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ligC

Gene
ligC
Protein
DNA ligase C
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
358 amino acids
Function
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
Similarity
Belongs to the ATP-dependent DNA ligase family.
Mass
40.16 kDa
Sequence
MQLPVMPPVSPMLAKSVTAIPPDASYEPKWDGFRSICFRDGDQVELGSRNERPMTRYFPELVAAIRAELPHRCVIDGEIIIATDHGLDFEALQQRIHPAESRVRMLADRTPASFIAFDLLALGDDDYTGRPFSERRAALVDAVTGSGADADLSIHVTPATTDMATAQRWFSEFEGAGLDGVIAKPPHITYQPDKRVMFKIKHLRTADCVVAGYRVHKSGSDAIGSLLLGLYQEDGQLASVGVIGAFPMAERRRLLTELQPLVTSFDDHPWNWAAHVAGQRTPRKNEFSRWNVGKDLSFVPLRPERVVEVRYDRMEGARFRHTAQFNRWRPDRDPRSCSYAQLERPLTVSLSDIVPGLR

Gene
ligC
Protein
DNA ligase C1
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
348 amino acids
Function
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway.
Similarity
Belongs to the ATP-dependent DNA ligase family.
Mass
39.495 kDa
Sequence
MDLPVQPPIEPMLAKAQVKVPDEAGVWSYEPKWDGFRALVFRDGDDVVLQSRNGKDLGRYFPELLDALRDELVEKCVLDGEVVVPRDIAGRVRLDWESLSQRIHPAASRIKMLAEQTPAHFIGFDALALGDRSLLKEPFRVRREALAEAVDNKRWCHVTRTSEDPALGTEWLKTFEGAGLDGVIAKRLDGPYLPGKREMVKVKHHRDADCVAMGYRIHKSGDGIGSILLGLYRDDGELQMVGGAASFTAKDRIKLLAELEPLREGDEMREGDPSRWNSAADKRWTPLRPEKVCEVAYDQMEGNSVEGRRFRHAVKFLRWRPDREPSSCTFDQLDTPLNYDLYDVLEEQ

Gene
ligC
Protein
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase
Organism
Sphingobium sp. (strain NBRC 103272 / SYK-6)
Length
315 amino acids
Function
Involved in the degradation of protocatechuate (PCA) via the PCA 4,5-cleavage pathway. Catalyzes the oxidation of the hemiacetal form of 4-carboxy-2-hydroxymuconate-6-semialdehyde (CHMS) to produce 2-pyrone-4,6-dicarboxylate (PDC). LigC has 10-times-higher affinity to NADP than to NAD.
Similarity
Belongs to the Gfo/Idh/MocA family.
Mass
34.629 kDa
Sequence
MRIALAGAGAFGEKHLDGLKNIDGVEIVSIISRKAEQAAEVAAKYGAKHSGTDLSEALARDDVDAVILCTPTQMHAEQAIACMNAGKHVQVEIPLADSWADAEAVMKKSQETGLVCMVGHTRRFNPSHQYIHNKIVAGELAIQQMDVQTYFFRRKNMNAKGEPRSWTDHLLWHHAAHTVDLFAYQAGKIVQANAVQGPIHPELGIAMDMSIQLKSETGAICTLSLSFNNDGPLGTFFRYICDNGTWIARYDDLVTGKEEPVDVSKVDVSMNGIELQDREFIAAIREGREPNSSVARVLDCYRVLGELEVQLEKQG