSREQAATAILAKGIKLVVSGSFGNIFFRNSINNALLTLEIPALINMLRDRYKDAPKELTRRTGWFLKWDVSQAKVYVTEGSVNGPIVLEQKVGELGKNLQEIIVKGGLESWVKSQL