Protein
Tropomyosin isoforms a/b/d/f
Organism
Caenorhabditis elegans
Function
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction (PubMed:9113409, PubMed:11901171). Involved in muscle actin filament organization and muscle arm extension and morphology (PubMed:15930100). Protects actin filaments from depolymerization by unc-60 in vitro (PubMed:17684058). Also has a role in male mating behavior by regulating the copulatory spicules (PubMed:16399684). Binds to F-actin (PubMed:11901171).
Similarity
Belongs to the tropomyosin family.
Sequence
MDAIKKKMQAMKIEKDNALDRADAAEEKVRQITEKLERVEEELRDTQKKMTQTGDDLDKAQEDLSAATSKLEEKEKTVQEAEAEVASLNRRMTLLEEELERAEERLKIATEKLEEATHNVDESERVRKVMENRSLQDEERANTVEAQLKEAQLLAEEADRKYDEVARKLAMVEADLERAEERAEAGENKIVELEEELRVVGNNLKSLEVSEEKALQREDSYEEQIRTVSSRLKEAETRAEFAERSVQKLQKEVDRLEDELVHEKERYKTISEELDSTFQELSGY