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lst

Gene
lst
Protein
N-acetyllactosaminide alpha-2,3-sialyltransferase
Organism
Neisseria gonorrhoeae
Length
371 amino acids
Function
Catalyzes the transfer of sialic acid from the substrate CMP-N-acetylneuraminate to the terminal galactose residue of the lacto-N-neotetraose branch of surface lipooligosaccharide (LOS), forming an alpha-2,3-sialyl linkage. Thus, functions in the sialylation of LOS, which plays a role in the evasion of the host immune response by protecting N.gonorrhoeae from complement-mediated serum killing and from phagocytic killing by neutrophils, and which is critical for establishing infection.
Similarity
Belongs to the glycosyltransferase 52 family.
Mass
42.682 kDa
Sequence
MGLKKVCLTVLCLIVFCFGIFYTFDRVNQGERNAVSLLKDKLFNEEGKPVNLIFCYTILQMKVAERIMAQHPGERFYVVLMSENRNEKYDYYFNQIKDKAERAYFFYLPYGLNKSFNFIPTMAELKVKSMLLPKVKRIYLASLEKVSIAAFLSTYPDAEIKTFDDGTNNLIRESSYLGGEFAVNGAIKRNFARMMVGDWSIAKTRNASDEHYTIFKGLKNIMDDGRRKMTYLPLFDASELKAGDETGGTVRILLGSPDKEMKEISEKAAKNFNIQYVAPHPRQTYGLSGVTALNSPYVIEDYILREIKKNPHTRYEIYTFFSGAALTMKDFPNVHVYALKPASLPEDYWLKPVYALFRQADIPILTFDDKN

Gene
lst
Protein
N-acetyllactosaminide alpha-2,3-sialyltransferase
Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Length
371 amino acids
Function
Catalyzes the transfer of sialic acid from the substrate CMP-N-acetylneuraminate to the terminal galactose residue of the lacto-N-neotetraose branch of surface lipooligosaccharide (LOS), forming an alpha-2,3-sialyl linkage. Thus, functions in the sialylation of LOS, which plays a role in the evasion of the host immune response by protecting N.meningitidis from complement-mediated serum killing and from phagocytic killing by neutrophils.
Similarity
Belongs to the glycosyltransferase 52 family.
Mass
42.554 kDa
Sequence
MGLKKACLTVLCLIVFCFGIFYTFDRVNQGERNAVSLLKDKLFNEEGEPVNLIFCYTILQMKVAERIMAQHPGERFYVVLMSENRNEKYDYYFNQIKDKAERAYFFHLPYGLNKSFNFIPTMAELKVKSMLLPKVKRIYLASLEKVSIAAFLSTYPDAEIKTFDDGTGNLIQSSSYLGDEFSVNGTIKRNFARMMIGDWSIAKTRNASDEHYTIFKGLKNIMDDGRRKMTYLPLFDASELKAGDETGGTVRILLGSPDKEMKEISEKAAKNFNIQYVAPHPRQTYGLSGVTTLNSPYVIEDYILREIKKNPHTRYEIYTFFSGAALTMKDFPNVHVYALKPASLPEDYWLKPVYALFTQSGIPILTFDDKD

Gene
lst
Protein
N-acetyllactosaminide alpha-2,3-sialyltransferase
Organism
Neisseria meningitidis serogroup B (strain MC58)
Length
371 amino acids
Function
Catalyzes the transfer of sialic acid from the substrate CMP-N-acetylneuraminate to the terminal galactose residue of the lacto-N-neotetraose branch of surface lipooligosaccharide (LOS), forming an alpha-2,3-sialyl linkage. Thus, functions in the sialylation of LOS, which plays a role in the evasion of the host immune response by protecting N.meningitidis from complement-mediated serum killing and from phagocytic killing by neutrophils. In vitro, can use a number of different synthetic acceptors with lactose or galactose as the saccharide portion, but shows a strong preference for the N-acetyllactosamine containing acceptor.
Similarity
Belongs to the glycosyltransferase 52 family.
Mass
42.611 kDa
Sequence
MGLKKACLTVLCLIVFCFGIFYTFDRVNQGERNAVSLLKEKLFNEEGEPVNLIFCYTILQMKVAERIMAQHPGERFYVVLMSENRNEKYDYYFNQIKDKAERAYFFHLPYGLNKSFNFIPTMAELKVKSMLLPKVKRIYLASLEKVSIAAFLSTYPDAEIKTFDDGTGNLIQSSSYLGDEFSVNGTIKRNFARMMIGDWSIAKTRNASDEHYTIFKGLKNIMDDGRRKMTYLPLFDASELKTGDETGGTVRILLGSPDKEMKEISEKAAKNFKIQYVAPHPRQTYGLSGVTTLNSPYVIEDYILREIKKNPHTRYEIYTFFSGAALTMKDFPNVHVYALKPASLPEDYWLKPVYALFTQSGIPILTFDDKN

Gene
lst
Protein
N-acetyllactosaminide alpha-2,3-sialyltransferase
Organism
Neisseria gonorrhoeae
Length
371 amino acids
Function
Catalyzes the transfer of sialic acid from the substrate CMP-N-acetylneuraminate to the terminal galactose residue of the lacto-N-neotetraose branch of surface lipooligosaccharide (LOS), forming an alpha-2,3-sialyl linkage. Thus, functions in the sialylation of LOS, which plays a role in the evasion of the host immune response by protecting N.gonorrhoeae from complement-mediated serum killing and from phagocytic killing by neutrophils, and which is critical for establishing infection.
Similarity
Belongs to the glycosyltransferase 52 family.
Mass
42.682 kDa
Sequence
MGLKKVCLTVLCLIVFCFGIFYTFDRVNQGERNAVSLLKDKLFNEEGKPVNLIFCYTILQMKVAERIMAQHPGERFYVVLMSENRNEKYDYYFNQIKDKAERAYFFYLPYGLNKSFNFIPTMAELKVKSMLLPKVKRIYLASLEKVSIAAFLSTYPDAEIKTFDDGTNNLIRESSYLGGEFAVNGAIKRNFARMMVGDWSIAKTRNASDEHYTIFKGLKNIMDDGRRKMTYLPLFDASELKAGDETGGTVRILLGSPDKEMKEISEKAAKNFNIQYVAPHPRQTYGLSGVTALNSPYVIEDYILREIKKNPHTRYEIYTFFSGAALTMKDFPNVHVYALKPASLPEDYWLKPVYALFRQADIPILTFDDKN

Gene
lst
Protein
N-acetyllactosaminide alpha-2,3-sialyltransferase
Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Length
371 amino acids
Function
Catalyzes the transfer of sialic acid from the substrate CMP-N-acetylneuraminate to the terminal galactose residue of the lacto-N-neotetraose branch of surface lipooligosaccharide (LOS), forming an alpha-2,3-sialyl linkage. Thus, functions in the sialylation of LOS, which plays a role in the evasion of the host immune response by protecting N.meningitidis from complement-mediated serum killing and from phagocytic killing by neutrophils.
Similarity
Belongs to the glycosyltransferase 52 family.
Mass
42.554 kDa
Sequence
MGLKKACLTVLCLIVFCFGIFYTFDRVNQGERNAVSLLKDKLFNEEGEPVNLIFCYTILQMKVAERIMAQHPGERFYVVLMSENRNEKYDYYFNQIKDKAERAYFFHLPYGLNKSFNFIPTMAELKVKSMLLPKVKRIYLASLEKVSIAAFLSTYPDAEIKTFDDGTGNLIQSSSYLGDEFSVNGTIKRNFARMMIGDWSIAKTRNASDEHYTIFKGLKNIMDDGRRKMTYLPLFDASELKAGDETGGTVRILLGSPDKEMKEISEKAAKNFNIQYVAPHPRQTYGLSGVTTLNSPYVIEDYILREIKKNPHTRYEIYTFFSGAALTMKDFPNVHVYALKPASLPEDYWLKPVYALFTQSGIPILTFDDKD

Gene
lst
Protein
N-acetyllactosaminide alpha-2,3-sialyltransferase
Organism
Neisseria meningitidis serogroup B (strain MC58)
Length
371 amino acids
Function
Catalyzes the transfer of sialic acid from the substrate CMP-N-acetylneuraminate to the terminal galactose residue of the lacto-N-neotetraose branch of surface lipooligosaccharide (LOS), forming an alpha-2,3-sialyl linkage. Thus, functions in the sialylation of LOS, which plays a role in the evasion of the host immune response by protecting N.meningitidis from complement-mediated serum killing and from phagocytic killing by neutrophils. In vitro, can use a number of different synthetic acceptors with lactose or galactose as the saccharide portion, but shows a strong preference for the N-acetyllactosamine containing acceptor.
Similarity
Belongs to the glycosyltransferase 52 family.
Mass
42.611 kDa
Sequence
MGLKKACLTVLCLIVFCFGIFYTFDRVNQGERNAVSLLKEKLFNEEGEPVNLIFCYTILQMKVAERIMAQHPGERFYVVLMSENRNEKYDYYFNQIKDKAERAYFFHLPYGLNKSFNFIPTMAELKVKSMLLPKVKRIYLASLEKVSIAAFLSTYPDAEIKTFDDGTGNLIQSSSYLGDEFSVNGTIKRNFARMMIGDWSIAKTRNASDEHYTIFKGLKNIMDDGRRKMTYLPLFDASELKTGDETGGTVRILLGSPDKEMKEISEKAAKNFKIQYVAPHPRQTYGLSGVTTLNSPYVIEDYILREIKKNPHTRYEIYTFFSGAALTMKDFPNVHVYALKPASLPEDYWLKPVYALFTQSGIPILTFDDKN

Gene
LST
Protein
Luciferin sulfotransferase
Organism
Photinus pyralis
Length
370 amino acids
Function
Catalyzes the production of firefly sulfoluciferin from luciferin using the sulfo-donor 3'-phosphoadenylyl sulfate (PAPS). Is also able to catalyze the reverse reaction, i.e. the adenosine 3',5'-bisphosphate-dependent desulfonation of sulfoluciferin. Can use either D- or L-luciferin stereoisomer as substrate. Sulfoluciferin, which is not a substrate of P.pyralis luciferase, likely serves as a luciferin storage form in fireflies.
Similarity
Belongs to the sulfotransferase 1 family.
Mass
43.274 kDa
Sequence
MFASILGKIPQYSTISSKCSLKECRKVKKVENSDEIGEIIHRDFLDPFCNEYVLIGEEETSLGINYLQFEEEIRTFEIRDSDIIVASYPKAGTTWTQELVWLIGNDLDFKAAEEHLDKRFPHFELCTIVNFAKMTEMLGSTRPEYIGNSINYLRDLEGTRFIKTHLTYNLLPEQILNGNRKPKIIYVMRDPKDVCVSYYHHGRLIQGWRADFQNFSKVFLSEKIMFGSYWKHVLGYWEHRDKPNVLILTYEEMKKDLLSVIRKTAQFLDKKLNENKIPQLLKHLSFESMKNNRAVNQQDKIESRMKHKLVPEQGAFMRSGTSQNYKGEMSEELILKFDEWTKKSISGSSFVTEPIADLYLNTSQKSVPKM

Gene
LST
Protein
Luciferin sulfotransferase
Organism
Photinus pyralis
Length
370 amino acids
Function
Catalyzes the production of firefly sulfoluciferin from luciferin using the sulfo-donor 3'-phosphoadenylyl sulfate (PAPS). Is also able to catalyze the reverse reaction, i.e. the adenosine 3',5'-bisphosphate-dependent desulfonation of sulfoluciferin. Can use either D- or L-luciferin stereoisomer as substrate. Sulfoluciferin, which is not a substrate of P.pyralis luciferase, likely serves as a luciferin storage form in fireflies.
Similarity
Belongs to the sulfotransferase 1 family.
Mass
43.274 kDa
Sequence
MFASILGKIPQYSTISSKCSLKECRKVKKVENSDEIGEIIHRDFLDPFCNEYVLIGEEETSLGINYLQFEEEIRTFEIRDSDIIVASYPKAGTTWTQELVWLIGNDLDFKAAEEHLDKRFPHFELCTIVNFAKMTEMLGSTRPEYIGNSINYLRDLEGTRFIKTHLTYNLLPEQILNGNRKPKIIYVMRDPKDVCVSYYHHGRLIQGWRADFQNFSKVFLSEKIMFGSYWKHVLGYWEHRDKPNVLILTYEEMKKDLLSVIRKTAQFLDKKLNENKIPQLLKHLSFESMKNNRAVNQQDKIESRMKHKLVPEQGAFMRSGTSQNYKGEMSEELILKFDEWTKKSISGSSFVTEPIADLYLNTSQKSVPKM

Gene
lst
Protein
CMP-N-acetylneuraminate:beta-galactoside alpha-2,3-sialyltransferase
Organism
Pasteurella multocida (strain Pm70)
Length
308 amino acids
Function
Catalyzes the transfer of sialic acid from the substrate CMP-N-acetylneuraminate to lactosyl lipids as preferred acceptor substrates in vitro, forming alpha-2,3-linked sialosides. Beta-1,4-linked galactosyl lipids are better substrates than beta-1,3-linked galactosyl lipids. The natural acceptor substrate may be cell surface oligosaccharides in lipooligosaccharide (LOS), whose sialylation has been demonstrated vital for the virulence of P.multocida.
Similarity
Belongs to the glycosyltransferase 52 family.
Mass
35.724 kDa
Sequence
MNLIICCTPLQVLIAEKIIAKFPHMPFYGVMLSTVSNKKFDFYAKRLAQQCQGFFSMVQHKDRFNLLKEILYLKRTFSGKHFDQVFVANINDLQIQFLLSAIDFNLLNTFDDGTINIVPNSLFYQDDPATLQRKLINVLLGNKYSIQSLRALSHTHYTIYKGFKNIIERVEPIELVAADNSEKVTSAVINVLLGQPVFAEDERNIALAERVIKQFNIHYYLPHPREKYRLAQVNYIDTELIFEDYILQQCQTHKYCVYTYFSSAIINIMNKSDNIEVVALKIDTENPAYDACYDLFDELGVNVIDIRE

Gene
lst
Protein
CMP-N-acetylneuraminate:beta-galactoside alpha-2,3-sialyltransferase
Organism
Pasteurella multocida (strain Pm70)
Length
308 amino acids
Function
Catalyzes the transfer of sialic acid from the substrate CMP-N-acetylneuraminate to lactosyl lipids as preferred acceptor substrates in vitro, forming alpha-2,3-linked sialosides. Beta-1,4-linked galactosyl lipids are better substrates than beta-1,3-linked galactosyl lipids. The natural acceptor substrate may be cell surface oligosaccharides in lipooligosaccharide (LOS), whose sialylation has been demonstrated vital for the virulence of P.multocida.
Similarity
Belongs to the glycosyltransferase 52 family.
Mass
35.724 kDa
Sequence
MNLIICCTPLQVLIAEKIIAKFPHMPFYGVMLSTVSNKKFDFYAKRLAQQCQGFFSMVQHKDRFNLLKEILYLKRTFSGKHFDQVFVANINDLQIQFLLSAIDFNLLNTFDDGTINIVPNSLFYQDDPATLQRKLINVLLGNKYSIQSLRALSHTHYTIYKGFKNIIERVEPIELVAADNSEKVTSAVINVLLGQPVFAEDERNIALAERVIKQFNIHYYLPHPREKYRLAQVNYIDTELIFEDYILQQCQTHKYCVYTYFSSAIINIMNKSDNIEVVALKIDTENPAYDACYDLFDELGVNVIDIRE