LON4

Lon protease homolog 4, chloroplastic/mitochondrial

942 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

104.925 kDa

MLKFLTPTAYASHHVTPATRFRSTPVKNLLFKQLTLLTGWNRSSYELGRRSFSSDLDSDTKSSTTTVSAKPHLDDCLTVIALPLPHKPLIPGFYMPIYVKDPKVLAALQESRRQQAPYAGAFLLKDDASSDSSSSSETENILEKLKGKELINRIHEVGTLAQISSIQGEQVILIGHRQLRITEMVSESEDPLTVKVDHLKDKPYDKDDDVIKATYFQVMSTLRDVLKTTSLWRDHVRTYTQACSLHIWHCLRHIGEFNYPKLADFGAGISGANKHQNQGVLEELDVHKRLELTLELVKKEVEINKIQESIAKAVEEKFSGDRRRIILKEQINAIKKELGGETDSKSALSEKFRGRIDPIKDKIPGHVLKVIEEELKKLQLLETSSSEFDVTCNYLDWLTVLPWGNFSDENFNVLRAEKILDEDHYGLSDVKERILEFIAVGGLRGTSQGKIICLSGPTGVGKTSIGRSIARALDRKFFRFSVGGLSDVAEIKGHRRTYIGAMPGKMVQCLKNVGTENPLVLIDEIDKLGVRGHHGDPASAMLELLDPEQNANFLDHYLDVPIDLSKVLFVCTANVTDTIPGPLLDRMEVITLSGYITDEKMHIARDYLEKTARRDCGIKPEQVDVSDAAFLSLIEHYCREAGVRNLQKQIEKIFRKIALKLVRKAASTEVPRISDDVTTDTEETKSLAKTDLESPETSAEGSTVLTDELATGDPTESTTEQSGEVAETVEKYMIDESNLSDYVGKPVFQEEKIYEQTPVGVVMGLAWTSMGGSTLYIETTFVEEGEGKGGLHITGRLGDVMKESAEIAHTVARRIMLEKEPENKLFANSKLHLHVPAGATPKDGPSAGCTMITSLLSLALKKPVRKDLAMTGEVTLTGRILAIGGVKEKTIAARRSQVKVIIFPEANRRDFDELARNVKEGLEVHFVDEYEQIFELAFGYDH

lon4

Lon protease 4

799 amino acids

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Belongs to the peptidase S16 family.

85.866 kDa

MSQLRSGASAPRSPFPLLPLRTGVLFPGTVLTLPVGRPRSVALLNAVHAGDVIGVIAQRDPKREDPRREDLHDIGTFARVVDISRVSNGYRLVIEGLDRFALSALVETEPTWRAEGTLAPEFLGDAEEARLLAASLRERAREVGPKTGTNLAEIAATSRAEPGVFADQVAGALGLPTEKEMEVLSELRVVPRLQRVAGLLAEASALADLKKKIDGDVRRELGKGQREVILREQLRAIQKELAGGEEGEDELSALRRRLDEAGLPEEARAVADRELRRLESVGPQSAEHNVIRTYLEWIADLPWSARAEVKDDLDAVKAKLDEEHRGLDDVKRRILEHMAVLKLTGKARATILCFAGPPGVGKTSLGQSIADATGRPFVRISLGGVHDEAELRGHRRTYVGALPGRIVHALKKAKVKNPIVLLDEVDKLGAGWRGSPEAALLEVLDPEQNRTFVDHYLELPFDLSEVVFLCTVNDLGALSAPLRDRLEVIELSGYTPDEKIAIARSHLVPKQLKEHAIDPGSLSITDEALAAIVRDYTREAGVRQLGREIKKLCRAVALEIARAADGKAPRVVVEASDLGTYLGKVRFFSDVAERTSVAGVATGLAWTPVGGDILFIETSRMPGKGRVEITGQLGDVMKESAKAALTYVRSHAIELGVDTAKLEAEDLHIHVPAGGVPKDGPSAGVTMFTALTSLLSARRVRSDTAMTGECTLRGRVLPVGGIKSKVLAAHRAGIKRVVLPQKNARDAEEIPKEVRAELELIFVEDMSQVIAAALEEAPIEAAGTGGVTGAAAGEPAAAA