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leuA

Gene
LEUA
Protein
3-isopropylmalate dehydratase
Organism
Rhizomucor pusillus
Length
755 amino acids
Function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Similarity
Belongs to the aconitase/IPM isomerase family.
Mass
82.486 kDa
Sequence
MGRTLYDKVWDDHVVDQQEDGTCLIYIDRHLVHEVTSPQAFEGLRNAGRKVRRPDCTLATVDHNIPTTPRKNFKNVSTFIQEADSRTQCETLEHNVKEFGLTYFGMDDSRQGIVHVIGPEQGFTLPGCTVNCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLLQKKSKNMRVKVDGKLAPGVTSKDIVLHIIGVIGTAGGTGCVIEFCGSAFEQMSMEARMSVCNMSIEAGARAGMIAPDETTFEYIRGRPLAPTGAEWDKAVEYWRSLRSDPDAKYDVDVFIDAADIAPTLTWGTSPQDVVAITGTTPDPSTVSDPIRRQAMERALDYIGLKPNTPMQEVKIDKVFIGSCTNSRIEDLRAAAAIAKGRHVADWVYAMVVPGSGLVKKQAEQEGLDRIFKEAGFDWREAGCSMCLGMNPDQLKPGERCASTSNRNFEGRQGAGGRTHLMSPAMAAAAAVTGYFTDVRKLTPAQQDRPASPTPKKIETELEPPVEDHAKAADQADIVTDAPATGASPPSPAPSDAAGMPKFTTLRGYAAPLDIANVDTDMIIPKQFLKTIKRTGLGTALFYNIRFDGATGEENPDFVLNQEPYRQSRILVCTGPNFGCGSSREHAPWAFNDFGIRSIIAPSFADIFFNNCFKNGMLPITLPQDKVEMLAEHAKQKAELEVDLVNQVVRYPGGEVPFDVEPFRKHCLVNGLDDIGLTMQKADLIEAFEAKRSQTWPWLDGKDYAGKATKFTPVATNTAKKQKLDW

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
701 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
75.683 kDa
Sequence
MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAHRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
644 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
70.114 kDa
Sequence
MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
644 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
70.114 kDa
Sequence
MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR

Gene
LEUA
Protein
3-isopropylmalate dehydratase
Organism
Mucor circinelloides f. lusitanicus
Length
644 amino acids
Function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Similarity
Belongs to the aconitase/IPM isomerase family.
Mass
69.939 kDa
Sequence
MISSISLSQDKCKYLLYNNLLVDERENFLVSLTCSYILFQKTIPYIQNVSTLYDKVWDDHVIDQQEDGTCLIYIDRHLVHEVTSPQAFEGLRNANRPVRRPDCTLATVDHNIPTTTRKIFKNITTFIKEADSRTQCETLEQNIEAFGLTYFGMEDSRQGIVHVIGPEQGFTLPATTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLLQKKSKNMRIRVQGKALPGVTSKDIVLHIIGVIGTAGGTGCVIEFCGDTIAALSMESRMSICNMSIEAGARAGMVAPDEVTFEYLRDKPLAPKGADWDRAVKYWKSLSSDADAKYDINVEINAADIAPTLTWGTSPQDVVPITGSTPDPAKIEDPIRRSAVQRALDYIGIAPNTPMEGVKVDKVFIGSCTNSRIEDLRAAAAVVKGKRAAEWVDAMVVPGSGLVKRQAEREGLDKIFTDAGFDWREAGCSMCLGMNPDQLKPGERCASTSNRNFEGRQGAGGRTHLVSPAMAAAAGIKGCLTDVRNMEVSEIPGTPKQSPRQEVVAEFESEEDDVDSSSVDSAPVATPPSTGDSAGMPKFTTLKGYAAPLDISNVDTDMIIPKQFLKTIKRTGLGSALFYALRFDPATGAENPDFVLNLRALPSRTYLGLHRS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Length
638 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
70.506 kDa
Sequence
MGQDQSSVFDLAAVAAASNGGNNDPLLPPARFIGDPQKPSRMPYNKYASYSEQIPFDYPERTWPGKRLQRAPRWCSVDLRDGNQALVNPMDSERKLRFWNLLVSMGFKEIEVGFPSASETDFDFIRMLIERELIPDDVTIVVLTQCREHLIRRTYEALKGAKRAIVHFYNSVSVLQREVVFRKNKEEIKKLATDAAELCKDLENEAKGIDLYYEYSPESFTGTEPEYAVEVCNAVIGVIKPTPEHPMIINLPATVEMTTPNVFADEVEYVSTHLDDRDSVVLSLHPHNDEGMGVAATELAVLAGADRVEGCLLGNGERTGNVDLVTLGLNWLTQGIDPQLDLSNVPEIRKTVEYCNQIKISERHPYAGNFVFTAFSGSHQDAIKKGLEARQVAAERAGADLDSFVWLVPYLPIDPKDIGRTYEAIIRVNSQSGKGGMAYLLKTNHNLDLPKRLQIEFDKIVQNYADTTKKEVKDGDIWRLFKDEYLPVEQSGMTAAGVVVGDTHDASLEPWGRLKLLKVAVSSGEDGSDTVLKARLLDRGVNVGDDEPVEREASGIGNGPIAAFLNAISNFGVEASIMDYVEHTMSVGTDAMAASYVECQIGEADDAQIVWGVGIDSSITTSALKAIISAINRSQRQR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Corynebacterium glutamicum (strain R)
Length
616 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
68.227 kDa
Sequence
MSPNDAFISAPAKIETPVGPRNEGQPAWNKQRGSSMPVNRYMPFEVEVEDISLPDRTWPDKKITVAPQWCAVDLRDGNQALIDPMSPERKRRMFELLVQMGFKEIEVGFPSASQTDFDFVREIIEKDMIPDDVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRNVVFRMDKDQVKKLATDAAELIKTIAQDYPDTNWRWQYSPESFTGTEVEYAKEVVDAVVEVMDPTPENPMIINLPSTVEMITPNVYADSIEWMHRNVNRRDSIILSLHPHNDRGTGVGAAELGYMAGADRIEGCLFGNGERTGNVCLVTLALNMLTQGVDPQLDFTDIRQIRSTVEYCNQLRVPERHPYAGDLVFTAFSGSHQDAVNKGLDAMAAKVKPGANSTDVSWEELRDTEWEVPYLPIDPKDVGRDYEAVIRVNSQSGKGGVAYIMKTDHGLQIPRSMQVEFSAVVQNVTDAEGGEVNSKAMWDIFATEYLERTAPVEQIALRVENAQTENEDASITAELIHNGKDVTVDGHGNGPLAAYANALEKLGIDVEIQEYNQHARTSGDDAEAAAYVLAEVNGRKVWGVGIAGSITYASLKAVTSAVNRALDVNHEAVLAGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Length
616 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
68.188 kDa
Sequence
MSPNDAFISAPAKIETPVGPRNEGQPAWNKQRGSSMPVNRYMPFEVEVEDISLPDRTWPDKKITVAPQWCAVDLRDGNQALIDPMSPERKRRMFELLVQMGFKEIEVGFPSASQTDFDFVREIIEKGMIPDDVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRNVVFRMDKVQVKKLATDAAELIKTIAQDYPDTNWRWQYSPESFTGTEVEYAKEVVDAVVEVMDPTPENPMIINLPSTVEMITPNVYADSIEWMHRNLNRRDSIILSLHPHNDRGTGVGAAELGYMAGADRIEGCLFGNGERTGNVCLVTLALNMLTQGVDPQLDFTDIRQIRSTVEYCNQLRVPERHPYGGDLVFTAFSGSHQDAVNKGLDAMAAKVQPGASSTEVSWEQLRDTEWEVPYLPIDPKDVGRDYEAVIRVNSQSGKGGVAYIMKTDHGLQIPRSMQVEFSTVVQNVTDAEGGEVNSKAMWDIFATEYLERTAPVEQIALRVENAQTENEDASITAELIHNGKDVTVDGRGNGPLAAYANALEKLGIDVEIQEYNQHARTSGDDAEAAAYVLAEVNGRKVWGVGIAGSITYASLKAVTSAVNRALDVNHEAVLAGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Mycobacterium leprae (strain TN)
Length
607 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
66.898 kDa
Sequence
MASFSESLSQDPADAYKSAPSITKPMGPPSPGQPQWNPQRATSMPVFRYRPFAKEVEPIRLVDRTWPDRVIDCAPLWCAVDLRDGNQALIDPMSPICKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIITDGTIPDDVTIQVLTQCRPELIERTFEACENASRVIVHFYNSTSILQRRVVFRADQATVKAIATDGARKCVEEAFKYPGTHWRFEYSPESYTGTELEYAKQVCDAVGEVIQPTPDNPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGYHAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNKLRVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKIDADAADSDVDDILWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLELPRRLQIEFSRAIQKISEGEGGEITPTEMWDVFFEEYLSPVQPLERIKQRVNAAEEDGGSTSIAATVKINGEETEISGVGNGPLAAFIDALGHVGLQVAVLDYSEHAMNAGDDAQAAAYVEASVHGHTAWGVGIAPSITTASLRAVVSAVNRAMPR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Length
590 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
64.818 kDa
Sequence
MKNTQAPSAMPIHKYRPFHEQIAVDLPDRTWPAKRIAVAPRWCAVDLRDGNQALIDPMSPERKRIMFDLLVRMGYKEIEVGFPSASQTDFDFVRSLIEENAIPDDVTIQVLTQAREHLIKRTYDSLVGAKRAIVHLYNSTSVLQREVVFRSDRQGIVDIALAGARLCRQFEALAPGTEIYYEYSPESYTGTELEFAADICNQALEVFEPTPERKVIINLPATVEMATPNVYADSIEWMSRHLNHRENVILSLHPHNDRGTAVAAAELGYLAGADRIEGCLFGNGERTGNVDLVTLGVNLFTQGIDPQIDFSDIDHIKRTVEHCNQLPVGERSPWGGDLVFTAFSGSHQDAIKKGFEAMAARAQRESVDVDDLVWAVPYLPIDPKDLGRSYEAVIRVNSQSGKGGVAYLLKSDHALDLPRKLQIEFSGVVQAKTDAEGGEVTSNEIWAIFQDEYLPAPETESDAKWGRFELGSTSTANENGDHVTLTVTLRDGETVSKATGEGNGPIAAFFDILNARGINVHLYDYSQHTLSASESATAAAYVEVNVDGRRLWGVGIDADTTTASFKAVISAVNRSVRASASSVPAELAGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
Length
588 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
64.9 kDa
Sequence
MKSTQTPSGMPIHKYRPFHEQIAVDLPDRTWPARRITEAPRWCAVDLRDGNQALIDPMSPERKRIMFDLLVRMGYKEIEVGFPSASQTDFDFVRSLIEEGAIPDDVTIQVLTQAREHLIARTYESLRGAKQAIVHLYNSTSVLQREVVFRTDKQGIIDIALEGARLCKRYEETIPEVDVYYEYSPESYTGTELEFAAEICNRVVEVLEPTPERKVILNLPATVEMATPNVYADSIEWMCRHLDRRDEVIVSLHPHNDRGTAVAAAELGYLAGADRIEGCLFGNGERTGNVDLVALGINLFTQGIDPQIDFSDLDGIKRTAEHCNQLAVPERSPWAGDLVYTAFSGSHQDAIKKGFEAMAADAAAQGVTVDEIPWAVPYLPVDPQDLGRSYEAVIRVNSQSGKGGVAYLLKADHSLDLPRRLQIEFSGVVQAKTDAEGGEIPSAQIWSIFQDEYLPAPLDRVEEKWGRFELTSTRTSSDMGGSVSLEVELRDGDRVREASASGNGPIAAFLKVLADQGVDVRLLDYVEHALSASGDALAASYVELEVEGVRLWGVGIDEDSSTASLEAIVSGVNRAIRRTVREPELAAV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1)
Length
588 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
64.985 kDa
Sequence
MKSTQTPSGMPIHKYRPFHEQITVDLRDRTWPARRITEAPRWCAVDLRDGNQALIDPMSPERKRIMFNLLVRMGYKEIEVGFPSASQTDFDFVRSLIEEGAIPDDVTIQVLTQAREHLIARTYESIRGAKQAIVHLYNSTSVLQREVVFRTDRQGIIDIALEGARLCKRYEETIPETDVYYEYSPESYTGTELEFAAEICNRVVEVFDPTPERKVILNLPATVEMATPNVYADSIEWMCRHLDRRDEILVSLHPHNDRGTAVAAAELGYLAGADRIEGCLFGNGERTGNVDLVALGINLFTQGIDPQIDFSDLDGIKRTAEHCNQLAVPERSPWAGDLVYTAFSGSHQDAIKKGFEAMAVDAAAQGVTVDDIPWAVPYLPVDPQDLGRSYEAVIRVNSQSGKGGVAYLLKADHSLDLPRRLQIEFSGVVQAKTDAEGGEVTSAQIWSVFQDEYLPAPLDRVEEKWGRFELTSTRTSSDMGGSVSLDVVLRDGDEVREASASGNGPIAAFLQVLADQGVEVRLLDYVEHALSASGDALAASYVELEVEGVRLWGVGIDEDSSTASLEAIVSGVNRAIRRTVREPELAAV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
Length
588 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
64.9 kDa
Sequence
MKSTQTPSGMPIHKYRPFHEQIAVDLPDRTWPARRITEAPRWCAVDLRDGNQALIDPMSPERKRIMFDLLVRMGYKEIEVGFPSASQTDFDFVRSLIEEGAIPDDVTIQVLTQAREHLIARTYESLRGAKQAIVHLYNSTSVLQREVVFRTDKQGIIDIALEGARLCKRYEETIPEVDVYYEYSPESYTGTELEFAAEICNRVVEVLEPTPERKVILNLPATVEMATPNVYADSIEWMCRHLDRRDEVIVSLHPHNDRGTAVAAAELGYLAGADRIEGCLFGNGERTGNVDLVALGINLFTQGIDPQIDFSDLDGIKRTAEHCNQLAVPERSPWAGDLVYTAFSGSHQDAIKKGFEAMAADAAAQGVTVDEIPWAVPYLPVDPQDLGRSYEAVIRVNSQSGKGGVAYLLKADHSLDLPRRLQIEFSGVVQAKTDAEGGEIPSAQIWSIFQDEYLPAPLDRVEEKWGRFELTSTRTSSDMGGSVSLEVELRDGDRVREASASGNGPIAAFLKVLADQGVDVRLLDYVEHALSASGDALAASYVELEVEGVRLWGVGIDEDSSTASLEAIVSGVNRAIRRTVREPELAAV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / DSM 20744 / JCM 9667 / LMG 2889 / C-1)
Length
588 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
64.985 kDa
Sequence
MKSTQTPSGMPIHKYRPFHEQITVDLRDRTWPARRITEAPRWCAVDLRDGNQALIDPMSPERKRIMFNLLVRMGYKEIEVGFPSASQTDFDFVRSLIEEGAIPDDVTIQVLTQAREHLIARTYESIRGAKQAIVHLYNSTSVLQREVVFRTDRQGIIDIALEGARLCKRYEETIPETDVYYEYSPESYTGTELEFAAEICNRVVEVFDPTPERKVILNLPATVEMATPNVYADSIEWMCRHLDRRDEILVSLHPHNDRGTAVAAAELGYLAGADRIEGCLFGNGERTGNVDLVALGINLFTQGIDPQIDFSDLDGIKRTAEHCNQLAVPERSPWAGDLVYTAFSGSHQDAIKKGFEAMAVDAAAQGVTVDDIPWAVPYLPVDPQDLGRSYEAVIRVNSQSGKGGVAYLLKADHSLDLPRRLQIEFSGVVQAKTDAEGGEVTSAQIWSVFQDEYLPAPLDRVEEKWGRFELTSTRTSSDMGGSVSLDVVLRDGDEVREASASGNGPIAAFLQVLADQGVEVRLLDYVEHALSASGDALAASYVELEVEGVRLWGVGIDEDSSTASLEAIVSGVNRAIRRTVREPELAAV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)
Length
584 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
64.634 kDa
Sequence
MKNLQRPSGMPAHKYTPYHQNFPFDMSDRTWPDKVATTAPRWCAVDLRDGNQALIDPMDSERKLRMFQLLVGMGYKEIEVGFPSASQTDFDFVRTLVEGGHIPEDVSIQVLTQSREHLIERTYEAIDGAPNAIVHLYNSTSTLQRRVVFHQDMDGIVDIALTGARLCRKYEEQLSGTAVTYEYSPESYTGTELEFAARICNEVAETFEIGNGRKMIVNLPATVEMATPNVYADSIEWMGRHLYQREDIILSLHPHNDRGTGVAAAELGYLAGADRIEGCLFGNGERTGNVDLVTLGLNLLTQGVDPQIDFSDIEEIRRTVEYCNQLPVPERSPYGGDLVFTAFSGSHQDAIKKGFEAMERDAEQQGVGVDELEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGVAYLLKSEYGIDLPRRAQIEFSGVVQKFTETSGSEVSAQQLWTIFRDEYLPSRDGSGSTWGHYRITSISTHAEDQANTVLEIGLDVGGEHKERTAQGTGPIDALINLFNREGMDVRLLDYTEHTLSASANAQAASYVELAVGDRVLWGAGMDSNTTRASLKAVISAVNRAVRDAQEAAQD

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Length
582 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.841 kDa
Sequence
MRNAQKPSGMPVHRYLPFHEQIEVELPDRTWPTKRITTAPRWCAVDLRDGNQALIDPMSPARKLKMFELLVKMGYKEIEVGFPSASQTDFDFVRQLIQGGHIPEDVTIQVLTQAREHLIERTYESLVGAKQAIVHLYNSTSVLQRRVVFNEDQDGIMALATQGALLCKKYQETLTDTKITYEYSPESFTGTELDYAVRVCNAVADIFEASADNQVIVNLPATVEMITPNVYADSIEWMSHNLHPREGIILSLHPHNDRGTGVAAAELGYLAGADRIEGCLFGNGERAGNVDLVTLGLNMFSQGVDPMIDFSDIDEIRRTVEYCNQLPAPERMPYGGDLVFTAFSGSHQDAIKKGFEALERDADAAGIAVADTVWAVPYLPVDPKDLGRSYEAVIRVNSQSGKGGVAYLLKSEHSLDLPRRAQIEFSGVIQRRTDSVGGEVSADQRWEAFTDEYLPSPAGHPGGQWGRYALGSMNADTEEDGTTKLNTAMRIDGVEQRRSGSGNGPIAALLNILHDDGVDVRVLDYSEHALSEGGNASAASYVECAVGDRVLWGLGIDPNTTVSSLKAVISAVNRAIRDNQVD

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Length
581 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
64.688 kDa
Sequence
MPVKRYLPFEVEVEDITLPDRTWPDKKITQAPQWCAVDLRDGNQALIDPMSPERKRRMFELLVKMGFKEIEVGFPSASQTDFDFVREIIEKNMIPDDVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRDVVFRMNKDQVKTLATDAAELIKTIAQDYPDTNWRWEYSPESYTGTEVEYAKEVVDAVVEVMDPTPENPIIINLPATVEMITPNVYADSIEWMHRNLNRRDSIILSLHPHNDRGTGVAAAELGYMAGADRIEGCLFGNGERTGNVCLVTLALNMLTQGVDPQLDFSDIKHIRRTVEYCNQLRVPERHPYGGDLVFTAFSGSHQDAINKGLDALAAKVKPGASSTEVAWEELRSTEWEVPYLPIDPKDVGRDYEAVIRVNSQSGKGGVAYIMKTDHGLKMPRSMQVEFSAVVQNVTDAEGGEVNSKEMWDIFATEYLDRSAPVEQIALRVENAQTENDDATITAELVVDGENQTVSGRGNGPLAAYANALESLNIDVEIQEYSQHARTSGDDAEAAAYVLAEVNGRMVWGVGIAGSITYASLKAVTSAVNRALDFKHQQLQNGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Length
581 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
64.688 kDa
Sequence
MPVKRYLPFEVEVEDITLPDRTWPDKKITQAPQWCAVDLRDGNQALIDPMSPERKRRMFELLVKMGFKEIEVGFPSASQTDFDFVREIIEKNMIPDDVTIQVLVQAREHLIRRTFEACEGAKNVIVHFYNSTSILQRDVVFRMNKDQVKTLATDAAELIKTIAQDYPDTNWRWEYSPESYTGTEVEYAKEVVDAVVEVMDPTPENPIIINLPATVEMITPNVYADSIEWMHRNLNRRDSIILSLHPHNDRGTGVAAAELGYMAGADRIEGCLFGNGERTGNVCLVTLALNMLTQGVDPQLDFSDIKHIRRTVEYCNQLRVPERHPYGGDLVFTAFSGSHQDAINKGLDALAAKVKPGASSTEVAWEELRSTEWEVPYLPIDPKDVGRDYEAVIRVNSQSGKGGVAYIMKTDHGLKMPRSMQVEFSAVVQNVTDAEGGEVNSKEMWDIFATEYLDRSAPVEQIALRVENAQTENDDATITAELVVDGENQTVSGRGNGPLAAYANALESLNIDVEIQEYSQHARTSGDDAEAAAYVLAEVNGRMVWGVGIAGSITYASLKAVTSAVNRALDFKHQQLQNGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Nocardia farcinica (strain IFM 10152)
Length
580 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.442 kDa
Sequence
MSATAFPTLSTPAGEIPATAPAWNRQRRSQMPSHRYRDVHSRVAVPLTDRQWPTRRLTEAPLWVPVDLRDGNQALAEPMDPARKRRFFELLVAMGYKEIEVGYPSASQTDFDFVRLLADTDLAPDDVTVVVFTPARRDLIERTVESIRGITNPVVVHMYTATAPTWREVVLGHDRAALRALILDGGREVLRCAGDLPTVRFEFSPEVFNLTEPDFVLEICDAMTELWQATPQRPVILNLPATVEVATPNVYADQIEYMHRNLARRDSVILSVHPHNDRGTGIACAELAVLAGAQRVEGCVFGNGERTGNVDIATLALNLHAQGVDPMIDFSDIDEIRRTVEYCNRVEIHARHPYVGDLVHTAFSGTHQDAIKKGLAEHRARAAARGVPEREIDWRVPYLPIDPADIGRSYDAVIRVNSQSGKGGIAYLLESEYGTVLPRRLQIDFARHVQQHTDDTGREVTAAELWSLFSAVYLREGEADAPQADLGNRLGIDGVVASGASAAELGAALRRHGVELEVLAVHHTTVTGELLALVEYRDGAGVRWSAGRGRTAGEAVGNAVAAAVGPATAPARAVAEVRPG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Arthrobacter sp. (strain FB24)
Length
579 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.597 kDa
Sequence
MRNAQKPSGMPVHRYMPFQDQITVELPDRTWPDKVITKAPRWCAVDLRDGNQALIDPMSPARKMKMFDLLVRMGYKEIEVGFPSASQTDFDFVRQLIEGNHIPDDVTIQVLTQAREHLIERTYESLVGAKQAIVHLYNSTSVLQRRVVFNQDEDGILDIALQGARLCKKYEETLADTHITYEYSPESFTGTELEYAVRVCNAVADVFEASADSQVIINLPATVEMATPNVYADSIEWMSRHLHPREGIILSLHPHNDRGTGVAAAELGYLAGADRIEGCLFGNGERTGNVDLVTLGLNMFVQGIDPMIDFSDIDDVRRTVEYCNQLPVAERSPYGGDLVFTAFSGSHQDAIKKGFEALEKDAAAAGKDVADYTWQVPYLPVDPKDLGRSYEAVIRVNSQSGKGGVAYLLKNEHSLDLPRRAQIEFSGVIQKRTDTVGGEVSGAQLWQIFQDEYLPSSKEDGQWGRYSLGSFSTETDDDGAMTLHATVTVDGVQVRRTGSGNGPIAALLSILGQDGVDVRVLDYSEHALSEGGNARAAAYVECAVGERVLWGVGIDSNTTTSSLKAVISAVNRAIRDAQA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Paenarthrobacter aurescens (strain TC1)
Length
579 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.749 kDa
Sequence
MRNAQKPSGMPIHRYLPFQDQITVEVPDRTWPDKVITKAPRWCAVDLRDGNQALIDPMSPARKLKMFQLLVKMGYKEIEVGFPSASQTDFDFVRQLIEGGHIPDDVSIQVLTQAREHLIERTYESLVGAKQAIVHLYNSTSVLQRRVVFNQDEDGILDIALQGARLCKKYEETLTDTHITYEYSPESFTGTELEYAARVCNAIADVFEASADKQVIINLPATVEMATPNVYADSIEWMHRNLHPREGIIISLHPHNDRGTGVAAAELGYLAGADRIEGCLFGNGERTGNVDLVTLGLNMFVQGVDPMIDFSDIDEIRRTVEYCNQLPVPERSPYGGDLVFTAFSGSHQDAIKKGFEALEKDAAAAGKSVDDFTWQVPYLPIDPKDLGRSYEAVIRVNSQSGKGGVAYLLKNEHNLDLPRRAQIEFSGVIQRRTDAVGGEVSGAQLWQIFQDEYLPSDEEQAQWGRYGLGSVSTETDESGAMTMNANLRIDGVEVRRTGHGNGPIAALLDILHHDGVDVRVLDYSEHALSEGGSASAAAYVECAVGERVLWGVGIDPSTTTSSLKALISAVNRAVRDAQA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Length
579 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.689 kDa
Sequence
MKTTTRQTGRYGAFTPVPLPGRTWPNNIIGSAPRWLSTDLRDGNQSLATPMSPDRKLAMFELLVSMGYKEIEVGFPVASQDDFDFLRVLIEQERIPEDVRISVLVQARDELIRRTVESLEGAPRATIHLYNATSPLFRRVVFGMSRNECKDLAVQGTRLMMKYAEKTLGDCDLGFQYSPELFSDTELDFSLEVCEAVMDVWQPEPGRGIILNFPTTVERSLPNVFADQIEWLSRNLSRREHVCLSIHPHNDRGTAVASAELALLAGAERIEGCLFGNGERAGNVCLVTLGLNMFTHGVDPGIDFSDINEIRRTVERCNGLAVHPRHPYGGDLVYTSFSGSHQDAIKKGFDALEREAAHRGAAVGDLPWEMPYLPLDPEDVGRTYEAVVRINSQSGKGGVAYVMSAWHGLNLPRDLQIDFAHVVQSQADAEGGEITPDRVKRLFEREYLSSSDLPVPLASGTELVTTSLHIDGERFDVGADRADTVQAVRATLTRWGFDVRAVHRTGIAGQDRGPDADVAVYAECRVEGRVSWGVGIDRDIEAASLAAVRSAVIRARLKRLPARGGEATGIVAPLVAAGR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6)
Length
579 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.608 kDa
Sequence
MRNAQKSSGMPFHRYTPFQDQITVEMPDRTWPDKVITKAPRWCAVDLRDGNQALIDPMSPARKMKMFDLLVRMGYKEIEVGFPSASQTDFDFVRQLIEGNHIPDDVTIQVLTQAREHLIERTYESLVGAKQAIVHLYNSTSVLQRRVVFNQDEDGILDIALQGARLCRKYEETLADTHITYEYSPESFTGTELEYAVRVCNAVADVFEASADRQVIINLPATVEMATPNVYADSIEWMSRHLHPREGIILSLHPHNDRGTGVAAAELGYMAGADRIEGCLFGNGERTGNVDLVTLGLNLFVQGIDPMIDFSDIDDVRRTVEYCNQLPVPERSPYGGDLVFTAFSGSHQDAIKKGFEALERDAAAAGKDVADVTWQVPYLPVDPKDLGRSYEAVIRVNSQSGKGGVAYLLKNEHSLDLPRRAQIEFSGVIQRRTDTVGGEVSGAQLWQIFQDEYLPSGKADGQWGRYSLGSVKTETDDDGGMTLHASLTVDGAQVSRTGTGNGPIAALLNILTQDGVDVRVLDYSEHALSEGGNAMAAAYVECAVGERVLWGVGIDANTSMSSLKAVISAVNRAIRDAQS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Herbaspirillum seropedicae (strain SmR1)
Length
575 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.65 kDa
Sequence
MLTDPSQKYRAIAPVDLPDRRWPSRTLRQAPTWLSTDLRDGNQALFEPMNRERKLRLFHELVRIGFKEIEVGFPAASRIDFETVRHLIDEHLIPDDVTPMVMTQLRADLITETVKSVAGARRVIVHFYNAIAPAWREIVFGMSVPQIITLVEDHIALFRRLTAVHPETEWILQYSPETFCMAELEVSLEVCNAAIRAWDAGPRRRMIINLPTTVEVSTPNVFADQIEWMDRRLERREHLILSVHPHNDRGTAVACAEQAMLAGAQRVEGCLFGNGERSGNVDVVTLALNLYTQGIAPGLDFSDIAALARVAEECTALPIHPRHPYVGDLVFTAFSGSHQDAIAKGFAAQRPDAPWRVPYLPIDPTDLGRTYDSIVRVNSQSGKGGIAFLLQRDHHITMPRRMQVEFSAIVQALADASETELTSEHLWDVFERTYLAPVQASPDFSDRTSLAPALEQRRFIYRSHCLHPHPDGERIVLELADTEGNVRTVEGSGNGPIAATVAALGLALRIDSYEERSLGVGVGADAQALAIVEAALPTVPGSRFGVGRHENITTASIMAVLSAASRFAGEEQGKG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Length
575 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.185 kDa
Sequence
MQNTQTPSPMPFGKYTPFQDQIRVELPDRTWPTRTITKAPRWCAVDLRDGNQALIDPMNSERKLRMFTLLVQMGYKDIEVGFPSASQTDFDFVRTLIENDLIPDDVRIQVLTQAREHLIERTYESLRGAKQAIVHLYNSTSVLQRRVVFGMDEDGIVDLALQGARLCRKFEETIPGTTVYYEYSPESYTGTELEFAARICNAVVAVFEPTPERQVIVNLPATVEMATPNVYADSIEWMSRHLDQRENVIISLHPHNDRGTGVAAAELGYLAGADRIEGCLFGNGERTGNVDLVTLGMNLFSQGIDPQIDFSDIDHIRRTVEHCNQLPVGERVPYGGDLVFTAFSGSHQDAIKKGLEAMERDAAAAGKTVDEIPWAVPYLPIDPRDVGRSYEAVIRVNSQSGKGGVAYLLKAEHQLDLPRRLQIEFSRVIQERTDAQGGEVSAAQIFDVFSDEYLPSGSGTPEWGRFALRGTRSVSVVDGADTLEVDLHDDGAENTVRGTGNGPIAAFCAALGSRGVDVRVLDYAEHALSAGGDAQAAAYVECAVAGRVLWGVGIDHNITTASLKAIVSAVNRALR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
Length
573 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
62.543 kDa
Sequence
MPSHRYRSVFDRVEVPLTDRTWPDQRFSAAPLWVPVDLRDGNQALAEPMDTARKTKMFDLFLRMGYKEIEVAYPSASQTDFDFVRSLAVRDDIPEDVTISVFTPARPELIERTFESVEGLPNVLVHLYTATAPAWRDLVLRGSRAEVLALIEDAAGLVAKLADQRLGTKHGPGAGRMRFEFSPEVFNLTEPDYVIEVCDRVTEIWDACADRPVVHNLPATVEVATPNVYADQIEYMSRSLARREHVILSVHPHNDRGTGVACAELAVLAGAQRVEGCLFGNGERTGNVDLVTLALNLHAQGVDPMIDLSDIDAVKAVVEECNRIPVHVRHPYGGDLVYTAFSGTHQDAISKGMAHHAARAAELGVPASQAPWDVPYLPIDPADVGRSYQGVIRVNSQSGKGGIAYLLRTHYGVDLPRDFQPGFSKVVQRATDEHGREMTPQDLWELFRTTYVVPGEDGAWKLTDTAFQEIEGGGHRVEATAVRADGTVIPVAGIGNGPLSALTVALAKAGIGFEVVDYTENAVYSEHAVSEGADAVAVCYIRARVEGREVWGVGMDTSVLTAMVRAAVSAVNR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
Length
573 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
62.543 kDa
Sequence
MPSHRYRSVFDRVEVPLTDRTWPDQRFSAAPLWVPVDLRDGNQALAEPMDTARKTKMFDLFLRMGYKEIEVAYPSASQTDFDFVRSLAVRDDIPEDVTISVFTPARPELIERTFESVEGLPNVLVHLYTATAPAWRDLVLRGSRAEVLALIEDAAGLVAKLADQRLGTKHGPGAGRMRFEFSPEVFNLTEPDYVIEVCDRVTEIWDACADRPVVHNLPATVEVATPNVYADQIEYMSRSLARREHVILSVHPHNDRGTGVACAELAVLAGAQRVEGCLFGNGERTGNVDLVTLALNLHAQGVDPMIDLSDIDAVKAVVEECNRIPVHVRHPYGGDLVYTAFSGTHQDAISKGMAHHAARAAELGVPASQAPWDVPYLPIDPADVGRSYQGVIRVNSQSGKGGIAYLLRTHYGVDLPRDFQPGFSKVVQRATDEHGREMTPQDLWELFRTTYVVPGEDGAWKLTDTAFQEIEGGGHRVEATAVRADGTVIPVAGIGNGPLSALTVALAKAGIGFEVVDYTENAVYSEHAVSEGADAVAVCYIRARVEGREVWGVGMDTSVLTAMVRAAVSAVNR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Length
573 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.564 kDa
Sequence
MANRQQPTSMPIHKYRPYEQVDIADRTWPDNRVTVAPRWLSTDLRDGNQALIDPMSPARKREMFDLLVKMGYKEIEVGFPASGQTDFDFVRSIIEDETAIPDDVTISVLTQAREDLIERTVESLVGAKRATVHLYNATAPVFRRVVFRGSKDQIKQIAVDGTRLVVEYAEKLLDERTTFGYQYSPEIFTDTELDFALEVCEAVMDVWQPGPDREIILNLPATVERSTPSTHADRFEWMSRNLSRREYVCLSVHPHNDRGTAVAAAELALMAGADRIEGCLFGQGERTGNVDLVTLGMNLFSQGVDPQIDFSNIDEVRRTAEYCNQMEVHARHPYVGDLVYTSFSGSHQDAIKKGFDAMEADAAAKGVTVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHKLDLPRRMQIEFSKIIQTKTDAEGGEVTPKDIWAVFQDEYLPNPRNPWGRIQVKTGQTTTDKDGVDTLTVEASVDGVDTVLTGSGNGPISAFFDALQSVGIDVRLLDYTEHTMSEGASAQAASYIECAIDGQVLWGIGIDANTTRASLKAVVSAVNRAAR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Length
573 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.323 kDa
Sequence
MANRQQPSPMPTAKYRGYDQVDIADRTWPNQRITTAPRWLSTDLRDGNQALIDPMSPVRKRAMFDLLVKMGYKEIEVGFPASGQTDFDFVRSIIEEPGAIPDDVTISVLTQAREDLIERTVESLKGARRATVHLYNATAPVFRRVVFRGSRDDIKQIAVDGTRLVMEYAEKLLGPETEFGYQYSPEIFTDTELDFALEVCEAVMDTYQPGPGREIILNLPATVERSTPSTHADRFEWMGRNLSRREHVCLSVHPHNDRGTAVAAAELALMAGADRIEGCLFGQGERTGNVDLVTLGMNLFSQGVDPQIDFSDIDEIRRTWEYCNQMEVHPRHPYVGDLVYTSFSGSHQDAIKKGFDAMEADAAARGVTVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHSLDLPRRMQIEFSKLIQAKTDAEGGEITPTAIWDVFQDEYLPNPDNPWGRIQVANGQTTTDRDGVDTLTVDATVDGAETTLVGSGNGPISAFFHALQGVGIDVRLLDYQEHTMSEGASAQAASYIECAIGDKVLWGIGIDANTTRASLKAVVSAVNRATR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Azoarcus sp. (strain BH72)
Length
572 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
62.629 kDa
Sequence
MLKNPHTKYRPANPFAGVVPGGRGLSDRTWPDNTITRPPVWMSTDLRDGNQALFEPMNSERKMRMFKMLVEIGLKEIEVAFPAASQTDFDFVRELIEGGHIPDDVTIEVLTQARPHLIERTFESVRGAKRAIVHVYNAVAPNFRRIVFDTDRAGVKQIAVDSARYFVEMAARQPGTDFTFQYSPEVFSGTELDFAVEVANAVIEVWQPTPQQKCIINLPATVEMSTPNVYADQIEWMHRHLARRDSVLLSVHPHNDRGTAVAAAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYSQGVHPGLDFSRINEVARTVEHCTQLPIHPRHPYVGDLVFTAFSGSHQDAIKKGFAVQQPDAVWEVPYLPVDPADLGRSYESIIRVNSQSGKGGIAYLLEAEYGLVMPRRLQVEFSAAIQRITDERGTELSAGDIWRAFEEEYLAVAAPYAYVEHHLAEHGGQQGISLTVEEAGVRRVLRGVGNGPIDAALHALDAGAVLLGYEERAIGQGGDARAVAYIELADGEGGGSTFGVGIHANIVTASVLAIVSALDRLAQRRERADGVGRQVAATR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)
Length
572 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.273 kDa
Sequence
MLKNPATKYRSFKPVTLTDRQWPSRTITHPPIWMSTDLRDGNQSLFEPMDAQRKMRMFKTLVQIGFKEIEVAFPSASQTDFNFVRELIEGGHIPDDVTIEVLTQARDDLIERTFESLRGVPRAIVHLYNATAPEFRKIVFNLEKSGVKELAQNAARTMKRIAATMPETQFTFQYSPEVFSGTEIEFAKEVCDAVFDVWQPTPEHKAIVNLPATVEMSTPNIYADQIEWMHRNLARRDSLIISVHPHNDRGTAVAAAELAVMAGADRIEGCLFGNGERTGNVDLVTLALNLYTQGVDPGLDFSNINEVARTAEECTQLPIHPRHPYVGDLVFTAFSGSHQDAIKKGFAVQKPDAVWEVPYMPIDPADLGRTYDSVIRVNSQSGKGGIAYLLEQGYGVVLPRRLQVDFSSAVQRFTDDSGQEVTSAQIWELFQQEYVQNTAPIHYVGHSLSEREGRERIKLTVDIHGTRRVLTGEGNGPLDALMHAIGVPVRIQHYEERALTQGADARAVAVAEMAGADVTGSAFGVGIDANLVTASIRAVISGVNRAYARVNAQAQENFFDAAMNDAAESVGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Paraburkholderia xenovorans (strain LB400)
Length
572 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.382 kDa
Sequence
MLKNPATKYRSFKPIDLTDRQWPSRTITRPPIWMSTDLRDGNQSLFEPMDAQRKMRMFKTLVQIGFKEIEVAFPSASQTDFNFVRELIEGGHIPDDVTIEVLTQARDDLIERTFESLRGVPRAIVHLYNATAPEFRKIVFNLEKSGVKELAQNAARTMKRIAATMPETQFTFQYSPEVFSGTEIEFAKEVCDAVFDIWEPTPEHKAIVNLPATVEMSTPNIYADQIEWMHRNLKRRDSLVISVHPHNDRGTAVAAAELAVMAGADRIEGCLFGNGERTGNVDLVTLALNLYTQGVDPGLDFSNINEVARTAEECTQLPIHPRHPYVGDLVFTAFSGSHQDAIKKGFAVQKPDAMWEVPYMPIDPADLGRTYDSVIRVNSQSGKGGIAYLLEQGYGVVLPRRLQVDFSSAVQRFTDDSGQEVTSAQIWELFQQEYVQNATPVHYVGHSLSERDGREHIKLTVDINGTRRVLNGAGNGPLDALMHAIGVPVRIQHYEERALTQGADARAVAVAEMAGADVTGSAFGVGIDANLVTASIRAVISGVNRAYARVNAQAKERFFEAAMNDATESVGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Ralstonia pickettii (strain 12J)
Length
570 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
62.582 kDa
Sequence
MLKNPATKYRPFPAIALADRTWPNKTITRAPIWMSTDLRDGNQALFEPMNAERKMRMFKMLVQIGFKEIEAAFPAASQTDFDFVRELIEGGHIPDGVAIEVLTQAREDLIRRTMESLRGAKRAIIHVYNATAPVFRRTVFNTDREGVKRIAVQSAKLIREIAQTMPETQWTYQYSPEVFSGTELDFALEVCNAVTEVWEPTPEHKIIFNLPATVEMATPNIYADQIEWMHRNLARRDSIILSVHPHNDRGTAVAAAELAVMAGADRVEGCLFGNGERTGNVDIVTLALNLYSQGVDPELDFSHINDVARTCEDCTQLPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAVQKPDAPWEMPYLPIDPADVGRTYDSIIRVNSQSGKGGIAYLLESGYGVAMPRRLQVEFSSTVQKLTDASGREATGADIWALFQQTYLRSDGAIGYVSHRLTERDDGSQHIRLVVNIDDHEHICEGSGNGPLDALVHALSHVLTAPVSIHHYEERALGQGANADAIAFAELAATGVAGSVFGVGVDANLTTASIRAVVGGVNRLIARTGQGMLRRSSAQATVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1)
Length
569 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
62.284 kDa
Sequence
MLVNPATKYRPAATVDIPDRTWPGRTITRAPRWMSTDLRDGNQALIEPMNPARKLRLFEQLVKIGLKEIEVAFPAASQTDFDFVRMLIEERRIPDDVTIVVLTQSREDLIRRTVESVRGAARATVHLYNPIAPAWRRIVFNASRDEIKAVAVSGTRLIKALTDAMPETAWTYEYSPETFSLAELDFSLEVSDAVSAAWQAGPGRPMILNLPTTVECSTPNVFADQIEWMHRRLARRAHIVLSVHPHNDRGTAVAAAELALMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVAPELDFSDIDAVRQCVEHCNQLPVHPRHPYVGDLVFTAFSGSHQDAIRKGFAQQQPDAIWEVPYLPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQVHGLYLPRRLQIEFSRAVQAMTDDTGLEASADDLYGLFRREYLARETPLRYVSHQLASDATGATAITVQMERDGQPCTVRGTGNGPIDAFIDALDLPVRVMDYHEHAMTAGADARAACYVEVRVGDSPTGFGAGIDASLVTASLRAVVSGVNRHLQAGFGARAQATQTASASAATEA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Thermobifida fusca (strain YX)
Length
568 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.389 kDa
Sequence
MIPQQQPSGMPFHRYQPFKPVDLPDRTWPSKTITKAPRWLSTDLRDGNQALIEPMDTERKREIFDLLVRMGYKEIEVGFPAASQTDYDFVRYLIEEDRIPDDVQISVLTQAREELIERTVQSLVGAKRATVHLYNATSPEFRRIVFGVNREECKGIAVEGTRTVLKFAEQYLKDTEYFGYEYSPEIFIDTELEFALEVCEAVMDVYQPGPDREIILNLPATVERATPNVYADQIEWMSRNLSRREYVCLSVHPHNDRGTAVAAAELAVMAGADRVEGCLFGHGERTGNVCLVTLGLNLFSQGIDPMIDFSNIDEIRRTVEHCTQLPVNPRHPYGGDLVYTAFSGSHQDAIKKGFHALEADAAAAGVPVDEYRWNMPYLPIDPKDVGRTYEAVIRVNSQSGKGGVSYVLQRDYSIDLPRRLQIEFSRVVQQFADAEGGEFSGERIWEIFTDTYLSEGVVGVMAYRSETSEDGEYCISADVRLRGEIREITGTGNGPISAFVDALAGVGFKLRVLDYSEHALSEGGDARAAAYVEAEVDGNVLWGVGISSNITTASLKAVCSAVNRAQQS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)
Length
568 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.075 kDa
Sequence
MLANPATKYVPFAPFARDFSERTWPSRRITQPPIWMSTDLRDGNQSLIEPMSVERKLRFFEQLVKIGFKEIEVGFPSASQTDFDFVRKLVDEKRIPDDVTIIVLTQSREDLISRTVEAAAGAKQAIVHLYNACAPAFRKVVFNMSKDEIKQIAISGTQWVKQYMAQHPETQWRYEYSPEVFSTTEPEFALEVSNAVADVWQPTPECKMVLNLPATIEATTPNLYADQIEWMHKNLARRDSIVLSVHPHNDRGTAVAAAEFAVMAGADRIEGCLFGSGERTGNVDLVTLALNLYTQGVHPGLDFSDIDEVRRCAEYCNQLPVHPRHPYAGDLVFTAFSGSHQDAIKKGFAQQKPDAVWEVPYLPIDPADLGRSYDAVIRVNSQSGKGGVSYLLEQEHGLVLPRRLQIEFSRAIQRVTDETGREVTADDVHTIFNREYLEQHSPWKLVRHRIDGDPAGGQGKQFSIQVELDYNGERRVVTGSGDGAISAFVAALGIPVRIMDYHEHAIGTGTDTRAASYVELRVGDSATGFGVGIDRDIVTASFQAVLSAVNRHLANGVTVTESETAQAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIMB 10654)
Length
567 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
64.043 kDa
Sequence
MNYKKYKGYETIVLEDRNWPSRKIEKAPQWCSVDLRDGNQALITPMGLKQKLRFFEYLVKMGFKTIEIGFPAASDTEYEFTRTLIEEGYIPEDVTIQVLTQSRIQIINKTFEALKGTKNAVVHLYNSTSTLQREVVFRNSKEETIELAVFGARAIKELALKNPETNFTFEYSPESFTGTEMDFAAEICNSVIDVWKPTKDKKVIINLPSTVEMATPNTYADQIEYMCRNLKSRENIIVSLHAHNDRGTGVAATELGLMAGADRVEGTLFGNGERTGNADILNLGMNLYTQGINPELDFSDINSMIEIYEESTAMNVHPRHPYAGDLVFTAFSGSHQDAIKKGMARMNKQAQYWEVPYLPLDPKDIGKSYEPIIRINSQSGKGGVSFILEQNYGLYIPKDFQKDAGRVITAYSDKMQTEIGAEEIYEVFLNEYVDIRTPLQLNYHKTQSVDSDWDLVFIEAEIEYNMQKHYVQAEGNGVVSAFCNSLKEIIGMDIDIVDYRGHSMEYGTKAKAISYIELKNETGERFYGAGTSSSVGKSSLRAVVSAINKMILAQQTKDMDTQEEDIA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Acetoanaerobium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIMB 10654)
Length
567 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
64.043 kDa
Sequence
MNYKKYKGYETIVLEDRNWPSRKIEKAPQWCSVDLRDGNQALITPMGLKQKLRFFEYLVKMGFKTIEIGFPAASDTEYEFTRTLIEEGYIPEDVTIQVLTQSRIQIINKTFEALKGTKNAVVHLYNSTSTLQREVVFRNSKEETIELAVFGARAIKELALKNPETNFTFEYSPESFTGTEMDFAAEICNSVIDVWKPTKDKKVIINLPSTVEMATPNTYADQIEYMCRNLKSRENIIVSLHAHNDRGTGVAATELGLMAGADRVEGTLFGNGERTGNADILNLGMNLYTQGINPELDFSDINSMIEIYEESTAMNVHPRHPYAGDLVFTAFSGSHQDAIKKGMARMNKQAQYWEVPYLPLDPKDIGKSYEPIIRINSQSGKGGVSFILEQNYGLYIPKDFQKDAGRVITAYSDKMQTEIGAEEIYEVFLNEYVDIRTPLQLNYHKTQSVDSDWDLVFIEAEIEYNMQKHYVQAEGNGVVSAFCNSLKEIIGMDIDIVDYRGHSMEYGTKAKAISYIELKNETGERFYGAGTSSSVGKSSLRAVVSAINKMILAQQTKDMDTQEEDIA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Mycobacterium ulcerans (strain Agy99)
Length
566 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.945 kDa
Sequence
MPVNRYRPFAEEVEHIRVTDRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIITEGAIPDDVTIQVLTQCRPELIERTFEACAGASKVIVHFYNSTSILQRRVVFRADRAAVEAIATDGARRCVEEAAKYPDTQWRFEYSPESYTGTELEYAKQVCDAVAEVIQPTPENPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLATLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVPERHPYGGDLVYTAFSGSHQDAINKGLDAMEFDADAADSDMDDMLWQVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLALPRRLQIEFSRAIQEIAEGSAGEGGEVSPKEMWDAFAEEYLAPVRPLERIKQRVIAAEEDGGTTSIDATVKIDGKEAEISGSGNGPLAAFVHALGTVGFDVAVLDYSEHAMSAGDDAQAAAYVEASVAGKTVWGVGIAPSITTASLRAVVSAINRASR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Frankia sp. (strain EAN1pec)
Length
565 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.634 kDa
Sequence
MITPQQPSGMPIEKYRPFPAVALPDRTWPNATITEAPRWCSVDLRDGNQALIDPMTPSRKMQLFELLVAMGYKEIEVGFPAASQTDFDFVRQLIEDDLIPDDVTIQVLTQAREELIERTVTSLVGSDRALIHLYNSTSTLQRRVVFGLDRAGVTDIAVQGARWCAQYAEKLLEGTDVRWQYSPESFTGTELDYALEVCEAVMDVWAPTPDNPVVLNLPATVEMSTPNVYADQIEWMSRNLTRRDAVVLSLHPHNDRGCAVAAAELGVMAGADRVEGCLFGNGERTGNVCLVTLGMNLFSQGIDPMIDLSDIDGVRRTVEYCNQLPVHPRHPYGGDLVYTAFSGSHQDAIKKGFEAMERTGQTLWEVPYLPIDPKDVGRSYEAVIRVNSQSGKGGVAYLMKSEYALDLPRRLQIEFSGVVQKHTDDAGGEVTAGQLWEIFTREYRPEGGDPAASLELLGSRTTAASGARDEVTVSVRLDGTETVITGSGNGPIDAFVAALSERGVPVRVLDYNEHALGSGADARAAAYLEVAVGETVLWGVGIDPNIVTASLRAVVSAVNRASRES

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Length
563 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
62.447 kDa
Sequence
MLKNPSVKYRAFAPVPLSDRQWPSKTITKPPIWMSTDLRDGNQALFEPMNAERKLRMFEMLVKIGFKEIEAGFPSASDTDFGFIRKLVEEGRVPDDVHIEVLTQARPELIARTMESLKGAKNAIVHVYNATAPNFREVVFQQGKQGVKAIATESARQIKEIAATQPETNWTFQYSPEVFSGTELDFAKEVVDAVTEIWEAGPERKVVINLPATVEMATPNIYADQIEWMHRNLERRDGIILSVHPHNDRGTAVAAAELAIMAGADRVEGCLFGNGERTGNVDLVTLALNLYSQGIDPGLDFAQINEIARTAEYCTQLPIHPRHPYVGDLVFTAFSGSHQDAIKKGLAAYKAGDIWQVPYLPLDPKDLGRTYESIIRVNSQSGKGGVSYLLEAEYDLRLPRRLQVEFSSAVQRVTDDTGKEVRAADIWRIFEEEYLTRAEPIEYLSHSLYDESGKQGVKIRIRRFGKEEELSGSGNGPIDAAMDALKLGVELRHYEEHSIGSGTDAKAVAFMEVADPEHPGDLFGVGIDANIITASFKAMLSAANRAAARRPKSEWARLCGGAE

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Length
560 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
62.262 kDa
Sequence
MPDAAVKYRAYPQVNIPDRTWPTKTITKAPVWCSVDLRDGNQALVDPMGHDRKARMFHLLIEMGFKEIEIGFPSASQTDFDFARWCVEEGNVPDDVSLQVLVQCRPELITRTFEALEGANRPIVHFYNSTSELQRRVVFAKDVQGIKQIAVDAAKMITDMATKAGGGYRFEYSPESFTGTELDVALEICNAVIEVVKPTPDNKLIINLPSTVEMATPNVYADQIEWMCRNLDNRENLIVSLHPHNDRGTGIAAAELALLAGADRVEGTLFGNGERTGNVDMVTMALNMFTQGVDPEIDCSNIERIKEVFEYSNQMAIGERHPYVGELVYTAFSGSHQDAINKGMKAAQVANHPVWEVPYLPIDPRDVGRSYEAIIRINSQSGKGGIAYILQQDYGLNLPRNLQVEFREDIQRITDVEGKELPSRRIYDRFIERYVTQPEGRLRFVDHHTYPDTEHKGQRIVAAEITDNGEIKRIEGRGNGPIDGFINALSHYLGIEMSVEDYSEHSLQHGSNAAAISYVETSYPGGKLFGAGINTNIVAASLEAIVSAANRVLDVKAGKA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)
Length
559 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.822 kDa
Sequence
MSFDHRKYRPVAVIDKPDRRWPNQRIEKAPLWAAVDLRDGNQALIKPMSVAQKRRFFQMLVELGFKEIEVGFPSASQIDFDFCRALIEEDLVPDDVHIQVLTQAREDLIARTFDSLKGAKNAIVHIYNATSPTFREQVFNVDKAGCKAIAVRAAEWVKENAAKQPDTHWSFQYSPETFSATETDFAIEVIDAVNAVWRPDQGQRVIINLPATVEVSTPNVFADQVEMVHDNIQYRDDVIISVHTHDDRGCGVAAAEMAVMAGADRVEGTLLGNGERTGNMDLVTAGMNLYSQGIDPGIDFSRMKEIVALVEEITDIQTHPRHPYAGDLVFSAFSGSHQDAIRKCLARYQEGDIWTAAYLPIDPADVGRRYEEVVRINSQSGKGGVAHVLERDFGIDLPRWLQQELAGVVQGDAEEDGGEITSERVHRRFNSDYLNVPMGWVLRSYDLNRSNEQVQAQISIGDDRQPVTLLSGRGDGAMSALVDALNRRIGGEVKVVSFDEYSLGDNTEANAMACVRVQVGDSTQSAVAMAVDTTAAALQAILSAVGRMQETSEQLIANS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)
Length
559 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.822 kDa
Sequence
MSFDHRKYRPVAVIDKPDRRWPNQRIEKAPLWAAVDLRDGNQALIKPMSVAQKRRFFQMLVELGFKEIEVGFPSASQIDFDFCRALIEEDLVPDDVHIQVLTQAREDLIARTFDSLKGAKNAIVHIYNATSPTFREQVFNVDKAGCKAIAVRAAEWVKENAAKQPDTHWSFQYSPETFSATETDFAIEVIDAVNAVWRPDQGQRVIINLPATVEVSTPNVFADQVEMVHDNIQYRDDVIISVHTHDDRGCGVAAAEMAVMAGADRVEGTLLGNGERTGNMDLVTAGMNLYSQGIDPGIDFSRMKEIVALVEEITDIQTHPRHPYAGDLVFSAFSGSHQDAIRKCLARYQEGDIWTAAYLPIDPADVGRRYEEVVRINSQSGKGGVAHVLERDFGIDLPRWLQQELAGVVQGDAEEDGGEITSERVHRRFNSDYLNVPMGWVLRSYDLNRSNEQVQAQISIGDDRQPVTLLSGRGDGAMSALVDALNRRIGGEVKVVSFDEYSLGDNTEANAMACVRVQVGDSTQSAVAMAVDTTAAALQAILSAVGRMQETSEQLIANS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)
Length
559 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.808 kDa
Sequence
MNGSMPFHKYSPYPPVALANRQWPNRTLTKAPLWCSVDLRDGNQALANPMGPQAKRRMFDLLVEIGFKEIEVGFPSASRDDFQFLRDLIEQKAIPDDVTVQMLVQSRAHLIERTFEALQGAKRAIVHLYTPTSSLQRRVVFGKSQQEIIDVAVEGTQMIKEHAQRSPETEIVLEFSPESFTGTELPFALAISEAVQQVWQPTPAQPMILNLPATVEMSTPNIYADQIEWMLSHLSDPQSIIISLHAHNDRGTAVAATELAMLAGAGRVEGTLFGNGERTGNTDVVAVAMNLHSQGIDAGLNFSEMPRIIATSEACTGMSVPPRQPYAGELVFTAFSGSHQDAIRKGLHLHKQEQAQQWAVPYLPIDPQDLGRHYEPVIRINSQSGKGGMAFIMEERCGIHMPKAMQVEFSRVIQAVTDEMGRELQADEIEQLFFKNFVLQENPLSLGHVEHREETEERHHLHAQVSYAGTVQALQAHGNGPMSALVNALETFYSMTIQIHDYHQHARTAGRDSEAVSFVQISVNGGKPTFGVGLHTDSSRSALEAVLCSINRALATSLT

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Length
559 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.55 kDa
Sequence
MTMLKDPSSKYRAFPTINLPDRTWPSKTITSAPIWCSSDLRDGNQSLIEPMDAVKKLRFWKTLVAVGVKEIEASFPAASQTDFDFVRTLIEGGHIPDDTTIQVLTQAREDLIARTFESLRGAKKAIVHLYNATSPSFRRIVFNQDKAGVKEIAVNAAKLFVKYAAQQPETQWQFEYSPETFSATELEFAKEVCDAVVEVWNATPSNKVILNLPATVEVATPNIYADQIEWFCRNINRRDSVLISLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTVALNLYTQGVNPELDFSDIDGVRKVVEECNQIAVHPRHPYVGDLVHTAFSGSHQDAIRKGFAQQKADGLWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGIAYLLEQEYGISLPRRMQIEFSQVVQRETDRLGLEMTAQQIHALLHSEYLQANTPYALVSHRLQEENGHSAVEVEVSSKGQGETNLSWRGKGNGALEALVAGLPVPVEIMDYNEHAIGAGTNAKAAAYIELRVNGERAVHGVGIDENITTASFKALFSALNRSLSEQQAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas fluorescens (strain SBW25)
Length
559 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
62.036 kDa
Sequence
MSMLKDPSSKYRAFPTIDIPDRTWPSKTITEAPIWCSSDLRDGNQSLIEPMDAVKKLRFWKTLVAVGVKEIEASFPAASQTDFDFVRTLIEDNHIPEDTTIQVLTQGREDLIARTFESLRGAKKAIVHLYNATSPSFRRIVFNQDKEGIKAIAVNAAKLFVKYAAQQPETQWTFEYSPETFSATELEFAKEVCDAVIEVWNPTPEHKMILNLPATVECATPNIYADQIEWFGRHINRRDSVIISLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTVALNMYTQGLDPQLDFSDIDGVRKVVEECNQIQVHPRHPYVGDLVHTAFSGSHQDAIRKGFTQQKDDALWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGIAYLLEQEYDISLPRRMQIEFSQVVQAETDRVGLEMTAPQIYALLQREYLQANTPYALVSHRLQEENGNSFVEVEVSGKGQGETNLHWKGKGNGALEALVAGLPIGVEIMDYNEHAIGAGTNAKAAAYIELRVNGERPVHGVGIDENITTASFKALFSALNRSLSQQEAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas fluorescens (strain Pf0-1)
Length
559 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.937 kDa
Sequence
MSMLKDPSSKYRAFPVINLPDRTWPSKTIDAAPIWCSSDLRDGNQSLIEPMDAVKKLRFWKTLVQVGVKEIEASFPAASQTDFDFVRTLIEDGHIPDDTTIQVLTQGREDLIERTFESLRGAKKAIVHLYNATSPSFRRIVFNQDKDGIKAIAVNAAKLFVKYAAMQPDTEWTFEYSPETFSATELEFAKEVCDAVIEVWNPTPEHKIILNLPATVECATPNVYADQIEWFHRNINRRDSVIISLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTVALNMYTQGINPDLDFSDIDGVRKVVEECNQIQVHPRHPYVGDLVHTAFSGSHQDAIRKGFAQQKPDTLWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGIAYLLEQEYGISLPRRMQIEFSQVVQRETDRLGLEMTAQQIHALLHSEYLQANTPYALVSHRLQEENGNSAVEVEVASKGQGETNLHWRGKGNGALEALVAGLPIPVEIMDYNEHAIGAGTNAKAAAYIELRVNGERAVHGVGIDENITTASFKALFSALNRSLSQPEAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Marinomonas sp. (strain MWYL1)
Length
558 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
62.96 kDa
Sequence
MLTQPSIKYRPAQIIDFPARTWPSKQLKTPPRWCSTDLRDGNQALANPMDHVKKMAFFKHLIECGFKEIEVAFPAASQTDFDFVRLLIEGKHIPDDVTIQVMTQSRVDLIERTIQSLVGAKKAIVHIYNATAPVFREIVFCQDKPATLELAVQGVKHIRQLCEQYPDTQWTLQYSPETFCFTEPDFALEVCEAAAKTWQPSLERPMILNLPTTVEVNTPNVFADQIEHFITSFSSLENITISVHPHNDRGTGVATAEMAILAGAQRVEGCLFGNGERTGNVDLVTLAMNLYSQGVYPNLDFSDMRRTVELVEECNELPVHPRHPYAGALAFTAFSGSHQDAIKKGFASQKSTSSMIWQIPYLPLDPKDIGCTYEEVIRVNSQSGKSGAAWLLQENHGLFLPRKLQIDFSKKVKNHTDQTGHEMPLADVWRLFRESYRLNPDDKGQMKLMDYRSHSSNGLQEIRATLRYQEKTWQLVGEGKGLLSAMLDALRKRFNWQINISDFHEHTLGQQTKSKAVSYVQIESDQATPSFGVAIDEDSTKASLQALINACHPLYKEA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Agrobacterium fabrum (strain C58 / ATCC 33970)
Length
558 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.978 kDa
Sequence
MTDASVKYRPYPTINIPDRTWPGKTIDKAPIWCSVDLRDGNQSLVNPMGHDRKARMFKLLLEMGFKEIEIGFPSASQTDFDFARWCVEEGNVPDDVSLQVLVQCRPELITRTFEALEGANKPIIHFYNSTSELQRRVVFGKDVHGIKQIAVDAAKMITDMAAKAGGGFRFEYSPESFTGTELEVALEICNAVVEVVKPTADNKLILNLPSTVEMATPNIYADQIEWMCRNIDNRENVIISLHPHNDRGTGIAATELALMAGADRVEGTLFGNGERTGNVDVVTLALNMYTQGVDPELDCRDIERIKAVYEYSNEMTIPERHPYVGELVYTAFSGSHQDAINKGMKAIKVANHPVWEVPYLPIDPKDVGRSYEAIIRINSQSGKGGIAYILQQDYGINLPRNLQVEFREDIQRITDEEGVELPAKRIYERFIERYVTQPNARIKFVDHHTYPAGDFKGVRIVAAEITDNGEVKRIEGKGTGPIDGFINALSVYLGVDLSVNDYSEHSLQHGSNASAIAYVEMEHPGGKLFGAGVNTNIVAASLEAIVSAANRVLEERAK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Length
558 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.443 kDa
Sequence
MLYNKYVKYPKVKLDNREWPDKQIEKAPIWCSVDLRDGNQALPKPMNVDEKIKMFKMLVDIGFKEIEIGFPSASETEYEFTRKLIEDKLIPEDVTIQVLTQAREHLVKKTFEALKGVKTAIVHVYNSTSELQRRVVFKKDKDEVKSLAIKGAQMVKKYSEYTEYSESKFVFEYSPESFTGTELDYALEVCEAVLNVWKPSKENKAIINLPSTVEMATPNIYADQIEWFCKKLLNRESVILSLHTHNDRGTCTASSELGILAGADRVEGTLFGNGERTGNLDIMNMALNMYSQGVDPELEFSNLNDIVEAYEECTKMVVHERHPYAGKLVFTAFSGSHQDAIRKGLKSLKEGKNKHWEVPYLAVDPHDLGREYEEIIRINSQSGKGGTAYIMESDFGFILPKAMHPEFGKVIKKKSDELDCELSPEQIFKFFKEEYLENRSPYYLKNYKIHSIQNIEEEKNTVDIEAVISVNGKDTSIEGVGNGPVDAFFNAMNNKKYNGCKFISYDEHALNIGSHSKAVAYVQIESQDKKYFGVGISDNIDTASINAIVSALNRSKLK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Agrobacterium fabrum (strain C58 / ATCC 33970)
Length
558 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.978 kDa
Sequence
MTDASVKYRPYPTINIPDRTWPGKTIDKAPIWCSVDLRDGNQSLVNPMGHDRKARMFKLLLEMGFKEIEIGFPSASQTDFDFARWCVEEGNVPDDVSLQVLVQCRPELITRTFEALEGANKPIIHFYNSTSELQRRVVFGKDVHGIKQIAVDAAKMITDMAAKAGGGFRFEYSPESFTGTELEVALEICNAVVEVVKPTADNKLILNLPSTVEMATPNIYADQIEWMCRNIDNRENVIISLHPHNDRGTGIAATELALMAGADRVEGTLFGNGERTGNVDVVTLALNMYTQGVDPELDCRDIERIKAVYEYSNEMTIPERHPYVGELVYTAFSGSHQDAINKGMKAIKVANHPVWEVPYLPIDPKDVGRSYEAIIRINSQSGKGGIAYILQQDYGINLPRNLQVEFREDIQRITDEEGVELPAKRIYERFIERYVTQPNARIKFVDHHTYPAGDFKGVRIVAAEITDNGEVKRIEGKGTGPIDGFINALSVYLGVDLSVNDYSEHSLQHGSNASAIAYVEMEHPGGKLFGAGVNTNIVAASLEAIVSAANRVLEERAK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Length
558 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
63.443 kDa
Sequence
MLYNKYVKYPKVKLDNREWPDKQIEKAPIWCSVDLRDGNQALPKPMNVDEKIKMFKMLVDIGFKEIEIGFPSASETEYEFTRKLIEDKLIPEDVTIQVLTQAREHLVKKTFEALKGVKTAIVHVYNSTSELQRRVVFKKDKDEVKSLAIKGAQMVKKYSEYTEYSESKFVFEYSPESFTGTELDYALEVCEAVLNVWKPSKENKAIINLPSTVEMATPNIYADQIEWFCKKLLNRESVILSLHTHNDRGTCTASSELGILAGADRVEGTLFGNGERTGNLDIMNMALNMYSQGVDPELEFSNLNDIVEAYEECTKMVVHERHPYAGKLVFTAFSGSHQDAIRKGLKSLKEGKNKHWEVPYLAVDPHDLGREYEEIIRINSQSGKGGTAYIMESDFGFILPKAMHPEFGKVIKKKSDELDCELSPEQIFKFFKEEYLENRSPYYLKNYKIHSIQNIEEEKNTVDIEAVISVNGKDTSIEGVGNGPVDAFFNAMNNKKYNGCKFISYDEHALNIGSHSKAVAYVQIESQDKKYFGVGISDNIDTASINAIVSALNRSKLK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Helicobacter hepaticus (strain ATCC 51449 / 3B1)
Length
558 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
62.975 kDa
Sequence
MSYTKYQRGYFMPPTPSLEWSKKEYIAKAPIWCSVDLRDGNQALITPMSLEEKITFFKLLLKVGFKEIEVGFPAASETEYRFLRTLIEEDLIPDDVSVQVLTQAREHIIKKTFESLEGCKNAIVHVYNSTSYAQREQVFRKSKDEIKHIACEGAICLKESAAATKGNFRFEYSPESFSGTEVDYALEVCNAVIDIFEPTLEKKLIINLPVTVEMSLPHIYASQVEYMSKHLKNRENVLISLHPHNDRGCAIADAELGLLAGADRIEGTLFGNGERTGNVDIITLAMNMHSHGVDPKLDFSNIPSICDVYEKVTKMQVYERQPYSGKLVFAAFSGSHQDAIAKGMAYHKEHNLSTWSVPYLPIDPKDVGRVYESDVIRINSQSGKGGIAYILHHHYGVNLPPLFREEFSYYVKNISDKAHKELSPDEICEIFQNDFVNLNNTLCVQDFHFTHIDSKPSQEFNVKLHILYAKENSKTQQEITGKGNGRLDSIANALREHLNLDFEIIDYSEHSLKKGSTSQAVSYVQIESKGKKCFGVGIDNDIITASIYGLVSALNRII

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
Length
558 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.553 kDa
Sequence
MPDAARKYQPYPTVGLTDRTWPNKVIDKAPIWCSVDLRDGNQALIDPMGHERKARMFGLLLDMGFKEIEIGFPSASQTDFDFARWCIEEGNVPADVSLQVLVQCRPELITRTFEALKGATNPIVHFYNSTSELQRRVVFEKDVGGIKRIATDAAKMITDMAAKAGGGYRFEYSPESFTGTELEVALEICNAVTEIVRPKPDNKLIINLPSTVEMSTPNIYADRIEWMCRNLDNRENLIISLHPHNDRGTGIATTELGLMAGADRVEGTLFGNGERTGNVDIVTLALNMYTQGVDPGIDCSDINRMKDVYEYSNQLKIPERHPYVGELVYTAFSGSHQDAINKGMKALKKANTSLWEVPYLPIDPADVGRSYEAIIRINSQSGKGGIAYVLQADYGLNLPRNLQIEFSQAIQAITDAEGKEVPAKRIHERFLETYVDQPGARLKFLDHHTYPDTAVKGRRVIEAVILDKGKEVTISGTGTGPIDGFVDALSRHVGVEMSVLDYSEHSMQRGSNASAISYVEMEYPGGKLFGAGINTNIVAASLEAVTSAANRIVGRKAR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Rhizobium meliloti (strain 1021)
Length
558 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.751 kDa
Sequence
MPEAAVKYQPYPQIVLPDRTWPSKAITEAPIWCSVDLRDGNQALVDPMGHDRKARMFHLLLDMGFKEIEIGFPSASQTDYDFARWCVEEGNVSEDVSLQVLVQCRPELIARTFEALEGAHRPIVHFYNSTSELQRRVVFGKDVAGIKQIATDAAKMITDMAAKAGGGYRFEYSPESFTGTELEVALEICNAVIEIVRPTADNKLIINLPSTVEMATPNIYADQIEWMCRNLDNRENLIVSLHPHNDRGTGIAATELGLMAGADRVEGTLFGNGERTGNVDVVTLALNMFTQGVDPKLDCSDIERIKEVYEYSNQMVIPERHPYVGELVYTAFSGSHQDAINKGMKAIKQANKPTWEVPYLPIDPRDVGRSYEAIIRINSQSGKGGIAYILQEDYGINLPRNLQIEFREEVQRITDEEGKELPSKRIHQRFIESYVEQPGARIKFVDHHTYPAGEHKGLRVVAAEITDGGETRQIEGKGTGPIDGFINALSIYLGIELSVADYSEHSLQHGSNAAAIAYVEVEYPGGKLFGVGINTNIVAASLEAIVSAANRVLDVVGK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)
Length
558 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.146 kDa
Sequence
MMIDPSKKYRPFPPVALADRTWPSATITKAPIWCAVDLRDGNQALVEPMGADRKVRMFQLLCELGYKEIEVGFPSASQTDFDFLRQLIERDMIPADVTIQVLTQAREDLISRTFQALEGASSAIVHLYNSTSTLQRRVVFALDRAGITDLAVRGAEMVREGAAKASASTKLRFQYSPESFTGTELDYAVEICEAVMGVFEPTAEAPLILNLPSTVEMATPNVYADQIEWFCRALPHRDRVLISLHPHNDRGTAVAAAELALMAGADRIEGTLFGNGERTGNVDLVTLGMNMFTQGIDPGIDFSNIDHIREIAEECNRLPVHPRHPYAGDLVFTAFSGSHQDAINKGLHAMEKTNQDVWEVPYLPIDPKDIGRSYEAVIRVNSQSGKGGVAHILERDYGIRMPRGLQVEFSKVVQAITDTTGEEITSRGLWKTFEETYLGAGSPYSFLEHHTRPDPAGKDQRILTATVKAGGKVRDIDGRGTGPIEALVDALRKDSGLAITIEDYEEHTLRPGSDAQAVAFIKASLPDGRAHYGVGIDANFVVASLKAVLCAANHLSDK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Length
557 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.761 kDa
Sequence
MPMLKDPSQKYRPFAPIALRDRTWPDRVIDKAPLWLSTDLRDGNQSLIEPMDAAKKMRFFKTLVQVGLKEIEVGFPSASQTDFDFVRELIEGGHIPDDVTIQVLTQARDDLIERTFESLKGAKKAIVHYYNACAPSFRRIVFDQDKEGVKRIAVAAGRTIKRLAAAAPETRWGFEYSPEVFSSTESDFAVEVCNAVVEVFQPTPANRLILNLPATIECATPNHYADQIEWFCRHVDRRDSVIVSLHTHNDRGTGVAASELGLMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVDPGLDFSDIDAVRKVVEECNQLPVHPRHPYVGDLVHTAFSGSHQDAIRKGFAQQDPEGVWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGIAYLLEQEYGISLPRRMQIEFSQVVQKETDRLGLEMSAAQIHALLEAEYLRAETPYALKGHRLQEENGTCALDVEVFDKGESRHWRGIGKGPLEALVACLPVRVEIMDYHEHAIGAGSHARAAAYIELRLDGQRSLHGLGIDENLTTASIRALFSALNRALGQQASIRAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Desulfitobacterium hafniense (strain Y51)
Length
557 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
62.708 kDa
Sequence
MKNVDNYRRGYFMPPVKSLKWAEKEYITTPPTWCSVDLRDGNQALVVPMSLEEKLEYYHMLLKIGFKEIEVGFPAASETEYAFLRTLIEQNLIPEDVTIQVLTQSRDHIIEKTFKALVGVKKAVVHLYNSTSVAQREQVFKMSREEIVEIAVSGARLLKKYAAETEGNFQFEYSPESFTGTEMEFALEICNQVLDVFEPTPENKVIINLPATVSLSMPHVYASQIEYMSEHLKYRDNVILSLHPHNDRGTAVADAELGLLAGGQRIEGTLFGNGERTGNVDIVTLALNLFSHGVDPGLNFASMLEITAKYEALTRMKVHDRQPYGGKLVFAAFSGSHQDAITKGIKWREEHECHYWNVPYLLIDPQDIGREYEGDVIRINSQSGKGGIAYMLEQHYALDLPAKMREAFGYKVKNVSDNLHKELMPEEIKDIFFKEYVNIENPIKFLNFHFLNHDDFQTTVTLEFKGEIQELSGEGDGRLDAISNALQARLGLSYSNLIYKEHALELGSKSQAVSYVGVTGPDGVIHWGCGIHTDIFTSSVKALISAINTMIKDSAAV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas entomophila (strain L48)
Length
557 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.817 kDa
Sequence
MTMLKDPSKKYRAFPTIDLPDRTWPSKTITQAPIWCSSDLRDGNQSLIEPMDSEKKLRFWKTLVQVGVKEIEASFPSASQTDFDFVRTLIEDGHIPDDTTIQVLTQAREDLIARTFESLRGAKKAIVHLYNATCPSFRRIVFNQDKQGVKDIAVNAAKLFVKYAAQQPDTHWTFQYSPETFSATELEFAKEVCDAVIEVWNPTPEHKIILNLPATVEVATPNVYADQIEWFCRNINRRDSVIISLHTHNDRGTGIAATELGLMAGADRAEGCLFGNGERTGNVDLVTLALNLYTQGIDPQLDFSDIDGVRKVVEECNQLPVHPRHPYVGDLVHTAFSGSHQDAIRKGFAKQQEGELWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGITYLLEQEYGISLPRRMQIEFSQVVQGETDRLGLEMTAEQIYKLLQKEYLQANAPYALVSHRLQEENGSSHVQVEVSGEGETTLHWHGKGNGALEALVAGLPVNVEIMDYNEHAIGAGTNAKAAAYIELRVAGGRPVHGVGIDENITTASFKALFSALNRSLSQQQAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Length
557 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.712 kDa
Sequence
MTMLKDPSKKYRAFPTIDLPDRTWPSKTITQAPIWCSSDLRDGNQSLIEPMDSEKKLRFWKTLVQVGVKEIEASFPSASQTDFDFVRTLIQDGHIPDDTTIQVLTQAREDLIARTFESLRGAKKAIVHLYNATSPSFRRIVFNQDKQGVKDIAVNAAKLFVKYAAQQPETQWTFQYSPETFSATEMEFAKEVCDAVIEVWNPTPEHKIILNLPATVEVSTPNIYADQIEWFCRNVSRRDSVIISLHCHNDRGTGIAATELGLMAGADRAEGCLFGNGERTGNVDLVTLALNLYTQGIDPLLDFSDIDGVRKVVEECNQLPVHPRHPYVGDLVHTAFSGSHQDAIRKGFAKQQDGELWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGITYLLEQEYGISLPRRMQIEFSQVVQGETDRLGLEMTAQQIYSLLHKEYLQANAPYALVSHRLQEENGHSAVEVEVAGEGETTLHWRGKGNGALEALVAGLPIAVEIMDYNEHAIGAGTNAKAAAYIELRVAGGRPVHGVGIDENITTASFKALFSALNRSLSQQEAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas putida (strain GB-1)
Length
557 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.794 kDa
Sequence
MTMLKDPSKKYRAFPTIDLPDRTWPSKTITEAPIWCSSDLRDGNQSLIEPMDSEKKLRFWKTLVQVGVKEIEASFPSASQTDFDFVRTLIQDGHIPDDTTIQVLTQAREDLIARTFESLRGAKKAIVHLYNATSPSFRRIVFNQDKQGVKDIAVNAAKLFVKYAAQQPETHWTFQYSPETFSATEMEFAKEVCDAVIEVWNPTPEHKIILNLPATVEVSTPNIYADQIEWFCRNVSRRDSVIISLHCHNDRGTGIAATELGLMAGADRAEGCLFGNGERTGNVDLVTLALNLYTQGIDPQLDFSDIDGVRKVVEECNQLPVHPRHPYVGDLVHTAFSGSHQDAIRKGFAKQQEGERWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGITYLLEQEYGISLPRRMQIEFSQVVQGETDRLGLEMTAQQIYSLLHKEYLQANAPYALVSHRLQEENGHSAVEVEVAGEGETTLHWRGKGNGALEALVAGLPIAVEIMDYNEHAIGAGTNAKAAAYIELRVAGGRPVHGVGIDENITTASFKALFSALNRSLSQQEAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Length
557 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.713 kDa
Sequence
MTMLKDPSKKYRAFPTIDLPDRTWPSKTITQAPIWCSSDLRDGNQSLIEPMDSEKKLRFWKTLVQVGVKEIEASFPSASQTDFDFVRTLIEDGHIPDDTTIQVLTQAREDLIARTFESLRGAKKAIVHLYNATSPSFRRIVFNQDKQGVKDIAVNAAKLFVKYAAQQPETQWTFQYSPETFSATEMEFAKEVCDAVIEVWNPTPEHKIILNLPATVEVSTPNIYADQIEWFCRNVSRRDSVIISLHCHNDRGTGIAATELGLMAGADRAEGCLFGNGERTGNVDLVTLALNLYTQGIDPLLDFSDIDGVRKVVEECNQLPVHPRHPYVGDLVHTAFSGSHQDAIRKGFAKQQDGELWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGITYLLEQEYGISLPRRMQIEFSQVVQGETDRLGLEMTAQQIYSLLHKEYLQANAPYALVSHRLQEENGHSAVEVEVAGEGETTLHWRGKGNGALEALVAGLPIAVEIMDYNEHAIGAGTNAKAAAYIELRVAGGRPVHGVGIDENITTASFKALFSALNRSLSQQEAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas putida (strain W619)
Length
557 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.725 kDa
Sequence
MTMLKDPSKKYRAFPTIELPDRTWPSKTITEAPIWCSSDLRDGNQSLIEPMDSEKKLRFWKTLVQVGVKEIEASFPSASQTDFDFVRTLIEDGHIPDDTTIQVLTQAREDLIARTFESLRGAKKAIVHLYNATSPSFRRIVFNQDKQGVKDIAVNAAKLFVKYAAQQPETQWTFQYSPETFSATELEFAKEVCDAVIEVWNPTPEHKVILNLPATVEVATPNIYADQIEWFCRNISRRDSVIISLHCHNDRGTGIAATELGLMAGADRAEGCLFGNGERTGNVDLVTLALNLYTQGIDPQLDFSDIDGVRKVVEECNQLPVHPRHPYVGDLVHTAFSGSHQDAIRKGFAKQQDGELWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGITYLLEQEYGISLPRRMQIEFSQVVQGETDRLGLEMTAQQIYSLLHKEYLQANSPYALVSHRLQEENGHSAVEVEVAGEGETTLHWRGKGNGALEALVAGLPIAVEIMDYNEHAIGAGTNAKAAAYIELRVAGGRPVHGVGIDENITTASFKALFSALNRSLSQQEAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)
Length
556 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.525 kDa
Sequence
MTMLKDPSKKYRAFPTIDLPDRTWPSKTIDAAPIWCSSDLRDGNQSLIEPMDAAKKLRFWKTLVSVGVKEIEASFPSASQTDFDFVRTLIEDGHIPDDTTIQVLTQAREDLIARTFESLRGAKKAIVHLYNATSPSFRRIVFNQDKAGVKEIAVNAAKLFVKYAAQQPETQWTFEYSPETFSATELEFAKEVCDAVIEVWNPTPENKVILNLPATVEVATPNIYADQIEWFGRNITRRDSVLISLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTVALNLYTQGIDPELDFSDIDGVRKVVEECNQIPVHPRHPYVGDLVHTAFSGSHQDAIRKGFTQQKDGELWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGITYLLEQEYGISLPRRMQIEFSQVVQGETDRLGLEMSAQQIHSLLRREYLQANTPYALISHKLQEENGNSAVDAEVHVDGETQHWRGKGKGALEALVAGLPVAVEIMDYNEHAIGSGTTAKAAAYIELRVNGERAVHGVGIDENITTASFRALFSALNRSLSQTQAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas aeruginosa (strain PA7)
Length
556 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.829 kDa
Sequence
MSMLKDPSQKYRPFPAINLPDRTWPSKTITEVPIWCSSDLRDGNQSLIEPMDAAKKMRFFKTLVQVGLKQIEVAFPSASDTDFNFVRELIEGNHIPDDVTIQVLTQAREDLITRTFESLRGAKKAIVHVYNATAPSFRRIVFNQDKQGVVDIATNAAKLIRKLAAEQPDTQWSFQYSPEIFSSTELEFSVEVCNAVIDVWQPTPEHKIILNLPATVECATPNVYADQIEWFGRHVNRRDSVIISLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTLALNMYTQGLHPQLDFSDIDAVRKVVEECNQLPVHPRHPYVGDLVHTAFSGSHQDAIRKGFAQQKEDAIWEVPYLPIDPADIGRDYEAVIRVNSQSGKGGITFLLEQEYGISLPRRMQIEFSQVVQGETDRLGLEMTAQQIYSLLENEYLKATSPYALASHRLQEENGTSAVDLEVTFDGEKQHWRGIGKGPLEALVAALPVKAEIMDYHEHAIGAGANARAAAYIEIRLEGQRPLHGIGIDENITTASFRALFSALNRAVTQAEAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
556 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.727 kDa
Sequence
MSMLKDPSQKYRPFSAINLPDRTWPSKTITEVPIWCSSDLRDGNQSLIEPMDAAKKMRFFKTLVQVGLKQIEVAFPSASDTDFNFVRELIEGNHIPDDVTIQVLTQAREDLITRTFESLRGAKKAIVHVYNATAPSFRRIVFNQDKQGVVDIATNAAKLIKKLAAEQPETQWSFQYSPEIFSSTELEFSVEVCNAVIDVWQPTPDNKIILNLPATVECATPNVYADQIEWFGRHVDKRDSVIISLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTLALNMYTQGLHPQLDFSDIDAVRKVVEECNQLPVHPRHPYVGDLVHTAFSGSHQDAIRKGFAQQKEDAIWEVPYLPIDPADIGRDYEAVIRVNSQSGKGGITFLLEQEYGISLPRRMQIEFSQVVQGETDRLGLEMTAQQIYSLLENEYLKATSPYVLASHRLQEENGTSAVDLEVSFDGEKQHWRGIGKGPLEALVAALPVKAEIMDYHEHAIGAGANAKAAAYIEIRLEGQRPLHGIGIDENITTASFRALFSALNRAVTQAEAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas mendocina (strain ymp)
Length
556 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.093 kDa
Sequence
MTMLKDPSQKYRPFTPIALPDRTWPDKVIDRAPIWLSTDLRDGNQSLIEPMDAEKKMRFFKCLVAVGLKEIEVGFPSASQTDFDFVRELIEGGHIPDDVTIQVLTQARDDLIERTFESLKGAKRAIVHYYNACAPSFRKIVFNQDKAGVKAIAVAAGKTIKRLAAAQPDTQWGFEYSPEVFSSTETDFAVEVCNAVIEVFQPTPANKLILNLPATVECATPNNYADQIEWFGRHVDRRDSVLISVHTHNDRGTGVAASELAVMAGADRVEGCLFGNGERTGNVCLVTLALNLYTQGVDPQLDFSDIDAVRKVVEDCNQIPVHPRHPYAGDLVHTAFSGSHQDAIRKGFAQQKDDAVWEVPYLPIDPADIGRDYEAVIRVNSQSGKGGITFLLEQEYGISLPRRMQIEFSQVVQRETDRLGLEMTAAQIYQLLESEYLQASAPYALKGHRLQEENGTSAVDVEVISAGESHHWRGIGKGPLEALVAGLPVAVEIMDYSEHAIGAGTNAKAAAYIELRVNGGRALHGIGIDENLTTASFRALFSALNRALSQAESRAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Length
556 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.544 kDa
Sequence
MTMLNDPSKKYRAFPTIDLPDRTWPSKTIDAAPIWCSSDLRDGNQSLIEPMDSVKKLRFWKTLVSVGVKEIEASFPAASQTDFDFVRTLIEDGHIPDDTTIQVLTQAREDLIARTFESLRGAKKAIVHLYNATCPSFRRIVFNQDKAGVKEIAVNAAKLFVKYAAQQPETQWTFEYSPETFSATELEFAKEVCDAVIEVWNPTPENKVILNLPATVEVATPNIYADQIEWFGRHITRRDSVLISLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTVALNLYTQGINPELDFSDIDGVRKVVEECNQIPVHPRHPYVGDLVHTAFSGSHQDAIRKGFTQQKEGELWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGIAYLLEQEYGISLPRRMQIEFSQVVQGETDRLGLEMTAEQIHALLRREYLQANTPYALISHRLQEENGNSAVDAEVHVDGETQHWRGKGKGALEALVAGLPVAVEIMDYNEHAIGSGTTAKAAAYIELRVNGDRAVHGVGIDENITTASFRALFSALNRSLSQAQAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas syringae pv. syringae (strain B728a)
Length
556 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.508 kDa
Sequence
MTMLKDPSKKYRAFPTIDLPDRTWPSKTIDAVPIWCSSDLRDGNQSLIEPMDAAKKLRFWKTLVSVGVKEIEASFPSASQTDFDFVRTLIEDGHIPDDTTIQVLTQAREDLIARTFESLRGAKKAIVHLYNATCPSFRRIVFNQDKAGVKEIAVNAAKLFVKYAAQQPETQWTFQYSPETFSATELEFAKEVCDAVIEVWNPTPENKVILNLPATVEVATPNIYADQIEWFGRNITRRDSVLISLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTVALNLYTQGINPGLDFSDIDGVRKVVEECNQIPVHPRHPYVGDLVHTAFSGSHQDAIRKGFTQQKEGELWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGIAYLLEQEYGISLPRRMQIEFSQVVQGETDRLGLEMTAEQIHSLLRREYLQANVPYALISHKLQEENGNSSVDAEVHVDGETQHWRGKGKGALEALVAGLPVAVEIMDYNEHAIGSGTTAKAAAYIELRVNGERAVHGVGIDENITTASFRALFSALNRSLSQTQAKAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudomonas stutzeri (strain A1501)
Length
556 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.568 kDa
Sequence
MTMLKNPSNKYRAFPAIDIPDRTWPSKAITQAPIWLSSDLRDGNQSLIEPMDAAKKMRFFKTLVQVGLKEIEVGFPSASQTDFDFVRELIEGGHIPDDVTIQVLTQAREDLITRTFESLKGAKQAIVHYYNATAPSFRRIVFNQDKAGVIQIAVNAGRIIKRLAEQNPETNWRFEYSPEIFSSTEPEFAVEVCNAVIEVFQPTPEQKLILNLPATVEAATPNVYADQIEWFCRHIDRRDSVLVSLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTVALNMYTQGVDPQLDFSDIDAVRKVVEECNQLPVHPRHPYVGDLVHTAFSGSHQDAIRKGFSQQDPNGLWEVPYLPIDPADIGRSYEAVIRVNSQSGKGGITFLLEQEYGISLPRRMQIEFSQVVQKETDRLGLEMSAKQIYALLEAEYLQATAPYTLKGHRLQEENGTSAVDVEVAADGEVIHWRGIGKGPLEALVAALPVKLEIMDYHEHAIGAGSNAKAAAYIEVRLDGERPLHGIGIDENITTASIRALFSAMNRALHQAQEAAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Length
555 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.614 kDa
Sequence
MPIAGTKYAPFPAPQLDDRTWPSKRIEKAPIWCSVDLRDGNQALIDPMGHDRKERMFRLLIDMGFPEIEIGFPSASQTDFDFCRWAIEQGDVPDDVDLQVLVQCRPELITRTFEALEGAKTPIIHFYNSTSELQRRVVFAKDVGGIKQIATDAAKMIMDMAAKAGGGYRFQYSPESFTGTELDVALEICNAVIEIVKPTPDNKLIVNLPSTVEMNTPNVYADQIEWMCRNLDNRESLIISLHPHNDRGTGIAATELGLMAGADRGEGTLFGNGERTGNVDVVTLALNMYTQGIDPGLDCTDINRMKEVYEYSNQLKIAERHPYVGELVYTAFSGSHQDAINKGMKARRSANSPVWEVPYLPIDPQDVGRSYEAIIRINSQSGKGGIAYILQADYGLNLPRNLQVEFREIIQHITDEEGKELPSKRIYEEFQKLYVTQPDARIKFVDHHTYPHPEQKGRRILTAEITDNGVTKTIEGKGTGPIDGFVDALSKYLGVKMSVVDYSEHSLQQGSDASAISYVEMVYPGGKLFGVGINDNIVSASLEAVVSAANRVIAK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Brucella suis biovar 1 (strain 1330)
Length
555 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Mass
61.634 kDa
Sequence
MPIAGTKYAPFPAPQLDDRTWPSKRIEKAPIWCSVDLRDGNQALIDPMGHDRKERMFRLLIDMGFPEIEIGFPSASQTDFDFCRWAIEQGDVPDDVDLQVLVQCRPELITRTFEALEGAKTPIIHFYNSTSELQRRVVFAKDVGGIKQIATDAAKMIMDMAAKAGGGYRFQYSPESFTGTELDVALEICNAVIEIVKPTPDNKLIVNLPSTVEMNTPNVYADQIEWMCRNLDNRESLIISLHPHNDRGTGIAATELGLMAGADRVEGTLFGNGERTGNVDVVTLALNMYTQGIDPGLDCTDINRMKEVYEYSNQLKIAERHPYVGELVYTAFSGSHQDAINKGMKARRSANSPVWEVPYLPIDPQDVGRSYEAIIRINSQSGKGGIAYILQADYGLNLPRNLQVEFREIIQHITDEEGKELPSKRIYEEFQKLYVTQPDARIKFVDHHTYPDPEQKGRRILTAEITDNGVTKTIEGKGTGPIDGFVDALSKYLGVKMSVVDYSEHSLQQGSDASAISYVEMVYPGGKLFGVGINDNIVSASLEAVVSAANRVIAK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9301)
Length
546 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
59.176 kDa
Sequence
MSKNPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKIASAVGKEHGPTICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHKLKKSRKDVLQIVPEMVNYAKSLVDDIEFSCEDASRSDPDFLYEVIQLAISAGATTINIPDTVGFTTPSEFGNLIADINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRKSFFNSFFKRNPDSPTPLTAIRTEEITKTSRLVSNLTGMTVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSEQVQLPEAKFQLSLVQVSCGNASKPTATISLLNTEDNTEDTAVSIGTGPVDAVCEALNKLAKVPNELIEFSVKSVTEGIDALGEVTIRIRRDNKIYSGHSADTDVVVAAANAYINALNRLVFSEKKNSIHPQFDNLENSNNTYISNPAN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9215)
Length
546 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
59.189 kDa
Sequence
MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKIANSVGKENGPIICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHKLKKSRKDVLQIVPEMVNYAKSLVDDIEFSCEDASRSDPDFLYEVIQLAISAGATTINIPDTVGFTTPNEFGKLISDINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRKSFFNKFFNRNSDSPTPLTAIRTEEITKTSRLVSNLTGMIVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSEQVQLPEAKFQLSLVQVSCGNASKPTATISLINTEDNSEDTAVSIGTGPVDAVCEALNKLAKVPNELIEFSVKSVTEGIDALGEVTIRIRRDNKIYSGHSADTDVVVAAANAYVNALNRLVFSEKKSSIHPQFDNLENADKTLLSNPGK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9515)
Length
546 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
59.386 kDa
Sequence
MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKISEVVGGENGPIICGLARASTSDIKACYEAIIPAPKKRIHTFIATSDIHLKHKLRKSRKDVLSIVPEMVSYAKSLVDDIEFSCEDASRSDPEFLYEVIQLAITSGATTINIPDTVGFTTPSEFGKLIFDINKNVPNIDEAVISVHGHNDLGLAVANFLEAAKNGARQLECTINGIGERAGNASLEELVMALHVRKSFFNSFFGRSSDSPTPLTAIRTEEITKTSRLVSNLTGMNVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLNDNKISLGKLSGRSAVRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSEQVQLPESRFQLSHVQVSCGSTSKPTATVTILNTETHTEDTSVAIGTGPVDAVCEAINELAKVPNELIEFSVKSVTEGIDALGEVTIRIRNKNKIYSGHSADTDVVVAAANAFLNALNRLIFSEKKECIHPQFDNLENSEKKVFSNPKN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9312)
Length
546 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
59.253 kDa
Sequence
MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKISNDVGKENGPIICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHKLKKSRKDVLQIVPEMVNYAKTLVEDIEFSCEDASRSDPDFLYEVIQLAISAGATTINIPDTVGFTTPSEFGKLISDINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRKSFFNSFFKRNPDSPTPLTAIRTEEITKTSRLVSNLTGMTVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSEQVQLPEAKFQLCLVQVSCGNASKPTATITLLNTADNTEDTAVSVGTGPVDAVCEALNKLAKVPNELIEFSVKSVTEGIDALGEVTIRIRRDNKIYSGHSADTDVVVAAANAYVNALNRLVFSEKKNSIHPQFDNLENSNKTFLSNPAN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9301)
Length
546 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
59.176 kDa
Sequence
MSKNPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKIASAVGKEHGPTICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHKLKKSRKDVLQIVPEMVNYAKSLVDDIEFSCEDASRSDPDFLYEVIQLAISAGATTINIPDTVGFTTPSEFGNLIADINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRKSFFNSFFKRNPDSPTPLTAIRTEEITKTSRLVSNLTGMTVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSEQVQLPEAKFQLSLVQVSCGNASKPTATISLLNTEDNTEDTAVSIGTGPVDAVCEALNKLAKVPNELIEFSVKSVTEGIDALGEVTIRIRRDNKIYSGHSADTDVVVAAANAYINALNRLVFSEKKNSIHPQFDNLENSNNTYISNPAN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9215)
Length
546 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
59.189 kDa
Sequence
MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKIANSVGKENGPIICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHKLKKSRKDVLQIVPEMVNYAKSLVDDIEFSCEDASRSDPDFLYEVIQLAISAGATTINIPDTVGFTTPNEFGKLISDINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRKSFFNKFFNRNSDSPTPLTAIRTEEITKTSRLVSNLTGMIVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSEQVQLPEAKFQLSLVQVSCGNASKPTATISLINTEDNSEDTAVSIGTGPVDAVCEALNKLAKVPNELIEFSVKSVTEGIDALGEVTIRIRRDNKIYSGHSADTDVVVAAANAYVNALNRLVFSEKKSSIHPQFDNLENADKTLLSNPGK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9515)
Length
546 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
59.386 kDa
Sequence
MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKISEVVGGENGPIICGLARASTSDIKACYEAIIPAPKKRIHTFIATSDIHLKHKLRKSRKDVLSIVPEMVSYAKSLVDDIEFSCEDASRSDPEFLYEVIQLAITSGATTINIPDTVGFTTPSEFGKLIFDINKNVPNIDEAVISVHGHNDLGLAVANFLEAAKNGARQLECTINGIGERAGNASLEELVMALHVRKSFFNSFFGRSSDSPTPLTAIRTEEITKTSRLVSNLTGMNVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLNDNKISLGKLSGRSAVRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSEQVQLPESRFQLSHVQVSCGSTSKPTATVTILNTETHTEDTSVAIGTGPVDAVCEAINELAKVPNELIEFSVKSVTEGIDALGEVTIRIRNKNKIYSGHSADTDVVVAAANAFLNALNRLIFSEKKECIHPQFDNLENSEKKVFSNPKN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9312)
Length
546 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
59.253 kDa
Sequence
MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKISNDVGKENGPIICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHKLKKSRKDVLQIVPEMVNYAKTLVEDIEFSCEDASRSDPDFLYEVIQLAISAGATTINIPDTVGFTTPSEFGKLISDINKNVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRKSFFNSFFKRNPDSPTPLTAIRTEEITKTSRLVSNLTGMTVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSEQVQLPEAKFQLCLVQVSCGNASKPTATITLLNTADNTEDTAVSVGTGPVDAVCEALNKLAKVPNELIEFSVKSVTEGIDALGEVTIRIRRDNKIYSGHSADTDVVVAAANAYVNALNRLVFSEKKNSIHPQFDNLENSNKTFLSNPAN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4)
Length
546 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
59.247 kDa
Sequence
MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKIAEVVGGENGPIICGLARASTNDIKACYEAISPAPKKRIHTFIATSDIHLKHKLRKTRSDVLCIVPEMVSYAKSLVDDIEFSCEDASRSDPEFLYEVIQLAITSGATTINIPDTVGFTTPSEFGKLIFDINKNVPNIDEAIISVHGHNDLGLAVANFLEAAKNGARQLECTINGIGERAGNASLEELVMALHVRKSFFNSFFGRSSDSPTPLTAIRTEEITKTSRLVSNLTGMNVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLNDNKISLGKLSGRSAVRARLEEMGYDLSREDLNDAFARFKELADRKREITDRDLEAIVSEQVQLPESKFQLSHVQVSCGSTSKPTATVTLINTEDHTEDTAVAIGTGPVDAVCEALNALTKVPNELIEFSVKSVTEGIDALGEVTIRIRNKNKIYSGHSADTDVVVAAANAFVNALNRLVFSEKKNSIHPQFDDLENPKNKVLSNPKK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain AS9601)
Length
546 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
59.139 kDa
Sequence
MSKDPGRILIFDTTLRDGEQSPGASLNLEEKLAIAHQLARLGVDVIEAGFPFASPGDFKAVNKIANAVGKENGPIICGLARASKGDIKACYEAVSPAPKKRIHTFIATSDIHLKHKLKKSRKDVLQIVPEMVNYAKSLVDDIEFSCEDASRSDPDFLYEVIQLAISAGATTINIPDTVGFTTPSEFGNLIADINKNVPNINEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRKSFFNSFFKRNPDSPTPLTAIRTEEITKTSRLVSNLTGMTVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEEMGYDLSREDLNDAFARFKDLADRKREITDRDLEAIVSEQVQLPEAKFQLSLVQVSCGNASKPTATISLLNTEDNTEDTAVSIGTGPVDAVCEALNKLAKVPNELIEFSVKSVTEGIDALGEVTIRIRRDNKIYSGHSADTDVVVAAANAYVNALNRLVFSEKKNSIHPQFDSLENSTNTFLSNNAN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salinibacter ruber (strain M8)
Length
546 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.464 kDa
Sequence
MSDSITIFDTTLRDGEQAPGASMTVPEKVHIAHKLADLNVDVIEAGFPISSPAQTEAVTRIATEVDGPVTCALARTKEDDIDAAGEALADGTDTRLHTFIATSDVHIEAKFDKLGNTMAEKREAIIQRAVRAIEQALTYTDNVEFSAEDAGRTDPEFLCEVVQAAAEAGATTINIPDTTGYCAPSEYTDLLETVVDCLPDPDAVTLSTHCHDDLGLATANTLAGIRAGARQVECTINGIGERAGNAALEEIVMALTVRADAFDVTADVHTEHLTPTSQTVSAATGFPVQPNKAIVGSNAFSHEAGIHQHGVLEERTTYEIMSATDVGQDAEQIRLGRHSGRHGLFNRLEAMGYAVPEGHRDALYDRFLDLADRKKEVFEEDLEQMMNDFGGDAVAAATGLPDNGVALNGGTPAYRLDQFSVHLSSDDEAKVSVRLQRDDGSAREEQATGEGPVDALYRALDHAVDAPHTLVDYSIRSISEGADAQGEVEVTIRYGENQFAGTARNTDVIRASAEAYVDALNRLVAAQEHAESVEFVQNGIMHTYGE

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Trichodesmium erythraeum (strain IMS101)
Length
541 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.747 kDa
Sequence
MITSQDRVIIFDTTLRDGEQSPGATLNIDEKLTIARQLSLLGVDVIEAGFPYASIGDFEAVQKIAEIVGVEGGPTICGLARTTRADIEAAGKALKPAAKARIHTFIATSDIHLAYKLKKTRAEVLEIASEMVAYAKTFVDDVEFSPEDAGRSDPEFLYQVLEKAIAAGATTVNIPDTVGYTTPAEFGGLIRGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMAFHVRRQYFNPFFGRPPESETPLTNINTRHIYKTSRLVSSLTGMFVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAQSIGLTDNQIVLGKLSGRHAFQSRLQELGFKLSDEEINKAFIKFKDLADKKKEITDWDLESIVNAEIQQPPELFRLELVQVSCGDRSRPTATVIIRTPNGEELTDAAIGTGPVDAVYKAINRVVNVENDLVEFSVQSVTAGIDAIGEVTIRVRHEGRVYSGHAANTDIIVASAEAYLSALNRLYAVLQRGVEKINLPKDQPTEVVAGS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9303)
Length
540 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.068 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASQGDFSAVQRIAQQVGGDEGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEHKLRKSRAEVLAIVPEMVAYARSLVDDVEFSCEDAARSDPEFLYEVIEAAIAAGAGTINIPDTVGFTTPSEFGALIAGIDCHVPNMNEAILSVHGHNDLGLAVANFLEAVKSGARQFECTINGIGERAGNAALEELVMALYVRRRYFNPFFGRESDSPTPLTAVRTEEITKTSRLVSNLTGMVVQPNKAIVGSNAFAHESGIHQDGVLKNRLTYEIVDARTVGLTDNRISLGKLSGRSAVRARLEELGYDLTREDLDEAFARFKDLADRKRDITDRDLEAIVSEQVQQPEARFQLRLVQVSCGSSLRPTATVILAQEDGQEQTAAAVGTGPVDAVCRALNALAGEPNELIEFSVKSVTEGIDAMGEVTIRLRRDGQLFSGHSADTDVVVAAAQAFVNALNRLVAGCGRQSLHPQHDAVLADRRPGI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9313)
Length
540 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.97 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASQGDFAAVQRIAQQVGGDEGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEHKLRKSRAEVLAIVPEMVAYARSLVDDVEFSCEDAARSDPEFLYEVIEAAIAAGAGTINIPDTVGFTTPSEFGALIAGIDCHVPNMNEAVISVHGHNDLGLAVANFLEAVKSGARQFECTINGIGERAGNAALEELVMALYVRRRYFNPFFGREPDSPTPLTAVRTEEITKTSRLVSNLTGMVVQPNKAIVGSNAFAHESGIHQDGVLKNRLTYEIVDARTVGLSDNRISLGKLSGRSAVRARLEELGYDLTREDLDEAFARFKDLADRKRDITDRDLEAIVSEQVQQSEARFQLRLVQVSCGSSLRPTATVILAQEDGQEQTAAAVGTGPVDAVCRALNALAGEPNELIEFSVKSVTEGIDAMGEVTIRLRRDGQLFSGHSADTDVVVAAAQAFVNALNRLVAGCGRQSLHPQHDAVLADLRSGI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9303)
Length
540 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.068 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASQGDFSAVQRIAQQVGGDEGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEHKLRKSRAEVLAIVPEMVAYARSLVDDVEFSCEDAARSDPEFLYEVIEAAIAAGAGTINIPDTVGFTTPSEFGALIAGIDCHVPNMNEAILSVHGHNDLGLAVANFLEAVKSGARQFECTINGIGERAGNAALEELVMALYVRRRYFNPFFGRESDSPTPLTAVRTEEITKTSRLVSNLTGMVVQPNKAIVGSNAFAHESGIHQDGVLKNRLTYEIVDARTVGLTDNRISLGKLSGRSAVRARLEELGYDLTREDLDEAFARFKDLADRKRDITDRDLEAIVSEQVQQPEARFQLRLVQVSCGSSLRPTATVILAQEDGQEQTAAAVGTGPVDAVCRALNALAGEPNELIEFSVKSVTEGIDAMGEVTIRLRRDGQLFSGHSADTDVVVAAAQAFVNALNRLVAGCGRQSLHPQHDAVLADRRPGI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9313)
Length
540 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.97 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASQGDFAAVQRIAQQVGGDEGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEHKLRKSRAEVLAIVPEMVAYARSLVDDVEFSCEDAARSDPEFLYEVIEAAIAAGAGTINIPDTVGFTTPSEFGALIAGIDCHVPNMNEAVISVHGHNDLGLAVANFLEAVKSGARQFECTINGIGERAGNAALEELVMALYVRRRYFNPFFGREPDSPTPLTAVRTEEITKTSRLVSNLTGMVVQPNKAIVGSNAFAHESGIHQDGVLKNRLTYEIVDARTVGLSDNRISLGKLSGRSAVRARLEELGYDLTREDLDEAFARFKDLADRKRDITDRDLEAIVSEQVQQSEARFQLRLVQVSCGSSLRPTATVILAQEDGQEQTAAAVGTGPVDAVCRALNALAGEPNELIEFSVKSVTEGIDAMGEVTIRLRRDGQLFSGHSADTDVVVAAAQAFVNALNRLVAGCGRQSLHPQHDAVLADLRSGI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Synechococcus sp. (strain WH7803)
Length
540 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.925 kDa
Sequence
MAHDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASPGDFNAVQRIAQQVGGEQGPIICGLARASRGDIKACADAVAPAPRRRIHTFIATSDIHLEHKLRKSRQEVLAIVPEMVAYARSLVDDVEFSCEDAGRSDPEFLYAVIEAAINAGASTINIPDTVGYTTPAEFGALIAGIDQHVPNISEAVLSVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMALHVRRRYFNPFFGRAEDSPTPLTGVRTEEITKTSRLVSNLTGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIVDARTVGLTDNRISLGKLSGRSAVRARLEELGYDLSREDLDDAFARFKELADRKRDITDRDLEAIVSEQVQQPDARYQLKLVQVSCGSSLQPTATVTLLDEEGQEQSEAAIGTGPVDAVCRALNALAGEPNELVEFSVKSVTEGIDAMGEVTIRLRRDGQLFSGHAADTDVVVAAAQAFVNALNRLVAGSLNPTLHPQRDATPLDASPTL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Synechococcus sp. (strain WH8102)
Length
540 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.287 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASAGDFAAVQRIAQQVGGENGPIICGLARASQRDIKACAEAVSPAPRRRIHTFIATSDIHLEHKLRKSRADVLGIVPEMVSYARSLMDDIEFSCEDAGRSDPEFLYEVIEAAIAAGATTINIPDTVGYTTPSEFGDLIAGINRYVPNIGEAVLSVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRRRYFNPFFGRDQDSPTPLSAVRTEELTKTSRLVSNLTGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNRISLGKLSGRSAVRARLEELGYDLTREDLDEAFARFKDLADRKREITDRDLEAIVSEQVQQPEARYQLQLVQVSCGTRLKPTATVALSEENGPDQTVSAVGTGPVDAVCRALNQLAGVPNELIEFSVKSVTEGIDAMGEVTIRLRRDGSLYSGHAADTDVVVAAAMAFINALNRLVAAQEHQPLHPQRDAVVLDARPTL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Synechococcus sp. (strain CC9311)
Length
540 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.01 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASPGDFAAVQRIAQQVGGENGPIICGLARASRGDIKACADAVAPAPKQRIHTFIATSDIHLEHKLRKSRKDVLGIVPEMVAYARSFVDDVEFSCEDAGRSDPEFLYEVIEAAISAGASTVNIPDTVGYTTPTEFGRLIEGINRNVPNIDEAVISVHGHNDLGLAVANFLEAVKSGARQLECTVNGIGERAGNAALEELVMAMHVRRRYFNPFFGRDEDSPTPLTAVRTEEITKTSRLVSNLTGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIVDARTVGLTDNRISLGKLSGRSAVRARLEELGYDLSREDLDDAFARFKDLADRKREITDRDLESIVSVQVQQPDAKYQLKLVQVSCGSSLQPTATVTLADENGQEQTAASVGTGPVDAVCRSLNQLAGEPNELVEFSVKSVTEGIDAMGDVTIRLRRDGQLYSGHSAHTDVVVAAAEAFVNALNRLVAGTAGPTIHPQLDMAQLDSSPVH

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Synechococcus sp. (strain CC9902)
Length
540 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.075 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASAGDFAAVQRIAQQVGGDNGPIICGLARASKADIKACADAVAPAPRGRIHTFIATSDIHLEHKLRKSRKDVLAIVPEMVSYARSLIEDVEFSCEDAGRSDPEFLYEVIEAAIAAGATTINIPDTVGYTTPSEFGGLIAGINQHVPNIDEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMAMHVRRRYFNPFLGRKEDSPTPLTAVRTEELTKTSRLVSNLTGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDARTVGLSDNRISLGKLSGRSAVRARLEELGYNLTREDLDEAFARFKDLADRKREITDRDLEAIVSEQVQQPEARFQLKFVQVSCGSTSRPTATVALMDEEGGERTVSAVGTGPVDAVCRALNCLADVPNDLIEFSVKSVTEGIDAIGEVTIRLRRDGSLYSGHAADTDVVVAAAMAFVNALNRLVAGQERQSLHPQKDPVVLDARPTL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Synechococcus sp. (strain CC9605)
Length
540 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.999 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASPGDFAAVQRIAQQVGGDNGPIICGLARASRADIKACADAVAPAPRRRIHTFIATSDIHLEHKLRKSRGDVLGIVPEMVSYARSLVEDVEFSCEDAGRSDPEFLYEVIEAAIAAGATTINIPDTVGYTTPSEFGALIAGINQHVPNIGEAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRRRYYNPFFGREEDSPTPLTAVRTEEITKTSRLVSNLTGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAQTVGLSDNRISLGKLSGRSAVRARLEELGYDLTREDLDEAFARFKELADRKREITDRDLEAIVSEQVQQPEARFQLKLVQVSCGSSLRPTATVTLLDEEGSETTGSAVGTGPVDAVCRALNDLAGVPNELIEFSVKSVTEGIDAMGDVTIRLRRNGALYSGHAADTDVVVAAGMAFVNALNRLVAGEERQSLHPQKDPVVLESRPTL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain NATL1A)
Length
539 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.092 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASPGDFAAVQKIAENVGGEEGPIICGLSRASKPDIKACANAIAPAPKKRIHTFIATSDIHLEHKLRKSRKEVLDIVPDMVGYAKSFVDDVEFSCEDAARSDLDFLYEVIELAISSGANTINIPDTVGYITPSEFGDLILNINENVPNINEAVLSVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELIMALHVRRSYFNPFFGRPPESPTPLTAVRTEEITKSSRLVSNLTGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEDLGYDLNREDLNDAFARFKDLADRKREITDRDLEAIVSEQVQLPEALFQLKLVQVSCGTSLMPTATVTVVGEDGEEKTAVSLGTGPVDAVVRALDSLTEEPNELIEFSVKSVTEGIDALGEVTIRIRRDGNLFSGHSADTDVVVAAAQAYINALNRLVAAHGRKSIHPQHDLAKVDKKGI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain NATL1A)
Length
539 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.092 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASPGDFAAVQKIAENVGGEEGPIICGLSRASKPDIKACANAIAPAPKKRIHTFIATSDIHLEHKLRKSRKEVLDIVPDMVGYAKSFVDDVEFSCEDAARSDLDFLYEVIELAISSGANTINIPDTVGYITPSEFGDLILNINENVPNINEAVLSVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELIMALHVRRSYFNPFFGRPPESPTPLTAVRTEEITKSSRLVSNLTGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEDLGYDLNREDLNDAFARFKDLADRKREITDRDLEAIVSEQVQLPEALFQLKLVQVSCGTSLMPTATVTVVGEDGEEKTAVSLGTGPVDAVVRALDSLTEEPNELIEFSVKSVTEGIDALGEVTIRIRRDGNLFSGHSADTDVVVAAAQAYINALNRLVAAHGRKSIHPQHDLAKVDKKGI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain NATL2A)
Length
539 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.105 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDVIEAGFPFASPGDFAAVQKIAENVGGEEGPIICGLSRASKPDIKACANAIAPAPKKRIHTFIATSDIHLEHKLRKSRKEVLDIVPDMVGYAKSFVDDVEFSCEDAARSDLDFLYEVIELAISSGANTINIPDTVGYITPSEFGDLILNINKNVPNINEAVLSVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELIMALHVRRSYFNPFFGRPPESPTPLTAVRTEEITKSSRLVSNLTGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDAKTVGLSDNKISLGKLSGRSAVRARLEDLGYDLNREDLNDAFARFKDLADRKREITDRDLEAIVSEQVQLPEALFQLKLVQVSCGTSLMPTATVTVVGEDGEEKTAVSLGTGPVDAVVRALDSLTEEPNELIEFSVKSVTEGIDALGEVTIRIRRDGNLFSGHSADTDVVVAAAQAYINALNRLVAAHGRKSIHPQHDLAKVEKKGI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
Length
538 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.035 kDa
Sequence
MFQDRLIIFDTTLRDGEQSPGATLNADEKVEIARQLARLGVDVIEAGFAYASPGDFEAVERVARTVGTEDGPVICSLARAIRSDIQAAAEAIRPAARGRIHTFISTSDIHLEHQLRKSRAEVLAIAAEMVAFAKGFVDDVEFSPMDAGRSAPEYLYRVLEAAIAAGATTVNIPDTVGYLTPAEFGGLIRGITQNVRGIERAVISVHCHNDLGLAVANSLAAIENGARQIECTVNGIGERAGNCSLEEIVMALHVRRQFFNPIFGRPADSTVPLSTIDTRQIYKSSRLVSHLTGMLVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIMDAETVGVNENRIVLGKHSGRNAFRTRLVELGYELGDADLNRAFLRFKELADKKKTVSDWDIEAVISDEIRLIPEAYRLEQVQVSCGEPGLPTATVRLTGPDGVERVDAAVGTGPVDAVYKAINRLIELPNELIEFSVQSVTAGIDAMGEVTIRVRQDGRTFSGHAANTDIIVASARAYLNALNKLHFALAHPTHSGGALAHPDAAAQKL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Synechococcus sp. (strain RCC307)
Length
537 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.643 kDa
Sequence
MARDPGRVLIFDTTLRDGEQSPGASLNLDEKLAIAQQLARLRVDIIEAGFPFASPGDFDAVQTIARQVGRPDGPVICGLARATRGDIKACADAVAPAANQRIHTFLATSDIHLEHKLRKSRAEVLQIVPEMVAYARSLVDDVEFSCEDAGRSDPEFMYQVIEAAIEAGATTINIPDTVGYSTPAEFGALIAGIDAHVPNIGQAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRRSYFNGYLGRAEDSSEPLTGIQTEEIYKTSRLVSNLTGMAVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIIDARTIGLTDNRISLGKLSGRSAVRARLEELGYQLDGDDLNDAFARFKELADRKREITDRDLEAIVRQNAQQIEAYYQLAGVQVSCGRDLRATATVTLRTSDGEECSQAAIGTGPVDAVCQALNGLVQVPNELVEFSVKSVTEGIDAMGEVTIRLRQDGRLYSGHAADTDVVVAAAQAFVNALNRLVSGQKHSPLHPQRAPLPAPAL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Cyanothece sp. (strain ATCC 51142)
Length
537 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.474 kDa
Sequence
MSNQPDHIIIFDTTLRDGEQSPGASLTVEEKLTIARALARLGVDIIEAGFPYASPGDFEAVQKIAKTVGNESGPRICGLARATKNDIKAAGEALKPAFKSRIHTFIATSDIHLKHKLKKTRQEVLAIVPEMVAYAKTFTDDVEFSPEDAGRSDPEFMYQVLETAIAAGATTVNIPDTVGYTTPSEFGALIKGIKDNVPNIDQAIISVHGHDDLGLAVANFLEALKNGARQLECTINGIGERAGNAALEELVMALHVRRQYFNPFLGRPVDSMEPLTNINTKEIYKTSRLVSNLTGMIVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAESIGLTNNQIVLGKLSGRNAFRTRLDELGFELSERDLNNAFLRFKEVADKKKEITDWDLEAIVNDEIQQAPELFRLELVQVSCGDHSAPTATVTLRTPEGKELTDAAIGTGPVDAVYKAINRVVNVPNELIEFSVKSVTAGIDAMGEVTIRLRHEGRIYSGYAANTDIITASARAYISALNRLYGAIQEQTKVHPSEPVLTSKN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9211)
Length
536 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.1 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDIIEAGFPYASQGDFTAVQRIAEQVGGEEGPIICGLARASKADIKACGEAIAPAPKKRIHTFIATSDIHLEHKLRKTREEVIQIVPEMVHYAKSFSEDVEFSCEDAARSDPDFLYELIELAISAGAGTINIPDTVGYITPSEFGELIQGIDANVPNIDEAILSVHGHNDLGLAVANFLEAIKRGARQLECTINGIGERAGNAALEELVMALHVRRSFYNPFFGRDPESPTPLTAIRTEEITKTSRLVSNLTGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIVDAKTVGLTDNRISLGKLSGRSAVRARLEELGYDLTRDDLNEAFAKFKDLADRKREITDRDLEAIVSEQVMQPDARFQLQLVQVSCGTTLKPTATVTLADQDGTEQTAVALGTGPVDAVCKALDSLAGESNELIEFSVKSVTEGIDALGEVTIRLRREGKIFSGHSADTDVVVAAAQAYVNALNRLIYFEKKNPIHPQHDLIKANL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Length
536 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.836 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDIIEAGFPYASQGDFKAVQRIADQVGGEEGPIICGLARASKADIKACAEAIAPAPRKRIHTFIATSDIHLKHKLRKSRADVLKIVPEMVGYARSLASDVEFSCEDAARSDPDFMYEVIESAIAAGAGTINIPDTVGYITPAEFGDLIIGINKNVSNIDESILSVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMALHVRRRYFNPFFGKDSESPTPLTAIRTEEITKTSRLVSNLTGMVVQPNKAIVGANAFAHESGIHQDGVLKNPLTYEIVDAKTVGLAENRISLGKLSGRSAVRARLEELGYDLTREDLNDAFARFKDLADRKREISDRDLEAIVSEQVMQPEARFKLHLVQVSCGTALRPTATVTIADQDGIENTAVALGTGPVDAVCKALRSLTNEKNDLIEFSVKSVTEGIDALGEVTIRLRRDGKIFSGHSADTDVVVAAAQAYINALNRLVYSLKKSSLHPQHDVVKANL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain MIT 9211)
Length
536 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.1 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDIIEAGFPYASQGDFTAVQRIAEQVGGEEGPIICGLARASKADIKACGEAIAPAPKKRIHTFIATSDIHLEHKLRKTREEVIQIVPEMVHYAKSFSEDVEFSCEDAARSDPDFLYELIELAISAGAGTINIPDTVGYITPSEFGELIQGIDANVPNIDEAILSVHGHNDLGLAVANFLEAIKRGARQLECTINGIGERAGNAALEELVMALHVRRSFYNPFFGRDPESPTPLTAIRTEEITKTSRLVSNLTGMVVQPNKAIVGANAFAHESGIHQDGVLKNRLTYEIVDAKTVGLTDNRISLGKLSGRSAVRARLEELGYDLTRDDLNEAFAKFKDLADRKREITDRDLEAIVSEQVMQPDARFQLQLVQVSCGTTLKPTATVTLADQDGTEQTAVALGTGPVDAVCKALDSLAGESNELIEFSVKSVTEGIDALGEVTIRLRREGKIFSGHSADTDVVVAAAQAYVNALNRLIYFEKKNPIHPQHDLIKANL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)
Length
536 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.836 kDa
Sequence
MAKDPGRVLIFDTTLRDGEQSPGASLNLEEKLAIAQQLARLGVDIIEAGFPYASQGDFKAVQRIADQVGGEEGPIICGLARASKADIKACAEAIAPAPRKRIHTFIATSDIHLKHKLRKSRADVLKIVPEMVGYARSLASDVEFSCEDAARSDPDFMYEVIESAIAAGAGTINIPDTVGYITPAEFGDLIIGINKNVSNIDESILSVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMALHVRRRYFNPFFGKDSESPTPLTAIRTEEITKTSRLVSNLTGMVVQPNKAIVGANAFAHESGIHQDGVLKNPLTYEIVDAKTVGLAENRISLGKLSGRSAVRARLEELGYDLTREDLNDAFARFKDLADRKREISDRDLEAIVSEQVMQPEARFKLHLVQVSCGTALRPTATVTIADQDGIENTAVALGTGPVDAVCKALRSLTNEKNDLIEFSVKSVTEGIDALGEVTIRLRRDGKIFSGHSADTDVVVAAAQAYINALNRLVYSLKKSSLHPQHDVVKANL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Cyanothece sp. (strain PCC 7424)
Length
536 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.09 kDa
Sequence
MSNQPNRIIIFDTTLRDGEQSPGATLNGDEKLTVARALARLGVDVIEAGFPYASPGDFEAVQQIAKVVGVEGGPSICGLARATKADIAKAAEALKPAAKPRIHTFLATSDIHLAYKLKKTRQEVLEIVPEMVAYAKSFVDDVEFSPEDAGRSDPEFLYQVLERAIAAGATTVNIPDTVGYLTPSEFGQLIRGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMALHVRRQYYNPFLGRPVDSTEPLTNINTKEIYKTSRLVSNLTGMAVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAESIGLTNNQIVLGKLSGRHAFSTRLKELGFELSETDLNKAFLRFKEVADKKKEITDWDLEAIVNDEIQQAPEVFRLELVQVSCGDQARPTATVILRGPEGQELMDAAIGTGPVDAVYKAINRVVNVPNQLIEFSVKSVTAGIDAMGEVTIRLKYENRIFSGHAANTDIIVASARAYISALNRLYAAIEQEKAEKEKAAVTSAS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Cyanothece sp. (strain PCC 8801)
Length
536 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.285 kDa
Sequence
MSNQPDRIIIFDTTLRDGEQSPGASLTVEEKLTIARSLARLGVDIIEAGFPYASPGDFEAVQKIAQTVGTEDGPRICGLARATQKDIQTAAEAVKPAAKGRIHTFLATSDIHLQYKLKKTRQEVLAIVPDMVAYAKSLVDDVEFSPEDAGRSDPEFLYQVLERAIAAGATTINIPDTVGYTTPSEFGALIGGIKQNVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMALHVRRQYFNPFLGRPPESTEPLTNINTKEIYRTSRLVSQLTGMMVQPNKAIVGKNAFAHESGIHQDGVLKNKLTYEIMDAESIGLTHNQIVLGKLSGRNAFRTRLKELGFELSDTEINNAFLRFKEVADKKKEITDWDLAAIVNDEMQQAPELFRLELVQVSCGDHACPTATVTLRTPDGQELTDAAIGTGPVDAVYKAINRVVQVPNELIEFSVKSVTAGIDAMGEVTIRLRYEDKIYSGYAANTDIITASARAYISALNRLYGSIQDQSATEVTKSEVAAI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Thermosynechococcus elongatus (strain BP-1)
Length
535 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.765 kDa
Sequence
MRIKYPPQTVDRVLIFDTTLRDGEQSPGASLNVDEKLTIARQLARLGVDIIEAGFPFASPGDFEAVQRIAETVGTETGPVICGLARATRQDIEAAAKALKPAYYPRIHTFIATSDIHLEYKLRKTRAEVLEIAQEMVAYAKSFVDDVEFSPEDAGRSDPEFLYEVLERVIDAGATTVNIPDTVGYTTPAEFGALIKGIKENVPNIDRAVISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMALYVRRQYFNPFLGRPPESEAPLTNINTREIYKTSRLVSNLTGMLIQPNKAIVGANAFAHQSGIHQDGVLKHKQTYEIMDAQLIGLADNQIVLGKLSGRNAFATRLRELGFELSETELNKAFLRFKDLADKKKEITDWDLEAIAKDETQGIDLQGYQLEFVQVSCGDHARPTATVTVRTPSGEELTDAAIGTGPVDAVYRAINRVVQIPNRLIEYSVQSVTAGIDAIGEVTIRLQHQDRIYSGHAANTDIIVASAQAYMNALNRLYRGLEQRALHPQA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Microcystis aeruginosa
Length
533 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.989 kDa
Sequence
MNTSPDRVIIFDTTLRDGEQSPGAALNVDEKLTIARALARLGVDVIEAGFPHASPGDFEAVQKIAGSVGSEADSPIICGLARATQKDIKSAADALRPAAKPRIHTFLATSDIHLQYKLKKTRQEVLEIVPEMVAYAKSFLNDVEFSPEDAGRSDPEFLYQVLERAIAAGATTVNIPDTVGYTTPSEFGALIRGIKENVPNIDQAIISVHGHDDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRRSYFNPFLGRPAESTEPLTKINTKEIYRTSRLVSNLTGMIVQPNKAIVGANAFAHESGIHQDGVLKHKLTYEIMDAESIGLTNNQIVLGKLSGRNAFRSRLQELGFELSETELNNAFIQFKEMADRKKEITDRDLEAIVNDEIDTVPDHFRLELVQVSCGNNARPTATVTIRTPDGSELSDAAIGTGPVDALCKAIDRVVQIPNELISFSVREVTEGIDALGEVTIRLRYAGRTYSARAADTDIIVASARAYVSALNRLHVALQQKEKTPEMLQV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Microcystis aeruginosa (strain NIES-843)
Length
533 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.027 kDa
Sequence
MNTSPDRVIIFDTTLRDGEQSPGAALNVDEKLTIARALARLGVDVIEAGFPHASPGDFDAVQKIAASVGSEADSPIICGLARTTQKDIKSAADALRPAAKPRIHTFLATSDIHLQYKLKKTRQEVLEIVPEMVAYAKSFVDDVEFSPEDAGRSDPDFLYQVLERAIAAGATTVNIPDTVGYTTPSEFGALIRGIKENVPNIDQAIISVHGHDDLGLAVANFLEAVKNGARQLECTINGIGERAGNASLEELVMALHVRRSYFNPFLGRPAESTEPLTKINTKEIYRTSRLVSNLTGMIVQPNKAIVGANAFAHESGIHQDGVLKHKLTYEIMDAESIGLTHNQIVLGKLSGRNAFRSRLQELGFELSETELNNAFIQFKEMADRKKEITDRDLEAIVNDEIDTVPDHFRLELVQVSCGNSARPTATVTIRTPDGSELSDAAIGTGPVDALCKAIDRVVKIPNELISFSVREVTEGIDALGEVTIRLRYEGRTYSAHAADTDIIVASARAYVSALNRLHVALQQKEKTPEMLQV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
533 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.413 kDa
Sequence
MNSPVDRILIFDTTLRDGEQSPGATLTVEEKLSIARALARLGVDIIEAGFPFASPGDFEAVQKIAQTVGTENGPVICGLARATQKDIKAAAEALKPAAKHRIHTFLATSDIHLEHKLKKTRAEVLAIVPEMVAYAKSLVNDIEFSPEDAGRSDPEFLYQVLEAAISAGATTINIPDTVGYTTPAEYGALIKGIADNVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMALHVRRSYFNPFLGRPADSTAPLTNIDTKHIYATSRLVSELTGMMVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAESIGLTNNQIVLGKLSGRNAFGTRLKELGFDLSDTELNNAFIRFKEVADKRKEITDWDLEAIVNDEIRQPPELFRLERVQVSCGEPSVPTATLTIRTPAGPEETAVAIGTGPVDAVYKAINQIVQLPNELLEYSVTSVTEGIDALGKVSVRLRHNGVIYTGYAANTDIIVASARAYLGALNRLYAALEKSREHPPVVASL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6)
Length
533 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.65 kDa
Sequence
MNNQDDRIIIFDTTLRDGEQSPGATLNGDEKLAIARALARLGVDVIEAGFPRASRGDFDAVQRIAAEVGTENGPTICGLARATKGDIEAAGNALKPAFSNRIHTFIATSDIHLEYKLRKSRKDVLAIAPEMVAYAKTFTNDVEFSPEDAGRSDPEFLYQILEAVIDAGATTVNIPDTVGYTTPAEFGALIKGIKENVPNIDRAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMALHVRRQYYNPFLGRPADSEAPLTSINTKEIYKTSRLVSNLTGLSVQANKAIVGLNAFAHESGIHQDGVLKNKLTYEIMDAQSIGLTDNQIILGKHSGRNAFRTRLAELGFDLSDNDLNKAFLRFKDLADKKKEITDWDLEAIVKDETQQPPELFRLELVQVSCGDHAQPTATITIRTPGGKELTDAAIGTGPVDAIYKAINRVVQVPNELIEYSVQSVTAGIDAIGEVTIRLRHEGRIYSGHAANTDIVVASARAYISALNRLYAALQEDVSANPAKASL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
Length
532 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.712 kDa
Sequence
MSEQVIIFDTTLRDGEQALQASLSVKEKLQIAFALERMGVDVMEVGFPVSSPGDFESVQTIARNIKNSRVCGLTRCVEKDIDVAAEALRVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMIKRARNYTDDVEFSCEDAGRTPIPDLCRVVEAAINAGARTINIPDTVGYTMPHEFGNIIASLYQHVPNIDKAIISVHTHDDLGLAVGNAMAAVHAGARQVEGTLNGIGERAGNCSLEEVIMAIKTRHDILNVHTNINHQEIYRTSQLVSQICNMPIPANKAVVGANAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDNDYNLDDLYSAFLKLADKKGQVFDYDLEALAFISRQQEEPEFYHLDYFSVQSGSSVMATASVKLICGEETQSEAATGNGPVDAVYQAINRITGYQVSLVKYQLTAKGQGRDALGQVDIVADYQGRRFHGVGLATDIVESSAQAMVNVLNNIKRAQQVEKEIQRLQQHNNQQQNDSKQQNSQETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Length
532 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.727 kDa
Sequence
MSEQVIIFDTTLRDGEQALQASLSVKEKLQIAFALERMGVDVMEVGFPVSSPGDFESVQTIARNIKNSRVCGLTRCVEKDIDVAAEALRVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMIKRARNYTDDVEFSCEDAGRTPIPDLCRVVEAAINAGARTINIPDTVGYTMPHEFGNIISSLYQHVPNIDKAIISVHTHDDLGLAVGNAMAAVHAGARQVEGTLNGIGERAGNCSLEEVIMAIKTRHNILNVHTNINHQEIYRTSQLVSQICNMPIPANKAVVGANAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDSDYNLDDLYSAFLKLADKKGQVFDYDLEALAFINRQQEEPEFYHLDYFSVQSGSSVMATASVKLICGEETQSEAATGNGPVDAVYQAINRITGYQVSLVKYQLTAKGQGRDALGQVDIVADYQGRRFHGVGLATDIVESSAQAMVNVLNNIKRAQQVEKEIQRLQQHNNQQQNDSKQQNSQETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
Length
532 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.712 kDa
Sequence
MSEQVIIFDTTLRDGEQALQASLSVKEKLQIAFALERMGVDVMEVGFPVSSPGDFESVQTIARNIKNSRVCGLTRCVEKDIDVAAEALRVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMIKRARNYTDDVEFSCEDAGRTPIPDLCRVVEAAINAGARTINIPDTVGYTMPHEFGNIIASLYQHVPNIDKAIISVHTHDDLGLAVGNAMAAVHAGARQVEGTLNGIGERAGNCSLEEVIMAIKTRHDILNVHTNINHQEIYRTSQLVSQICNMPIPANKAVVGANAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDNDYNLDDLYSAFLKLADKKGQVFDYDLEALAFISRQQEEPEFYHLDYFSVQSGSSVMATASVKLICGEETQSEAATGNGPVDAVYQAINRITGYQVSLVKYQLTAKGQGRDALGQVDIVADYQGRRFHGVGLATDIVESSAQAMVNVLNNIKRAQQVEKEIQRLQQHNNQQQNDSKQQNSQETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Length
532 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.727 kDa
Sequence
MSEQVIIFDTTLRDGEQALQASLSVKEKLQIAFALERMGVDVMEVGFPVSSPGDFESVQTIARNIKNSRVCGLTRCVEKDIDVAAEALRVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMIKRARNYTDDVEFSCEDAGRTPIPDLCRVVEAAINAGARTINIPDTVGYTMPHEFGNIISSLYQHVPNIDKAIISVHTHDDLGLAVGNAMAAVHAGARQVEGTLNGIGERAGNCSLEEVIMAIKTRHNILNVHTNINHQEIYRTSQLVSQICNMPIPANKAVVGANAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDSDYNLDDLYSAFLKLADKKGQVFDYDLEALAFINRQQEEPEFYHLDYFSVQSGSSVMATASVKLICGEETQSEAATGNGPVDAVYQAINRITGYQVSLVKYQLTAKGQGRDALGQVDIVADYQGRRFHGVGLATDIVESSAQAMVNVLNNIKRAQQVEKEIQRLQQHNNQQQNDSKQQNSQETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Length
531 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.844 kDa
Sequence
MTTKPERIIIFDTTLRDGEQCPGATLNIDEKLAIAKQLARLGVDIIEAGFAFASPGDFEAVHKIAQTVGTENGPVICSLARARHDDIKAAAEAIKPAAKGRIHTFIATSDIHLQYKLKKTRPEVIAIAEEMVAYAKSFTDDVEFSPEDAGRSDPEFLYQVLERAIAAGATTINIPDTVGYTTPSEFGAIIKGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMAMHVRRQYFNPFLGRHPDSEEPLTNIDTKQIYKTSRLVSNLTGMLVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAQLIGLTDNQIVLGKHSGRNAFRTRLKELGFELSETELNKAFVKFKEVADKKKEISDWDLEAIVNDEIQQAPDLFRVELVQVSCGSNARPTATVTLRTPDGEELTDAAIGTGPVDAVYKAINRVVNVPNQLIEFSVQSVTAGIDAIGEVTIRLRYESRVFSGHAANTDIIVASAQAYVNALNRLYASLQTQDKQTEVTA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Length
531 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.844 kDa
Sequence
MTTKPERIIIFDTTLRDGEQCPGATLNIDEKLAIAKQLARLGVDIIEAGFAFASPGDFEAVHKIAQTVGTENGPVICSLARARHDDIKAAAEAIKPAAKGRIHTFIATSDIHLQYKLKKTRPEVIAIAEEMVAYAKSFTDDVEFSPEDAGRSDPEFLYQVLERAIAAGATTINIPDTVGYTTPSEFGAIIKGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMAMHVRRQYFNPFLGRHPDSEEPLTNIDTKQIYKTSRLVSNLTGMLVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAQLIGLTDNQIVLGKHSGRNAFRTRLKELGFELSETELNKAFVKFKEVADKKKEISDWDLEAIVNDEIQQAPDLFRVELVQVSCGSNARPTATVTLRTPDGEELTDAAIGTGPVDAVYKAINRVVNVPNQLIEFSVQSVTAGIDAIGEVTIRLRYESRVFSGHAANTDIIVASAQAYVNALNRLYASLQTQDKQTEVTA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Length
531 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.762 kDa
Sequence
MTTKPEKIIIFDTTLRDGEQCPGATLNIDEKLAIAKQLARLGVDIIEAGFAFASPGDFEAVHKIAQTVGTQSGPVICSLARARHDDIKAAAEAIKPAAKGRIHTFIATSDIHLQYKLKKTRPEVIAIAEEMVAYAKSFTDDVEFSPEDAGRSDPEFLYQVLERAIAAGATTINIPDTVGYTTPSEFGAIIKGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMAMHVRRQYFNPFLGRHPDSEEALTNIDTKQIYKTSRLVSNLTGMLVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAQLIGLTDNQIVLGKHSGRNAFRTRLKELGFELSETELNKAFVKFKEVADKKKEISDWDLEAIVNDEIQQAPDLFRVELVQVSCGSNARPTATVTLRTPDGEELTDAAIGTGPVDAVYKAINRVVNVPNQLIEFSVQSVTAGIDAIGEVTIRLRYESRVFSGHAANTDIIVASAQAYVNALNRLYASLQTQDKQTEVTA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Stenotrophomonas maltophilia (strain R551-3)
Length
528 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.113 kDa
Sequence
MTTIERITTPRIRIFDTTLRDGEQSPGCSMSPPQKLVMARALDELGVDIIETGFPASSQSDRDAMALIGRELRRPSLSLAVLSRCLQADIETSARALEAAANPRLHVFLSTSPLHREHKLRMTREQVLESVRKHVSLARSYIDDVEFSAEDATRTELDYLIEVSRAAISAGATTINLPDTVGFTTPEEIREMFQQVIAGVADVPNAANVIFSAHCHNDLGLAVANSLAAIEGGARQVECTVNGIGERAGNCSLEEIAMVLKVRQAFYEQDSSINTPRIVGTSQLLQRLVGMPVQRNKAIVGANAFAHESGIHQHGMLRHRGTYEIMRPEDVGWEDSQMVLGRHSGRAAVEARLRALGFWLEEDELKLVFEQFKGLCEQQRVVTDADLQTLMQGGSNAQGYRLASMTISDVGSRANALVELSDPDGNRVAETAQGDGPVDALFGALSAATGVQLMLDSYHVHSVGIGADARGEANLSVRHEGVEYDGTGTSKDIIEASALAWLDVANRLLRQRQANAASTTEAPAPATA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Stenotrophomonas maltophilia (strain K279a)
Length
528 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.161 kDa
Sequence
MTTIERITTPRIRIFDTTLRDGEQSPGCSMSPPQKLVMARALDELGVDIIETGFPASSQSDREAMALIGRELRRPSLSLAVLSRCLQADIETSARALEAAANPRLHVFLSTSPLHREHKLRMTREQVLESVRKHVSLARSYIDDVEFSAEDATRTELDYLIEVARVAIAAGATTINLPDTVGFTTPEEIRAMFQQVIAGVADVPNAANVIFSAHCHNDLGLAVANSLAAIEGGARQVECTVNGIGERAGNCSLEEIAMVLKVRQAFYEQDSSINTPRIVGTSQLLQRLVGMPVQRNKAIVGANAFAHESGIHQHGMLRHRGTYEIMRPEDVGWEDSQMVLGRHSGRAAVEARLRALGFWLDEDELKLVFEQFKGLCEQQRVVTDADLQTLMQGGSNAQGYRLASMTISDVGSRANALVELSDPDGNRVAETAQGDGPVDALFGALSAATGVQLMLDSYHVHSVGIGADARGEANLSVRHEGVEYDGTGTSKDIIEASALAWLDVANRLLRQRQATAHNSTDVPTPATA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Length
527 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.35 kDa
Sequence
MNQSAEAPSSENVATRQIRIFDTTLRDGEQSPGASMNLAEKLEVASALVDLGVDIIEAGFPIASPGDFESVRQIATTIRGATICGLARCAEKDIDRAWEALKTAPQARIHVFLATSAIHREFKLRMTPDEIVERAVAGVRRAASHCDDVEFSPEDACRTEHDFLCRVVEAAIDAGATTINVPDTVGYTTPGEIYDRFKMLRDRVPNMDKAVLSTHCHDDLGMAVANSLAAVDAGAGQIECTINGIGERAGNAALEELVMAMKTRQDFYHCQTNINSKRLVPVSRLVSKTTGINVQRNKAIVGRNAFAHESGIHQDGMLKERTTYEIMSPEEVGFTKTDLVLGKHSGRAALADRAKQLGMTLTGEQLQEVFEAFKELADKKKEIYDGDIVALVQQKISETVAPEWTLVDYEVTSGKNQTPNVRVTLRRDEQDITEQVAQGDGPIDAAFWAVEKITGIQVVCKDFRVRSATLGRDAIGEVNLEVEHEGKTYRGTGVSTDSVESTILAMLNAINRIVAGIASDPGELPQP

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Edwardsiella ictaluri (strain 93-146)
Length
526 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.806 kDa
Sequence
MKQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPISSPGDFASVRAIAQRVKQSRVCALARCVDADIDAAAEALRAADAFRIHTFLATSTLHLESKLRRSFDDAIAMARHAILRARRYTDDVEFSCEDAGRTPIDNLCRIVEAAIDAGAKTVNIPDTVGYTTPYQFGGIIHTLFERVPNIDKAVISVHCHDDLGMACANSISAIQSGARQVEGTLNGIGERAGNCALEEVIMAIRTRQDLLRVHTGIRHQEIYRTSQLVSQLCNMPIPANKAVVGANAFAHSSGIHQDGVLKNRENYEIMTPESIGLPQTQLNLTSRSGRAAVKHRMEEMGYCEGNDFDLERLYQAFLRLADKKGQVFDYDLEALAFIDRQQEEADHFRLEYFSVQSGSSVMATASVRLICGAETRAEAATGNGPVDAVYQAISRITDISVDIVKYQLSAKGQGRDALGQVDIVAEHQGRRFHGVGLTTDIVESSAQALIHVLNHIWRARQVEQERQRLHSPVPSISTSSTH

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bradyrhizobium sp. (strain ORS 278)
Length
525 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.274 kDa
Sequence
MSNPVQSDKDRVVIFDTTLRDGEQCPGATMTFEEKLNIAAMLDDMGVDIIEAGFPIASDGDFEAVNEIAKRSKNAVICGLSRAGAKDIDRCAEAIRPAKRGRIHTFLSTSPVHMKYKLQMDPQQVFELVISSVTRARNHTDDVEWSSEDGTRTEFDFLCRCVEAAIKAGASTINIPDTVGYAVPEEYYDLFKRVRETVPNSDKAVFSVHCHNDLGMAVANSMAGVRAGARQIECTINGIGERAGNAALEEVVMAMRVRNDKLPFWNKIDTTQLTHASKVVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMLKNAQTYEIMLPETVGVKQTSLVMGKHSGRHAFIHKLEEMGHKLSSNQVEDAFVRFKALADRKKQIYDEDIEALIDEGMVSAHDRIKLLSLSVIAGTRGPQRATMKLDIDGVTRIEESEGNGPVDAVFNCIKSLVPHEAKLELYQVHAVTEGTDAQAEVSVRLSQDGRSMTARAADPDTLVASAKAYLGALNKLVMKRQRDVAPGHGASAAAAS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Sodalis glossinidius (strain morsitans)
Length
525 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.869 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQVAQALERMGVDVMEVGFPVSSPGDFESVQTIARQIKNSRVCGLARCVDRDIDVAAEALRVAEAFRIHLFLATSTLHVESKLKKSFDQVVEMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRIVEATIKAGARTINIPDTVGYTTPNQFGGIISSLYQHVPNIDKAIISVHCHDDLGMAVGNSIAAIQSGARQVEGTLNGIGERAGNTALEEVIMAIKVRQDLLNVHTGIHHQEIYRTSQVVSQLCNMPIPANKAVVGANAFAHSSGIHQDGVLKNRQNYEIMTPEIIGLKEVQLNLTSRSGRAAVKHRMQEMGYQESNYSLDELYDAFLKLADKKGQVFDYDLEALAFINNQQEQSEHFRLEYFSVQSSSADIATASVKLAFGDEVHAEAATGNGPVDAVYEALNRITQLPIQLEKYQLTAKGHGRDALGQVDIVVEYEGRRFHGVGLATDIIESSALAMVNSMNTIWRARQVGIELRRLHQHNNSQDMQETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.233 kDa
Sequence
MSDRVIIFDTTLRDGEQALAASLTVKEKLQIAQALERLGVDVMEVGFPVSSPGDFQSVQTIARHIKQSRVCALARALPKDIDAAGEALRVAEAFRIHTFISTSSIHVESKLKKSFEDVLEMGVSAIKHARRYTDDVEFSCEDAGRTPIDNLCRMVEAAIKAGARTINIPDTVGYTVPTEFSGIIQTLFNRVPNIDQAIISVHCHDDLGLSVANSIGAVQMGARQIECTINGIGERAGNCSLEEVAMILKTRADLLGVHTNIRHSEIHRTSALVSQLCNMPVQPNKAIVGANAFSHSSGIHQDGVLKAKNTYEIITPESIGLTQNNLNMTSRSGRHVIKHRMESMGYAESSYDLDDLYGKFLTLADKKGQVFDYDLEALAFFSQIHEEPEHFKLEYLGVQSGSSVMATASVKLKVGQEIVSEAATGNGPVDAVYQCINRITGYEISIDKYELKGKGEGKNALGQVDIVAQYKGRKFHGMGLATDIIESSAQALIHVINSIWRADQVAEQMERNVAKTDKINTESV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aeromonas salmonicida (strain A449)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.248 kDa
Sequence
MSDRVIIFDTTLRDGEQALAASLTVKEKLQIAQALERLGVDIMEVGFPVSSPGDFQSVQTIARHIKNSRVCALARALPQDIDAAGEALRVAEAFRIHTFISTSSIHVESKLKKSFEDVLEMGVSAIKHALRYTDDVEFSCEDAGRTPIDNLCRMVEAAIKAGARTINIPDTVGYTVPTEFSGIIQTLFNRVPNIDKAIISVHCHDDLGLSVANSIGAVQMGARQIECTINGIGERAGNCSLEEVAMILKTRADLLGVHTNIRHSEIHRTSALVSQLCNMPVQPNKAIVGANAFSHSSGIHQDGVLKAKNTYEIITPESIGLPQNNLNMTSRSGRHVIKHRMESMGYAESSYDLDHLYGKFLTLADKKGQVFDYDLEALAFFSQIHEEPEHFKLEYLGVQSGSSVLATASVKLKVGQDLVCEAATGNGPVDAVYQCINRITGYEIRIDKYALKAKGEGKNALGQVDIVAEYKGRKFHGMGLATDIIESSAQALIHVINSIWRADQVAEQMERNVTKTDKINTESV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Caulobacter sp. (strain K31)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.832 kDa
Sequence
MTPVTPAAFEKRDNVVIFDTTMRDGEQSPGASMSHDEKLELAKILEEMGVDVIEAGFPIASNGDFEAVREIAKIVKNSTIAGLCRAHQVDIDRCAEALKGTQRGRIHVVIATSDLHMKHKLQMEPDAVIDVIARSVTHARNLRDDVEWSAEDATRSDRQFLRRAIETAIKAGATTINLPDTVGYTYPSEYADLFSWMTQNVEGADKVIFSTHCHNDLGLAVANSLAGVQGGARQIECAINGLGERAGNAALEEVVMALKVRGDKLPYETKIDTTHITRASRYVSAITGFPVQYNKAIVGKNAFAHESGIHQDGMLKNRETYEIMTPESVGQAPSSLVMGKHSGSHAFRAKLKDLGYELGQNALKEAFGRFKDLADRKKHVYDDDIIALVDDALARGSERIRVQRLRVVAGTDGQSAELTLEVDGEVKTSEASGDGPVDAVFNAIQQIVPHDAALRLFQVHAVTEGTDAQAQVSVRLEEDGRIATGQAADTDTLTASAKAYVNALNNLMARKEKSRPEAAIASGF

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.99 kDa
Sequence
MTSVPAGAISKRDNVVVFDTTMRDGEQSPGASMSLEEKLELAKILEEMGVDVIEAGFPIASNGDFEAVRQIAELITESTVCGLARAAAGDIDRCAEAVRRAKRGRIHTFISTSPVHMKYKLQMEPDAVLEAITRSVSHARNLVGDVEWSAEDATRTERDFLKRCVEAAIKAGATTINLPDTVGYSYPSEYGELFRDVITSVPGADKAIFSAHCHNDLGLAVANSIAAIEGGARQVEVAINGIGERAGNAALEEIVMALRVRGDHLPYGTSVDPVHITRASRYVSAITGFPVQFNKAIVGKNAFAHESGIHQDGMLKNAETYEIMKPEDVGQGATNLVMGKHSGRHAFREKLKALGYELGQNALNDAFGRFKELADKKKHVFDDDIVALVDDALARGSEKIRVSRLRVVAGTDGQSAELTLDIDGVASTAEATGDGPVDAVFNAIHKIVPHSAALRLFQVHAVTEGTDAQAQVSVRLEEDGRIATGAAADTDTLTASAKAYVNALNNLFARKEKSRPEAAIASGF

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Caulobacter vibrioides (strain NA1000 / CB15N)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.99 kDa
Sequence
MTSVPAGAISKRDNVVVFDTTMRDGEQSPGASMSLEEKLELAKILEEMGVDVIEAGFPIASNGDFEAVRQIAELITESTVCGLARAAAGDIDRCAEAVRRAKRGRIHTFISTSPVHMKYKLQMEPDAVLEAITRSVSHARNLVGDVEWSAEDATRTERDFLKRCVEAAIKAGATTINLPDTVGYSYPSEYGELFRDVITSVPGADKAIFSAHCHNDLGLAVANSIAAIEGGARQVEVAINGIGERAGNAALEEIVMALRVRGDHLPYGTSVDPVHITRASRYVSAITGFPVQFNKAIVGKNAFAHESGIHQDGMLKNAETYEIMKPEDVGQGATNLVMGKHSGRHAFREKLKALGYELGQNALNDAFGRFKELADKKKHVFDDDIVALVDDALARGSEKIRVSRLRVVAGTDGQSAELTLDIDGVASTAEATGDGPVDAVFNAIHKIVPHSAALRLFQVHAVTEGTDAQAQVSVRLEEDGRIATGAAADTDTLTASAKAYVNALNNLFARKEKSRPEAAIASGF

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.233 kDa
Sequence
MSDRVIIFDTTLRDGEQALAASLTVKEKLQIAQALERLGVDVMEVGFPVSSPGDFQSVQTIARHIKQSRVCALARALPKDIDAAGEALRVAEAFRIHTFISTSSIHVESKLKKSFEDVLEMGVSAIKHARRYTDDVEFSCEDAGRTPIDNLCRMVEAAIKAGARTINIPDTVGYTVPTEFSGIIQTLFNRVPNIDQAIISVHCHDDLGLSVANSIGAVQMGARQIECTINGIGERAGNCSLEEVAMILKTRADLLGVHTNIRHSEIHRTSALVSQLCNMPVQPNKAIVGANAFSHSSGIHQDGVLKAKNTYEIITPESIGLTQNNLNMTSRSGRHVIKHRMESMGYAESSYDLDDLYGKFLTLADKKGQVFDYDLEALAFFSQIHEEPEHFKLEYLGVQSGSSVMATASVKLKVGQEIVSEAATGNGPVDAVYQCINRITGYEISIDKYELKGKGEGKNALGQVDIVAQYKGRKFHGMGLATDIIESSAQALIHVINSIWRADQVAEQMERNVAKTDKINTESV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aeromonas salmonicida (strain A449)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.248 kDa
Sequence
MSDRVIIFDTTLRDGEQALAASLTVKEKLQIAQALERLGVDIMEVGFPVSSPGDFQSVQTIARHIKNSRVCALARALPQDIDAAGEALRVAEAFRIHTFISTSSIHVESKLKKSFEDVLEMGVSAIKHALRYTDDVEFSCEDAGRTPIDNLCRMVEAAIKAGARTINIPDTVGYTVPTEFSGIIQTLFNRVPNIDKAIISVHCHDDLGLSVANSIGAVQMGARQIECTINGIGERAGNCSLEEVAMILKTRADLLGVHTNIRHSEIHRTSALVSQLCNMPVQPNKAIVGANAFSHSSGIHQDGVLKAKNTYEIITPESIGLPQNNLNMTSRSGRHVIKHRMESMGYAESSYDLDHLYGKFLTLADKKGQVFDYDLEALAFFSQIHEEPEHFKLEYLGVQSGSSVLATASVKLKVGQDLVCEAATGNGPVDAVYQCINRITGYEIRIDKYALKAKGEGKNALGQVDIVAEYKGRKFHGMGLATDIIESSAQALIHVINSIWRADQVAEQMERNVTKTDKINTESV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Caulobacter sp. (strain K31)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.832 kDa
Sequence
MTPVTPAAFEKRDNVVIFDTTMRDGEQSPGASMSHDEKLELAKILEEMGVDVIEAGFPIASNGDFEAVREIAKIVKNSTIAGLCRAHQVDIDRCAEALKGTQRGRIHVVIATSDLHMKHKLQMEPDAVIDVIARSVTHARNLRDDVEWSAEDATRSDRQFLRRAIETAIKAGATTINLPDTVGYTYPSEYADLFSWMTQNVEGADKVIFSTHCHNDLGLAVANSLAGVQGGARQIECAINGLGERAGNAALEEVVMALKVRGDKLPYETKIDTTHITRASRYVSAITGFPVQYNKAIVGKNAFAHESGIHQDGMLKNRETYEIMTPESVGQAPSSLVMGKHSGSHAFRAKLKDLGYELGQNALKEAFGRFKDLADRKKHVYDDDIIALVDDALARGSERIRVQRLRVVAGTDGQSAELTLEVDGEVKTSEASGDGPVDAVFNAIQQIVPHDAALRLFQVHAVTEGTDAQAQVSVRLEEDGRIATGQAADTDTLTASAKAYVNALNNLMARKEKSRPEAAIASGF

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.99 kDa
Sequence
MTSVPAGAISKRDNVVVFDTTMRDGEQSPGASMSLEEKLELAKILEEMGVDVIEAGFPIASNGDFEAVRQIAELITESTVCGLARAAAGDIDRCAEAVRRAKRGRIHTFISTSPVHMKYKLQMEPDAVLEAITRSVSHARNLVGDVEWSAEDATRTERDFLKRCVEAAIKAGATTINLPDTVGYSYPSEYGELFRDVITSVPGADKAIFSAHCHNDLGLAVANSIAAIEGGARQVEVAINGIGERAGNAALEEIVMALRVRGDHLPYGTSVDPVHITRASRYVSAITGFPVQFNKAIVGKNAFAHESGIHQDGMLKNAETYEIMKPEDVGQGATNLVMGKHSGRHAFREKLKALGYELGQNALNDAFGRFKELADKKKHVFDDDIVALVDDALARGSEKIRVSRLRVVAGTDGQSAELTLDIDGVASTAEATGDGPVDAVFNAIHKIVPHSAALRLFQVHAVTEGTDAQAQVSVRLEEDGRIATGAAADTDTLTASAKAYVNALNNLFARKEKSRPEAAIASGF

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Caulobacter vibrioides (strain NA1000 / CB15N)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.99 kDa
Sequence
MTSVPAGAISKRDNVVVFDTTMRDGEQSPGASMSLEEKLELAKILEEMGVDVIEAGFPIASNGDFEAVRQIAELITESTVCGLARAAAGDIDRCAEAVRRAKRGRIHTFISTSPVHMKYKLQMEPDAVLEAITRSVSHARNLVGDVEWSAEDATRTERDFLKRCVEAAIKAGATTINLPDTVGYSYPSEYGELFRDVITSVPGADKAIFSAHCHNDLGLAVANSIAAIEGGARQVEVAINGIGERAGNAALEEIVMALRVRGDHLPYGTSVDPVHITRASRYVSAITGFPVQFNKAIVGKNAFAHESGIHQDGMLKNAETYEIMKPEDVGQGATNLVMGKHSGRHAFREKLKALGYELGQNALNDAFGRFKELADKKKHVFDDDIVALVDDALARGSEKIRVSRLRVVAGTDGQSAELTLDIDGVASTAEATGDGPVDAVFNAIHKIVPHSAALRLFQVHAVTEGTDAQAQVSVRLEEDGRIATGAAADTDTLTASAKAYVNALNNLFARKEKSRPEAAIASGF

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Rhodopseudomonas palustris (strain HaA2)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.474 kDa
Sequence
MTTTPKSEQDRVIIFDTTLRDGEQCPGATMTFEEKLNVARMLDDMGVDVIEAGYPFASDGDFEAVHEIAKRSKNSVICGLSRASHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQMEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTVGYAVPEEYREMFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTINGIGERAGNAALEELVMAMRVRQDKLPYWNNIETTMLTHASKTVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKLEELGYKLSRNQIEDVFVRFKALADRKKDVYDEDIEALVDEQLLHGQDQIKLNSLTVIAGTHGPQRATMKLDVDGQIRIEEAEGNGPVDAVFNCIKALVPHDAKLELYQVHAVTEGTDAQAEVSVRLSHEGRSMTARAADPDTLVASAKAYLGALNKIVAKRQRDVREAVPAVAAAG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.551 kDa
Sequence
MTTTTQSEQDRVIIFDTTLRDGEQCPGATMTFEEKLNVARMLDDMGVDVIEAGYPFASDGDFEAVHEIAKRSKNSVICGLSRAAHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQMEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTVGYAVPEEYRELFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTINGIGERAGNAALEEVVMAMRVRQDRLPYWNRIETTMLTHASKTVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKMEELGYKLSRNQIEDVFVRFKALADRKKDVYDEDIEALVDEQLLHGQDQIKLMSLTVIAGTHGPQRATMKLDVDGQIRIEEAEGNGPVDAVFNCIKALVPHDAKLELYQVHAVTEGTDAQAEVSVRLSHEGRSMTARAADPDTLVASAKAYLGALNKIVAKRQRSVREDAPAVAVAG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Rhodopseudomonas palustris (strain BisB5)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.526 kDa
Sequence
MTTTPKSEQDRVIIFDTTLRDGEQCPGATMTFEEKLNVAAMLDEMGVDVIEAGYPFASDGDFEAVHEIAKRSKNSVICGLSRAAHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQMEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTVGYAVPEEYREMFRKVRETVPNADKARFSVHCHDDLGMAVANSIAGVQGGARQIECTINGIGERAGNAALEEVVMAMRVRQDKVPYWNRIESKMLTHASKTVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKMEELGYKLSRNQIEDVFVRFKALADRKKDVYDEDIEALVDEQLLHGQDLIRLKSLTVIAGTHGPQRATMKIDVDGQLRIEEAEGNGPVDAVFNCIKALVPHDAKLELYQVHAVTEGTDAQAEVSVRLSHEGRSMTARAADPDTLVASAKAYLGALNKIVAKRQRDVRQDAPAVAVAG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Rhodopseudomonas palustris (strain TIE-1)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.553 kDa
Sequence
MTTTTQSEQDRVIIFDTTLRDGEQCPGATMTFEEKLNVARMLDDMGVDVIEAGYPFASDGDFEAVHEIAKRSKNSVICGLSRAAHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQMEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTVGYAVPEEYRELFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTINGIGERAGNAALEEVVMAMRVRQDKLPYWNRIETTMLTHASKTVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMIKNAQTYEIMTPETVGVKGTSLVMGKHSGRAGLIHKMEELGYKLSRNQIEDVFVRFKALADRKKDVYDEDIEALVDEQLLHGQDQIKLMSLTVIAGTHGPQRATMKLDVDGQIRIEEAEGNGPVDAVFNCIKALVPHDAKLELYQVHAVTEGTDAQAEVSVRLSHEGRSMTARAADPDTLVASAKAYLGALNKIVAKRQRSVREDAPTVAVAG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Serratia proteamaculans (strain 568)
Length
524 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.646 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKIQIAMALERMGVDVMEVGFPVSSPGDFESVQTIARQIKNSRVCGLARCVDKDIDVAAEALRVAEAFRIHVFLATSTLHIESKLKRSFDEVLEMAIRSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAINAGATTINIPDTVGYTTPNQFGGIITTLYDRVPNIDKAIISVHCHDDLGMAVGNSIAAVQAGARQVEGTLNGIGERAGNTSLEEVIMAIKVRQDIMNVHTNINHQEIFRTSQIVSQLCNMPIPANKAIVGSNAFAHSSGIHQDGVLKNRENYEIMSPQTIGLKDVQLNLTSRSGRAAVKHRMEGMGYKEQDYNLDNLYAAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFSLDYFSVQSGSSIMATASVKLICGEEEKAEAATGNGPVDAVYQAINRITGYPIELVKYQLTAKGQGRDALGQVDIVVSYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRSQQVEKEKQRLQQSKHQNNQETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.312 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEVANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O45:K1 (strain S88 / ExPEC)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli (strain 55989 / EAEC)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O157:H7
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.314 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRATEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O157:H7 (strain EC4115 / EHEC)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.314 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRATEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O7:K1 (strain IAI39 / ExPEC)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O81 (strain ED1a)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.241 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIALQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O8 (strain IAI1)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.298 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O9:H4 (strain HS)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O1:K1 / APEC
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli (strain K12)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.298 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.314 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRATEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli (strain SE11)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli (strain SMS-3-5 / SECEC)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.256 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia coli (strain UTI89 / UPEC)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella halifaxensis (strain HAW-EB4)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.787 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLTVKEKLQIALALERLGVDVMEVGFPVSSPGDFESVQTIAKTIKNSRVCALSRALESDIDAAAQALSVAEQFRIHTFISTSTIHVENKLKRSFDQVLDMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEEAIKAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIECTVNGIGERAGNCSLEEIAMILSTRKGELGLETGINAKEIHRTSSLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMSELGYGEQDYDMDVLYEEFLALADKKGQVFDYDLEALAFMEAQAEDDDHFELQQLVVHSDSTEGSATATVKVAVNGETITEAATGNGPVDAAYKAVARASGCKTNITSYQLSAKGEGHNALGQVDITAKYREQNFHGVGLATDVVEASAKALIHVMNLTWRADKVADCKQRIQQNKQEFGSV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.57 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLTVKEKLQIALSLERLGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARALEKDIDAAAQSLSVAEQFRIHTFISTSTIHVESKLKRSFDQVLDMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAIKAGAKTINIPDTVGYTVPSEFGGIIQNLFDRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIECTVNGIGERAGNCSLEEIAMIIATRKASLGLETGINAKEIHRTSNLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGVLKSQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYGEQDYDMDTLYEAFLKLADKKGQVFDYDLEALVYVEAQAEDENHYGLQQLVVHSDSTQGQATATVTLSIDGKAVTEAATGNGPVDAAYKAIARASGCEINISSYQLSAKGQGQDALGQVDITAKYHDQSFHGVGLATDVVEASAAALIHVMNLTWRADKVAENKHKLKQARTELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.785 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLTVKEKLQIALALERLGVDVMEVGFPVSSPGDFESVQTIAKTIKNSRVCALSRALEKDIDAAAQALSVAEQFRIHTFISTSTIHVESKLKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEEAIKAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIECTVNGIGERAGNCSLEEIAMILSTRKGELGLETGINAKEIHRTSSLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMSELGYGEQDYNMDVLYEEFLTLADKKGQVFDYDLEALAFMEAQAETDDHYKLQQLVVHSDSTEGSATATVKVAVNGETITEAATGNGPVDAAYKAVARASGCEINISSYQLSAKGEGQNALGQVDITAKYREQNFHGVGLATDVVEASAKALVHVMNLTWRADKVADCKQRIQQNKRELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella piezotolerans (strain WP3 / JCM 13877)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.697 kDa
Sequence
MSDRVIIFDTTLRDGEQALAASLTVKEKLQIALALERLGVDVMEVGFPVSSPGDFESVQTIARTVKNSRVCALSRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESKLKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEEAIKAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIECTVNGIGERAGNCSLEEIAMILSTRKGELGLETGINAKEIHRTSSLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMSELGYGDQDYDMDVLYEDFLVLADKKGQVFDYDLEALAFMEAQAEDDDHFKLQQLVVHSDSTEGSATATVKVEVNGETVTEAAIGNGPVDAAYKAVARASGCEIDITSYQLGAKGEGQNALGQVDITASYRNQNFHGVGLATDVVEASVKALVHVMNLTWRADKVADCKQKIQQEKQVLGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella sediminis (strain HAW-EB3)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.773 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLTVKEKLQIALSLERLGVDVMEVGFPVSSPGDFNSVQTIANTVKNSRVCALARALEKDIDAAAQSLSVADQFRIHTFISTSTIHVESKLKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEEAIKAGARTINIPDTVGYTIPSEFGGIIETLFNRVPNIDQAIISVHCHDDLGLSVANSITAVQQGARQIECTVNGIGERAGNCSLEEIAMILSTRKDSLGLETGINAKEIHRTSNLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGMLKSQNTYEIMTPESIGLHRNNLNMTSRSGRHVIKHRMEEMGYGNKDYDMDTLYEAFLQLADKKGQVFDYDLEALAFMEAQVDEEADYKLAQLVVHSDSTEGNATATVKLEIDGKTVTEAATGNGPVDAAYNAIARASQCEVNITSYKLSAKGEGQNALGQVDIEANYNEQSFHGVGLATDVVEASVQALVHVMNLTSRADKVADCKEKIQKDRSELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.872 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLTVKEKLQIALSLERLGVDVMEVGFPVSSPGDFKSVETIARTVKNSRVCALARALEKDIDAAAQSLSVADQFRIHTFISTSTIHVESKLKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEEAIKAGAKTINIPDTVGYTVPSEFGGIIETLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQQGARQIECTVNGIGERAGNCSLEEIAMILSTRKAALGLETGINAKEIHRTSSLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGMLKSQNTYEIMTPESIGLPRNNLNMTSRSGRHVIKHRMEEMGYGEHDYDMDVLYESFLKLADKKGQVFDYDLEALTFMEAQAEEESFYQLKQLVVHSDSTQGNATATVKIELDGEVVTEAATGNGPVDAAYNAIARASKCEINITSYKLSAKGEGQDALGQVDIEASYQQQSFHGVGLATDVVEASVQALIHVMNLTWRADKVADCKQKIQQKARSLGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shigella boydii serotype 4 (strain Sb227)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.284 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.446 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIDDLARVVEAAINAGAKTINIPDTVGYTMPFEFGGIISGLYERVPNIDKAIISVHTHDDLGLGVGNALAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRQDILNVHTRINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSNDIATASVKLACGDDIKAEAANGNGPVDAIYQAINRITDYNIELVKYSLSAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.446 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIDDLARVVEAAINAGAKTINIPDTVGYTMPFEFGGIISGLYERVPNIDKAIISVHTHDDLGLGVGNALAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRQDILNVHTRINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSNDIATASVKLACGDDIKAEAANGNGPVDAIYQAINRITDYNIELVKYSLSAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.863 kDa
Sequence
MSSTTPSDKDRVVIFDTTLRDGEQCPGATMTFEEKLNIAAMLDGMGVDVIEAGFPIASDGDFEAVNEIAKRTQNAVVCGLSRAGAKDIDRCAEAIRPAKRGRIHTFLSTSPVHMKYKLQMEPQAVFELVVSSVTRARNHTDDVEWSSEDGTRTEFDFLCRCVEAAIKAGATTINIPDTVGYAVPEEYYDLFKRVRETVPNSDKAVFSVHCHNDLGMAVANSMAGIRAGARQIECTINGIGERAGNAALEEVVMAMRVRNDKLPFWNKIDTTQLTHASKVVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMLKNAQTYEIMLPETVGVKQTSLVMGKHSGRHAFIHKLEEMGHKLAGNQVEDAFVRFKALADRKKHIYDEDIEALIDEGMVSAHDRIKLLSLSVIAGTRGPQRATMKLDVDGVTKIEESEGNGPVDAVFNCIKSLVPHEAKLELYQVHAVTEGTDAQAEVSVRLSQDGRSMTARAADPDTLVASAKAYLGALNKLVMKRQRDVAQGAAAAAAS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Enterobacter sp. (strain 638)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.528 kDa
Sequence
MSQQVVIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMIKRARHYTDDVEFSCEDAGRTPIADLARVVEAAINAGAKTINIPDTVGYTMPFEFSNIITGLYERVPNIDQAIISVHTHDDLGLAVGNAIAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDIMNVQTRINHNEIWRTSQTVSQICNMPIPANKAIVGTGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYKETDYNMDHLYDAFLKLADKKGQVFDYDLEAIAFINKQQEEPEHFRMDYFSVQSGSSDIATASVKLACGDEIKAEAANGNGPVDAIYQAINRVTGYDVELVKYDLSAKGHGKDALGQVDIVVTYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.256 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Klebsiella pneumoniae (strain 342)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.458 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQSIARTIKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEYANIISGLYDRVPNIDKAIISVHTHDDLGIAVGNALAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGTGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQESDYNLDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASIKLVCGDEIKTEAANGNGPVDAIYQAINRVTNYNIDLVKYGLSAKGHGKDALGQVDIVVDYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.514 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEYANIISGLYDRVPNIDKAIISVHTHDDLGIAVGNALAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGTGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQESDYNLDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFNVQSGSSDIATASIKLVCGDEIKTEAANGNGPVDAIYQAINRVTDYNIELVKYGLSAKGHGKDALGQVDIVVDYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Cronobacter sakazakii (strain ATCC BAA-894)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.53 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTLPFEFSNIISGLYERVPNIDKAVISVHTHDDLGMAVGNALAAVQAGARQVEGTLNGIGERAGNCALEEVIMAIKLRQNLMNVHTRINHQEIWRTSQTVSQICNMPIPANKAVVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYHENDYNLDDLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLEYFSVQSGSNAMATASVKLACGEEIKAEAANGNGPVDAVYQAINRITDYDIELVKYQLGAKGHGKNALGQVDIVVSYNGRHFHGVGLTTDIVESSARAMINVLNNIWRAGEVEKELQRKAQNKEHNQETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella agona (strain SL483)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.431 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRLTGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.553 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARIIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVNDLARVVEAAINAGARTINIPDTVGYTMPFEFARIISGLYERVPNIDNAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPTNKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQVQLNLTSRSGRAAVKHRMEEMGYQESDYNLDRLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEETKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAHNKENNKEIV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella choleraesuis (strain SC-B67)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.445 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMIKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella dublin (strain CT_02021853)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.431 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella enteritidis PT4 (strain P125109)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.431 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella gallinarum (strain 287/91 / NCTC 13346)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.431 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella heidelberg (strain SL476)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.431 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella newport (strain SL254)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.413 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNIDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.463 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMMHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.431 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella paratyphi C (strain RKS4594)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.445 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMIKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella paratyphi A (strain AKU_12601)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.463 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMMHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella schwarzengrund (strain CVM19633)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.431 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella typhi
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.355 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIINVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMGHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.431 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRSTLDEVIERAVYMVKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVIMAIKVRKDIMNVHTNINHHEIWRTSQTVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMEEMGYKDTDYNMDHLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHFRLDYFSVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINRITGYDVELVKYDLNAKGQGKDALGQVDIVVNHHGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQNKENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.314 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSSSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shigella flexneri serotype 5b (strain 8401)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.226 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIGKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shigella flexneri
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.344 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVTNYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKTQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shigella sonnei (strain Ss046)
Length
523 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.314 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSSAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella baltica (strain OS223)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.924 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLSVKEKLQIAMALERLGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALSRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESKLKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAILVGARTINIPDTVGYTVPSEFGTIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIECTINGIGERAGNCSLEEIAMILATRKGMLGLETGINAKEIHRTSNLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYSEHDYNMDALYEEFLKLADKKGQVFDYDLEALAFMEAQAEEDNHYQLQQLVVQSDSTEGVATATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRRIDIISYKLGAKGVGQNALGQVDITAVYHEQNFHGVGLATDVVEASARALVHVMNLTCRADKVADYKQSMQKNRELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella baltica (strain OS155 / ATCC BAA-1091)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.926 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLSVKEKLQIAMALERLGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALSRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESKLKRSFDQVLEMAVSAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAILAGARTINIPDTVGYTVPSEFGTIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIECTINGIGERAGNCSLEEIAMILATRKGMLGLETGINAKEIHRTSNLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYSEHDYNMDALYEEFLKLADKKGQVFDYDLEALAFMEAQAEEDNHYQLQQLVVQSDSTEGVATATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRRIDIISYKLGAKGVGQNALGQVDITAVYHEQNFHGVGLATDVVEASARALVHVMNLTCRADKVADYKQSMQKNRELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella baltica (strain OS185)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.923 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLSVKEKLQIAMALERLGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALSRALEKDIDAAAQALSVAEQFRIHTFISTSTIHVESKLKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAILAGARTINIPDTVGYTVPSEFGNIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIECTINGIGERAGNCSLEEIAMILATRKGMLGLETGINAKEIHRTSNLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYSEHDYNMDALYEEFLKLADKKGQVFDYDLEALAFMEAQAEEDNHYQLQQLVVQSDSTEGVATATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRRIDIISYKLGAKGVGQNALGQVDITAVYHEQNFHGVGLATDVVEASARALVHVMNLTCRADKVADYKQSMQKNRELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella baltica (strain OS195)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.953 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLSVKEKLQIAMALERLGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALSRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESKLKRSFDQVLEMAVSAVKYARRFTDDVEFSCEDAGRTPIENLCRMVEAAILAGARTINIPDTVGYTVPSEFGNIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIECTINGIGERAGNCSLEEIAMILATRKGMLGLETGINAKEIHRTSNLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYSEHDYNMDALYEEFLKLADKKGQVFDYDLEALAFMEAQAEEDNHYQLQQLVVQSDSTEGVATATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRRIDIISYKLGAKGVGQNALGQVDITAVYHEQNFHGVGLATDVVEASARALVHVMNLTCRADKVADYKQSMQKNRELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.698 kDa
Sequence
MPNRVIIFDTTLRDGEQALAASLSVKEKLQIALALERLGVDVMEVGFPVSSPGDFNSVQTIAKTIKNSRVCALARALPADIDAAAQALAVAEQFRIHTFISTSTIHVESKLKRSFDDVLAMAVNAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAITAGARTINIPDTVGYTIPSEFSTIIETLFNRVPNIDQAIISVHCHDDLGLSVANSIGAIEKGARQVECTVNGIGERAGNCSLEEIAMILATRKDKLGLETGIVAKEIHRTSNLVSQLCNMPVQANKAIVGSNAFSHSSGIHQDGMLKAKNTYEIMTPESIGLHRNNLNMTSRSGRHVIKHRMEEMGYHTDDFDIDSLYEQFLKLADKKGQVFDYDLEAIVFMATQVAEDDHYRLQHLSVHSDSSEGVATATVRIKVEGEDLTEAAIGNGPVDAAYKAIARASGREVEISSYKLSAKGQGQDALGQVDITAKYQGRTFHGVGLATDVVEASAQALVHVMNLICRADKVADIKSQIQFNREHAGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella frigidimarina (strain NCIMB 400)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.086 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLTVKEKLQIALALERLGVDVMEVGFPVSSPGDFKSVQTIAKTIKNSRVCALSRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESKLKRSFDDVLEMAVNAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEEAIKAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSIAAVEMGARQVECTINGIGERAGNCSLEEIAMILATRKGLLDLDCGINAKEIHRTSSLVSQLCNMPIQANKAIVGTNAFSHSSGIHQDGMLKAKNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYKPTDYDMDSLYEQFLTLADKKGQVFDYDLEALVFMESQAQDDDKYQLQHMMVHSDSTEGVATATVRIAVDGKDITEAATGNGPVDAAYNAIARATDRKINITNYKLSAKGEGQNALGQVDITAKYNEQMFHGVGLATDVVEASAQALVHVMNLVYRADKVADFKQQIHKERELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella oneidensis (strain MR-1)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.007 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLSVKEKLQIAMALERLGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALSRALEKDIDAAAQALSVAEQFRIHTFISTSTIHVESKLKRSFEQVLEMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAIHAGARTINIPDTVGYTVPSEFGSIIQTLFNRVPNIDQAIISVHCHDDLGLSVANSITAVQHGARQIECTMNGIGERAGNCSLEEIAMILATRKNLLGFETGINAKEIHRTSNLVSQLCNMPIQSNKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYSSQDYNLDALYEQFLHLADKKGQVFDYDLEALAFIEAQAAEDNFYQLRQLVVQSDSTEGVATATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRRIDIISYKLGAKGVGQDALGQVDITAVYHEQNFHGVGLATDVVEASARALVHVMNLTCRADKVADYKQNMHKNRELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.939 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLSVKEKLQIAMALERLGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALSRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESKLKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAILAGARTINIPDTVGYTVPSEFGNIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIECTINGIGERAGNCSLEEIAMILATRKGMLGLETGINAKEIHRTSNLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYSEHDYNMDTLYEEFLKLADKKGQVFDYDLEALAFMEAQAEEDNHYQLQQLVVQSDSTEGVATATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRRIDIISYKLGAKGVGQNALGQVDITAVYHEQNFHGVGLATDVVEASARALVHVMNLTCRADKVADYKQSMQKNRELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella sp. (strain ANA-3)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.978 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLSVKEKLQIAMALERLGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALSRALEKDIDAAAQALSVAEQFRIHTFISTSTIHVESKLKRSFEQVLEMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAIHAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDQAIISVHCHDDLGMSVANSITAVQHGARQIECTMNGIGERAGNCSLEEIAMILATRKNLLGVETGINAKEIHRTSNLVSQLCNMPIQSNKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYSEQDFNLDALYEQFLHLADKKGQVFDYDLEALAFMEAQAAEDNFYQLQQLVVQSDSTEGVATATVRIDVGGEIKTEAATGNGPVDAAYNAIARATDRRIDIISYKLGAKGEGQNALGQVDITAVYHEQNFHGVGLATDVVEASARALVHVMNLTCRADKVADYKQNMHKNRELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella sp. (strain MR-4)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.994 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLSVKEKLQIAMALERLGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALSRALEKDIDAAAQALSVAEQFRIHTFISTSTIHVESKLKRSFEQVLEMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAIHAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDQAIISVHCHDDLGMSVANSITAVQHGARQIECTMNGIGERAGNCSLEEIAMILATRKNLLGVETGINAKEIHRTSNLVSQLCNMPIQSNKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYSEQDYNLDALYEQFLHLADKKGQVFDYDLEALAFMEAQAAEDNFYQLQQLVVQSDSTEGVATATVRIDVGGEIKTEAATGNGPVDAAYNAIARATDRRIDIISYKLGAKGEGQNALGQVDITAVYHEQNFHGVGLATDVVEASARALVHVMNLTCRADKVADYKQNMHKNRELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella sp. (strain MR-7)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.023 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLSVKEKLQIAMALERLGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALSRALEKDIDAAAQALSVAEQFRIHTFISTSTIHVESKLKRSFEQVLEMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAIHAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDQAIISVHCHDDLGMSVANSITAVQHGARQIECTMNGIGERAGNCSLEEIAMILATRKNLLGVETGINAKEIHRTSNLVSQLCNMPIQSNKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYSEQNYNLDALYEQFLHLADKKGQVFDYDLEALAFMEAQAAEDNFYQLQQLVVQSDSTEGVATATVRIDVGGEIKTEAATGNGPVDAAYNAIARATDRRIDIISYKLSAKGEGQNALGQVDITAVYHEQNFHGVGLATDVVEASARALVHVMNLTCRADKVADYKQNMHKNRELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella sp. (strain W3-18-1)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.939 kDa
Sequence
MSNRVIIFDTTLRDGEQALAASLSVKEKLQIAMALERLGVDVMEVGFPVSSPGDFESVQTIARTIKNSRVCALSRALEKDIDAAAQALSVADQFRIHTFISTSTIHVESKLKRSFDQVLEMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAILAGARTINIPDTVGYTVPSEFGNIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSITAVQHGARQIECTINGIGERAGNCSLEEIAMILATRKGMLGLETGINAKEIHRTSNLVSQLCNMPVQANKAIVGANAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYSEHDYNMDTLYEEFLKLADKKGQVFDYDLEALAFMEAQAEEDNHYQLQQLVVQSDSTEGVATATVRIEVGGEIKTEAATGNGPVDAAYNAIARATDRRIDIISYKLGAKGVGQNALGQVDITAVYHEQNFHGVGLATDVVEASARALVHVMNLTCRADKVADYKQSMQKNRELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.505 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQIKNSRVCGLARCVEKDIDAAYEALRVADAYRIHTFLATSPMHIATKLRSTLPEVIERAVKMIRRARNYTDDVEFSCEDGGRTPIDDLCRVVEAAINAGATTINIPDTVGYTLPYEYANIFSALRARVPNIDKAILSVHTHDDLGMAVGNALAAVNAGARQIEGAMNGLGERAGNCALEETIMAIKTRGQLMNVHTRINHQEIYRTCQTVSKICNMPIPAHKAIIGSNAFAHSSGIHQDGVLKNRENYEILTPESIGLKQVQLNLTSRSGRAAVKHRMEEMGYGETEYNMDRLYDAFKALADKKGQVFDYDLEALAFINQQSEEPEYFRLDTFNVQSGSSVIATATVQLRCGDEQKTEAATGNGPVDAVYQAINRLTEFDAELVSYQLTAKGHGKDALGQVDIVVQYNGRKFHGVGLATDIVESSAKAMVNALNTIWRARQVEQELQRKSQVKDQKETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.623 kDa
Sequence
MAMTQTENQTAPQQHIRIFDTTLRDGEQSPGVALNHAQKLEIAHTLARMGVDVIEAGFPIASPGDLEGVSRIAREVRGPVITALARANRADIEAAAKGVEAAEKSRIHTFIATSPIHMQKKLNLEPDAVIERAVEAVRLARQYVDDVEFSAEDATRSEWDFLSRIFKAAVEAGATTINVPDTVGYTTPEEMRKLFAYLKAKLPAHVILSSHCHDDLGMAVANSIAAAEGGARQIECTINGIGERAGNASLEEIVMAFHTRRDVYGYETGIRTRELYRASRLVSRLSGMPVQPNKAIVGDNAFAHESGIHQDGVIKARETYEIMNAELVGREAAVLVMGKHSGRAAFRKALTDLGYGDIPDDKVQHLFGRFKDLADRKGQIYAEDLRALVDARSDVPQTFSLEGFQITSGMNMMPVAFVRLHTPDGPVDATAHGDGPVEAAFQAISKITGISPTLESYRIQSVTRGDDALGEVSIHVRHGETQLNGTGVATDIVEASARAWIRVMNMIVAGMGKNKAITQMTP

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Length
522 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.857 kDa
Sequence
MSDRVIIFDTTLRDGEQALAASLSVKEKLQVALALERLGVDVMEVGFPVSSPGDFESVQTIARHIKNSRVCALSRALEKDIDAAAQALSVAEQFRIHTFISTSNIHVESKLKRSFDQVLDMAVGAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAISAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDQAVISVHCHDDLGLSVANSIAAVQAGARQIECTVNGIGERAGNCSLEEIAMILATRKDMLGLYTNINAREIHRTSSLVSQLCNMPIQPNKAIVGSNAFTHSSGIHQDGMLKAQNTYEIMTPESIGLNRNNLNMTSRSGRHVIKHRMEEMGYGAGDYDMDTLYAAFLKLADKKGQVFDYDLEALAFMEAQAEDDDHYVMEQLVVQSDSTEGKATATVRMRVGDEVITEAATGNGPVDAAYNAIARATHRTINISSYKLGAKGEGQNALGQVDITARYDDRNFHGVGLATDVVEASAQALVHVMNLTWRADKVAYCKQQMQQTRELGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Length
521 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.242 kDa
Sequence
MSDRVIIFDTTLRDGEQALPASLTVREKLQIALALERLGVDVMEVGFPVSSPGDFESVQTIARQIKNSRVCALSRALQKDIDAAAEALKVADQFRIHTFLATSTIHVESKLKKSFEDVLEMGINAVKYARRFTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYTIPSEFGGIIHNLFNRVPNIDKAVISVHCHDDLGLSVANSISAVQMGARQVECTINGIGERAGNTSLEEVAMILRTRQDLIGVHTNIKHQEIHRTSQLVSQLCNMPVQPNKAIVGANAFSHSSGIHQDGVLKAKNTYEIITPESVGLNQNTLNLTSRSGRHVIKHRLALLGYPEGSYDLDQIYTSFLQLADKKGQVFDYDLEALLFFSQIQEEPEHFKLNYLSVQSGGSIMATASVRMKVGDEEVTEAATGNGPVDAVYQCINRITGYEINISKYDLKSKGIGKDALGQVDIVAEFKGRKFHGMGLATDIVESSAQALVHVINNIYRALQVAEHKERFAQKTVMETL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Rhodopseudomonas palustris (strain BisA53)
Length
521 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.776 kDa
Sequence
MTAPHTSANDRVIIFDTTLRDGEQCPGATMTFEEKLEVASLLDSMGVDVIEAGFPIASDGDFEAVHEIAKRAKNAVICGLSRAGAKDIDRCAEAIKPAKQGRIHTFLSTSPVHMKYKLQMDAAQVYELVISSVTRARNHTDNVEWSSEDGTRTEFDFLCKCVEAAIKAGASTINIPDTVGYSVPEEYYDLFKRVRENVPNSDKAIFSVHCHDDLGMAVANSLAGIRGGARQIECTVNGIGERAGNTALEEVVMAMKVRNDKLPYWNKIDTTMLTRASKVVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMLKNAETYEIMLPESVGVKQTSLVMGKHSGRHAFIHKLEEMGYKLGQNQLEDAFVRFKALADRKKDIYDEDIEALVDLEIAQSHDRIKLVSLTVIAGTHGPQRATMKLDVDGQTKIEEAEGNGPVDAVFNCIKALVPHVAKLELYQVHAVTEGTDAQAEVSVRLSHEGRSVTSRASDPDTLVASAKAYLGALNKIVMKRQRDMAAPAAAAS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Rhodopseudomonas palustris (strain BisB18)
Length
521 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.026 kDa
Sequence
MTATTPSDKDRVIIFDTTLRDGEQCPGATMTFEEKLEVASLLDAMGVDVIEAGFPIASDGDFAAVHEIAKRAKNAVICGLSRAGAKDIDRCAEAIRPAKQGRIHTFLSTSPVHMKYKLQMDAEQVYQLVISAVTRARNHTDNVEWSSEDGTRTEFDFLCKCVEAAIKAGATTINIPDTVGYSVPEEYFDLFKRVRENVPNSDKAIFSVHCHDDLGMAVANSLAGIRGGARQIECTVNGIGERAGNTALEEVVMAMRVRNDKLPFWNKIDTTMLTRASKVVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMLKNAETYEIMRPESVGVKQTSLVMGKHSGRHAFVHKLEEMGYKLGQNQLEDAFVRFKALADRKKEIYDEDIEALVDQEIAQSHDRIKLLSLTVIAGTHGPQRATMKLDVEGQTRIEEAEGNGPVDAVFNCIKALVPHVAKLELYQVHAVTQGTDAQAEVSVRLAHEGRSMTARAADPDTLVASAKAYLSALNKIVMKRERDLPVPEAAAS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.363 kDa
Sequence
MTETAASSAERVLIFDTTLRDGEQCPGATMTFEEKLAVAEMLDGMGVDIIEAGFPIASNGDFDAVAEIARRTKTSVVAGLARAISADIARAGEAVRLAKRGRIHTFVSTSPIHLAHQMRKSEEEVLEIIQKTVAQARDLVEDVEWSAMDATRTPIDYLCRCVEMAIKMGATTINLPDTVGYATPDEYRAMFRSVRERVPNADRAIFSVHCHNDLGLAIANSLAGIEGGARQVECTINGIGERAGNAALEEVVMALRTRADVLPYTTGIDTTQIMRASKLVAAATHFPVQYNKAVVGRNAFAHESGIHQDGMLKNQSTYEIMTPESVGVQKTSLVMGKHSGRAAFRSKLEELGYRLSDNQFQDAFERFKALADRKKNVYDEDIEALVDENLATAHDRIRLLSLTVIAGTRGPQRATMRLDIDGRQATEEADGNGPVDAVFNAIHALVPHEAKLELYDVHAVTEGTDAQAEVSVRLRQGERSVTARGADPDTLVASAKAYLAALNKLLAGANRLHAQHAAAE

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.122 kDa
Sequence
MANTTESAKDRVVIFDTTLRDGEQCPGATMTLDEKLAVAELLDAMGVDIIEAGFPIASNGDFEAVSEIARRTKRATIAGLARAIPADIARAGEAVRHAKAGRIHTFVSTSAIHLAHQMRKTQDEVIEIILKTVTQARDLVEDVEWSAMDATRTDIDYLCRCVEAAIRSGATTINLPDTVGYATPQEYGAMFRQVRERVPNSDKAIFSVHCHNDLGLAVANSLAGLEGGARQIECTVNGIGERAGNAALEEIVMAIRTRADVMPYDTGIDTTMLTRASKLVSHAANFPVQYNKAIVGRNAFAHESGIHQDGMLKHSETYEIMTPASVGLSKTSLVMGKHSGRAAFKSKLAELGISLSDNQFQDVFERFKDLADRKKHVYDEDIEALVDEKLATAHDRIKLLSLSVIAGTRGPQRATMKIEMDGRTFTEEADGNGPVDAVFNAIHEIVPHDAVLELYQVHAVTEGTDAQAEVSVRLKAGERSVTARGADPDTLVASAKAYLSALNKLSAASVRLHAQHAAVV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aquifex aeolicus (strain VF5)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.103 kDa
Sequence
MGEKVYIFDTTLRDGEQAPGFSMTTEEKLQMAHQLAKLNVDIIEAGFAAASKGDFEAVNRIAKEVKGPVICSLARALESDIEIAAKALEPAERKRIHTFIATSPIHMEYKLRMTPDQVLERIKKAVSFARNFTDDVEFSCEDATRSEREFLYRAIETAIKHGATVINIPDTVGYAIPEEFGQLIEDIMNNVPNIDKVILSVHCHDDLGLATANSLTAVKHGARQVECTINGIGERAGNAALEEVVMALKVRKDFFGDLYTDVNTKEIYKTSRLLCRITGNFVQPNKAIVGDNAFAHESGIHQHGVLSHRMTYEIMNPEDVGFPMSRIVLGKHSGRHALKRRLEELGFKFTKEELDRIFEKFKELADRKKEVYDEDLEALIYQEFMKIEDHEPVKVLHFQVQSGDNMIPTATVKLEFKGEEREASSTGNGPVDATIKAIQKALGIEPKLLDYSIKALTPNTDAQAEARVVLELDGVKASGRGVDTDIIKASVKAFTDALNRAIVRKEYIIQRQEIREEGTV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.484 kDa
Sequence
MNQQVIIFDTTLRDGEQALQASLCVNEKLQIALALERMGVDIMEVGFPVSSPGDFESVQTIAKQIKNSRVCALARCVEKDIDVAAEALKVADAFRIHVFLATSDLHIESKLKKTFENVMEMATQSIKRARRYTDDVEFSCEDAGRTPIDNLCRIVENAIKAGATTINIPDTVGYTTPYQFGGIITNLIERVPNIDKAIISVHCHDDLGMSVANSITAVQSGARQIEGTINGLGERAGNCSLEEVIMAIKVRQQMLGVYTNINHQEIYRTSQLVSQLCNMPIPANKAIVGSNAFSHSSGIHQDGVLKNRETYEIMTPESIGLKEIQLNLTSRSGRAAVKHRMEEMGYQDKDYDLGSLYEAFLRLADKKGQVFDYDLEALAFINLQQQEPEFFHLDNFNIQSGSNVMATAAVCLVCGKELKSEAATGNGPVDAVYQAISRITEYPIELVSYQLSGKGQGKNALGQVNIVVECFGRRFHGMGLETDIVESSAKAMVHALNCVWRTEQVKKEKQRIQQNTKEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas axonopodis pv. citri (strain 306)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.289 kDa
Sequence
MNTTVSNQTPRIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDELGVDIIETGFPASSHSDREAVAMMGRELRRPTLAVLSRCLQADIETSAKALETAANPRLHVFLSTSPLHREHKLRMSREQVLESVHRHVTLARGYVDDVEFSAEDATRTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEEEVKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPEGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVVAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.303 kDa
Sequence
MNTTVSNQTPRIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDELGVDIIETGFPASSHSDREAVAMMGRELRRPTLAVLSRCLQADIETSAKALETAANPRLHVFLSTSPLHREHKLRMSREQVLESVHRHVTLARGYIDDVEFSAEDATRTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEEEVKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPEGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVVAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas campestris pv. campestris (strain 8004)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.222 kDa
Sequence
MNTTVSNQTPHIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDALGVDIIETGFPASSYSDREAVAMMGRELRRPTLAVLSRCLQADIEISARALEAAANPRLHVFLSTSPLHREHKLRMSREQVLESVHKHVTLARGYIDDIEFSAEDATRTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGAEKVIFSTHCHNDLGLAAANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNLDTAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEDEAKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPDGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVVAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas campestris pv. campestris (strain B100)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.222 kDa
Sequence
MNTTVSNQTPHIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDALGVDIIETGFPASSYSDREAVAMMGRELRRPTLAVLSRCLQADIEISARALEAAANPRLHVFLSTSPLHREHKLRMSREQVLESVHKHVTLARGYIDDIEFSAEDATRTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGAEKVIFSTHCHNDLGLAAANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNLDTAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEDEAKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPDGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVVAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.222 kDa
Sequence
MNTTVSNQTPHIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDALGVDIIETGFPASSYSDREAVAMMGRELRRPTLAVLSRCLQADIEISARALEAAANPRLHVFLSTSPLHREHKLRMSREQVLESVHKHVTLARGYIDDIEFSAEDATRTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGAEKVIFSTHCHNDLGLAAANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNLDTAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEDEAKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPDGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVVAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.372 kDa
Sequence
MNTTISNQTPHIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDELGVDIIETGFPASSHSDREAVAMMGRELRRPTLAVLSRCLQADIETSAKALETAANPRLHVFLSTSPLHREHKLRMSREQVLESVHRHVTLARGYIDDVEFSAEDATRTEEDFLAEVTRVAVAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVERRLRALGYLLEEEEVKLMFEQFKALCEKQRLVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPEGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVIAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.37 kDa
Sequence
MNTTISNQTPHIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDALGVDIIETGFPASSHSDREAVAMMGRELRRPTLAVLSRCLQADIETSARALETVANPRLHVFLSTSPLHREHKLRMSREQVLESVHRHVTLARGYIDDVEFSAEDATRTEEDFLAEVTRVAVAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVERRLRALGYLLEEEEVKLMFEQFKALCEKQRLVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPEGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVIAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.354 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVRTIAQQMKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRIVEAAINAGATTINIPDTVGYTTPYQFGGIITDLYQRVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRENMLGVHTNINHQEIYRTSQLVSKLCNMPIPANKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPQSIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSANGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEIEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pseudotuberculosis serotype IB (strain PB1/+)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pestis
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pestis bv. Antiqua (strain Angola)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aquifex aeolicus (strain VF5)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.103 kDa
Sequence
MGEKVYIFDTTLRDGEQAPGFSMTTEEKLQMAHQLAKLNVDIIEAGFAAASKGDFEAVNRIAKEVKGPVICSLARALESDIEIAAKALEPAERKRIHTFIATSPIHMEYKLRMTPDQVLERIKKAVSFARNFTDDVEFSCEDATRSEREFLYRAIETAIKHGATVINIPDTVGYAIPEEFGQLIEDIMNNVPNIDKVILSVHCHDDLGLATANSLTAVKHGARQVECTINGIGERAGNAALEEVVMALKVRKDFFGDLYTDVNTKEIYKTSRLLCRITGNFVQPNKAIVGDNAFAHESGIHQHGVLSHRMTYEIMNPEDVGFPMSRIVLGKHSGRHALKRRLEELGFKFTKEELDRIFEKFKELADRKKEVYDEDLEALIYQEFMKIEDHEPVKVLHFQVQSGDNMIPTATVKLEFKGEEREASSTGNGPVDATIKAIQKALGIEPKLLDYSIKALTPNTDAQAEARVVLELDGVKASGRGVDTDIIKASVKAFTDALNRAIVRKEYIIQRQEIREEGTV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.484 kDa
Sequence
MNQQVIIFDTTLRDGEQALQASLCVNEKLQIALALERMGVDIMEVGFPVSSPGDFESVQTIAKQIKNSRVCALARCVEKDIDVAAEALKVADAFRIHVFLATSDLHIESKLKKTFENVMEMATQSIKRARRYTDDVEFSCEDAGRTPIDNLCRIVENAIKAGATTINIPDTVGYTTPYQFGGIITNLIERVPNIDKAIISVHCHDDLGMSVANSITAVQSGARQIEGTINGLGERAGNCSLEEVIMAIKVRQQMLGVYTNINHQEIYRTSQLVSQLCNMPIPANKAIVGSNAFSHSSGIHQDGVLKNRETYEIMTPESIGLKEIQLNLTSRSGRAAVKHRMEEMGYQDKDYDLGSLYEAFLRLADKKGQVFDYDLEALAFINLQQQEPEFFHLDNFNIQSGSNVMATAAVCLVCGKELKSEAATGNGPVDAVYQAISRITEYPIELVSYQLSGKGQGKNALGQVNIVVECFGRRFHGMGLETDIVESSAKAMVHALNCVWRTEQVKKEKQRIQQNTKEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas axonopodis pv. citri (strain 306)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.289 kDa
Sequence
MNTTVSNQTPRIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDELGVDIIETGFPASSHSDREAVAMMGRELRRPTLAVLSRCLQADIETSAKALETAANPRLHVFLSTSPLHREHKLRMSREQVLESVHRHVTLARGYVDDVEFSAEDATRTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEEEVKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPEGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVVAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.303 kDa
Sequence
MNTTVSNQTPRIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDELGVDIIETGFPASSHSDREAVAMMGRELRRPTLAVLSRCLQADIETSAKALETAANPRLHVFLSTSPLHREHKLRMSREQVLESVHRHVTLARGYIDDVEFSAEDATRTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEEEVKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPEGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVVAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas campestris pv. campestris (strain 8004)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.222 kDa
Sequence
MNTTVSNQTPHIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDALGVDIIETGFPASSYSDREAVAMMGRELRRPTLAVLSRCLQADIEISARALEAAANPRLHVFLSTSPLHREHKLRMSREQVLESVHKHVTLARGYIDDIEFSAEDATRTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGAEKVIFSTHCHNDLGLAAANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNLDTAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEDEAKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPDGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVVAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas campestris pv. campestris (strain B100)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.222 kDa
Sequence
MNTTVSNQTPHIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDALGVDIIETGFPASSYSDREAVAMMGRELRRPTLAVLSRCLQADIEISARALEAAANPRLHVFLSTSPLHREHKLRMSREQVLESVHKHVTLARGYIDDIEFSAEDATRTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGAEKVIFSTHCHNDLGLAAANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNLDTAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEDEAKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPDGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVVAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.222 kDa
Sequence
MNTTVSNQTPHIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDALGVDIIETGFPASSYSDREAVAMMGRELRRPTLAVLSRCLQADIEISARALEAAANPRLHVFLSTSPLHREHKLRMSREQVLESVHKHVTLARGYIDDIEFSAEDATRTEEDFLAEVTRVAIAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGAEKVIFSTHCHNDLGLAAANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNLDTAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVEQRLRALGYLLEEDEAKLVFEQFKALCEKQRVVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPDGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVVAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.372 kDa
Sequence
MNTTISNQTPHIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDELGVDIIETGFPASSHSDREAVAMMGRELRRPTLAVLSRCLQADIETSAKALETAANPRLHVFLSTSPLHREHKLRMSREQVLESVHRHVTLARGYIDDVEFSAEDATRTEEDFLAEVTRVAVAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVERRLRALGYLLEEEEVKLMFEQFKALCEKQRLVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPEGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVIAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.37 kDa
Sequence
MNTTISNQTPHIRIFDTTLRDGEQSPGCSMTPQQKLVMARALDALGVDIIETGFPASSHSDREAVAMMGRELRRPTLAVLSRCLQADIETSARALETVANPRLHVFLSTSPLHREHKLRMSREQVLESVHRHVTLARGYIDDVEFSAEDATRTEEDFLAEVTRVAVAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVERRLRALGYLLEEEEVKLMFEQFKALCEKQRLVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPEGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVIAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.354 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVRTIAQQMKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRIVEAAINAGATTINIPDTVGYTTPYQFGGIITDLYQRVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRENMLGVHTNINHQEIYRTSQLVSKLCNMPIPANKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPQSIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEHYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSANGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEIEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pseudotuberculosis serotype IB (strain PB1/+)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pestis
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pestis bv. Antiqua (strain Angola)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.764 kDa
Sequence
MAPVNKSDKDRVIIFDTTLRDGEQCPGATMTFEEKLEVAELLDDMGVDVIEAGFPITSEGDFQAVSEIARRSKNAVIAGLSRAHPADIDRCAEAVKFAKRGRVHTVIATSPLHMRVKLNKTPEQVIETSVAMVARARNQIDDVEWSAEDGTRSEMDYLCRIVEAVIKAGATTVNIPDTVGYTVPEEYTHFMKTLIERVPNSDKAVFSVHCHNDLGMAVANSLAGVVGGARQVECTINGIGERAGNAALEEIVMAINVRNDKFPYWNKIDTTQLTRASKVVSAATSFPVQYNKAIVGRNAFAHESGIHQDGVLKDASTYEIMRPEMVGLKQSSLVLGKHSGRHAFVHKLEEMGYKLGPNQLEDAFTRMKALADRKKDIYDEDIEALVDEEMAASHDRIKLTSLTVIAGTHGPQRATMKLDVDGQIKIEEAEGNGPVDAVFNCIKRLVPHEAKLELYQVHAVTEGTDAQAEVSVRLSHDGRSMTARAADPDTLVASAKAYLGALNKIVMKRQRDTVTTAAAS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.33 kDa
Sequence
MTSANKSDKDRVVIFDTTLRDGEQCPGATMTFEEKLEVAEMLDDMGIDIIEAGFPIASVGDFEAVAEIAKNAKNAVIAGLARAIPGDIARAGEAVRHARRGRIHTFVSTSPIHLAHQMRKSEAEVLEIITATVTQARNLVEDVEWSAMDATRTPIDYLCKCVETAIAAGATTVNLPDTVGYAVPDEYRRMFRTIRERVPNADKAIFSVHCHDDLGLAVANSLAGVEGGARQVESTINGIGERAGNAALEEVVMAIKTRGDVMPYWCNVESTMLTRASKLVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMLKNAQTYEIMTPESVGVKQTSLVMGKHSGRHAFQHKLEELGYKLAENQLQDAFVRFKALADRKKDIYDEDIVALVDEEMAASHDRIKLTSLTVIAGTHGPQRATMKLTVDGQTRIEEAEGNGPVDAVFNCIKRLVPHEAKLDLYQVHAVTHGTDAQAEVSVRLSQDGRAMTSKAADPDTLVASAKAYLGALNKIVMKHQRDVPSAAAAS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pestis (strain Pestoides F)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.375 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDIMEVGFPVSSPGDFESVRTIAQQVKNSRVCALARCVDKDIDVAAEALRIAEAFRIHVFLATSTLHIESKLKRSFDDVLAMAVHSVKRARNYTDDVEFSCEDAGRTPIDNLCRVVEAAITAGATTINIPDTVGYTTPYQFGGIITDLYERVPNIDKAIISVHCHDDLGMSVANSITAVQAGARQVEGTINGLGERAGNCSLEEVIMAIKVRHEMLGVHTNINHQEIYRTSQLVSKICNMPIPGNKAIVGSNAFAHSSGIHQDGVLKNRENYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYQDKDYNLDSLYDAFLKLADKKGQVFDYDLEALAFINKQQEEPEYYRLDYFSVQSGSSVMATASVKLVCGEEIKSEAATGNGPVDAVYQAINRITDYPIELVKYQLSAKGQGKDALGQVDIVVDHKGRRFHGVGLATDIVESSAKALVHVLNNIWRAHQVEKEKQRLQQNNQEMV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Streptococcus gallolyticus (strain UCN34)
Length
520 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.573 kDa
Sequence
MRKVEFLDTTLRDGEQTPGVNFSIKEKVAIAKQLEKWGIASIEAGFPAASPDSFEAVRQISAAMTTTAVSGLARSVKSDIDACYEALKDAKYPQCHVFIATSPIHREYKLKKTKEEILDIIKEHVTYARSKFDVVEFSPEDATRTELDYLLQVVQTAVDAGATYINIPDTVGFTTPEEYGNIFKYLIENTKSDREIIFSPHCHDDLGMATANTLAAIKNGAGRVEGTVNGIGERAGNVALEEIAVALNIREDYYQATSDIVLNETVNTSELISRFSGISIPKNKAVVGGNAFSHESGIHQDGVLKNPLTYEIITPELVGVKHNSLPLGKLSGRHAFVEKLKELELAFEESEIATLFGKFKKLADKKHEITDADIRALVAGTEIENPEGFHFGDLKLTSNADDTVTAEVLMVNADGEEVEVIANGKGSVEAIYNAVDKFFNQTVRLLSYTMDAVTDGIDSQARVSVSIENVDTGTIFNASGIDFDVLKAGAIAYVNANAFVQKENAGEIGKAVSFRDVPTN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Proteus mirabilis (strain HI4320)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.217 kDa
Sequence
MSNNVIIFDTTLRDGEQALQASLSVKEKLQIAYALERLGVDIIEAGFPVSSPGDFESVQTIAREIKNSRICALARCVDNDIDVAAESLNIAEAFRIHVFLATSALHAEHKLKKSFDDIIEMGTRSIKRARRYTDDVEFSCEDAGRTHIDNLCRIVESAINAGATTINIPDTVGYTTPYQFGGIITNLFERVPNIDKAVISVHCHDDLGMAVANSITAVQAGARQVEGTINGLGERAGNCALEEVIMAIKVREQMMNVQTRINHKEIYRTSQLVSQLCNTPIHANKSIVGSNAFAHSSGIHQDGVLKNRETYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYRETDYNLDSLYAAFLRLADKKGQVFDYDLEALAFMGQQQQEPDEFVMNYFNTQSGSSTVATASVSISRKNEEITEAATGNGPVDAVYQAISRATGYPLKLVTYQLTAKGEGRDALGQVDIVVEYQGRKFHGMGLETDIVGSSANAMMHVINSIWRSEQVEIEKRKHHTTQEAV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.539 kDa
Sequence
MSAEMIKIFDTTLRDGEQSPGASMNTEEKIRIAKQLERLGVDVIEAGFAAASPGDFDAISKIASAVSESTICSLARAVEKDIKAAADSLAPAKLKRIHTFIATSPIHMEYKLRMTPSEVIKRAVEAIAYAKSFMEDVEFSCEDAGRSDVGFLKEILAAVIEAGAGTLNIPDTVGYRLPHEMGAIIKELHEFVGNRAILSVHCHNDLGLAVANSLYCIQSGARQVECTVNGLGERAGNAALEEIVMAIKTRRDIFGGLDTRINTKEIYASSQLVANITGIRPQPNKAIVGKNAFAHESGIHQDGVLKHKETYEIMHASDIGLGEQESIVLGKHSGRHAFKDKIKALGFEVSYEELNAAFDRFKALCDQKKEIYDEDIRAILAEETSHIPKVYELVGIQLSDCSMGRPYAAITLKKEGSEEIVDAAIGNGSVDALFKTIDRISQIKGELKDYKVEAVTQGKDALAKVVVKVEFEENKPAIIGHGLHIDTMLATAKAYVGALNSYLSMRELMGKKKCEEERI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xylella fastidiosa (strain M23)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.792 kDa
Sequence
MNTSISSQPPCIRIFDTTLRDGEQSPGCSMPAQQKLVMARALDALGVDIIETGFPASSQSDYEAMTLIARELRRPTLAVLSRCLQADIETSARALESATKPRLHVFLSTSPLHREHKLRMSKEQVLESVHKHVSLSRTLIDDVEFSAEDATRTEEDFLIEVTRVAIAAGATTINLPDTVGFSTPEEIRNMFTRVIANVEGANKVIFSAHCHDDLGLAVANSLAAIEGGARQIECTINGIGERAGNCALEELTMVLKVRNAFYNIDTSIHTSRIVSTSQLLQRLVGMPVQRNKAVVGANAFAHESGIHQHGMLRHRGTYEIMRPQEVGWVCSHMVLGRHSGRAAVEQRLRALGYLLEEEDLKLVFEEFKQLCEKQRLVTDVDLQVLMQDTTVQHGYRLASMTISDVGNRANALVELSDPQGQRVAETAQGNGPVDALFGALAAATGVKLELDSYQVHSVGIGADARGEANLSVRHNDTQYEGTGTSKDIIEASALAWLEVANRLLRNPENMQNKQNTALA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xylella fastidiosa (strain 9a5c)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.859 kDa
Sequence
MNTSISSQPPRIRIFDTTLRDGEQSPGCSMPAQQKLVMARALDALGVDIIETGFPASSQSDYEAMTLIARELRRPTLAVLSRCLQADIETSARALESATKPRLHVFLSTSPLHREHKLRMSKEQVLESVHKHVSLSRTLIDDVEFSAEDATRTEEDFLIEVTRVAIAAGATTINLPDTVGFSTPEEIRNMFTRIIANVEGANKVIFSAHCHDDLGLAVANSLAAIEGGARQIECTINGIGERAGNCALEELTMVLKVRNAFYNIDTSIHTSRIVSTSQLLQRLVGMPVQRNKAVVGANAFAHESGIHQHGMLRHRGTYEIMRPQEVGWVCSHMVLGRHSGRAAVEQRLRALGYLLEEEDLKLVFEEFKQLCEKQRLVTDVDLQVLMQDTTVQHGYRLASMTISDIGNRANALVELSDPQGQRVAETAQGNGPVDALFGALAAATGVKLELDSYQVHSVGIGADARGEANLSVRHNDTQYEGTGTSKDIIEASALAWLDVANRLLRNPENMQNKQNTALA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.792 kDa
Sequence
MNTSISSQPPCIRIFDTTLRDGEQSPGCSMPAQQKLVMARALDALGVDIIETGFPASSQSDYEAMTLIARELRRPTLAVLSRCLQADIETSARALESATKPRLHVFLSTSPLHREHKLRMSKEQVLESVHKHVSLSRTLIDDVEFSAEDATRTEEDFLIEVTRVAIAAGATTINLPDTVGFSTPEEIRNMFTRVIANVEGANKVIFSAHCHDDLGLAVANSLAAIEGGARQIECTINGIGERAGNCALEELTMVLKVRNAFYNIDTSIHTSRIVSTSQLLQRLVGMPVQRNKAVVGANAFAHESGIHQHGMLRHRGTYEIMRPQEVGWVCSHMVLGRHSGRAAVEQRLRALGYLLEEEDLKLVFEEFKQLCEKQRLVTDVDLQVLMQDTTVQHGYRLASMTISDVGNRANALVELSDPQGQRVAETAQGNGPVDALFGALAAATGVKLELDSYQVHSVGIGADARGEANLSVRHNDTQYEGTGTSKDIIEASALAWLEVANRLLRNPENMQNKQNTALA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Proteus mirabilis (strain HI4320)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.217 kDa
Sequence
MSNNVIIFDTTLRDGEQALQASLSVKEKLQIAYALERLGVDIIEAGFPVSSPGDFESVQTIAREIKNSRICALARCVDNDIDVAAESLNIAEAFRIHVFLATSALHAEHKLKKSFDDIIEMGTRSIKRARRYTDDVEFSCEDAGRTHIDNLCRIVESAINAGATTINIPDTVGYTTPYQFGGIITNLFERVPNIDKAVISVHCHDDLGMAVANSITAVQAGARQVEGTINGLGERAGNCALEEVIMAIKVREQMMNVQTRINHKEIYRTSQLVSQLCNTPIHANKSIVGSNAFAHSSGIHQDGVLKNRETYEIMTPESIGLKEVQLNLTSRSGRAAVKHRMEEMGYRETDYNLDSLYAAFLRLADKKGQVFDYDLEALAFMGQQQQEPDEFVMNYFNTQSGSSTVATASVSISRKNEEITEAATGNGPVDAVYQAISRATGYPLKLVTYQLTAKGEGRDALGQVDIVVEYQGRKFHGMGLETDIVGSSANAMMHVINSIWRSEQVEIEKRKHHTTQEAV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.539 kDa
Sequence
MSAEMIKIFDTTLRDGEQSPGASMNTEEKIRIAKQLERLGVDVIEAGFAAASPGDFDAISKIASAVSESTICSLARAVEKDIKAAADSLAPAKLKRIHTFIATSPIHMEYKLRMTPSEVIKRAVEAIAYAKSFMEDVEFSCEDAGRSDVGFLKEILAAVIEAGAGTLNIPDTVGYRLPHEMGAIIKELHEFVGNRAILSVHCHNDLGLAVANSLYCIQSGARQVECTVNGLGERAGNAALEEIVMAIKTRRDIFGGLDTRINTKEIYASSQLVANITGIRPQPNKAIVGKNAFAHESGIHQDGVLKHKETYEIMHASDIGLGEQESIVLGKHSGRHAFKDKIKALGFEVSYEELNAAFDRFKALCDQKKEIYDEDIRAILAEETSHIPKVYELVGIQLSDCSMGRPYAAITLKKEGSEEIVDAAIGNGSVDALFKTIDRISQIKGELKDYKVEAVTQGKDALAKVVVKVEFEENKPAIIGHGLHIDTMLATAKAYVGALNSYLSMRELMGKKKCEEERI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xylella fastidiosa (strain M23)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.792 kDa
Sequence
MNTSISSQPPCIRIFDTTLRDGEQSPGCSMPAQQKLVMARALDALGVDIIETGFPASSQSDYEAMTLIARELRRPTLAVLSRCLQADIETSARALESATKPRLHVFLSTSPLHREHKLRMSKEQVLESVHKHVSLSRTLIDDVEFSAEDATRTEEDFLIEVTRVAIAAGATTINLPDTVGFSTPEEIRNMFTRVIANVEGANKVIFSAHCHDDLGLAVANSLAAIEGGARQIECTINGIGERAGNCALEELTMVLKVRNAFYNIDTSIHTSRIVSTSQLLQRLVGMPVQRNKAVVGANAFAHESGIHQHGMLRHRGTYEIMRPQEVGWVCSHMVLGRHSGRAAVEQRLRALGYLLEEEDLKLVFEEFKQLCEKQRLVTDVDLQVLMQDTTVQHGYRLASMTISDVGNRANALVELSDPQGQRVAETAQGNGPVDALFGALAAATGVKLELDSYQVHSVGIGADARGEANLSVRHNDTQYEGTGTSKDIIEASALAWLEVANRLLRNPENMQNKQNTALA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xylella fastidiosa (strain 9a5c)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.859 kDa
Sequence
MNTSISSQPPRIRIFDTTLRDGEQSPGCSMPAQQKLVMARALDALGVDIIETGFPASSQSDYEAMTLIARELRRPTLAVLSRCLQADIETSARALESATKPRLHVFLSTSPLHREHKLRMSKEQVLESVHKHVSLSRTLIDDVEFSAEDATRTEEDFLIEVTRVAIAAGATTINLPDTVGFSTPEEIRNMFTRIIANVEGANKVIFSAHCHDDLGLAVANSLAAIEGGARQIECTINGIGERAGNCALEELTMVLKVRNAFYNIDTSIHTSRIVSTSQLLQRLVGMPVQRNKAVVGANAFAHESGIHQHGMLRHRGTYEIMRPQEVGWVCSHMVLGRHSGRAAVEQRLRALGYLLEEEDLKLVFEEFKQLCEKQRLVTDVDLQVLMQDTTVQHGYRLASMTISDIGNRANALVELSDPQGQRVAETAQGNGPVDALFGALAAATGVKLELDSYQVHSVGIGADARGEANLSVRHNDTQYEGTGTSKDIIEASALAWLDVANRLLRNPENMQNKQNTALA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.792 kDa
Sequence
MNTSISSQPPCIRIFDTTLRDGEQSPGCSMPAQQKLVMARALDALGVDIIETGFPASSQSDYEAMTLIARELRRPTLAVLSRCLQADIETSARALESATKPRLHVFLSTSPLHREHKLRMSKEQVLESVHKHVSLSRTLIDDVEFSAEDATRTEEDFLIEVTRVAIAAGATTINLPDTVGFSTPEEIRNMFTRVIANVEGANKVIFSAHCHDDLGLAVANSLAAIEGGARQIECTINGIGERAGNCALEELTMVLKVRNAFYNIDTSIHTSRIVSTSQLLQRLVGMPVQRNKAVVGANAFAHESGIHQHGMLRHRGTYEIMRPQEVGWVCSHMVLGRHSGRAAVEQRLRALGYLLEEEDLKLVFEEFKQLCEKQRLVTDVDLQVLMQDTTVQHGYRLASMTISDVGNRANALVELSDPQGQRVAETAQGNGPVDALFGALAAATGVKLELDSYQVHSVGIGADARGEANLSVRHNDTQYEGTGTSKDIIEASALAWLEVANRLLRNPENMQNKQNTALA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Blochmannia floridanus
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
58.332 kDa
Sequence
MHQQVIIFDTTLRDGEQSLQTSLSVKEKLQIAFALEKLGVDVMEVGFPISSPGDFESVHTIAQNIQNSCVCGLARCLEKDIDIAAEALKSAKKFRIHIFLPTSAIHIQSKLRKNFDQIIDMTTHSIRYARKYTDDVEFSCEDAGRTSIDNLCRIVEIAIKSGARTINIPDTVGYTIPNQFSEIIYSLYKKVPIIDQAIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEIIMAIKIRHDLLHVYTNIHHHEIYQTSQVVSQLCNMPIPANKAIVGSNAFSHSSGIHQDGVLKNKKNYEIMNPKNIGLKKVQLNLTSRSGRAAVKYHMEKMGYQEHDYNIDELYKVFLKLADQKGRVFNYELEALAFTKYSQEYLEYFALESFHIHSTSSALSNAIINLYCGKEKKIHSCSTTGRGPIDAAYKALTLISKLPIKLEKYQLHSKKYEYNILGQVNIIVSYQGRHFHGIGSNIDIIKASIIAMIQALNNIWQTKQITINHKNTQHIKK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.592 kDa
Sequence
MKSKVVIFDTTLRDGEQALQASLSVKEKLQIALSLEKCGIDILEIGFPVSSPGDFKSVQTISKNIKNSRICSLARCIEKDIDAAGEAMSSSDSFRIHIFLATSTLHMESKLKKNFNEIIDMAVFSVKKALRYTDDIEFSCEDATRTTMDNLCRIVETLIKSGVKTINIPDTVGYTVPNELSCIIKNLFERVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEIIMAIKVREDILSVSTNINYKEIYRTSKIVSQICNMPIPSNKAIVGSNAFAHSSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMDEMGYNNSDYNIDELYTAFLKLADKKGQVFDYDLEALAFINKQQDEWEYFSLKFFSVQSISNSLSTASVKLLCGKKTYTESSTTSNGPVDAIYQALNRIACFPIILQKFQLVAKGKGKDALGQVDILVEHKKRKFHGVGLATDIIEASAQAMINVLNNIWKAKQVNKKLKILKDFKKK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.216 kDa
Sequence
MTPANKSDKDRVVIFDTTLRDGEQCPGATMTFEEKIEVAEMLDGMGVDIIEAGFPIASVGDFEAVAEIARNARNAVIAGLARAIPGDIARAGEAVRHARRGRIHTFVSTSPIHLAHQMRKSEAEVLEIITATVKQARNLVEDVEWSAMDATRTPIDYLCKCVEAAIAAGATTINLPDTVGYAVPDEYRRMFKTIRERVPSADKAIFSVHCHDDLGLAVANSLAGVEGGARQVESTINGIGERAGNAALEEVVMAIKTRADVMPYWCNVESTMLTRASKMVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMLKNAQTYEIMTPESVGVKQTSLVMGKHSGRHAFQHKLEELGYKLAENQLQDAFVRFKALADRKKDIYDEDIIALVDEEMAATHDRIKLSSLTVIAGTHGPQRATMKLTVSGQTRIEEAEGNGPVDAVFNCIKRLVPHEAKLELYQVHAVTQGTDAQAEVSVRLSQDGRAMTSKAADPDTLVASAKAYLGALNKIVMKHQRDVPAAAAS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.157 kDa
Sequence
MTSPSTSDKDRVVIFDTTLRDGEQCPGATMTHEEKLEVAEMLDTMGVDIIEAGFPIASVGDFEAVAEIAKRANNAVIAGLARAIPADIVRAGEAVRHAKRGRIHTFVSTSPIHLAHQMRKSEEDVLGIITATVAQARNLVDDVEWSAMDSTRTPIDYLCRCVETAIAAGATTINLPDTVGYAVPEEYRRMFKVIRERVPNADKAVFSVHCHDDLGLAVANSLAGVEGGARQIECTINGIGERAGNAALEEVVMAIKTRGDVMPYWCNVESTTLTRASKVVSAATSFPVQYNKAIVGRNAFAHESGIHQDGVLKNAQTYEIMTPESVGVKQTSLVMGKHSGRHAFQHKLRELGYELADNQLQDAFVRFKALADRKKDIYDEDIEALVDQELAQTHDRLRLVSLTVIAGTHGPQRATMKVEVDGKVRIDEAEGNGPVDAVFNAVKTLVPHEAKLELYQVHAVTAGTDAQAEVSVRLSQDGRSVTARSSDPDTLVASAKAYLSALNKIISRQQREAPVAAAS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Psychromonas ingrahamii (strain 37)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.774 kDa
Sequence
MSDQVIIFDTTLRDGEQALSASLTVKEKLQIAFALERLGVDVMEVGFPISSPGDFESVKTIAREIKNSRVCGLSRALPKDIDAAWNALKGADAFRIHTFISTSTIHVENKLKRTFDAVLEMGINAVKHARNYTDDVEFSCEDAGRTPIDNLCRIVEEAIKAGATTINIPDTVGYTYPSEFGGIIKTLFNRVPNIDQAIISVHCHDDLGMSVANSITAVENGARQIECTMNGLGERAGNCSLEEVAMILQTRKDKLGFTTNVNPMEISRTSQLVSQLCNMPIQANKAIVGANAFSHSSGIHQDGVLKSQNTYEIMTPESVGISTNKLNLTSRSGRHVIQHRMQELGYRDTDYDLEQLYASFVELADKKGQVFDYDLEALMFFNKVDSDPQHYRLESINVQSGSGLVATATIVMSIGEDKKVVEAATGNGPIDAAYQCLMRISGLDINMDDYHINAKGAGKDALGQVDIVATYNGQKFHGLGLSTDIIESSTKAMVHVMNHIHLAKAVAIEKEQLIHIDQV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Length
519 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.545 kDa
Sequence
MSNQVKIFDTTLRDGEQALAASLSMKEKLQIALALERLGVDIIEAGFPVSSPGDFRSVRSIAQEVKNATVCGLSRALEKDIDACGEALSVADNFRIHTFIATSDIHVANKLRKSQDEVVEMAVNAIKHAGRYTDDIEFSCEDAGRTPIDYLCRMVESAINAGATTVNIPDTVGYTTPTEFGGIIQNLFNRVPNIDKATISVHCHNDLGLAVANSLVAVEYGARQIECTINGIGERAGNCSLEEIAMILQTRQAMLGLNTNIRSHEISRTSKLVSQLCNMPVQSNKAIVGANAFSHSSGIHQDGVLKAQNTYEIMTPESVGINKNNLNLTSRSGRHVIKHRLEELGYKAEDYDLDTLYASFVKLADKKGQVFDYDLEALLFFDKQKPADEHYKLLYLQASSGKEIIPSATVKLQVGEEEIIESCTGNGPVDAAYKAIIKVLGHEQLEIVDFKLDSKGEGADALAQVSVIVEYNGRRFNGIGLATDIVESGVKALIHVLNNTHLADQIDHQKKQQTQTAGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Length
518 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.86 kDa
Sequence
MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAQQLEKLGVNIMEAGFPASSPGDFNAVKEIARTIKNCSVTGLARSVKGDIDSAWEALKDGAEPRLHIFIATSDIHLKYKLKKTREQVLEQAVAMVKYAKERFPIVQWSAEDACRTDLPFLAEIVSEVIAAGADVVNLPDTVGYLAPAEYGNIFRYIKENARNADKVQLSAHCHDDLGMAVANSLAAIENGADQVESVINGIGERAGNASLEEIAVALHIRKDFYQAESTIQLNEIKRTSDLVSKLTGMAVPRNKAVVGDNAFAHESGIHQDGFLKEKTTYEIISPELVGVKTDALVLGKHSGRHAFKDKLQNLGFQLGEEEINKFFNIFKELTGKKKEFTDEDLISLILEEKTADRKIGYDFISLQVHYGTSQVPTATVSLKDQETDQVIQEAATGAGSVEAVYNTLKRCMDKEVQLLDYRIQSNRKGQDAFAQVYVRVMIDGKESGGRGVAQDVLEASAKAYLNAVNRYLVLKTNTEGLSKQAAVGS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus subtilis (strain 168)
Length
518 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.912 kDa
Sequence
MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEAGFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATSDIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDAGASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIENGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLTGMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEFLSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDYRIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMSGLKNHTAVGS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42)
Length
518 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.951 kDa
Sequence
MRKINVFDTTLRDGEQSPGVNLNSREKLAIAKQLERLGVDIIEAGFPASSRGDFLAVQEIARTIKNCSVTGLARSVKGDIDAAWEALKDGVSPRIHIFIATSDIHLKHKLKMTREEVKEKAVEMVKYAKERFPIVQWSAEDACRTELPFLAEIVEEVIDAGASVINLPDTVGYLTPDEYGNIFKYMKEHVPNISRVKLSAHCHDDLGMAVANSLSAIENGADQIECAINGIGERAGNAALEEIAVALHVRNDAHQADSSLNLHELKRTSDLVSKLTGMAVPRNKAIVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLNTLGFQFDSDEINKYFTMFKELTEKKKEITDDDLISLILEEKVTDKKIGYEFLSLQVHYGTSQVPTATVSLKNQENEQLMQEAATGAGSVEAVYNTLGRCIDKNIELTDYRIQSNRKGEDALAQVFVRVTVNGKESSGRGIAQDVLEASAKAYLNAVNRQLVLDCNLDGLKRQTAVGS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
518 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
56.62 kDa
Sequence
MIIYREENEIIKKALENLNIPDRVYIFDTTLRDGEQTPGVSLTPEEKIDIAIKLDDLGVDVIEAGFPVSSLGEQEAIKKICSLNLDAEICGLARAVKKDIDVAIDCGVDRIHTFIATSPLHRKYKLKKSKEEIIDIAVDAIEYIKEHGIRVEFSAEDATRTEIDYLIEVYKKAVDAGADIINVPDTVGVMIPRAMYYLINELKKEIKVPISVHCHNDFGLAVANSLAAVEAGAEQVHCTINGLGERGGNAALEEVVMSLMSIYGVKTNIKTQKLYEISQLVSKYTEIKVQPNKAIVGENAFAHESGIHAHGVLAHALTYEPIPPELVGQKRKIILGKHTGTHAIEAKLKELGIEVGKDINKDQFDEIVKRIKALGDKGKRVTDRDVEAIVEDVVGKLAKKDRVVELEQIAVMTGNRVIPTASVALKIEEEIKKSSAIGVGPVDAAVKAIQKAIGEKIKLKEYHINAITGGTDALAEVIVTLEGYGREITTKAASEDIVRASVEAVIDGINKILAKREK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pasteurella multocida (strain Pm70)
Length
518 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.52 kDa
Sequence
MADNIIIFDTTLRDGEQALKASLTVKEKLQIAFALERLGVDVMEVGFPISSAGDFESVQTIARHIKHSRVCALSRAVDKDIDAAAEALKVAEAFRIHTFIATSALHVEAKLRRTFEDVVDMAINAVKRARNYTDDVEFSCEDAGRTGVDNICRIVEAAIKAGATTVNIPDTVGYCLPYQYGDIIANVMNRVPNIDKAIISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTALEEVVMAIKTRQDMFNGLDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGMVKHKNTYEIMSPESIGLKKEKLNLTARSGRAAVKNHMSEMGYQESDYDLDKLYEAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLTLDVITSQCISHLPASAFVQVELDGKKMSQVSNGGNGPVDAVYNAILAITGLEMKMLNYNLTAKGEGAEALGQVDIVVEHEGRRFHGVGLATDIVESSARALIHAINAIYRSQKVADLKLHKIAGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pasteurella multocida (strain Pm70)
Length
518 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.52 kDa
Sequence
MADNIIIFDTTLRDGEQALKASLTVKEKLQIAFALERLGVDVMEVGFPISSAGDFESVQTIARHIKHSRVCALSRAVDKDIDAAAEALKVAEAFRIHTFIATSALHVEAKLRRTFEDVVDMAINAVKRARNYTDDVEFSCEDAGRTGVDNICRIVEAAIKAGATTVNIPDTVGYCLPYQYGDIIANVMNRVPNIDKAIISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTALEEVVMAIKTRQDMFNGLDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGMVKHKNTYEIMSPESIGLKKEKLNLTARSGRAAVKNHMSEMGYQESDYDLDKLYEAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLTLDVITSQCISHLPASAFVQVELDGKKMSQVSNGGNGPVDAVYNAILAITGLEMKMLNYNLTAKGEGAEALGQVDIVVEHEGRRFHGVGLATDIVESSARALIHAINAIYRSQKVADLKLHKIAGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Length
518 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.221 kDa
Sequence
MNSQVIIFDTTLRDGEQALQASLSVKQKLQIALSLENAGIDIIEVGFPISSPGDFKSVQTISKNIKNSRICSLARCLNKDIDTAAEAMSSSNTFRIHIFLATSTLHMESKLKKNFDQIIDMAISSVKRALRYTDDVEFSCEDASRTTMDNLCRIVEQLIKAGVKTINIPDTVGYTVPNELSTIIHNLFKRVPNIDQSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVREDILGVSTNIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAHSSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKYYMTQMGYKECDYNIDELYTSFLKLADKKGQVFDYDLEALAFINMQQEESEYFSLSFFSVQSISNGLSTASVKLLCGKKVSIESATTSNGPIDAIYQALNRITNFPITLQKYQLVAKGKGRDALGQVDILVEYKKRKFHGVGLATDIIESSAQAMVNVLNNIWKANQVNEKLKTLKKVNN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Rhopalosiphum padi
Length
518 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.336 kDa
Sequence
MNSQVIIFDTTLRDGEQALQASLSVKQKLQIALSLENTGIDIIEVGFPISSPGDFKSVQTISKNIKNSRICSLARCLDKDIDAAAEAMHSSNAFRIHIFLATSILHMESKLKKNFDQIIDMAITSVKRALRYTDDVEFSCEDASRTTMDNLCRIVEKLINAGVKTINIPDTVGYTVPNELSSIIHNLFQRVPNIDKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIIAIKVREDVLGVSTKIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAHSSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMTEMGYRECDYKIDELYASFLKLADKKGQVFDYDLEALAFINQQQEELEHFSLSFFSVQSISNGLSTASVKLLCGKKTFIESATTSNGPIDAIYQALNRITHFPIILQKYQLIAKGKGKDALGQVDILVEHKKRKFHGMGLATDIIESSAQAMVNVLNNIWKANQVNEKLKKLKKINN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Geobacillus sp. (strain Y412MC10)
Length
518 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.944 kDa
Sequence
MERNIIVLDTTLRDGEQVPGAKLNVQQKIEFAQQLKRLNVDIIEAGFPASSAGDFQAVQEIARTVGDSVSITALARAVKGDIDAVYESIKLAQNPLIHIVLGTSNIHVEKKFNRSKDAVLQMGVDAVKYAKTLLPQVQYSTEDASRSDFEYLWKTIEAVVKAGATMINVPDTVGYAVPDEFGELIRKINERLKNLNDQVILSVHCHNDLGLATANTLSAVRNGAEKVECTINGLGERAGNTSLEEVVMGLKVRENHFKASTNVRLKELIRTSRLLTHLTGLDVQVNKAITGENAFAHSSGIHQDGLLKDKQVYEIMSPEEVGADSMELILTARSGRHAFKNAVEKLGFETGEGDDFEALFEKFLLLADAKKEVYDHDVFYLVTQHRTHEEVSSHLYELDSFQVVTNDMYPTATVKLKKGSETFRDSMVGDGPIDALYSAIKALVGLDVQLKDYKINSLSRGKEAIGRVNIRIEYQGKIYSGRAMDTDIIKASALAFLNGINAVLLDAGHDSQAPVSAR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Length
517 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.336 kDa
Sequence
MTQANRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGADIIEAGFAAASPGDFEAVNAIAKTITKSTVCSLSRAIERDIRQAGKAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQVIEAAVKAVKIAREYTDDVEFSCEDALRSQIDFLAEICGAVIEAGATTINIPDTVGYSIPYKTEEFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESGIHQDGVLKHRETYEIMSAESVGWSANRLSLGKLSGRNAFKTKLADLGIELESEEALNAAFARFKELADKKREIFDEDLHALVSDEMGNMNAESYKFISQKISTETGEEPRADIVFGIKGEEKRASATGSGPVDAIFKAIESVAQSGATLQIYSVNAVTQGTESQGETSVRLARGNRVVNGQGADTDILAATAKAYLSALSKLEFSAAKPKAQGSGTI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Length
517 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.381 kDa
Sequence
MTQANRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGVDIIEAGFAAASPGDFEAVNAIAKTITKSTVCSLSRAIERDIRQAGEAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQVIEAAVKAVKIAREYTDDVEFSCEDALRSEIDFLAEICGAVIEAGATTINIPDTVGYSIPYKTEEFFRELIVKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESGIHQDGVLKHRETYEIMSAESVGWATNRLSLGKLSGRNAFKTKLADLGIELESEEALNAAFARFKELADKKREIFDEDLHALVSDEMGSMNAESYKFISQKISTETGEEPRADIVFSIKGEEKRASATGSGPVDAIFKAIESVAQSGAALQIYSVNAVTQGTESQGETSVRLARGNRVVNGQGADTDVLVATAKAYLSALSKLEFGSAKPKAQGSGTI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Arcobacter butzleri (strain RM4018)
Length
517 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.95 kDa
Sequence
MDKNKIIVFDTTLRDGEQSPGCSMNTEEKIKVALQLEKLGVDVIEAGFAAASPGDFDAVSRIAQIIKNSSICSLARAVDNDIKQAGLAVQSAAKSRIHTFIATSPIHMQYKLKMSGDEVIKRAIRAVEYAKTFVDDVEFSLEDAGRSEIPFMKEVMDAVIGAGAKTINLPDTVGYRLPTELGAMVKELSAYAGDRAIISVHNHNDLGLATANTLAAVLNGARQIEVTINGLGERAGNSALEEAVMAIKTRKDAFGDLYTTINTPEIYATSRLVATITGVEPQQNKAIVGKNAFAHESGIHQDGVLKHQETYEIMKPEDVGVIKDSTLILGKHSGRAAFRDKIVQLGFDKVSDDELNAAFERFKVLADNKKEISDEDVRMLITDEALNHDKTYDLIGLQISDCTNGVPTAAVAIKYKDEIIKDAAIGDGTMDAIFKTIDRITGFSGELKDYKVISVTEGKDALAKVTTRVSFDETSPAFVGHGLSIDTMLATAKAYIGALNSYLSQKKRLSKSSEHQV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Arcobacter butzleri (strain RM4018)
Length
517 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.95 kDa
Sequence
MDKNKIIVFDTTLRDGEQSPGCSMNTEEKIKVALQLEKLGVDVIEAGFAAASPGDFDAVSRIAQIIKNSSICSLARAVDNDIKQAGLAVQSAAKSRIHTFIATSPIHMQYKLKMSGDEVIKRAIRAVEYAKTFVDDVEFSLEDAGRSEIPFMKEVMDAVIGAGAKTINLPDTVGYRLPTELGAMVKELSAYAGDRAIISVHNHNDLGLATANTLAAVLNGARQIEVTINGLGERAGNSALEEAVMAIKTRKDAFGDLYTTINTPEIYATSRLVATITGVEPQQNKAIVGKNAFAHESGIHQDGVLKHQETYEIMKPEDVGVIKDSTLILGKHSGRAAFRDKIVQLGFDKVSDDELNAAFERFKVLADNKKEISDEDVRMLITDEALNHDKTYDLIGLQISDCTNGVPTAAVAIKYKDEIIKDAAIGDGTMDAIFKTIDRITGFSGELKDYKVISVTEGKDALAKVTTRVSFDETSPAFVGHGLSIDTMLATAKAYIGALNSYLSQKKRLSKSSEHQV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Blochmannia pennsylvanicus (strain BPEN)
Length
517 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.5 kDa
Sequence
MSQQVIIFDTTLRDGEQALQASLNVKEKLQIAFALERLGVDIMEVGFPISSPGDFESVHTIAQKIKNSLVCALARCIDNDIDVAAEALKVAKNFRIHIFLPTSNVHIQSKLKKNFDQIIDMTVHAIRYARKYTDDIEFSCEDAGRTNIDNLCRIVEIAIQSGASTINIPDTVGYTTPYQFGQIITSLYNRVPIIDKAIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEIIMAIKVREDLLNVHTNVRCQEIYRASQVVSQLCNIPIPANKAIVGSNAFSHSAGIHQDGILKNRKNYEIMTPETIGLKDVKLNLTSRSGRAAVKHHMKTMGYQESDYDMDKLYDVFLELADKKGQVFDYDLEALAFINNQQEQSEFFRLKCFHVDSSSSEVAHASVKLYCGNNTYTHSSSGNGPIDAIYEALTHISKLSINLERYQLNAKGHGRNALGQVDIVVSYEGRNFHGVGLDTDVIKSSVKAMIHVLNNIWRAKQVIIQRKYIKKNNN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Neisseria meningitidis serogroup B (strain MC58)
Length
517 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.397 kDa
Sequence
MTQTNRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGVDIIEAGFAAASPGDFEAVNAIAKTITKSTVCSLSRAIERDIRQAGEAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQVIEAAVKAVKIAREYTDDVEFSCEDALRSEIDFLAEICGAVIEAGATTINIPDTVGYSIPYKTEEFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESGIHQDGVLKHRETYEIMSAESVGWATNRLSLGKLSGRNAFKTKLADLGIELESEEALNAAFARFKELADKKREIFDEDLHALVSDEMGSMNAESYKFISQKISTETGEEPRADIVFSIKGEEKRASATGSGPVDAIFKAIESVAQSGAALQIYSVNAVTQGTESQGETSVRLARGNRVVNGQGADTDVLVATAKAYLSALSKLEFSAAKPKAQGSGTI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Length
517 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.425 kDa
Sequence
MTQANRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGVDIIEAGFAAASPGDFEAVNAIAKTITKSTVCSLSRAIERDIRQAGEAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQVIEAAVKAVKIAREYTDDVEFSCEDALRSEIDFLAEICGAVIEAGATTINIPDTVGYSIPYKTEEFFRELIVKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGNASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESGIHQDGVLKHRETYEIMSAESVGWATNRLSLGKLSGRNAFKTKLADLGIELESEEALNAAFARFKELADKKREIFDEDLHALVSDEMGSMNAESYKFISQKISTETGEEPRADIVFSIKGEEKRASATGSGPVDAIFKAIESVAQSGATLQIYSVNAVTQGTESQGETSVRLARGNRVVNGQGADTDVLVATAKAYLSALSKLEFSAAKPKAQGSGTI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Haemophilus somnus (strain 129Pt)
Length
517 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.398 kDa
Sequence
MQNNIIIFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSAGDFESVQTIARHIKNSRVCALSRAMDKDIDIAADALKVAEAFRIHTFIATSALHVEAKLRRTFDDVVEMAIQAVKRARRYTDDVEFSCEDAGRTGVDNICRIVEAAIKAGATTVNIPDTVGFCLPTEYGNIINQVMNRVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTALEEVVMAIKTRQDIFKGLDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGMVKNKNTYEIMSPETIGLKKEKLNLTARSGRAAVKSHMDAMGYQQNDYDLDKLYAAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLSLDVITSQTISNLPASAFVQVELDGKKISQVSNGGNGPVDAVYNAILAITDMDITMLHYNLTAKGEGAEALGQVDIVVEHKGRRFHGVGLATDIVESSARALIHAINAIYRANKVADLKSHKISQ

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Histophilus somni (strain 2336)
Length
517 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.367 kDa
Sequence
MQNNIIIFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSAGDFESVQTIARHIKNSRVCALSRAVDKDIDIAADALKVAEAFRIHTFIATSALHVEAKLRRTFDDVVEMAIQAVKRARRYTDDVEFSCEDAGRTGVDNICRIVEAAIKAGATTVNIPDTVGFCLPTEYGNIIDQVMNRVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTALEEVVMAIKTRQDIFKGLDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGMVKNKNTYEIMSPETIGLKKEKLNLTARSGRAAVKSHMDAMGYQQNDYDLDKLYAAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLSLDVITSQTISNLPASAFVQVELDGKKISQVSNGGNGPVDAVYNAILAITDMDITMLHYNLTAKGEGAEALGQVDIVVEHKGRRFHGVGLATDIVESSARALIHAINAIYRANKVADLKSHKISQ

Gene
leuA
Protein
Probable 2-isopropylmalate synthase
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)
Length
516 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
55.799 kDa
Sequence
MYTLKEGIDFYIEPMQSKKVTVFDTTLRDGEQTPGVSLTSTQKLEIAHQLDKLGVDIIEAGFPISSEGDKESVKSISNAGLDTTVCGLARVLKKDIDACFESDVGLVHTFVPTSDVQRIYTIKKSREEVIQLAVEAVQYIKDHGLKCMFSAMDATRTDPEYLIEVFKAVQEAGCDIINVPDTVGVMVPSAMYRQIKGIAAEITIPIDVHCHNDFGLAVANSLMAVEAGASQVQVTINGIGERAGNADLSQTVMSLTSIYGAKTNIRTEYLVETSKMVENYTGIRLPPNTPVVGQNAFSHESGIHSQGVLEKSDTFEPGIMTPEMVGHRRRIVLGKHTGKHAVKQSLESAGIKTNDNQLDEIVIRIKEIANKGKQITDADLYAVASAVLGKASSEEELIKLKEVSVMTGNILTPTAVVKADIEGKEIIAARTGVGPVDAALHAVRDILGESNHFRLQDFRIDAITGGADALADVYIGLENEKGRIVTARSANPDIVMASVEALVNAMNLLYKKENKS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Uncultured termite group 1 bacterium phylotype Rs-D17
Length
516 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.219 kDa
Sequence
MEKDIIIFFDTTLRDGEQSPGASMNLKEKLLVANQLAALGVDVIEAGFPISSQGDFEAVKTISQQIKTSSIAGLCRASEKDITTCWNAVKYAKKPRIHIFLATSDLHIEKKLQKTRAQILDMAVKTIKYGKSLCKDVEFSAEDAGRSDMDFLCKVVEAVIDAGATTVNIPDTVGYTTPIEFGNKIAEIKRRVPNVNKAIISVHCHNDLGLAVANSLSAIENGARQIECTINGIGERAGNTSLEEIAMTLKVRHHYYNVKHTLKTNELYNTSKLVSRLTGILVQVNKAVVGANAFAHESGIHQDGVLKARETYEIMSPADVGVPESLLVLGKHSGRHAFFKRIKDLGYKLDEKTLEHLFEKFKILADKKKTVFDDDIIALIEEDTSSGKETFILNYLSATSGTGTIPTATVKISKSEGNKKTKSITLQAAACGSGPVDATYKAIDKIINMDIKLTDFSLRSVSSGEDALGEVVLKAEYKGTIYSGKGTSTDIIEASAKAYIQAINKAKLFYDNKKGK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Length
516 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.164 kDa
Sequence
MNNQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDIIEAGFPVSSPGDFESVQTIAKNIKNSRVCALSRAVAKDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSYDDVVAMAVKAVKHARQYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAIQAGARQVEGTINGIGERAGNCALEEIAMIIKTRQELLGVTTGIKHDEISRTSKLVSQLCNMPIQSNKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDSMGYNENEYNLDALYEDFLKLADRKGQVFDYDLEALMHFSNLREEDDFYKLNYLSVQSGSVMATTSIKLLCGGEEKCEAAVGNGPVDALYQCIYRITGYEIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGVSTDIVEASGQALLHVINSIHRADQIAQIKQKKSVATV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Vibrio cholerae serotype O1 (strain M66-2)
Length
516 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.164 kDa
Sequence
MNNQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDIIEAGFPVSSPGDFESVQTIAKNIKNSRVCALSRAVAKDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSYDDVVAMAVKAVKHARQYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAIQAGARQVEGTINGIGERAGNCALEEIAMIIKTRQELLGVTTGIKHDEISRTSKLVSQLCNMPIQSNKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDSMGYNENEYNLDALYEDFLKLADRKGQVFDYDLEALMHFSNLREEDDFYKLNYLSVQSGSVMATTSIKLLCGGEEKCEAAVGNGPVDALYQCIYRITGYEIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGVSTDIVEASGQALLHVINSIHRADQIAQIKQKKSVATV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)
Length
516 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.125 kDa
Sequence
MDEVGTQERIRIFDTTLRDGEQAPGISLDPLEKLEIAEQLARLGVDIIEAGFPVASQGDFDAVRQIARQVHGPVICGLSRTHVADIERCYEAVRDAEHHRIHVFISTSPSHLEHMLRMSEDQVVEAVRRAIARARELVDDVEFSPQDATRTPLPFLYRVLQVAVDEGASTLNIPDTVGYGIPWDFARMVESVRREVAGSYVISCHCHNDLGLATANSLAAVAAGARQVECCINGIGERAGNAALEEVVMGLAIRSDVIGDVTTGIDTRELARTSRLVSRLTGYPVQYNKAVVGRNAFAHESGIHQHGVLTDRSTYEVIDAASVGQEAAQIVLGKHSGRHAFQEALARMGIALEGDALNATFQRFKELADRKVELSEADLEAIVAEELGTTLADRFELVSFRVEAGTGREAVASATVLVDGTPVEASASGNGMVDALGRVLAEATALEARLTGFSVTSVTGGADALGSVAVTVDVGGHEVSGRGVSTDIVEASARALLNALNRAARVREKASNRETP

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)
Length
516 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.125 kDa
Sequence
MDEVGTQERIRIFDTTLRDGEQAPGISLDPLEKLEIAEQLARLGVDIIEAGFPVASQGDFDAVRQIARQVHGPVICGLSRTHVADIERCYEAVRDAEHHRIHVFISTSPSHLEHMLRMSEDQVVEAVRRAIARARELVDDVEFSPQDATRTPLPFLYRVLQVAVDEGASTLNIPDTVGYGIPWDFARMVESVRREVAGSYVISCHCHNDLGLATANSLAAVAAGARQVECCINGIGERAGNAALEEVVMGLAIRSDVIGDVTTGIDTRELARTSRLVSRLTGYPVQYNKAVVGRNAFAHESGIHQHGVLTDRSTYEVIDAASVGQEAAQIVLGKHSGRHAFQEALARMGIALEGDALNATFQRFKELADRKVELSEADLEAIVAEELGTTLADRFELVSFRVEAGTGREAVASATVLVDGTPVEASASGNGMVDALGRVLAEATALEARLTGFSVTSVTGGADALGSVAVTVDVGGHEVSGRGVSTDIVEASARALLNALNRAARVREKASNRETP

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Cinara cedri (strain Cc)
Length
516 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.461 kDa
Sequence
MNEKIIIFDTTLRDGEQALLTSLTSNEKIQIALALERLGVDVIEVGFPVSSPGDFKSVQMLSKIIKNSKICSLARCLPNDITIAADAMQFSKNFRIHLFLGTSDLHVSSKLKKNFNEIIEMAVASVKQAKKFTNDIEFSCEDAGRTTLQNLYCIIEAVIKAGATTVNIPDTVGYTTPTQFKKIITMLFNHVKNIHQAIISVHCHNDLGMAVANSISAVEAGVRQIEGTMNGLGERAGNAALEEVIMTLNVHKNSLKVSTDINIKEIHRTSKIVSQFCNTPIPLNKAIIGKNVFSHSSGIHQDGVLKNRKNYEIIDPNSIGFTDYCSLNLTSRSGRAAVKHHMKKMGYENSDYNLNELYIDFLKLADKKGRIFDYDLEALAFFKKQQNTEEYYKLEYFDVQSKLSGLSTAYIVLICGSQTNIQKATTYNGPVDAIYQALNKATLYSIVLKKFHLEANGEGKDALGKVNIIVQYKLRNFHGVGLATDIIEASAQAMVNVLNYIWKSQQVNKELERLQK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Diuraphis noxia
Length
516 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.259 kDa
Sequence
MSSKVIIFDTTLRDGEQALQASLSVKEKLQIALSLEKCGIDIIEVGFPISSPGDFKSVQTISKKIKNSRICSLARCVEKDIEVAGDAMSSSDFFRIHIFLATSTLHMESKLRKNFDEIIDMAVSSVKKALRYTDDVEFSCEDASRTTMDNLCRIVEKLIKAGVKTINIPDTVGYTIPNELSNIIKNLFERVPNIHKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEIIMAIKVREDILGVSTNIVHKEIYRTSQIISQICNMPIPANKAIVGSNAFAHSSGIHQDGVLKNRKNYEIMEPNTIGVKEVKLNLTSRSGRAAVKYYMDKMGYKDDDYDIDELYSAFLKLADKKGQVFDYDLEALAIFSKKQENAEYFYLKFFSVQSISNGLSTASVKLKCGKKVYTESSTTSNGPVDATYQALNKIINFPITLQKFQLVAKGKGKDALGQVDILVKYENRQFHGIGLATDIIESSAQAMINVLNNIWKSQQVNKKLKNLKKY

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)
Length
516 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.873 kDa
Sequence
MADKLIIFDTTLRDGEQSPGASMTKEEKIRIAKQLERMKVDVIEAGFAASSNGDFDAIHTIAGMIKDSTICSLARANDKDIQRAADALKPADHFRIHTFIATSPLHMEKKLRMSPEQVLEQAKLAVRFARKFTNDVEFSPEDGSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAVFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVRTRKDYFGLDLGIDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGISLDSESELNLAFQRFKELADRKAEIFDEDIIAIVTEESAEAQEKEHYKFVSLSQHSETGERPHARIVFSVEGKEVVGEANGNGPVDATLNAIETEVGSGSELLLYSVNAITTGTQAQGEVTVRLSKAGRIVNGVGTDPDIVAASAKAYISALNRLYAGADKLNPQRADI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Syntrophus aciditrophicus (strain SB)
Length
516 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.596 kDa
Sequence
MDSPEKRIYIFDTTLRDGEQSPGSSMNPAEKLRIARQLEKMGVDIIEAGFPIASEGDFLSVQQIAQEIRGAQIAGLARANNADIDRAWEAIRDAANPRIHTFISSSDIHLKYQLRKSREQVLKEAVAAVERARSYTPNVEFSPMDATRTDRGYLCEMVEAVIAAGASTVNIPDTVGYAIPQEFGELIAYLRANVPNISQAIISVHCHNDLGLAVANSLSAILNGARQVECTINGIGERAGNTAMEEVVMALRTRKDLFGFYTGIKTESIYQSSRLLTQITGVAVQPNKAIVGANAFAHESGIHQDGLIKEKITYEIMTPQSVGISDSHIVLGKHSGRHAVSEHLKKLGFNLSDTELNKIFVRFKELADAKKNVFDEDLEAIVYEELYRVEDKYKLIYLNVVSGNVAIPTATMQMEVDREIVQDAGFGVGPVDATFDAIRKITGTNYDLLRYVVNAISGGTDAQGEVTVQLKFNGRSVVGHGADLDVIVASARAYINALNRLEFLKRDAGKIKSEYE

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.186 kDa
Sequence
MRKISVFDTTLRDGEQSAGVNLNFEEKMEIAKQLERLGVDIIEAGFPASSQGDFQSVKAIAETVKGSSVTGLARSVQKDIDAAWEALKSAEEPRIHLFIATSPIHMEHKLRMTPEQVIEKAVESVKYAASRFKHVQWSAEDASRSDFPFLAQIIEAVIQAGATVINLPDTVGYTTPQEIKRMFQYMKQNVPSIDKVSLSTHNHDDLGMAVANSLAAIQGGADQVECTINGIGERAGNASLEEIAVALNIRKDHYETETGLILKEIKRTSSLVSKLTGMVVPNNKAVVGANAFAHESGIHQDGVLKNKQTYEIITPEMVGVSSNSMVLGKHSGRHAFKTKVQELGFTGTDEQLNNIFKAFKDLADKKKEITEDDLFALMTEQTVGGETNHYELQTLQVNYGSNLTNTATITMKLPSGEVAEEAATGSGSVEAIYNTLERLLDAPVKLLDYRIQSITGGRDALADVYVQMDYQGVVSSGRGTAHDVLEASAKAYLNAVNRTINRKKYAEVYGSKVEV

Gene
leuA
Protein
Probable 2-isopropylmalate synthase
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
55.693 kDa
Sequence
MYTLKEGIDFYIEPMQNKKVTVFDTTLRDGEQTPGVSLTSSQKLEISRQLDKLGVDIIEAGFPISSEGDKESVKSISNAGLETTVCGLARVLKKDIDACFESDVGLVHTFVPTSDVQRIYTIKKSQEEVIQLAVEAVQYIKDHGLKCMFSAMDATRTDPAYLIEVFKAVQEAGCDIINVPDTVGVMVPSAMYRQIKDIAAEITIPIDVHCHNDFGLAVANSLMAVEAGASQVQVTINGIGERAGNADLAQTVMSLASIYGIKTNIRTEYLVETSKMIENYTGIRLPPNTPVVGQNAFSHESGIHSQGVLEKSDTFEPGIMTPEMVGHRRRIVLGKHTGKHAVKQSLESAGVKTSENQLDEIVLRIKEIANKGKQITDADLYAVASAVLGKASSEEELIKLKEVSVMTGNILTPTAVVKADIEGKEIIAAKTGVGPVDAALKAVRDILGESNHFRLQEFRIDAITGGADALADVYIGLENEKGRIVTARSANPDIVMASVEALINAMNLLYKKEKS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.141 kDa
Sequence
MNDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPISSPGDFESVQTIAKHIKNSRVCALSRAVAKDIDAAAEALKVADQFRIHTFLATSTIHVQDKLRRSYDDVLEMAVNAVKHARNYTDDVEFSCEDAGRTPIDNLCRMVEAAIDAGASTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQIEGTINGIGERAGNCSLEEIAMIIKTRQELLGVSTGIKHEEIHRTSKLVSQLCNMPIQSNKAVVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDSMGYKEDEYNLDALYADFLKLADRKGQVFDYDLEALMHFSNLREEDDFYKLNYLSVQSGSVMATTSIKMQCGDAEMCEAAVGNGPVDALYQCIYRVTGYEIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGVSTDIVEASGQALLHVINSIHRADTIAEMKQKKIATV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Vibrio tasmaniensis (strain LGP32)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.388 kDa
Sequence
MNDQVIIFDTTLRDGEQALAASLTVKEKLQIAYALERLGVDVIEAGFPISSPGDFESVQTIAKHIKDSRICALSRAVAKDIDAAAEALKVADQFRIHTFISTSTVHVQDKLRRSYDDVVEMAVKAVKHARNYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGAKTINIPDTVGYTVPNEFGGIIKTLFDRVPNIDQAIISVHCHDDLGMSVANSIAAVQAGARQIEGTINGIGERAGNCSLEEIAMIIKTRQELLGVHTGLDHKEIHRTSKLVSQLCHMPIQDNKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNKALNLTSRSGRAAVKSHMDAMGYKDNEYNLDSLYEDFLKLADRKGQVFDYDLEALMHFANLRDEDDFYKLNYLSVQSGSVMSTTSIKLQCGDEEKCEAAVGNGPVDALYQCIYRLTGYEIALDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGVSTDIVEASGQALLHVINSIQRADTIAEMKQQKFATV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Vibrio vulnificus (strain CMCP6)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.419 kDa
Sequence
MNDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPVSSPGDFESVQTIARNIKNSRVCALSRAVEKDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSYDDVVEMGVRAVKHARKYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAGNCSLEEIAMIIKTRQELLGVRTGINHEEIHRTSKLVSQLCNMPIQANKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDAMGYKEDEYNLDALYQDFLKLADRKGQVFDYDLEALMHFSNLREEDDYYKLNYLSVQSGSVMATTSIKLLCGDEEKCEAAVGNGPVDALYQCIYRLTGYDIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGISTDIVEASGQALLHVINSIHRADEIAEMKQKKIATV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aliivibrio fischeri (strain ATCC 700601 / ES114)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.231 kDa
Sequence
MSDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPVSSPGDFESVKTIAQHIKNSRICGLSRAVAKDIDAAAEALKVAEAFRIHTFISTSTVHVQDKLRRSYDDVVEMGVKAVKHARKYTDDVEFSCEDAGRTPIDNLCRMVEAAIDAGANTINIPDTVGYTVPGEFGGIVQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAGNCSLEEIAMILKTRSEYLGVHTNLKHDEIHRTSKLVSQLCNMPIQSNKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDEMGYKEDEYNLDTLYADFVKLADRKGQVFDYDLEALMHFANLRDEDDFYKLNYLSVQSGSVMATTSIKLLCGDEEKCEAAVGNGPVDALYQCIYKLTGYDIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGLATDIIEASGQALLHVINSIHRADQIAEIKQKKVETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aliivibrio fischeri (strain MJ11)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.258 kDa
Sequence
MSDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPVSSPGDFESVRTIAQHIKNSRICGLSRAVAKDIDAAAEALKVAEAFRIHTFISTSTVHVQDKLRRSYDDVVEMGVKAVKHARKYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGANTINIPDTVGYTVPGEFGGIVQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAGNCSLEEIAMILKTRSEYLGVHTNLKHDEIHRTSKLVSQLCNMPIQSNKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDEMGYKEDEYNLDTLYADFVKLADRKGQVFDYDLEALMHFANLRDEDDFYKLNYLSVQSGSVMATTSIKLLCGDEEKCEAAVGNGPVDALYQCIYKLTGYDIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGLATDIIEASGQALLHVINSIHRADQIAEIKQKKVETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aliivibrio salmonicida (strain LFI1238)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.211 kDa
Sequence
MSDQVIIFDTTLRDGEQALSASLTVKEKLQIAFALERLGVDVIEAGFPISSPGDFESVRTIAKHIKNSRICALSRAVTKDIDVAADALKVAEAFRIHTFISTSTVHVQDKLRRSYDDVVEMGVKAVQRARKYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGANTINIPDTVGYTIPGEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAGNCSLEEIAMILQTRSEYLGVHTSLKNDEIHRTSKLVSQLCNMPIQSNKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNKALNLTSRSGRAAVKSHMDSMGYKAEEYNLDTLYADFVKLADRKGQVFDYDLEALMHFANLRDEDDFYKLNYLSVQSGSVMATTSIKLLCGDEEKCEAAVGNGPVDALYQCIYKLTGYEIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGLATDIIEASGQALLHVINSIHRADQIAEIKQNKITTV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.488 kDa
Sequence
MSDKVIIFDTTLRDGEQSPGASMTKDEKVRIARQLERLKVDVIEAGFAASSEGDFQAISAVAAAVKDSIVCSLARANDKDITRAADALQAANAKRIHAFLATSPLHMAVKLRMSPEEVLEQAKRSIRFARNLASDIEFSAEDGYRSEMDFLCRVVEAVINEGASTINIPDTVGYATPELYGDFIKTLRTRVPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAGNTALEEIVMALRTRKDYFDMVCGIDASQIVPASKLVSQITGFVVQPNKAVVGANAFAHTSGIHQDGILKNRDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGITVEAEADLNEAFTRFKALADQKSEIFDEDIIAIMSDSAAAEEGEHYHFISLSQHSETGERPKSRVIFRMGDKEVSSEAEGNGPVDASLNAIEEIAKSGAEQLLYSVNAITSGTQSQGEVTVRLSKGGRIVNGVGTDPDIIAASAKAYLSALNKLHDPSQAKLNAQMAP

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Polynucleobacter necessarius subsp. necessarius (strain STIR1)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.456 kDa
Sequence
MSDKVIIFDTTLRDGEQSPGASMTKDEKVRIARQLERLKVDVIEAGFAASSEGDFQAISAVAAAVKDSIVCSLARANDKDITRAADALQATNAKRIHAFLATSPLHMAVKLRMSPEEVLEQAKRSIRFACNLASDIEFSAEDGYRSEMDFLCRVVEAVINEGASTINIPDTVGYATPELYGEFIKTLRTRVPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAGNTALEEIVMSLRTRKDYFDMVCGIDATQIVPASKLVSQITGFIVQPNKAVVGANAFAHTSGIHQDGILKNRDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGITVEAEADLNVAFTRFKALADQKSEIFDEDIIAIMSDSAAAEEGEHYKFISLSQHSETGERPKSRVTFRMGDREISSEAEGNGPVDASLNAIEGIAKSGAEQLLYSVNAITSGTQSQGEVTVRLAKGGRIVNGVGTDPDIIAASAKAYLSALNKLHDPSQAKLNAQMTP

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Vibrio vulnificus (strain YJ016)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.419 kDa
Sequence
MNDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPVSSPGDFESVQTIARNIKNSRVCALSRAVEKDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSYDDVVEMGVRAVKHARKYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAGNCSLEEIAMIIKTRQELLGVRTGINHEEIHRTSKLVSQLCNMPIQANKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDAMGYKEDEYNLDALYQDFLKLADRKGQVFDYDLEALMHFSNLREEDDYYKLNYLSVQSGSVMATTSIKLLCGDEEKCEAAVGNGPVDALYQCIYRLTGYDIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGISTDIVEASGQALLHVINSIHRADEIAEMKQKKIATV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aliivibrio fischeri (strain ATCC 700601 / ES114)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.231 kDa
Sequence
MSDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPVSSPGDFESVKTIAQHIKNSRICGLSRAVAKDIDAAAEALKVAEAFRIHTFISTSTVHVQDKLRRSYDDVVEMGVKAVKHARKYTDDVEFSCEDAGRTPIDNLCRMVEAAIDAGANTINIPDTVGYTVPGEFGGIVQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAGNCSLEEIAMILKTRSEYLGVHTNLKHDEIHRTSKLVSQLCNMPIQSNKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDEMGYKEDEYNLDTLYADFVKLADRKGQVFDYDLEALMHFANLRDEDDFYKLNYLSVQSGSVMATTSIKLLCGDEEKCEAAVGNGPVDALYQCIYKLTGYDIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGLATDIIEASGQALLHVINSIHRADQIAEIKQKKVETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aliivibrio fischeri (strain MJ11)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.258 kDa
Sequence
MSDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPVSSPGDFESVRTIAQHIKNSRICGLSRAVAKDIDAAAEALKVAEAFRIHTFISTSTVHVQDKLRRSYDDVVEMGVKAVKHARKYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGANTINIPDTVGYTVPGEFGGIVQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAGNCSLEEIAMILKTRSEYLGVHTNLKHDEIHRTSKLVSQLCNMPIQSNKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDEMGYKEDEYNLDTLYADFVKLADRKGQVFDYDLEALMHFANLRDEDDFYKLNYLSVQSGSVMATTSIKLLCGDEEKCEAAVGNGPVDALYQCIYKLTGYDIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGLATDIIEASGQALLHVINSIHRADQIAEIKQKKVETV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aliivibrio salmonicida (strain LFI1238)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.211 kDa
Sequence
MSDQVIIFDTTLRDGEQALSASLTVKEKLQIAFALERLGVDVIEAGFPISSPGDFESVRTIAKHIKNSRICALSRAVTKDIDVAADALKVAEAFRIHTFISTSTVHVQDKLRRSYDDVVEMGVKAVQRARKYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGANTINIPDTVGYTIPGEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAGNCSLEEIAMILQTRSEYLGVHTSLKNDEIHRTSKLVSQLCNMPIQSNKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNKALNLTSRSGRAAVKSHMDSMGYKAEEYNLDTLYADFVKLADRKGQVFDYDLEALMHFANLRDEDDFYKLNYLSVQSGSVMATTSIKLLCGDEEKCEAAVGNGPVDALYQCIYKLTGYEIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGLATDIIEASGQALLHVINSIHRADQIAEIKQNKITTV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.488 kDa
Sequence
MSDKVIIFDTTLRDGEQSPGASMTKDEKVRIARQLERLKVDVIEAGFAASSEGDFQAISAVAAAVKDSIVCSLARANDKDITRAADALQAANAKRIHAFLATSPLHMAVKLRMSPEEVLEQAKRSIRFARNLASDIEFSAEDGYRSEMDFLCRVVEAVINEGASTINIPDTVGYATPELYGDFIKTLRTRVPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAGNTALEEIVMALRTRKDYFDMVCGIDASQIVPASKLVSQITGFVVQPNKAVVGANAFAHTSGIHQDGILKNRDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGITVEAEADLNEAFTRFKALADQKSEIFDEDIIAIMSDSAAAEEGEHYHFISLSQHSETGERPKSRVIFRMGDKEVSSEAEGNGPVDASLNAIEEIAKSGAEQLLYSVNAITSGTQSQGEVTVRLSKGGRIVNGVGTDPDIIAASAKAYLSALNKLHDPSQAKLNAQMAP

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Polynucleobacter necessarius subsp. necessarius (strain STIR1)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.456 kDa
Sequence
MSDKVIIFDTTLRDGEQSPGASMTKDEKVRIARQLERLKVDVIEAGFAASSEGDFQAISAVAAAVKDSIVCSLARANDKDITRAADALQATNAKRIHAFLATSPLHMAVKLRMSPEEVLEQAKRSIRFACNLASDIEFSAEDGYRSEMDFLCRVVEAVINEGASTINIPDTVGYATPELYGEFIKTLRTRVPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAGNTALEEIVMSLRTRKDYFDMVCGIDATQIVPASKLVSQITGFIVQPNKAVVGANAFAHTSGIHQDGILKNRDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGITVEAEADLNVAFTRFKALADQKSEIFDEDIIAIMSDSAAAEEGEHYKFISLSQHSETGERPKSRVTFRMGDREISSEAEGNGPVDASLNAIEGIAKSGAEQLLYSVNAITSGTQSQGEVTVRLAKGGRIVNGVGTDPDIIAASAKAYLSALNKLHDPSQAKLNAQMTP

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Vibrio vulnificus (strain YJ016)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.419 kDa
Sequence
MNDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPVSSPGDFESVQTIARNIKNSRVCALSRAVEKDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSYDDVVEMGVRAVKHARKYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYTVPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAVQAGARQVEGTINGIGERAGNCSLEEIAMIIKTRQELLGVRTGINHEEIHRTSKLVSQLCNMPIQANKAIVGANAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDAMGYKEDEYNLDALYQDFLKLADRKGQVFDYDLEALMHFSNLREEDDYYKLNYLSVQSGSVMATTSIKLLCGDEEKCEAAVGNGPVDALYQCIYRLTGYDIVLDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGISTDIVEASGQALLHVINSIHRADEIAEMKQKKIATV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Pemphigus spyrothecae
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.966 kDa
Sequence
MGEKIIIFDTTLRDGEQALQASLTTKKKLKIALSLEEMGIDIIEAGFPISSPGDFKSVETISKEFKSSIICSLARCVEKDIDIAAEAMRFAKHFRIHIFLGTSPLHVKSKLKKNFSEIIDMAIFAIKKAKRYTBDIEFSCEDAGRTPINQLCYIVENVIKAGATTINIPDTVGFTIPYEFNQIIKSLYNKVPNIDKVILSVHCHNGLGMATANSITAIQAGARQIEXTMNGMGERAGNTALEEVIIAIKLKKNNLNLHTNIKHKKIYKTRKLISEICNTVIPSNKAIIGTNAFSHSSGIHQDGILKNRKNYEIITPKSIGLKPIKLNLTSRSGRAAVKYHMTEMGYDEKLYKLDILYNSFLKLADRKGQVFDYELESLAFIDQKENTTEHFRLKKFNVQHQSTGITISSIELYCGKKIKTANTRTKKGLVNSIYITLNKITNLPIYLKNIQLITQKKPINIIISIKVQIEYKKRQFYGIGNSKDIVESTAQAMIHILNNIWKANKVNILLKNIKT

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.56 kDa
Sequence
MSRIKIFDTTLRDGEQSPGVNLNKAEKLEIAKQLEKYGVDRMEAGFPASSKGDFESVKQIAETIKSSSVIALARAVKSDIDIAYEALKGAEKPAIHIFLATSPIHMTYKLKKSPEQVIETAVNMVTYAKERFDEIEWSAEDATRSDWNFLAQIIEKVIEAGATVINLPDTVGYTTPEEYGKLFRFIKETVPNINQVALSCHCHNDLGMAVANSIAAVENGATQVEGTINGIGERAGNAALEEVAVALKIRSDYYPFETGLILKETKRTSDLVAKLTGMYVQANKAVIGRNAFSHESGIHQDGVLKNTETYEIITPEMVGVSSNTLFLGKHSGRHAFKDKLKEFGVELSEEELKTAFEQFKLLTDQKKEVTDDDLYTILMDIKTDSTVVDKYKLIQFGVSYDTAATPKANVILESPNGSLIEATQQGNGSVEALYKTINYLIAENITLVDYQINSVGGGKDALAESHVQIIINGETINGRGSAQDVLQASAVAFIQAVNRYYVQKKANLTRLVYES

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Geobacillus kaustophilus (strain HTA426)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.805 kDa
Sequence
MRKIKFFDTTLRDGEQSAGVNLNLQEKLEIARQLERLRVDIIEAGFPASSKGDFEAVKQIAETVRTCSVTGLSRSVRSDIDAAWEALKGGAEPRLHLFIATSPIHMVHKLRMTPEQVIEAAVEAVKYAKRFFPIVQWSAEDACRSELPFLAKIVAEVIKAGASVINIPDTVGYITPKEYGEIFLYLQNNVPNIENVSLSAHCHDDLGMAVVNSLSAIEHGATQVECTINGIGERAGNAALEEIAVALHIRKDYYQVETRLNLQEIKRTSNLVSKLTGVVVPPNKAVVGKNAFAHESGIHQDGVLKEKTTYEIISPELVGVPSNSMVLGKHSGRHALRNRVEELGYTLSDEEINQLFVRFKELADKKKDITDDDLIALIFEEKFDHFKDFYQLSSIQVQYGTNQIPTAVVVLKDGKGNEIQEAATGAGSVEALYNTLERCFQTPVTLLDYRIESVGGGRDALAQVFVKVRAHDIETSGRGTAQDVLEASAKAYINAINRVFMIEAMRGENEKVATP

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Geobacillus stearothermophilus
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.033 kDa
Sequence
MRNIKFFDTTLRDGEQSAGVNLNLQEKLEIARQLERLRVDIIEAGFPASSKGDFEAVKQIAETVRTCSVTGLSRSVRSDIDAAWEALKGGAEPRLHLFIATSPIHMVHKLRMTPEQVIEAAVEAVKYAKRFFPIVQWSAEDACRSELPFLAKIVAEVIKAGASVINIPDTVGYITPKEYGEIFLYLQNNVQNIENVSLSAHCHDDLGMAVVNSLSAIEHGATQVECTINGIGERAGNAALEEIAVALHIRKDYYQVETRLNLQEIKRTSNLVSKLTGVVVPPNKAVVGKNAFAHESGIHQDGVLKEKTTYEIISPELVGVPSNSMVLGKNSGRHALRYRVEELGYTLSDEEINQLFVRFKELADKKKDITDDDLIALIFEEKFDHFKDFYQLSSIQVQYGTNQIPTAVVVLKYGKGNEIQEAATGSGSVYALYNTLERCFQTEVTLLDYRIESVGGGRDALAQVFVKVRVRDVETSGRGTAQDVLEASAKAYINAMNRVFMIEAMRAENEKVATS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Geobacillus sp. (strain WCH70)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.758 kDa
Sequence
MRKINIFDTTLRDGEQSAGINLNLQEKLEIARQLERLGVDIIEAGFPASSKGDFQAVKQIAETIKTCSVTGLARSVQSDIDAAWEALKGGAEPRLHLFIATSPIHMKYKLQMTPEQVIETAVESVKYAKRYFPIVQWSAEDACRSELPFLAKIITEVIKAGATVINIPDTVGYITPKEYGNIFTFLSNNVPNIEKVSLSAHCHDDLGMAVANSLAAIEHGATQIEGTINGIGERAGNAALEEIAVALYIRKDYYQAETRLNLQEIKRTSNLVSKLTGVVIPPNKAVIGKNAFAHESGIHQDGVLKEKTTYEIISPELVGVQSNSMVLGKHSGRHALRNRVEELGYTLSDEEVNKLFVRFKELADKKKDITDDDLVALIFEEKFDHFKDFYQLSSLQVQYGTNQIPTAVVVLKDGQGNEIQEAATGAGSVEALYNTLERCFKTSVTLLDYRIESVSGGRDALAQVFVKVRVNDIETSGRGTAQDVLEASAKAYINAVNRVFMIETMRAENQKVAMQ

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Geobacillus thermodenitrificans (strain NG80-2)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.916 kDa
Sequence
MRKIKFFDTTLRDGEQSAGVNLNLQEKLEIARQLERLQVDIIEAGFPASSKGDFEAVKQIAETVRTCSVTGLSRSVRSDIDAAWEALKGGAEPRLHLFIATSPIHMVHKLRMTPEQVIEAAVEAVKYAKRFFPIVQWSAEDACRSELPFLAKIVTEVIKAGASVINIPDTVGYITPKEYGEIFLYLRNNVPNIENISLSAHCHDDLGMAVINSLSAIEHGATQVECTINGIGERAGNAALEEIAVALHIRKDYYQVETRLNLQEIKRTSNLVSKLTGMVVPPNKAVVGKNAFAHESGIHQDGVLKEKTTYEIISPELVGVSSNSMVLGKHSGRHALRNRVEELGYTLSEEEINQLFVRFKELADKKKDVTDDDLIALIFEEKFDHFKDFYQLSSIQVQYGTNQIPTAVVVLKDGKGNTIQEAATGAGSVEALYNTLERCFQTAVTLLDYRIESVGGGRDALAQVFVKVRVNDVETSGRGTAQDVLEASAKAYINAMNRMFMIEAMRAENEKVTTP

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Haemophilus influenzae (strain 86-028NP)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.085 kDa
Sequence
MTDRVIIFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSQGDFESVQTIARHIKNARVAALSRAVDKDIDAAYQALKVAEAFRIHTFIASSALHVEAKLKRSFDDVVGMAVAAVKRARNYTDDVEFSCEDAGRTGIDNICRIVEAAINAGATTVNIPDTVGFCLPNEYGNIIAQVRNRVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTSLEEVVMAMKVRQDFMGVDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGMLKNKNTYEIMSPETIGLKKEKLNLTARSGRAAVKGHMADMGYNEQDYDLDKLYDAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLVLDKLSAHSTKEYPATAFVQLKLDGEKLSTSSIGGNGPVDAVYNAILNLTGLEIKMSHYNLTAKGEGAEALGQVDIVVEHKGRKFHGVGLATDIVESSALALVHAINAIYRAHKVADIKSHKHH

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Haemophilus influenzae (strain PittEE)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.154 kDa
Sequence
MTDRVIIFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSQGDFESVQTIARHIKNARVTALSRAVDKDIDAAYEALKVAEAFRIHTFIASSALHVEAKLKRSFDDVVGMAVAAVKRARNYTDDVEFSCEDAGRTGIDNICRIVEAAINAGATTVNIPDTVGFCLPNEYGNIIAQVRNRVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTSLEEVVMAMKVRQDFMGVDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGMLKNKNTYEIMSPETIGLKKEKLNLTARSGRAAVKGHMADMGYNEQDYDLDKLYDAFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLVLDKLSAHSTKEYPATAFVQLKLDGNKLITSSIGGNGPVDAVYNAILNLTGLEIKMSHYNLTAKGEGAEALGQVDIVVEHKGRKFHGVGLATDIVESSALALVHAINAIYRAHKVADIKNHKHH

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.081 kDa
Sequence
MTDRVIIFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSQGDFESVQTIARHIKNARVAALSRAVDKDIDAAYEALKVAEAFRIHTFIASSALHVEAKLKRSFDDVVGMAVAAVKRARNYTDDVEFSCEDAGRTGIDNICRIVEAAINAGATTVNIPDTVGFCLPNEYGNIIAQVRNCVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTSLEEVVMAMKVRQDFMGVDTHINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIHQDGMLKNKNTYEILSPETIGLKKEKLNLTARSGRAAVKGHMADMGYNEQDYDLDKLYDEFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLVLDKLSAHSTKEYPATAFVQLKLDGEKLSTSSIGGNGPVDAVYNAILNLTGLEIKMSHYNLTAKGEGAEALGQVDIVVEHKGRKFHGVGLATDIVESSALALVHAINAIYRAHKVADIKNHKHH

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
57.025 kDa
Sequence
MGEVKIFDTTLRDGEQSPGVSLIPEEKLAIAKQLARMKVDVIEAGFPISSPGDFEAVQIISENIRDVEVAALARSRKKDIDRAWEALRNGGDPRIHVFIATSPIHMKYKLKLSEEQVIEKAVEAVKYASKYTSNIEFSAEDASRSQPVFLYRLFERVINAGAKVINIPDTVGYAIPEEFGKLIRDIKENVSNIDKVDISVHCHNDLGLAVANSLAAVENGANQIEVAVNGIGERAGNTALEEIIMALYTRKDFYNIGINQDTTQIARLSKLVSNLTGMTIQPNKAIVGANAFAHESGIHQDGVIKERTTYEIMDARTIGLKDNKLVLGKHSGRHAFREFIQKLGYDIDDETFEEIFIEFKKLADKKKNITHVEIEALIDNHYHTFDKVYELDYLSVNTGNKVLPTATIKLKKENNIIEKAACSGDGPVDAIFQAINEIVGIDDIKLISYHINAVTEGKDALGEVIVKTKIEDNTYTGHSAMTDITEASALAYLETINKFLTSEQTRQTTSAQEGI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia pseudomallei (strain 1106a)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.586 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKQLERMKVDVIEAGFAASSNGDFDAIQTIASQVKDSTICSLARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNIEFSPEDGSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDLGIDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFARFKDLADRKAEIFDEDIIAIVTEEESALAQEHEHYKFVSLAQRSETGERPQAKVVFAVDGDEVAGEASGNGPVDATFNAIETEVGSGAELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYIAALNKLYSNADKLNPQRA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia pseudomallei (strain 1710b)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.586 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKQLERMKVDVIEAGFAASSNGDFDAIQTIASQVKDSTICSLARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNIEFSPEDGSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDLGIDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFARFKDLADRKAEIFDEDIIAIVTEEESALAQEHEHYKFVSLAQRSETGERPQAKVVFAVDGDEVAGEASGNGPVDATFNAIETEVGSGAELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYIAALNKLYSNADKLNPQRA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia pseudomallei (strain 668)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.586 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKQLERMKVDVIEAGFAASSNGDFDAIQTIASQVKDSTICSLARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNIEFSPEDGSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDLGIDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFARFKDLADRKAEIFDEDIIAIVTEEESALAQEHEHYKFVSLAQRSETGERPQAKVVFAVDGDEVAGEASGNGPVDATFNAIETEVGSGAELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYIAALNKLYSNADKLNPQRA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia pseudomallei (strain K96243)
Length
515 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.586 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKQLERMKVDVIEAGFAASSNGDFDAIQTIASQVKDSTICSLARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNIEFSPEDGSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDLGIDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFARFKDLADRKAEIFDEDIIAIVTEEESALAQEHEHYKFVSLAQRSETGERPQAKVVFAVDGDEVAGEASGNGPVDATFNAIETEVGSGAELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYIAALNKLYSNADKLNPQRA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus clausii (strain KSM-K16)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.925 kDa
Sequence
MRKINVFDTSLRDGEQMPGIALTVKEKLEIARQLERLGVDIIEAGFPASSPGDFQAVKEIAETVKGSSITGLARAKKSDIDSAWEALKSSAEPRVHVFLATSPIHMEHKLKLTPDQVVERAVESVRYAAEKFPHVQFSAEDANRSEWPFLKRIIEAAIDAGASVINLPDTVGYRTPEEISKLFEFVTENVKNIDRAILSTHNHDDLGMGVANSLAAISAGAGQVECTINGIGERAGNAALEEIAVALQIRSDYYQAKTGLKLSELKRTSALVSRLTSMNVPGNKAVVGANAFAHESGIHQDGMLKNKETYEIITPELVGATSSLPLGKHSGRHAFKTKLNELGFSGSDEKLQTIFSAFKQLCDKKKEVTEDDLYALIADATDDQDSTAYELTALQVTYGMNHVPTATIRLKKQDDREIEEAGTGSGSVEAIYNTLAKMTGGNYSLADYRIQSVNGGEDALAEVHVRIQADDFEQSGRGVAHDVLEASAKAYLHAVNRVIARKHYAKREMAKVES

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.98 kDa
Sequence
MHDRLIIFDTTLRDGEQSPGASMTRDEKVRIARALERLKVDVIEAGFPAASPGDFEAVQAVARTIKDSRVCGLARALDRDIDRAGEALKDAQRARIHTFIATSPIHMRHKLQMSPDQVVEYAVKAVKRARQYTDDVEFSPEDAGRSEEDFLCRILEAVIDAGATTLNIPDTVGYAFPEQFGHMIGRLIERIPNSDKAVFSVHCHNDLGLAVANSLAAVLHGARQVECTINGLGERAGNAALEEIVMAVRTRKDIFPCHTDIETREIVACSKLVSSITGFPIQPNKAIVGANAFAHESGIHQDGVLKSRETYEIMSAEDVGWSTNRMVLGKHSGRNAFRTRMQELGIEFASEEELNSVFQRFKVLADKKHEIFDEDLQALITEAGAEAEDERVKLVALRVCSETGEIPHAQVTIKVDNEERTGTSSGGGAVDASLKAIESLLHTDTALTLYSVNNITSGTDAQGEVTVRLEKGGRIVNGQGADTDIVIASAKAYVNAVNKLLAPIQRTHPQVGDV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.502 kDa
Sequence
MRKINIFDTTLRDGEQSAGVNLNLHEKLEIARQLERLGVDIIEAGFPAASKGDFQAVQAIAQTVRNCSVTGLSRSVQSDIDAAWEALKDGAEPRLHVFIATSPIHMQYKLRMTPEQVVETAVESVRYAKKYFPIVQWSAEDACRSDLPFLATIVEKVIEAGANVINIPDTVGYITPKQYGDIFSFLKKNVRNIEKISLSAHCHDDLGMAVANSLAAIEAGATQIEGTINGIGERAGNAAIEEVAVALYIRKDYYQAETRLNLQEIKRTSSLVSKLTGMIVPANKAIVGKNAFAHESGIHQDGVLKEKTTYEIISPQLVGVQSNSMVLGKHSGRHAFRTRIQELGYSLTEEEVNRLFVRFKDLADKKKDITDDDLIALILDEKLDTYKNFYQLCSIQVQYGTNQIPTAVVVLKDGEGNDIQEAATGAGSVEALYNALEKALQLPVTLLDYRIESVGSGRDALAQVYVKVSLDRKEASGRGTAQDVLEASAKAYIHAVNRMFVIEKMKEEQALAAQ

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clostridium kluyveri (strain NBRC 12016)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.24 kDa
Sequence
MTKKIYIFDTTLRDGEQTPKVSLNINDKITIAKQLQKLSVDVIEAGFPKASHGDFEAVKAIAESIQGPVIVGLARASKEDIDCAWEALKGSLKPRIHIFLATSDIHMEHKLKMKPEEVLKRAADMVRYAKGLCPSIEFSPEDATRTRPEFLYKVLEAVIEAGADVVNIPDTVGYTTPVEYGAFIRGIKENVKNIEDAIISVHCHNDLGLAVANSLAAIESGAEQVECAINGLGERAGNAALEEIVMAISTRADSFNCHTDIVTEEITKTSSIVSHVTGMQVQGNKAIVGANAFAHESGIHQHGVLNCRETYEIMTPESVGLKKNFIVLGKHSGRHAFVEHLHEMGYKDLSVEKTDEIFKKFKELADKKKHISDEDIESLVKNEIFHVPEVFKLKYYQVFTGNTVVSTSTVEIECNGKKLSEASCGDGPVDATFKAIEKATGIDVTLNDYFIKAVGSGKDAMGEVTVRIEKEGKIFSAKGISTDIVEASGIAFINAVNKLYYETYSKDLQKISAN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.24 kDa
Sequence
MTKKIYIFDTTLRDGEQTPKVSLNINDKITIAKQLQKLSVDVIEAGFPKASHGDFEAVKAIAESIQGPVIVGLARASKEDIDCAWEALKGSLKPRIHIFLATSDIHMEHKLKMKPEEVLKRAADMVRYAKGLCPSIEFSPEDATRTRPEFLYKVLEAVIEAGADVVNIPDTVGYTTPVEYGAFIRGIKENVKNIEDAIISVHCHNDLGLAVANSLAAIESGAEQVECAINGLGERAGNAALEEIVMAISTRADSFNCHTDIVTEEITKTSSIVSHVTGMQVQGNKAIVGANAFAHESGIHQHGVLNCRETYEIMTPESVGLKKNFIVLGKHSGRHAFVEHLHEMGYKDLSVEKTDEIFKKFKELADKKKHISDEDIESLVKNEIFHVPEVFKLKYYQVFTGNTVVSTSTVEIECNGKKLSEASCGDGPVDATFKAIEKATGIDVTLNDYFIKAVGSGKDAMGEVTVRIEKEGKIFSAKGISTDIVEASGIAFINAVNKLYYETYSKDLQKISAN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Photobacterium profundum (strain SS9)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.201 kDa
Sequence
MKDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPISSPGDFESVQTIAKHIKNSRVCALSRAVAKDIDVAAESLKVAEAFRIHTFISTSTIHVQDKLRRSYDDVIEMAIAAVKRARNYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYTLPSEFGGIVAQLFNRVPNIDKAIISVHCHDDLGMSVANSMAAVQAGARQVEGTINGLGERAGNCSLEEIAMIIKTRSDFLGVETNIKHEEIHRTSKMVSQLCNMPIQANKAIVGANAFNHSSGIHQDGMIKNKNTYEIMTPESIGLKSQALNLTSRSGRAAVKNHMDTLGYIDGDYNLDTLYADFLKLADRKGQVFDYDLEALMYFANLRDEDDFFKLNYLSVQSGSIMATTSIKLQCGDEEKCEAAVGNGPVDALYQCIYRLTGYEIALDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGLATDIVEASGQALLHVINSIYRADQIAEIKERIATV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.502 kDa
Sequence
MRKINIFDTTLRDGEQSAGVNLNLHEKLEIARQLERLGVDIIEAGFPAASKGDFQAVQAIAQTVRNCSVTGLSRSVQSDIDAAWEALKDGAEPRLHVFIATSPIHMQYKLRMTPEQVVETAVESVRYAKKYFPIVQWSAEDACRSDLPFLATIVEKVIEAGANVINIPDTVGYITPKQYGDIFSFLKKNVRNIEKISLSAHCHDDLGMAVANSLAAIEAGATQIEGTINGIGERAGNAAIEEVAVALYIRKDYYQAETRLNLQEIKRTSSLVSKLTGMIVPANKAIVGKNAFAHESGIHQDGVLKEKTTYEIISPQLVGVQSNSMVLGKHSGRHAFRTRIQELGYSLTEEEVNRLFVRFKDLADKKKDITDDDLIALILDEKLDTYKNFYQLCSIQVQYGTNQIPTAVVVLKDGEGNDIQEAATGAGSVEALYNALEKALQLPVTLLDYRIESVGSGRDALAQVYVKVSLDRKEASGRGTAQDVLEASAKAYIHAVNRMFVIEKMKEEQALAAQ

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clostridium kluyveri (strain NBRC 12016)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.24 kDa
Sequence
MTKKIYIFDTTLRDGEQTPKVSLNINDKITIAKQLQKLSVDVIEAGFPKASHGDFEAVKAIAESIQGPVIVGLARASKEDIDCAWEALKGSLKPRIHIFLATSDIHMEHKLKMKPEEVLKRAADMVRYAKGLCPSIEFSPEDATRTRPEFLYKVLEAVIEAGADVVNIPDTVGYTTPVEYGAFIRGIKENVKNIEDAIISVHCHNDLGLAVANSLAAIESGAEQVECAINGLGERAGNAALEEIVMAISTRADSFNCHTDIVTEEITKTSSIVSHVTGMQVQGNKAIVGANAFAHESGIHQHGVLNCRETYEIMTPESVGLKKNFIVLGKHSGRHAFVEHLHEMGYKDLSVEKTDEIFKKFKELADKKKHISDEDIESLVKNEIFHVPEVFKLKYYQVFTGNTVVSTSTVEIECNGKKLSEASCGDGPVDATFKAIEKATGIDVTLNDYFIKAVGSGKDAMGEVTVRIEKEGKIFSAKGISTDIVEASGIAFINAVNKLYYETYSKDLQKISAN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.24 kDa
Sequence
MTKKIYIFDTTLRDGEQTPKVSLNINDKITIAKQLQKLSVDVIEAGFPKASHGDFEAVKAIAESIQGPVIVGLARASKEDIDCAWEALKGSLKPRIHIFLATSDIHMEHKLKMKPEEVLKRAADMVRYAKGLCPSIEFSPEDATRTRPEFLYKVLEAVIEAGADVVNIPDTVGYTTPVEYGAFIRGIKENVKNIEDAIISVHCHNDLGLAVANSLAAIESGAEQVECAINGLGERAGNAALEEIVMAISTRADSFNCHTDIVTEEITKTSSIVSHVTGMQVQGNKAIVGANAFAHESGIHQHGVLNCRETYEIMTPESVGLKKNFIVLGKHSGRHAFVEHLHEMGYKDLSVEKTDEIFKKFKELADKKKHISDEDIESLVKNEIFHVPEVFKLKYYQVFTGNTVVSTSTVEIECNGKKLSEASCGDGPVDATFKAIEKATGIDVTLNDYFIKAVGSGKDAMGEVTVRIEKEGKIFSAKGISTDIVEASGIAFINAVNKLYYETYSKDLQKISAN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Photobacterium profundum (strain SS9)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.201 kDa
Sequence
MKDQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDVIEAGFPISSPGDFESVQTIAKHIKNSRVCALSRAVAKDIDVAAESLKVAEAFRIHTFISTSTIHVQDKLRRSYDDVIEMAIAAVKRARNYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYTLPSEFGGIVAQLFNRVPNIDKAIISVHCHDDLGMSVANSMAAVQAGARQVEGTINGLGERAGNCSLEEIAMIIKTRSDFLGVETNIKHEEIHRTSKMVSQLCNMPIQANKAIVGANAFNHSSGIHQDGMIKNKNTYEIMTPESIGLKSQALNLTSRSGRAAVKNHMDTLGYIDGDYNLDTLYADFLKLADRKGQVFDYDLEALMYFANLRDEDDFFKLNYLSVQSGSIMATTSIKLQCGDEEKCEAAVGNGPVDALYQCIYRLTGYEIALDKFDLTAKGEGEDGLGQADIIANYKGRKYHGTGLATDIVEASGQALLHVINSIYRADQIAEIKERIATV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Nitratiruptor sp. (strain SB155-2)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.33 kDa
Sequence
MAEIVKIFDTTLRDGEQSPGASMNTEEKIQIAKQLEKLGVDVIEAGFAAASPGDFEAIRKISEVVQKSTVCSLARALEKDIKAAGEAIAPAKHKRIHTFIATSPIHMKYKLRMEPDEVIKRAVEAVQYAKTFVEDVEFSCEDAGRSEMSFLKEIILAVIEAGAGTINIPDTVGYRFPHEMGEMIKELHETIQDRAVISVHCHNDLGLAVANSLYSVLNGARQVECTINGLGERAGNAALEEIVMAIKTRKDIFGDIDTNINTKEIYPTSRLVAAITGIEPQPNKAIVGKNAFAHESGIHQDGVLKHQETYEIMRAEDIGLDKNAIVLGKHSGRHAFKKKIEELGFSLSEEEINKAFERFKMLADKKKEVTDDDIRMLITNEIASAPEVYKLKKLQINDCSEGVPSAAVTVEYEGKEITDAGIGDGTIDAIFKTIDRITGVQGKLNDYQVIAVSKGKDALAKVVVKVVFDENKPAVIGHGLSIDTMIASAKAYVGALNSYISMKDMLRTKRDEEI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia ambifaria (strain MC40-6)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.555 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKHLERMKVDVIEAGFAASSNGDFDAIHTIAGLVKDSTICSLARANDKDIQRAADALKPANSARIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNVEFSPEDGSRSDLDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDVGLDTTQIVPTSKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSETELNAAFMRFKDLADRKSEIFDEDIIAIVSEESALAQEQEHYKFVSLSQRSETGEQPQAKVVFALDGKEVTGEARGNGPVDATFNAIEGEVGSGSELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYIAALNKLHSKDDKLNPQRS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia cenocepacia (strain AU 1054)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.507 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKHLERMKVDVIEAGFAASSNGDFDAIHTIAGLVKDSTICSLARANDKDIQRAADALKPANSARIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNVEFSPEDGSRSDLDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDVGIDTTQIVPTSKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFMRFKDLADRKAEIFDEDIIAIVSEESALAQEQEHFKFVSLSQRSETGEQPQAKVVFAVEGKEVTGEARGNGPVDATFNAIEGEVGSGSELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYISALNKLHSKDDKLNPQRA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia cenocepacia (strain MC0-3)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.507 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKHLERMKVDVIEAGFAASSNGDFDAIHTIAGLVKDSTICSLARANDKDIQRAADALKPANSARIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNVEFSPEDGSRSDLDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDVGIDTTQIVPTSKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFMRFKDLADRKAEIFDEDIIAIVSEESALAQEQEHFKFVSLSQRSETGEQPQAKVVFAVEGKEVTGEARGNGPVDATFNAIEGEVGSGSELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYISALNKLHSKDDKLNPQRA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia cenocepacia (strain HI2424)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.507 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKHLERMKVDVIEAGFAASSNGDFDAIHTIAGLVKDSTICSLARANDKDIQRAADALKPANSARIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNVEFSPEDGSRSDLDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDVGIDTTQIVPTSKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFMRFKDLADRKAEIFDEDIIAIVSEESALAQEQEHFKFVSLSQRSETGEQPQAKVVFAVEGKEVTGEARGNGPVDATFNAIEGEVGSGSELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYISALNKLHSKDDKLNPQRA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.552 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKNLERMKVDVIEAGFAASSNGDFDAIHTIAGLVKDSTICSLARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNVEFSPEDGSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDVGIDTSQIVPTSKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFMRFKDLADRKAEIFDEDIIAIVSEESALAQEQEHFKFVSLSQRSETGEQPQAKVVFAVEGKEVTGEARGNGPVDATFNAIEGEVGSGSELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYISALNKLHSKDDKVNPQRS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.541 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKHLERMKVDVIEAGFAASSNGDFDAIHTIAGLVKDSTICSLARANDKDIQRAADALKPANSARIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNVEFSPEDGSRSDLDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDVGLDTTQIVPTSKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSETELNAAFMRFKDLADRKSDIFDEDIIAIVSEESAFAQEQEHYKFVSLSQRSETGEQPQAKVVLALDGKEVTGEARGNGPVDATFNAIEGEVGSGSELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYIAALNKLHSKDDKLNPQRS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.649 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKHLERMKVDVIEAGFAASSNGDFDAIHTIAGLIKDSTICSLARANDKDIQRAADALKPAESFRIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNVEFSPEDGSRSDMDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDVGIDTSQIVPTSKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSESELNAAFMRFKDLADRKAEIFDEDIIAIVSEESALAHEQEHFKFVSLSQHSETGEQPHAKVVFGVEGKEVTGEARGNGPVDATFNAIESEVGSGSELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYISALNKLHSKDDKVNPQRS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.643 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKHLERMKVDVIEAGFAASSNGDFDAIHTIAGLVKDSTVCSLARANDKDIQRAADALKPANSFRIHTFIATSPLHMEKKLRMTPEQVYEQARLAVRFARKFTDNVEFSPEDGSRSDMDFLCRVLEGVIAEGATTINITDTVGYGVPEMYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVMIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDVGIDTTQIVPTSKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFMRFKDLADRKSEIFDEDIIAIVSQESALAQEQEHFKFVSLSQHSETGEQPHAKVVFSVDGKEVTGEARGNGPVDATLNAIESEVGSGSELLLYSVNAITTGTQAQGEVTVRLSKSGRIVNGVGTDPDIVAASAKAYIAALNKLHSKDDKLNPQRS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.369 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKEEKIRIAKHLERMKVDVIEAGFAASSNGDFDAIHTIAGLVKDSTICSLARANDKDIQRAADALKPASSARIHTFIATSPLHMEKKLRMTPDQVFEQARLAVRFARKFTDNVEFSPEDGSRSDLDFLCRVLEAVIAEGATTINIADTVGYGVPELYGNLVKTLRERIPNSDKAIFSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNTSLEEIVMAVKTRKDYFGLDVGIDTTQIVPTSKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVSLDSEAELNAAFMRFKDLADRKAEIFDEDIIAIVSEESALAQEQEHVKFVSLSQHSETGEQPQAKVVFAVEGSEVTGEARGNGPVDATFNAIEGEVGSGSELLLYSVNAITTGTQAQGEVTVRLSKNGRIVNGVGTDPDIVAASAKAYIAALNKLHSKDDKLNPQRA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Length
514 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.9 kDa
Sequence
MTIESGRIRIFDTTLRDGEQSPGATMNLQEKIRLARQLETLGVDIMEAGFPASSQGDFEAVQAIARAVKGVEVAGLCRAMPADIDRAWEAVKVAENPRIHTFLATSPVHMQYKLRKEPDQVVEMAVAAVRHAAKYTSNVEFSAEDASRSNPDFLVRVFEAVINAGATTINVPDTVGYAQPEEFGRLIRYVIENTPNSHKAVFSVHCHNDLGMGVANTLAALKAGARQAEVTISGIGERAGNASLEEIVMALHTRRDFYQLDCGVVTEQLFPTCRLLSMIIGQPIPPNKAIVGANAFAHESGIHQDGMLKNRETYEIMTPESIGKTKTDLVIGKHSGRNAVKNKLDELGYRLEEAQLVTVFEAVKKLADKKKQIYDEDIEALVLEEVYRLPDLYRLVNLSVQCSDTGMPPTAAVVMDVMGEVKRAAGFGVGPIDAVFNVIGEIVGRAPVLERYSVTAITGGTDAQGEVTVRLRQNGSSAVGRGSDPDIILASARAYVNALNRLAKKEEEQEKEGI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.775 kDa
Sequence
MADKLIIFDTTLRDGEQSPGASMTKDEKLRIARQLERLRVDVIEAGFAASSNGDFEAVRAIADVIKESTVCSLARANDRDIARAAEALKSAARSRIHTFIATSELHMEKKLRMTREQVLEQARLSIRFARNLCEDIEFSPEDGYRSDPDFLCRVIEAVINEGATTINVPDTVGYGIPELYGNFIRTLRERVPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAGNCSLEEVVMAVRTRRDHFGLEVGIDTTQIVPASRLVSQTTGFIVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGIELESETDVNAAFARFKDLADRKSDIFDEDIIALVGDESVTHEQETYRLLSLEQQSATGERPHAKVAFAVGETEFHAESEGNGPVDASLKAIESKLKSGAEMLLYSVNAITSGSTESQGEVTVRLQHGGRVVNGVGADPDIVVASAKAYLSALNKLHSKNERVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.805 kDa
Sequence
MRRIKIFDTTLRDGEQSPGASMSIEEKVEMALMLEDLGVDLIEAGFPVSSPVQFEAVKRVASAVQKPIVVGLARCVEKDIDAAYEALKDRPKDKRMIHVFIATSPIHRKYKLRMEKEEILERIRRYVGYAKQFFDLVEFSAEDASRTEVPFLIEAYKTAIEAGATTINVPDTVGYALPDEFGELIKTLREGVPGIENVDLSVHCHNDLGLAVANSLAAVQNGATQVEVTLNGIGERAGNCALEEFVMILKVRKDKLPYETGIKTELIYPASRLLTHITGLIPSRNKPIVGENVFLHESGIHQDGVLKHRETYEIMKPSDIGRSSETLVLGRHSGKHALRKKLETYGIKLDEETFQKVFEKFTELADRKKEVYDDDLFSIVSEVLREPINGYKLVHFHVHTGNTLLPTAAVVLQVGNEKREAAEAGNGPVDAIFKAIDKALGIQPKLEEYIIQAVGTGKNAQGEVKLTLRIDNELYSGRGVSTDIVEASAIAYINAINKYLIAKGLLRKNGGAE

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.878 kDa
Sequence
MRRIKIFDTTLRDGEQSPGASMSVEEKVEMALMLEDLGVDLIEAGFPVSSPVQFEAVKRVAEAVQRPIVVGLARCVEKDIDAAYEALKDRPKDKRMIHVFIATSPIHRKYKLRMEKEEILERVRKYVTYARQFFDLVEFSAEDASRTEVPFLIEVYRTAIESGATTINVPDTVGYALPDEFGELIRTLKEGVPGIENVDLSVHCHNDLGLAVANSIAAVQNGATQVEVTLNGIGERAGNCALEEFVMALKVRKDRLPYETGIRTELIYPASRLLTHITGLIPARNKPIVGENVFLHESGIHQDGVLKHRETYEIMKPSDIGRSSETLVLGRHSGKHALRKKLESYGIKLDDETFQKVFEKFTELADRKKEVYDDDLFSIVSEVLKEPLNGYRLVHFHVHTGNTLLPTAAVVLQVGNEKKEAAETGNGPVDAIFKAIDKALGLQPKLEEYIIQAVGTGKNAQGEVKLTLKIDGELYSGRGVSTDIVEASAIAYINAINKYLIAKGLLRKNGGVE

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.72 kDa
Sequence
MRRIKIFDTTLRDGEQSPGASMSVEEKVEMALMLEDLGVDLIEAGFPVSSPVQFEAVKRVASAVQKPIVVGLARCVEKDIDAVYEALKDRPKDKRMIHVFIATSPIHRKYKLRMEKEEILERIRRYVGYAKQFFDLVEFSAEDASRTEVPFLIEAYKTAIEAGATTINVPDTVGYALPDEFGELIKTLREGVPGIENVDLSVHCHNDLGLAVANSLAAVQNGATQVEVTLNGIGERAGNCALEEFVMILKVRKDKLPYETGIKTELIYPASRLLTHITGLIPSRNKPIVGENVFLHESGIHQDGVLKHRETYEIMKPSDIGRSSETLVLGRHSGKHALRKKLESYGIKLDEETFQKVFEKFTELADRKKEVYDDDLFSIVSEVLREPINGYKLVHFHVHTGNTLLPTAAVVLQVGDEKKEAAEAGNGPVDAIFKAIDKALGIQPKLEEYIIQAVGTGKNAQGEVKLTLRINGELYSGRGVSTDIVEASAIAYINAINKYLIAKGLLRKNGGAE

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Thermotoga sp. (strain RQ2)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.805 kDa
Sequence
MRRIKIFDTTLRDGEQSPGASMSIEEKVEMALMLEDLGVDLIEAGFPVSSPVQFEAVKRVASAVQKPIVVGLARCVEKDIDAAYEALKDRPKDKRMIHVFIATSPIHRKYKLRMEKEEILERIRRYVGYAKQFFDLVEFSAEDASRTEVPFLIEAYKTAIEAGATTINVPDTVGYALPDEFGELIKTLREGVPGIENVDLSVHCHNDLGLAVANSLAAVQNGATQVEVTLNGIGERAGNCALEEFVMILKVRKDKLPYETGIKTELIYPASRLLTHITGLIPSRNKPIVGENVFLHESGIHQDGVLKHRETYEIMKPSDIGRSSETLVLGRHSGKHALRKKLETYGIKLDEETFQKVFEKFTELADRKKEVYDDDLFSIVSEVLREPINGYKLVHFHVHTGNTLLPTAAVVLQVGNEKREAAEAGNGPVDAIFKAIDKALGIQPKLEEYIIQAVGTGKNAQGEVKLTLRIDNELYSGRGVSTDIVEASAIAYINAINKYLIAKGLLRKNGGAE

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.634 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKDEKLRIARQLERLKVDVIEAGFAASSNGDFEAVQAIANTIRDSTICSLSRANDRDISRAAEALKGANNARIHTFIATSALHMEKKLRMTPEQVLEQARLSVRFARNLVADVEFSPEDGYRSDVDYLCRVLEAVIDEGATTINVPDTVGYAVPELYGHFIKTLRERVPNSDKAIWSVHCHNDLGMAVANSLAGVMIGGARQVECTINGLGERAGNCSLEEIVMAVKTRKDYFNLEMNIDPLHIVAASRMVSQTTGFVVQPNKAVVGANAFAHASGIHQDGMLKARETYEIMRAEDVGWSASKMVLGKLSGRNAFKQRLQDLGVALESEADINTAFARFKELADRKSEIFDEDILALVSDESITHHDQEQYGFVSLAQHSETGERPHAVVVFTVAGKEIRGESDGNGPVDASLKAIETHVKSGAEMVLYSVNAISGSTESQGEVTVRLQNNGRVVNGVGADPDIVVASAKAYLSALNKLQSKADRVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.634 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTKDEKLRIARQLERLKVDVIEAGFAASSNGDFEAVQAIANTIRDSTICSLSRANDRDISRAAEALKGANNARIHTFIATSALHMEKKLRMTPEQVLEQARLSVRFARNLVADVEFSPEDGYRSDVDYLCRVLEAVIDEGATTINVPDTVGYAVPELYGHFIKTLRERVPNSDKAIWSVHCHNDLGMAVANSLAGVMIGGARQVECTINGLGERAGNCSLEEIVMAVKTRKDYFNLEMNIDPLHIVAASRMVSQTTGFVVQPNKAVVGANAFAHASGIHQDGMLKARETYEIMRAEDVGWSASKMVLGKLSGRNAFKQRLQDLGVALESEADINTAFARFKELADRKSEIFDEDILALVSDESITHHDQEQYGFVSLAQHSETGERPHAVVVFTVAGKEIRGESDGNGPVDASLKAIETHVKSGAEMVLYSVNAISGSTESQGEVTVRLQNNGRVVNGVGADPDIVVASAKAYLSALNKLQSKADRVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Lactococcus lactis subsp. lactis (strain IL1403)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.803 kDa
Sequence
MRKIEFFDTSLRDGEQTPGVSFSISEKVTIAKQLEKWRISVIEAGFSAASPDSFEAVKQIADSLNDTAVTALARCVISDIDKAVEAVKGAKYPQIHVFIATSPIHMKYKLKISPEEVLKNIDKCVRYARERVEVVEFSPEDATRTELNFLLEAVQTAVDAGATYINIPDTVGYTTPEEYGKIFKFLIDNTKSDREIIFSPHCHDDLGMAVANSLAAIKAGAGRVEGTVNGIGERAGNAALEEIAVALHIRKDFYQAQSPLKLSETAATAELISQFSGIAIPKNKAIVGANAFAHESGIHQDGVLKNAETYEIITPELVGIKHNSLPLGKLSGRHAFSEKLTELNIAYDDESLAILFEKFKKLADKKKEITDADIHALFTGETVKNLAGFILDNVQIDGHKALVQLKNQEEEIYVSQGEGSGSVDAIFKAIDKVFNHQLKLISYSVDAVTDGIDAQATTLVSVENLSTGTIFNAKGVDYDVLKGSAIAYMNANVLVQKENLQGKVEQISAHDGI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.775 kDa
Sequence
MRKIEFFDTSLRDGEQTPGVIFSIAEKVTIAKQLEKWGISVIEAGFPAASPDSFEAVKQISKALKETAVTALARCVITDIDKAVEAVREAQHPQIHVFIATSPIHMKYKFKISPDEVLKTIDKCVRHAHEQVEVVEFSPEDATRTEPEFLLKAVQTAVDAGATYINIPDTVGYTTPEEYGKIFKMLIDNIKADREIIFSPHCHDDLGMAVANSLAAIKAGAGRVEGTVNGIGERAGNAAIEEIAVALHIRKDYYQAKSPLVLAETMATAELISQFSGIAIPKNKAVVGANAFAHESGIHQDGVLKNAETYEIISPELVGIKHNSLPLGKLSGRHAFTEKLTELNISYDAKELPNLFERFKRLADKKKEITDADIHALFTGETVKNLAGFILNNVQIDGHKALVELKNQDAEIYVSQGEGSGSVDAIFQAIDKVFNYQLKLISYSVDAVTNGIDAQATTVVSVENLATGTIFNAKGVDYDVLKGSAIAYMNANVLVQKENSQGKVEQISAHDGI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.5 kDa
Sequence
MSDQLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLKVDVIEAGFAASSNGDFEAVKAIADVIKDSTICSLARANDRDISRAAEALRGANRARIHTFIATSALHMEKKLRMSPDEVLEQARLSVRFARNLCGDIEFSPEDGYRSDPDFLCRVLEAVIDEGATTLNIPDTVGYAIPELYGNFIRNLRERVPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNCSLEEVVMAVKTRRDYFGLDLRVDTSQIVPASRMVAQTTGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQDLGIALESEAEVNAAFMKFKDLADRKSEIFDEDILALVSDEQSDNQAEHYRLLALSQHSEMGERPHAEVAFAAGDVEHHARSDGNGPVDASIKAIESKVGTGAELLLYSVNAITSGSTESQGEVTVRLQLGGRIVNGVGADPDIVVASAKAYLAALNKLHSKAERVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.793 kDa
Sequence
MSDKLIIFDTTLRDGEQSPGASMTREEKIRIARQLERLKVDVIEAGFAASSNGDFEAIRSIAQVVKDSTICSLARANDKDIARAAEALKPANSFRIHTFIATSALHMEKKLRMTPDQVYEQARLAVRFARQFTDDIEFSPEDGSRSDMDFLCRVLEGVIAEGATTINLPDTVGYAVPEGYAELIRSVRERIPNSDKAVWSVHCHNDLGMAVANSLAAVKLGGARQIECTINGLGERAGNTSLEEVVMAVKTRRDYFNMDVGIDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVQLESEAEINAAFARFKELADQKAEIFDEDIMAIVSDEEQEHANEHYRFISLSQRSETGERPHARVVFNIDGSEQTGEAEGNGPVDATLHAIEGKVNSGAELVLYSVNAITAGTQAQGEVTVRLSKAGRIVNGVGTDPDIVAASAKAYLAALNKLHDKAVQKINPQI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.788 kDa
Sequence
MSDKLIIFDTTLRDGEQSPGASMTREEKIRIARQLERLKVDVIEAGFAASSNGDFEAIRSIAQVVKDSTICSLARANDKDIARAAEALKPANSFRIHTFIATSALHMEKKLRMTPDEVYQQARLAVRFARQFTDDIEFSPEDGSRSDMDFLCRVLEGVIAEGATTINLPDTVGYAVPEGYAELIRSVRERIPNSDKAIWSVHCHNDLGMAVANSLAAVKMAGARQIECTINGLGERAGNTSLEEVVMAVKTRRDYFDLDIGVDTTQIVPASKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGIELESETEVNAAFTRFKELADQKAEIFDEDIVAIVSNEAQHDANEHFRFISLSQRSETGERPHARVVFSMDGQEQSGEGEGNGPVDATLHAIESRVSSGAEMVLYSVNAITGGTEAQGEVTVRLSKAGRIVNGVGTDPDIVAASAKAYLAALNKLHDKAVQKINPQI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Cupriavidus necator (strain JMP 134 / LMG 1197)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.696 kDa
Sequence
MSDKLIIFDTTLRDGEQSPGASMTREEKIRIAKQLERLKVDVIEAGFAASSNGDYEAIRSIAQVVKDSTICSLARANDKDIARAAEALKPANSFRIHTFIATSALHMEKKLRMTPDQVYEQARLAVRFARQFTDDIEFSPEDGSRSDMDFLCRVLEGVIAEGATTINLPDTVGYAVPEGYADLIRSVRERIPNSDKAVWSVHCHNDLGMAVANSLAAVKLGGARQIECTINGLGERAGNTSLEEVVMAVKTRRDYFNLDVGVDTSQIVPASKLVSQITGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQELGVELESEAEVNAAFGRFKELADQKAEIFDEDIMAIVSNEAQHDANEHYRFISLSQRSETGERPHARVVFNMDGQEHSGEGEGNGPVDATLHAIESQVNSGAEMVLYSVNAITGGTEAQGEVTVRLSKAGRIVNGVGTDPDIVAASAKAYLAALNKLHDKAVQKINPQI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Dechloromonas aromatica (strain RCB)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.764 kDa
Sequence
MKQHLVIFDTTLRDGEQSPGASMTKEEKIRVARQLEKMRVDVIEAGFAAASPGDFDAIHSIAQTIKDSTVCSLARANENDIRRAGEAIKPAQSGRIHTFIATSPIHMEKKLRMTPDQVVEQAVKAIGWAREYTDDIEFSAEDAGRSDLDFLCRIFEEVIKAGATTINVPDTVGYNIPSQYAETMRQLIERVPNSDKVVWSVHCHNDLGLAVSNSLAAVLCGARQVECTINGLGERAGNAALEEIVMAVRTRADVFPVETRIDTTQIVPASKLVSQITGYPVQPNKAVVGANAFAHESGIHQDGVLKHRETYEIMRAQDVGWTQNKLVLGKHSGRNAFKNRLQELGIELESDEALNAAFARFKELADKKHEIFDEDLHALVSDDLVTPDQEYYKLVYSRVCSETGEMPRASVILNIGGVEHKAEADGGGPVDATFKAIESIAGSGAELLLYSVNAITTGTDAQGEVTTRLSKGDRIVNGNGADTDIVIASARSYLNALNKLHSTLDKVKAQGGV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Desulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1)
Length
513 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.331 kDa
Sequence
MSDDNRVYIFDTTLRDGEQSPGATMTREEKVRMARQLETLGVDIIEAGFPAASEGDFQAVSAIAAAVKTPVVAALCRALASDIDRGFEAIKGAQRRRIHTFLATSELHMQHKLNKTPTQVLDMIEAAVSHAASKGVEVQFSAEDASRSEPAFLVAACERAINAGATILNIPDTVGYAQPAEFAELIRHLMTTVRGAGGVTFAVHCHNDLGLAVANTLAALHAGARQAEVTLSGIGERAGNASLEQVVMGLNTRPNYYNLTTGIVTEELFPSCRRLSGIIGQPIPPYAPIMGRNAFAHESGIHQHGVLKDRRTYEIMTAESIGRKGAVVVLGKHSGRHALDAKVKELGYALNDEELLVVFVAVKQLADRKQRILDEDIEALILEKVLRRPDRYALQFLSVHCGNVELAPFAVVEMQVEGQTVRHYSAGSGPVDAVFNAVCQAVGRKPDLEEYQINAITGGTDAQGEVTVRIKDGTATTVGRGVHDDVIMASTLAFINALNRLAKKEEERTCPQL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Variovorax paradoxus (strain S110)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.291 kDa
Sequence
MTDQLIIFDTTLRDGEQSPGASMTRDEKMRIAKQLERLKVDVIEAGFPASSNGDFEAVKAIADIIKESTVCGLSRANDRDISRAAEALKGAARGRIHTFIATSPLHMEKKLRMSPDEVHEQAKLAVRFARNLVSDVEFSPEDGYRSDPDFLCRVLETVINEGATTINVPDTVGYAIPELYGNFIKMLRERVPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNCSLEEVVMAVKTRRDYFGLDLNIDTTHIVAASRMVSQTTGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWAANKIVLGKLSGRNAFKQRLQELGVTMASEADINAAFLRFKELADRKSEIFDEDILALVSAEEHSNVDEQFAFVSLSQHSETGERPQAKVVFTVQGKEVTGESDGNGPVDASLKAIESHVKSGAEMVLYSVNAISGSTESQGEVTVRLQNAGRVVNGVGADPDIVVASAKAYLSALNKLQSQAEKVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Verminephrobacter eiseniae (strain EF01-2)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.138 kDa
Sequence
MADKLIIFDTTLRDGEQSPGASMTKDEKLRIARQLERLKVDVIEAGFAASSNGDFDAVRAIASTIREATICSLARANDRDIARAAQALEGAANARIHIFIATSALHMEKKLRMTPGQVLEQSLQSVRFARNLVADIEFSPEDGYRSDPDFLCRVIEAAIAEGATTINVPDTVGYAIPELYGNFIKMLRERVPNSDKAIWSVHCHNDLGMAVANSLAGVKMGGARQVECTINGLGERAGNCSLEEVVMAVKTRRDYFGLDLGIATQHILAASRMVSQTTGFAVQLNKAIVGANAFAHASGIHQDGVLKARDTYEIMRAQDVGWSANKMVLGKLSGRSAFKQRLQELGVSLDSEAEINLAFARFKELADRKSEIFDEDILALVSDESVSGDNEQYGFVSLFQQSETGKQPHARIVFTVNGQNVHAEAQGNGPVDASLKAIEAHVHSGAEMVLYSVNAISGSTESQGEVTVRLQNSGRIVNGVGADPDIVVASAKAYFSALNKLQNKADRVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Acidovorax citrulli (strain AAC00-1)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.193 kDa
Sequence
MSDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEAGFAASSNGDFEAVQAIAQAIKDSTVCSLSRANDRDIARAAEALKDAQRARIHTFIATSPLHMEKKLRMTPEQVLEQAKQSVRFARNLVADIEFSPEDGYRSEPDFLCRVLEAVIAEGATTINVPDTVGYAIPELYGNFIRNLRERIPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNCSLEEIVMAVKTRRDYFGLELGIDTQHIVAASRMVSQTTGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQDLGVQLESEADVNAAFLRFKELADRKSEIFDEDILALVSGDATAGAGERYGFVSLSQRSETGERPHAAVVFTVDGKEVHGASEGNGPVDASLKAIESHVHSGAEMVLYSVNAISGSTESQGEVTVRLQDSGRVVNGVGADPDIVVASAKAYLSALNKLQSKAERVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Acidovorax ebreus (strain TPSY)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.456 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEAGFAASSNGDFESVQAIARAVKDSTVCSLARANDRDIARAAEALKEANRARIHTFIATSALHMEKKLRMTPEQVLEQARQAVRFARNLVEDIEFSPEDGYRSDPDFLCRVIETVIAEGATTINVPDTVGYAIPELYGNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNCSLEEVVMAVKTRRDYFGLDVGIDTQHIVAASRMVSQTTGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGVQLESEGEINVAFAKFKELADRKSEIFDEDILALVSDESVTSEKEQFGFVSLAQHSETGERPEATIVFTVDGKEVRSSAEGNGPVDASMKAIEAHVRSGAEMVLYSVNAISGSTESQGEVTVRLQSAGRVVNGVGADPDIVVASAKAYLSALNKLQSKAERVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Acidovorax sp. (strain JS42)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.472 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEAGFAASSNGDFESVQAIARAVKDSTVCSLARANDRDIARAAEALKEANRARIHTFIATSALHMEKKLRMTPEQVLEQARQAVRFARNLVEDIEFSPEDGYRSDPDFLCRVIETVIAEGATTINVPDTVGYAIPELYGNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNCSLEEVVMAVKTRRDYFGLDVGIDTQHIVAASRMVSQTTGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGVQLESEGEINVAFAKFKELADRKSEIFDEDILALVSDESVTSEKEQFGFVSLAQHSETGERPEATIVFTVDGKEVRSSSEGNGPVDASMKAIEAHVRSGAEMVLYSVNAISGSTESQGEVTVRLQSAGRVVNGVGADPDIVVASAKAYLSALNKLQSKAERVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
54.963 kDa
Sequence
MGDRLYIFDTTLRDGEQSPGASMSKEEKIRIARQLERLGVDIIEAGFAAASPGDFDAIHAIAETIKDSTVCSLARANERDVRAAGEAIKPAARGRIHTFIATSPIHMEKKLRMSPDEVVDAAVKAVKIAREYTDDVEFSAEDALRSDIDFLARIFGEVIKAGATTLNVPDTVGYAVPRLTEAFFRELIARTPGGDKVVWSAHCHNDLGMAVANSLAAVLGGARQVECTINGLGERAGNASLEEVVMAVKTRRDVFGVDSRVDATQIVPASKLVSTVTGYPVQPNKAIVGANAFAHESGIHQDGVLKHRETYEIMSAESVGWSANRLTLGKLSGRNAFKTKLSELGIVLDSEEALNAAFARFKELADKKREIFDEDLHALVSDEMVTIEREDYKLVSLKVVSETGEPPLASIVFVEHGQEQHGESSGSGPVDAAFKAIEKVVGSGAELELYSVNAITKGTESQGEVTVRLSREGRIVNGQGADTDIIVASAKAYLSALNKLTIEEKMNAQAAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Polaromonas naphthalenivorans (strain CJ2)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.399 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLKVDVIEAGFAASSNGDFECVKAIAEVVKDSTICSLARANDRDISRAAEALKPANSGRLHLFLATSALHMEKKLRMTPDQVFEQARLSVRFARNLMADIEFSPEDGYRSDPDFLCRVIEAVINEGATTINVPDTVGYAIPELYGNFIRNLRERIPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNCSLEEVVMAVKTRKDYFGLDIGIDTQQILAASRLVSQTTGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGVAMESETDINNAFIKFKDLADRKSEIFDEDILALVSDESVTHSNEQYGFVSLSQHSETGERPQACVIFTVAGKEVKGESDGNGPVDASLKAIETHVKSGAEMVLYSVNAISGSTESQGEVTVRLQNSGRVVNGVGSDPDIVVASAKAYLSALNKLQSKADRVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Acidovorax citrulli (strain AAC00-1)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.193 kDa
Sequence
MSDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEAGFAASSNGDFEAVQAIAQAIKDSTVCSLSRANDRDIARAAEALKDAQRARIHTFIATSPLHMEKKLRMTPEQVLEQAKQSVRFARNLVADIEFSPEDGYRSEPDFLCRVLEAVIAEGATTINVPDTVGYAIPELYGNFIRNLRERIPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNCSLEEIVMAVKTRRDYFGLELGIDTQHIVAASRMVSQTTGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWTANKIVLGKLSGRNAFKQRLQDLGVQLESEADVNAAFLRFKELADRKSEIFDEDILALVSGDATAGAGERYGFVSLSQRSETGERPHAAVVFTVDGKEVHGASEGNGPVDASLKAIESHVHSGAEMVLYSVNAISGSTESQGEVTVRLQDSGRVVNGVGADPDIVVASAKAYLSALNKLQSKAERVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Acidovorax ebreus (strain TPSY)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.456 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEAGFAASSNGDFESVQAIARAVKDSTVCSLARANDRDIARAAEALKEANRARIHTFIATSALHMEKKLRMTPEQVLEQARQAVRFARNLVEDIEFSPEDGYRSDPDFLCRVIETVIAEGATTINVPDTVGYAIPELYGNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNCSLEEVVMAVKTRRDYFGLDVGIDTQHIVAASRMVSQTTGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGVQLESEGEINVAFAKFKELADRKSEIFDEDILALVSDESVTSEKEQFGFVSLAQHSETGERPEATIVFTVDGKEVRSSAEGNGPVDASMKAIEAHVRSGAEMVLYSVNAISGSTESQGEVTVRLQSAGRVVNGVGADPDIVVASAKAYLSALNKLQSKAERVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Acidovorax sp. (strain JS42)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.472 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLRVDVIEAGFAASSNGDFESVQAIARAVKDSTVCSLARANDRDIARAAEALKEANRARIHTFIATSALHMEKKLRMTPEQVLEQARQAVRFARNLVEDIEFSPEDGYRSDPDFLCRVIETVIAEGATTINVPDTVGYAIPELYGNFIKNLRERIPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNCSLEEVVMAVKTRRDYFGLDVGIDTQHIVAASRMVSQTTGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGVQLESEGEINVAFAKFKELADRKSEIFDEDILALVSDESVTSEKEQFGFVSLAQHSETGERPEATIVFTVDGKEVRSSSEGNGPVDASMKAIEAHVRSGAEMVLYSVNAISGSTESQGEVTVRLQSAGRVVNGVGADPDIVVASAKAYLSALNKLQSKAERVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
54.963 kDa
Sequence
MGDRLYIFDTTLRDGEQSPGASMSKEEKIRIARQLERLGVDIIEAGFAAASPGDFDAIHAIAETIKDSTVCSLARANERDVRAAGEAIKPAARGRIHTFIATSPIHMEKKLRMSPDEVVDAAVKAVKIAREYTDDVEFSAEDALRSDIDFLARIFGEVIKAGATTLNVPDTVGYAVPRLTEAFFRELIARTPGGDKVVWSAHCHNDLGMAVANSLAAVLGGARQVECTINGLGERAGNASLEEVVMAVKTRRDVFGVDSRVDATQIVPASKLVSTVTGYPVQPNKAIVGANAFAHESGIHQDGVLKHRETYEIMSAESVGWSANRLTLGKLSGRNAFKTKLSELGIVLDSEEALNAAFARFKELADKKREIFDEDLHALVSDEMVTIEREDYKLVSLKVVSETGEPPLASIVFVEHGQEQHGESSGSGPVDAAFKAIEKVVGSGAELELYSVNAITKGTESQGEVTVRLSREGRIVNGQGADTDIIVASAKAYLSALNKLTIEEKMNAQAAA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Polaromonas naphthalenivorans (strain CJ2)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.399 kDa
Sequence
MTDKLIIFDTTLRDGEQSPGASMTRDEKLRIARQLERLKVDVIEAGFAASSNGDFECVKAIAEVVKDSTICSLARANDRDISRAAEALKPANSGRLHLFLATSALHMEKKLRMTPDQVFEQARLSVRFARNLMADIEFSPEDGYRSDPDFLCRVIEAVINEGATTINVPDTVGYAIPELYGNFIRNLRERIPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNCSLEEVVMAVKTRKDYFGLDIGIDTQQILAASRLVSQTTGFVVQPNKAVVGANAFAHASGIHQDGVLKARDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGVAMESETDINNAFIKFKDLADRKSEIFDEDILALVSDESVTHSNEQYGFVSLSQHSETGERPQACVIFTVAGKEVKGESDGNGPVDASLKAIETHVKSGAEMVLYSVNAISGSTESQGEVTVRLQNSGRVVNGVGSDPDIVVASAKAYLSALNKLQSKADRVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.495 kDa
Sequence
MRTIEIFDTTLRDGEQSPGVNISTNEKVEIALQLEKLGVNRMEAGFAAASPGDQKSVAEVAKRVKNATVVSLARAVKDDMDKAYEALRNAQNASLHVFLATSPIHRQFKLNMSKEEVLARAVEAVTYAKKYFTEVQFSAEDAARTEIDFLAEVVEAVIKAGATTVNIPDTVGYMTPYQYGNIFRELKKRVPSTDLIRLSCHCHDDLGMAVANSLAAVEGGATQVEGTINGIGERAGNAALEEVALALETRKDYYQATTKLNLKEIARTSQLVSRLTGMIVPGNKAVVGANAFAHESGIHQDGVLKEVTTYEIIRPESVGFKSNKLVLGKHSGRHAFKEKLVDLGYHLEQEEVNAAFAAFKVLCDKKKEITDDDILALVDSKMVRGPEAFQLESVQLAYGNISVPTASVRLVRADGSVCEEAACGNGSVDSIYKAIDRATGEEVSLVDYKILSVTHGQDALGEVFVRLQQDDLIVTGRGVSTDVLEASAIAYVRAVNKIMERRGEPTPVSATI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.739 kDa
Sequence
MSKRVVIFDTTLRDGEQSPGVSLNLHEKLEIAQQLARLGVDVIEAGFPIASPGDFEAVKAVAEQVRGPVICALARANRKDIERAAEALRGAEEARIHTFIATSPIHMQHKLRMEPDKVLDTAVDAVKLAKSFTSNVEFSAEDAFRSDVGFLCRIFSAAIEAGATTINIPDTVGYATPQEFGAFIKAIINGTPNIDKAIVSVHCHNDLGLAVANTLAALENGALQVEGTINGIGERAGNASLEEVIMALYTRKPFYNLETSINKSEIYRTSRLVSNLTGMLVQPNKAIVGKNAFAHESGIHQDGVLKERTTYEIMNPEMIGIFTNNIVLGKHSGRHAFRERLKELGYSLDDEKLTKAFARFKALADRKREITDEDLVVLVEDELRAFPEAYSLEYLHITSGTVLVPTATVRLRREEENFEEASCGDGPVDAAYKAIEKITGTGARLASYAISATTAGEDSQGEVSVKLEREGRFYTGRGVDTDIIVASAKAYLNAVNKIVFDGLPKAKTERAV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.149 kDa
Sequence
MKKIQFFDTTLRDGEQTPGVNFDVKEKIQIALQLEKLGIDVIEAGFPISSPGDFECVKAIAKAIKHCSVTGLARCVEADIDRAEEALKDAVSPQIHIFLATSDVHMEYKLKMSRAEVLASIKHHISYARQKFDVVQFSPEDATRSDRAFLIEAVQTAIDAGATVINIPDTVGYTNPTEFGQLFQDLRREIKQFDDIIFASHCHDDLGMATANALAAIENGARRVEGTINGIGERAGNTALEEVAVALHIRKDFYQAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAHESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFNTRMEEMGYTLSEQEQKDAFKRFKQLADAKKDVTEEDLHALILGQSSESHDAFELKHLQVQYVTGGVQGAIVRIEERDGALIEDAATGSGSIEAIYNTINRLMKQDIELTDYRIQAITAGQDAQAEVHVVIKDDNGTEFHGIGIDFDVLTASAKAYLQASGKSKSTSKQADFEEVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.064 kDa
Sequence
MKKIQFFDTTLRDGEQTPGVNFDVKEKIQIALQLEKLGIDVIEAGFPISSPGDFECVKAIAKAIKHCSVTGLARCVEGDIDRAEEALKDAVSPQIHIFLATSDVHMEYKLKMSRAEVLASIKHHISYARQKFDVVQFSPEDATRSDRAFLIEAVQTAIDAGATVINIPDTVGYTNPTEFGQLFQDLRREIKQFDDIIFASHCHDDLGMATANALAAIENGARRVEGTINGIGERAGNTALEEVAVALHIRKDFYQAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAHESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFNTRMEEMGYTLTEQEQKDAFKRFKQLADAKKEVTEEDLHALILGQSSESADDFELKHLQVQYVTGGVQGAIVRIEERDGALVEDAATGSGSIEAIYNTINRLMKQDIELTDYRIQAITAGQDAQAEVHVVIKNDKGAVFHGIGIDFDVLTASAKAYLQASGKSKTASKQADFEEVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Listeria monocytogenes serotype 4b (strain F2365)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.064 kDa
Sequence
MKKIQFFDTTLRDGEQTPGVNFDVKEKIQIALQLEKLGIDVIEAGFPISSPGDFECVKAIAKAIKHCSVTGLARCVEGDIDRAEEALKDAVSPQIHIFLATSDVHMEYKLKMSRAEVLASIKHHISYARQKFDVVQFSPEDATRSDRAFLIEAVQTAIDAGATVINIPDTVGYTNPTEFGQLFQDLRREIKQFDDIIFASHCHDDLGMATANALAAIENGARRVEGTINGIGERAGNTALEEVAVALHIRKDFYQAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAHESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFNTRMEEMGYTLTEQEQKDAFKRFKQLADAKKEVTEEDLHALILGQSSESADDFELKHLQVQYVTGGVQGAIVRIEERDGALVEDAATGSGSIEAIYNTINRLMKQDIELTDYRIQAITAGQDAQAEVHVVIKNDKGAVFHGIGIDFDVLTASAKAYLQASGKSKTASKQADFEEVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Listeria monocytogenes serotype 4a (strain HCC23)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.03 kDa
Sequence
MKKIQFFDTTLRDGEQTPGVNFDVKEKIQIALQLEKLGIDVIEAGFPISSPGDFECVKAIAKAIKHCSVTGLARCVEGDIDRAEEALKDAVSPQIHIFLATSDVHMEYKLKMSRAEVLASIKHHISYARQKFEVVQFSPEDATRSDRAFLIEAVQTAIDAGATVINIPDTVGYTNPTEFGQLFQDLRREIKQFDDIIFASHCHDDLGMATANALAAIENGARRVEGTINGIGERAGNTALEEVAVALHIRKDFYQAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAHESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFQTRMEEMGYNLSEQELKDAFKRFKQLADAKKEVTEDDLHALILGQSSESADDFELKHLQVQYVTGGVQGAIVRIAERDGTLIEDAATGSGSIEAIYNTINRLMKQNIELTNYHIQAITAGQDAQAEVHVVIKDKSGAEFHGIGIDFDVLTASAKAYLQASAKSKTGSKQADFEEVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.096 kDa
Sequence
MKKIQFFDTTLRDGEQTPGVNFDVKEKIQIALQLEKLGIDVIEAGFPISSPGDFECVKAIAKAIKHCSVTGLARCVEGDIDRAEEALKDAVSPQIHIFLATSDVHMEYKLKMSRAEVLASIKHHISYARQKFEVVQFSPEDATRSDRAFLIEAVQTAIDAGATVINIPDTVGYTNPTEFGQLFQDLRREIKQFDDITFASHCHDDLGMATANALAAIENGARRVEGTINGIGERAGNTALEEVAVALHIRKDFYQAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAHESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFNTRMEEMGYTLTEQEQKDAFKRFKQLADAKKEVTEEDLHALILGQSSESADDFELKHLQVQYVTGGVQGAIVRIEERDGALVEDAATGSGSIEAIYNTINRLMKQDIELTDYRIQAITAGQDAQAEVHVVIKNDKGAEFHGIGIDFDVLTASAKAYLQASGKSKTASKQADFEEVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.412 kDa
Sequence
MKKIQFFDTTLRDGEQTPGVNFDVKEKIQIALQLEKLGIDVIEAGFPISSPGDFECVRAIAKAIKHCSVTGLARCVEGDIDRAEEALKEAVSPQIHIFLATSDVHMEYKLKMSRAEVLASIKHHIHYARQKFDIVQFSPEDATRSDRAFLIEAVQTAIDAGATVINIPDTVGYTNPTEFGQLFQDLRREIKQFDDIIFASHCHDDLGMATANALAAIENGARRVEGTINGIGERAGNTALEEVAVALHIRKDFYQAETNIVLNQFKNSSDLISRLSGMPVPRNKAVIGGNAYAHESGIHQDGVLKNPDTYEIITPALVGVDKNSLPLGKLSGKHAFHTRMEEMGYTLSEQELKDTFKRFKQLADAKKEVTEEDLHALILGQSSESTDNFELKHLQVQYVSGGVQGAIVRIEERDGALIEDAATGSGSIEAIYNTINRLMKQDIELIDYRIQAITAGQDAQAEVHVVIKDNNETEFHGIGIDFDVLTASAKAYLQASGKSKSTTKQVDFEEVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118)
Length
512 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.28 kDa
Sequence
MADQLIIFDTTLRDGEQSPGASMNKDEKLRIARQLERLKVDVIEAGFAASSNGDFEAVQGIARAIKDSTICSLSRANDRDISRAAEALKGANRSRIHTFIATSALHMEKKLRMTPDQVFEQAKLAVRFARNLVADVEFSPEDAYRSDEDFLCRVIEAAINEGATTINVPDTVGYAIPELYGTFIKTLRERVPNSDKAIWSVHCHNDLGMAVANSLAGVKIGGARQVECTINGLGERAGNCSLEEVVMAVKTRRDYFGLDVDIETQHILAASRMVSQITGFVVQPNKAIVGANAFAHAAGIHQDGVLKARDTYEIMRAEDVGWSANKIVLSKVSGRNAFKQRLQDLGAQMESESDVNAAFARFKELADRKSEIFDEDILALVGSESVAREKEQYSFVSLSQHSETGERPQASIVFTADGKEVKSSSDGDGPVDASLKAIEAQVKSGAEMVLYSVNAISGSTESQGEVTVRLQHGGRVVNGVGADPDIIVASAKAYLSALSKLHSKADRVAAQG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Aromatoleum aromaticum (strain EbN1)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.573 kDa
Sequence
MKDHLIVFDTTLRDGEQSPGASMTRDEKLRIARQLERMRVDVIEAGFPAASNGDFESVRAIAEAIRESTVCGLARANEADIRRAGEAIAPAARGRIHTFIATSPIHMEMKLRMSPDQVVEQAVRAIGWAKEYTDDIEFSAEDAGRSEIDFLCRIFEAVIKAGAKTINVPDTVGYNVPEQYAHTIRTLIERVPGADKVVWSVHCHNDLGLAVANSLAAVMAGARQVECTLNGLGERAGNAALEELVMAVRTRQDVFPCDTRIDATQIVPASKLVSGVTGFPVQPNKAIVGANAFAHESGIHQDGVLKHRETYEIMRAEDVGWGANKLVLGKHSGRNAFRSRLQEIGIVVASEEHLNHAFARFKELADKKHEIFDEDIQALMSDEVVTPDQEHYRLVASRFHSETGETPRADLTLSVDGQETRTSAEGSGPVDAAFKAIEAIAGSGTELLLYSVNAITTGTDAQGEVTVRLAREDKVVNGQGADTDIIVASAKAYLNALNKLHSKLERLNPQL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Thiobacillus denitrificans (strain ATCC 25259)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.298 kDa
Sequence
MNDRLFIFDTTLRDGEQSPGASMTKDEKLRIARQLEKLGVDVIEAGFAAASPGDADAIRAIAETVRNSTVCSLARANERDIHAAGGAIKPAKSGRIHTFIATSPIHMEKKLRMQPDQVVEAAVKAVKLAREYTDDVEFSAEDAVRSDMDFLVRIFDEVIKAGAKTINVPDTVGYSIPALWGERMKALIERVPGSDKVIWSTHCHNDLGMAVANSLAAVMNGARQVECTINGLGERAGNASLEEIVMAVRTRRDVFGCDTRIDATQIVPSSKLVSTITGYPVQPNKAIVGANAFAHESGIHQDGVLKHRETYEIMRAEDVGWNANRLTLGKLSGRNAFKTKLAELGIVLDSEEALNAAFARFKDLADKKREIFDEDLQALVSDEGYATEDERFKLLSMKVCSETGEVPRAQLVFTDDGAEKQASGEGSGPVDATFKALESVVHSGADLLLYSVNNITSGTDAQGEVTVRLAQDGRVVNGQGADTDIVVASAKAYLHALNKLHSKRERAHPQV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.459 kDa
Sequence
MTNKLIIFDTTLRDGEQSPGASMTKDEKIRIAKVLEKMKVDVIEAGFAIASEGDFEAVQAVANIVQNSVICSLARALDKDIDRAGEALKGANASRIHTFIATSNIHMKMKLQMTPDQVVGQAVRAVKRANRYTDNIEFSPEDAGRSDEDFLCYIIEAVIKAGATTINIPDTVGYNIPHQFGATIKSLIERIPNSDKAIFSAHCHNDLGLAVANSLSAVLNGARQVECTINGLGERAGNTSLEELVMAVRTRQDIFDCDTNIDTMHILSASRLASSVTGFIIQPNKAIVGANAFAHEAGIHQDGVLKHRETYEIMRAEDVGWNANQLVLGKHSGRNAFKVRLAKLGVEFNDDGSLNDAFRRFKELADKKHEIFDEDLQALVSETQTESCDEAIKLVSLKVCTETNEKNTATVVLFINDKKKTATANTSGAVDATFSAINSLASIKINLQLYSVSNVTQGTDALGEVNVRLEYNGRIVNGQGVDTDIITASAKAYVHGLNKVLTVTNKAHPQI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.423 kDa
Sequence
MKDNKIIIFDTTLRDGEQALGSSLGINQKLQIALALENLGVDVIEAGFPVSSQGDFKAVQKIASKVKNSTICALSRVLDKDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKKDFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTVGYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGLGERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSNAFSHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTYNLDDVYERFLRLADKKGQVYDYDLEALMFLSYENEEENKFILEKLSVISGNIPTACVCMRIKEELKTEACTGNGPVEAVFNCIARITNLKPALKAYSINAKSSGVDAQGQVDVDLEFKGRKFHGKGISTDVIEASAQAFVSAYNAIYRSLKVEERKMA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.304 kDa
Sequence
MKNNKIIIFDTTLRDGEQALGSSLGINQKLQIALALENLGVDVIEAGFPVSSQGDFKAVQKIASKVKNSTICALSRALDKDIDMAYEALKVAKHFRIHTFIATSTLHIQDKLKKDFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTVGYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGLGERAGNCALEEVVMAIKTRKDYLQGFYTDIKCENISKTSKLVSAITNESIPSHKAIVGSNAFSHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTYNLDDVYERFLRLADKKGQVYDYDLEALMFLSYESEEENEFVLEKLSVISGNIPTACVCMRIKEELKTEACTGNGPVEAVFNCIARITNLKPVLKAYSINAKSSGVDAQGQVDVDLEFKGRKFHGKGLSTDVIEASAQAFVSAYNAIYRSLKVEERKMA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.355 kDa
Sequence
MKDNKIIIFDTTLRDGEQALGSSLGINQKLQIALALENLGVDVIEAGFPVSSQGDFKAVQKIASKVKNSTICALSRALDKDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKKDFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTVGYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGLGERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSNAFSHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTYNLDDVYERFLRLADKKGQVYDYDLEALMFLSYESEEENEFVLEKLSVISGNIPTACVCMRIKEELKTEACTGNGPVEAVFNCIARITNLKPALKAYSINAKSSGVDAQGQVDVDLEFKGRKFHGKGLSTDVIEASAQAFVSAYNAIYRSLKVEERKMA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.35 kDa
Sequence
MKDNKIIIFDTTLRDGEQALGSSLGINQKLQIALALENLGVDVIEAGFPVSSQGDFKAVQKIASKVKNSTICALSRALDKDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKKDFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTVGYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGVATGNSLSAILQGARQIECTINGLGERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSNAFSHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTYNLDDVYERFLRLADKKGQVYDYDLEALMFLSYENEEENEFVIEKLSVISGNIPTACVCMRIKEELKTEACTGNGPVEAVFNCIARITNLKPALKAYSINAKSSGVDAQGQVDVDLEFKGRKFHGKGISTDVIEASAQAFVSAYNAIYRSLKVEERKMA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter jejuni (strain RM1221)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.368 kDa
Sequence
MKDNKIIIFDTTLRDGEQALGSSLGINQKLQIALALENLGVDVIEAGFPVSSQGDFKAVQKIASKVKNSTICALSRALDKDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKKDFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTVGYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGLGERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSNAFSHSSGIHQDGVLKNRQTYEIISPSAIGIHDNRMLMTARSGRAMIKTCLENLGYDENTYNLDDVYERFLRLADKKGQVYDYDLEALMFLSYENEEENEFVIEKLSVISGNIPTACVCMRIKEELKTEACTGNGPVEAVFNCIARITNLKPVLKAYSINAKSSGVDAQGQVDVDLEFKGRKFHGKGLSTDVIEASAQAFASAYNAIYRSLKVEERKMA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.457 kDa
Sequence
MRRIRIFDTTLRDGEQTPGVNLNIQEKVDIAKQLARLGVDVIEPGFPLTSPGDFEAVQRIAREVEGPYICGFSRAIIRDIDETWKAIKDAQKKCFHIFISSSDIQIKHQLGKTEKDVLEIVKSTVYHAKQYTDEVEYSPMDASRTRLEFLYEVIEAAIDNGATVINIPDTVGYATPIEFGELIQKIRKNVRNIDKAIISVHCHNDLGMAVANSIVAAMNGAQQIECTINGVGERAGNAALEEVVTHIAARKDYLGFETGIDLSQLYKTSKIVSRYMGIPIPVNKPIVGKNVFTHESGIHQDGVLKERSTYEVIDPRLVGRDDSVILLGKHSGRHALKVEAEKLGYDLDEERLNKLFNDFKKLTDVKKNVTTADLESLIIESAAKAVEEAYVLEKIRVVSGNIETPSAKVVIKDSKGNLLEAEQTGNGPVDAVFKAINSVIKETENLTLYKYSVSAVTEEMESLGEVSVTLREKEKLYTGIGTHTDIITSSAIAYIDAINKAIAANARAQKN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.423 kDa
Sequence
MKDNKIIIFDTTLRDGEQALGSSLGINQKLQIALALENLGVDVIEAGFPVSSQGDFKAVQKIASKVKNSTICALSRVLDKDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKKDFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTVGYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGLGERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSNAFSHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTYNLDDVYERFLRLADKKGQVYDYDLEALMFLSYENEEENKFILEKLSVISGNIPTACVCMRIKEELKTEACTGNGPVEAVFNCIARITNLKPALKAYSINAKSSGVDAQGQVDVDLEFKGRKFHGKGISTDVIEASAQAFVSAYNAIYRSLKVEERKMA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.304 kDa
Sequence
MKNNKIIIFDTTLRDGEQALGSSLGINQKLQIALALENLGVDVIEAGFPVSSQGDFKAVQKIASKVKNSTICALSRALDKDIDMAYEALKVAKHFRIHTFIATSTLHIQDKLKKDFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTVGYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGLGERAGNCALEEVVMAIKTRKDYLQGFYTDIKCENISKTSKLVSAITNESIPSHKAIVGSNAFSHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTYNLDDVYERFLRLADKKGQVYDYDLEALMFLSYESEEENEFVLEKLSVISGNIPTACVCMRIKEELKTEACTGNGPVEAVFNCIARITNLKPVLKAYSINAKSSGVDAQGQVDVDLEFKGRKFHGKGLSTDVIEASAQAFVSAYNAIYRSLKVEERKMA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.355 kDa
Sequence
MKDNKIIIFDTTLRDGEQALGSSLGINQKLQIALALENLGVDVIEAGFPVSSQGDFKAVQKIASKVKNSTICALSRALDKDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKKDFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTVGYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGLGERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSNAFSHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTYNLDDVYERFLRLADKKGQVYDYDLEALMFLSYESEEENEFVLEKLSVISGNIPTACVCMRIKEELKTEACTGNGPVEAVFNCIARITNLKPALKAYSINAKSSGVDAQGQVDVDLEFKGRKFHGKGLSTDVIEASAQAFVSAYNAIYRSLKVEERKMA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.35 kDa
Sequence
MKDNKIIIFDTTLRDGEQALGSSLGINQKLQIALALENLGVDVIEAGFPVSSQGDFKAVQKIASKVKNSTICALSRALDKDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKKDFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTVGYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGVATGNSLSAILQGARQIECTINGLGERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSNAFSHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTYNLDDVYERFLRLADKKGQVYDYDLEALMFLSYENEEENEFVIEKLSVISGNIPTACVCMRIKEELKTEACTGNGPVEAVFNCIARITNLKPALKAYSINAKSSGVDAQGQVDVDLEFKGRKFHGKGISTDVIEASAQAFVSAYNAIYRSLKVEERKMA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter jejuni (strain RM1221)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.368 kDa
Sequence
MKDNKIIIFDTTLRDGEQALGSSLGINQKLQIALALENLGVDVIEAGFPVSSQGDFKAVQKIASKVKNSTICALSRALDKDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKKDFDEILSMAKRAIIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTVGYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGLGERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSNAFSHSSGIHQDGVLKNRQTYEIISPSAIGIHDNRMLMTARSGRAMIKTCLENLGYDENTYNLDDVYERFLRLADKKGQVYDYDLEALMFLSYENEEENEFVIEKLSVISGNIPTACVCMRIKEELKTEACTGNGPVEAVFNCIARITNLKPVLKAYSINAKSSGVDAQGQVDVDLEFKGRKFHGKGLSTDVIEASAQAFASAYNAIYRSLKVEERKMA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.457 kDa
Sequence
MRRIRIFDTTLRDGEQTPGVNLNIQEKVDIAKQLARLGVDVIEPGFPLTSPGDFEAVQRIAREVEGPYICGFSRAIIRDIDETWKAIKDAQKKCFHIFISSSDIQIKHQLGKTEKDVLEIVKSTVYHAKQYTDEVEYSPMDASRTRLEFLYEVIEAAIDNGATVINIPDTVGYATPIEFGELIQKIRKNVRNIDKAIISVHCHNDLGMAVANSIVAAMNGAQQIECTINGVGERAGNAALEEVVTHIAARKDYLGFETGIDLSQLYKTSKIVSRYMGIPIPVNKPIVGKNVFTHESGIHQDGVLKERSTYEVIDPRLVGRDDSVILLGKHSGRHALKVEAEKLGYDLDEERLNKLFNDFKKLTDVKKNVTTADLESLIIESAAKAVEEAYVLEKIRVVSGNIETPSAKVVIKDSKGNLLEAEQTGNGPVDAVFKAINSVIKETENLTLYKYSVSAVTEEMESLGEVSVTLREKEKLYTGIGTHTDIITSSAIAYIDAINKAIAANARAQKN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.581 kDa
Sequence
MKDKLIVFDTTLRDGEQSPGASMTREEKVRIAKALERMRVDVIEAGFPVASQGDFEAVQAVARSVRESTVCGLARALGADIDRAGEALAEAESARIHTFIATSPIHMKRKLRMEPDQVLEHAVKAVKRAREYTDDVEFSPEDAGRSEIEFLCRILEAVIAAGARTVNIPDTVGYNLPEQFAQLIRTLRERVSNSDKAIFSVHCHNDLGMAVANSLAAVMSGARQVECTINGLGERAGNAALEEVVMAVRTRQDSFPCDTNVDISQIVPTSRLVSGITGFSVQPNKAIVGANAFAHASGIHQDGVLKERQTYEIMSAEDVGWHANQMILGKHSGRNAFRARLRELGIELETEEELNAAFQRFKELADKKHVIYDEDLQALVTDANLAAENERFKLSWLKVVSETGETAIASVTLSVDSIERQASAPGSGPVDAAYKAIDSILQSNTELLLYSVNSITSGTDAQGEVTVRLKKNGRIANGQGADTDIVMASAKAYVNALNKILYPVERAYPQV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Olsenella uli (strain ATCC 49627 / DSM 7084 / CIP 109912 / JCM 12494 / NCIMB 702895 / VPI D76D-27C)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
54.966 kDa
Sequence
MTRKIDIFDTTLRDGEQSPGASMNTEEKLIVAQQLLRMHVDVIEAGFPISSPGDFRSVQEIGRLAGDDAVVVGLTRAVDKDIDRAAEALSCAKRPRIHTGLGVSPQHLADKLRISEDECVERAIRCVRYAKRYVEDVQFYAEDAGRADQGFLERVIQAVIEAGATVVNIPDTTGYQMPAAFGARIKGLCDNVRGIENVTIAVHTHNDLGMATALALAGVENGATQIECTINGLGERAGNTALEEVVMALRMHGDELDGHTDVVTQELTRASRLVSRITGMQVQANKAIVGANAFAHSSGIHQDGVLKSRGTYEIIDPADVGAAGSEIILSARSGHAALRHRLSELGYSFPESEFDDVYQRFLEIADQKKEVFDEDLESMVQERQRDVTAIYALESVQVVCGDAAIPTATVHITDEVGGEHVVACTGTGPVDAAYKAIDKVVSVHGDLQEFAVKAITRGIDAIGEVTVRIVAGDGRLYTGRGSDTDIVVSSAKAYVNAINRMIQTTRSKQGK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.546 kDa
Sequence
MEEHIQIFDTTLRDGEQTPGVNFTFDERLKIAKQLEKWGVDVLEAGFPASSTGSFKSVEAIAKTLTTTAVCGLARCKKSDIDAVYEATKEAVKPQVHVFIATSPIHLEHKLKMTQDEVLTSIKEHVSYAKQFFEVVQFSPEDATRTEIPFLIECVQTAINAGATIINIPDTVGFSYPTEYGEIFKQLTQAVKSNSKIIFSAHCHDDLGMAVANSLAAIEGGARRIEGTVNGIGERAGNASLEEVALALYVRKDHYGLESQINLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVNTTELPLGKLSGKHAFAEKLKALGYEIKLEDQVTLFKQFKEIADKKKNVSDRDIHAIIHGSEHEHNAIFQLDNLQLQYVSKGLQSAVVVIKERNGQVKQDSSIGTGSIVAIYNAVDRIFKKDAELIDYRIDSVTEGTDAQAEVHVRIIINHIEVTGIGIDHDILKASCKAYIDAHAKYISEYELKEGIRT

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.546 kDa
Sequence
MEEHIQIFDTTLRDGEQTPGVNFTFDERLKIAKQLEKWGVDVLEAGFPASSTGSFKSVEAIAKTLTTTAVCGLARCKKSDIDAVYEATKEAVKPQVHVFIATSPIHLEHKLKMTQDEVLTSIKEHVSYAKQFFEVVQFSPEDATRTEIPFLIECVQTAINAGATIINIPDTVGFSYPTEYGEIFKQLTQAVKSNSKIIFSAHCHDDLGMAVANSLAAIEGGARRIEGTVNGIGERAGNASLEEVALALYVRKDHYGLESQINLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVNTTELPLGKLSGKHAFAEKLKALGYEIKLEDQVTLFKQFKEIADKKKNVSDRDIHAIIHGSEHEHNAIFQLDNLQLQYVSKGLQSAVVVIKERNGQVKQDSSIGTGSIVAIYNAVDRIFKKDAELIDYRIDSVTEGTDAQAEVHVRIIINHIEVTGIGIDHDILKASCKAYIDAHAKYISEYELKEGIRT

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.132 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFSFDERLKIAKQLEKWGVDIIEAGFPASSSGSFKSVEAIAKTLTTTAVCGLARCVKKDIDAVYESTKAAAKPRIHVFIATSPIHRDSKLMMSKEEVLASIKEHVSYAKQYFDVVQFSPEDATRTELPFLIECVQTAVDAGASVINIPDTVGFSYPKEYGEIFKTLQESVHADHDVIYSAHCHDDLGLAVANSMAAIENGAKRIEGTLNGIGERAGNTALEEVALGLYVRQDHYDNQTQINLEETKQTSDLIARFAGIRVPRNKAIVGQNAFSHESGIHQDGVLKNPETYEIMTPQLVGVKTTELPLGKLSGKHAFAEKLTALGYDVDPEEQKTLFKQFKTVADKKKAVTDRDIHALIQGTEHEQNAIYKVETLQLQFVSNGLQSAVVVIKDIDGNTYQDSSIGTGSIVSVYNAVDRIFDRKTELIEYRIDSVTEGTDAQAEVHVQIKIDDQIVTGVGIDHDILLASCKSYVEAHAKYVANTKVEEGIHS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Lysinibacillus sphaericus (strain C3-41)
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.118 kDa
Sequence
MRKIDIFDTTLRDGEQSAGINLNTAEKIEIAKQLERLGVTIIEAGFPASSPGDFDAVHRIAETVKNSVVTGLARCIQKDIDTTWEAIKGAQQPHIHIFLATSPIHMEYKLKKSPEQVIEQAVEAVKYAKKYFPLVQWSAEDAFRSDREFLVRIMNEVVTAGATTINVPDTVGYASPYEYGALFKYLLENVKGADKVKFSAHCHDDLGMATANTLAAIENGAAQVEGTINGIGERAGNVALEEIAVALHIRKDYYQVETGIQLQEIKRTSQLVSKLTNVVIQPNKAIVGRNAFAHESGIHQDGVLKNPETYEIISPALIGEGEIPLVLGKHSGRAAFRDRAETLGFDLSDEKLNKAFVEFKKLADRKKEITEEDLLTLLTEQQIQLEDVPLFELKMVQVQYGTENIPTATAIVLTPEGLEKTVVATGAGSVEAIFNTLEQLVPNAVHVIDYRVTSVGKGRDALGEAVVNIRYDHVSTTGRNSSQDVLEASAKAYLNAINRHLIKESLRAHPV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Ruthia magnifica subsp. Calyptogena magnifica
Length
511 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.287 kDa
Sequence
MPNKLIIFDTTLRDGEQSPGASMTRDEKVRIAKVLEKMQVDVIEAGFAIASVGDFEAVQTVANVVQDSIICSLSRALDKDIDCAGEALKGANASRIHTFIATSDIHMKMKLQMTPDQVVEQAVRAVKRAKRYTNDVEFSPEDAGRSDEDFLCRIIEATINAGATTINIPDTVGYNIPHQFGVTIKSLIGRVPNSDKAIFSAHCHNDLGLAVANSLSAVLNGARQVECTINGLGERAGNTSLEELVMAVRTRQDIFDCDTDINATHILSASRLVSSVTGFIVQPNKAIVGANAFAHEAGIHQDGVIKYRETYEIMRAEDVGWNANQLVLGKHSGRNAFKVRLAELGVEFNNEEGLNDAFRRFKELADKKHEIFDEDLQALVSETQTEAYEAIKLVSLKVCTETGEKNTATVVLSIDDKEQTATANTSGAVDATFIAISSLTGIKINLQLYSVSNVTQGTDALGEVNVRLECNGRIVNGQGVDTDIITASAKAYVHGLNKVLAATNKAQHPQI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Nitrosomonas eutropha (strain DSM 101675 / C91)
Length
510 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.835 kDa
Sequence
MKERLVIFDTTLRDGEQSPGASMTMEEKVRIARQLERMGVDVIEAGFPAASKGDFEAVKAVAEAVSNSTVCGLSRAIEADINRAGEALQANQNMRIHTFIATSPIHMKNKLRMSPDRVIEQAIKAVKWARQYTDNVEFSPEDAGRSEIDFLCRILEAVIDAGARTLNIPDTVGYTMPDQFGGLIRTLRERIPNSDKAVFSVHCHNDLGLAVANSLSAVMNGARQVECTINGLGERAGNAALEEVVMAVRTRQDYFPCDTRIDTTQIVSTSKLVSGITGFPVQPNKAIVGANAFAHESGIHQDGVLKHRETYEIMRAEDVGWGANKLLLGKHSGRNAFRSRLKELGIELESEEKLNTIFIRFKDLADKKHEIFDEDLHALVSDEAQIPEEHYRLLSLVAHSETGEIPFAQVVIATGNNEQQAESEGSGPVDATFRAIEKILNSKAELQLFSVNNITSGTDALGEVTVRLQKVGRIVNGHGADTDIIAASAKAYLNACNKLHSSLERTHPQV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Length
510 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.578 kDa
Sequence
MKEHLVIFDTTLRDGEQSPGASMTMEEKVRIARQLERMGVDVIEAGFPAASRGDFEAVRAVAEAVSNSTVCGLARAMEADIDRTGEALQVNQNVRIHTFIATSPIHMKNKLRMSPDQVIDQAIKAVKWARQYTDNVEFSPEDAGRSEIDFLCRVLEAVIDAGARTLNIPDTVGYTMPDQFGGLIRTLRERIPNSDKAIFSVHCHNDLGLAVANSLSAVMNGARQVECTINGLGERAGNAALEEIVMAVRTRQDYFPCDTRIDTTQIVPASKLVSGITGFPVQPNKAIVGANAFAHESGIHQDGVLKHRETYEIMRAEDVGWGANKLLLGKHSGRNAFRSRLKELGIGLESEEKLNAIFLRFKDLADKKHEIFDEDLHALVSDEAQIPEEHYRLLSLHAVSETGEIPSAQVVIAVGGSEKQAVSEGSGPVDATFRAIEKILDSKVELQLFSVNNITSGTDAQGEVTVRLQKAGRIVNGHGADTDIIAASAKAYLSACNKLHSSLERTHPQI

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Length
510 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.31 kDa
Sequence
MKDHLIIFDTTLRDGEQSPGASMTREEKVRIARQLERMRVDVIEAGFPAASNGDFEAVKAVAAAIKGSTICGLARAIEGDIRRAGEALRGANSARIHTFIATSPIHMEKKLRMSPDQVVEQAVKAVKFARQYTDDVEFSPEDAGRSDITFLCRVLEAVIDAGAGTVNIPDTVGYTMPQQFGELIRTLRERIPNSDKVIFSVHCHNDLGLAVANSLSAVMNGARQVECTVNGLGERAGNASLEEVVMAVRTRQDFFPCDTRIDSVHIVPASKLVSGITGFPVQPNKAIVGANAFAHESGIHQDGVLKHRETYEIMRAEDVGWGANKLLLGKHSGRNAFRSRLAELGIELESEETLNATFMRFKELADKKHDIFDEDLHALVSDDAAALQEHYKLLSLTAHSETGETPHASIVIGEEGRESRAESDGSGPVDATFRAIEKILNSGVELQLYSVNAITSGTDSQGEVTVRLQKSGRIVNGNGADTDIVVASAKAYLSALNKLHSKLERAHPQV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus carnosus (strain TM300)
Length
510 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.476 kDa
Sequence
MSHIQVFDTTLRDGEQTPGVSFSFDERLTIAKQLEKWGVDVIEAGFPASSQGSFDSVKAISETLTKTAVVGLARCKKSDIDAVYEATKDAKYPQLHVFIASSPIHLEHKLKMTQEELLENITENVSYGKSLFDVVQFSPEDATRTDLDFLVKCVQTAVDAGASIINIPDTVGFSYPSEFGNIFKVLIENVKSDHEVTYSAHCHDDLGLAVANSMAAIENGATRIEGAVNGIGERAGNTALEEVALGLYVRRDHYGIETNLKLDETKATSDLVASFAGIRVPRNKAIVGQNAFSHESGIHQDGFLKHPETYEIMTPQLVGIKSSELPLGKLSGKHAFAEKLKQLGYDITAEKQVELFKQFKSIADKKKNVSDHDVHALVQGHSHETNAAYQVETLQLQFVSEGVQSAVVVLKDHEGKEYPSAAIGTGSIVAVYNAVDQIFKAPSELLNYQITSVTEGSDAQAQVNVEIRIDGKTYYGIGVDHDVLLASCKAYVEANSNHLADTARKDGVVS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Length
510 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.179 kDa
Sequence
MESHIQIFDTTLRDGEQTPGVNFSFDERLKIAKQLETWGVDILEAGFPASSAGSFKSVQAISNTLTKTAVCGLARCKKSDIDAVYEATKDAVKPVIHVFIATSPIHLTHKLKMTQQQVLESIKEHVSYAKQYFDVVQFSPEDATRTDTDFLIKCVQMAVDCGATIINIPDTVGYSYPNEYGRIFKTLIENINSKQDITYSAHCHDDLGMAVANSLAAIENGAKRIEGTVNGIGERAGNTAIEELALALYVRKDHYGNETRLKLSETKNTSDIISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKNPETYEIMTPQLVGISKNDLPLGKLSGKHAFAEKLKSLGYDIEPQNQAELFKQFKAIADKKKSVTDRDIHAIIQGTEHEQNAIYQVDTLQLQFVSNGLQSAVVVIKDKNGNIYQDSSIGTGSIVAIYNAVDRIFKHKSELIDYRIDSVTEGTDAQAEVHVSLTIEGQPVNGIGIDHDVLYASCKAYVEAHAKYASEINKKEGNH

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.563 kDa
Sequence
MERVRIFDTTLRDGEQSPGVSLNAMEKLQIARQLQKLGVDVIEAGFPITSPGDKEAVSLIAREVKGVVVAALARASALDIETAWDAIKDAESPRIHTFIATSDIHLKYKLKMDRETVVERAVAAVKLAKKFTADVEFSAEDASRSDLDFLCRVVEAAVKAGATTINIPDTVGYAEPEEFGEFICKILEKVPVMDRAVLSVHCHDDLGLAVANSLAAIKNGARQVECTINGIGERAGNCSLEEIVMALYTRKDVLPFYTGIKTEEIYRTSKLVSNLTGMPVQPNKAIVGKNAFSHESGIHQDGVLKERTTYEIMNPRLVGIPESRLVLGKHSGRHALKERLLELGYELTEEQLNEAFVKFKALADKKKEVTDQDLEAMMEEEIRKVPETYTLDYFHISTGSTIIPTATVGLIKEGEKLEDAATGDGPVDAIYKAINKITGLTPVLEQYSINAVTSGEDALGEVVVKLKNGLGKIVTGRGVSTDILEASAKAYLNGINKLLFDYQAKGEKQ

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.563 kDa
Sequence
MERVRIFDTTLRDGEQSPGVSLNAMEKLQIARQLQKLGVDVIEAGFPITSPGDKEAVSLIAREVKGVVVAALARASALDIETAWDAIKDAESPRIHTFIATSDIHLKYKLKMDRETVVERAVAAVKLAKKFTADVEFSAEDASRSDLDFLCRVVEAAVKAGATTINIPDTVGYAEPEEFGEFICKILEKVPVMDRAVLSVHCHDDLGLAVANSLAAIKNGARQVECTINGIGERAGNCSLEEIVMALYTRKDVLPFYTGIKTEEIYRTSKLVSNLTGMPVQPNKAIVGKNAFSHESGIHQDGVLKERTTYEIMNPRLVGIPESRLVLGKHSGRHALKERLLELGYELTEEQLNEAFVKFKALADKKKEVTDQDLEAMMEEEIRKVPETYTLDYFHISTGSTIIPTATVGLIKEGEKLEDAATGDGPVDAIYKAINKITGLTPVLEQYSINAVTSGEDALGEVVVKLKNGLGKIVTGRGVSTDILEASAKAYLNGINKLLFDYQAKGEKQ

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Desulforudis audaxviator (strain MP104C)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.888 kDa
Sequence
MSERVYIFDTTLRDGEQSPGVSLNIREKLQIAHQLVKLNVDVIEAGFPFASPGDFKGVQAVAREVRGVSVAGLARANAADIDRAWEALCEAEQPRIHTFIATSDIHLQHKLRMSREAVLETAVEAVRRAKGYTSDVEFSAEDAFRSDPDYLCRVLAAVIAAGATTVNIPDTVGYAMPDEFGAFIAYIMDHTPGIENVVVSVHCHNDLGLAVANSLAAVRNGARQVECTVNGIGERAGNAALEEVVMGLFTRREKYGLITGIQCEEIYRTSKLVSTLTGMPVQFNKAIVGKNAFLHESGIHQDGVLKERATYEIICPTMVGITRTNLVLGKHSGRHAFRQRLTELGFELHEEELNRAFVRFKELADSKKQITDEDLEAILDETIRQVPATYELDYLHVFSGTTVKPTAVIGLLIDGQFVQEAACGNGPVDATYKAIEKATGRKYSLVSYVIDAVTGGTDALANVTLKMRDDDHRVYTGRGVSADVLEASARAYVNIMNKIVYDERTRKHE

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.704 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYNIDKEAQIDLFKQFKTIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain JH1)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.704 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYNIDKEAQIDLFKQFKTIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain USA300)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.675 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYDIDKEAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain NCTC 8325)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.675 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYDIDKEAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain JH9)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.704 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYNIDKEAQIDLFKQFKTIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.677 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESATSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSMTELPLGKLSGKHAFSEKLKALGYDIDKEAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain COL)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.675 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYDIDKEAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain Newman)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.675 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYDIDKEAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.704 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYNIDKEAQIDLFKQFKTIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain N315)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.704 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYNIDKEAQIDLFKQFKTIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain MRSA252)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.702 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYIRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSKKLKALGYDIDKEAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVIKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain MSSA476)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.617 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYGIDKEAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.675 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYDIDKEAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Staphylococcus aureus (strain MW2)
Length
509 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.617 kDa
Sequence
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYGIDKEAQIDLFKQFKAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Length
508 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.525 kDa
Sequence
MARTIKIFDTTLRDGEQTPGVNLNLQEKLEIAKQLVRLGVDVIEGGFAIASPGDFESIMTLSRNLKGVTIASLCRSVEKDIDRAWEAVQYAESPRIHTFIATSDIHMKYKLKMTEEEVLERAVSMVKRAKGYCSNVEFSAEDASRTREEFLYRVVEAVIKAGATTVNIPDTVGYSTPLEFGRLIRNIRNNVPNIDKADISVHCHNDLGLAVANSLAAVENGAVQVECTINGLGERAGNAALEEIIMGINTRKDYYDITHRIDTTQIYRASRLVSSLTGVNVQPNKAIVGANAFAHESGIHQHGVLSEKTTYEIMTPESVGMGTNRMVLGKLSGRHAFEDRLKEMGYSLSDEEVKTAFAKFKDLADKKKVVTDKDIEALVDENIAVPEIFVIDSFQINSGNKMISTSTVSVRKDEEIITEAATGDGPVDAAFNAVERATGVNAELVHYRIKAVTEGKDALGEVTVKISNNNSIFMGKGVSTDIIEASVKAYLNAINRSISEIGESIISQ

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Length
508 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.525 kDa
Sequence
MARTIKIFDTTLRDGEQTPGVNLNLQEKLEIAKQLVRLGVDVIEGGFAIASPGDFESIMTLSRNLKGVTIASLCRSVEKDIDRAWEAVQYAESPRIHTFIATSDIHMKYKLKMTEEEVLERAVSMVKRAKGYCSNVEFSAEDASRTREEFLYRVVEAVIKAGATTVNIPDTVGYSTPLEFGRLIRNIRNNVPNIDKADISVHCHNDLGLAVANSLAAVENGAVQVECTINGLGERAGNAALEEIIMGINTRKDYYDITHRIDTTQIYRASRLVSSLTGVNVQPNKAIVGANAFAHESGIHQHGVLSEKTTYEIMTPESVGMGTNRMVLGKLSGRHAFEDRLKEMGYSLSDEEVKTAFAKFKDLADKKKVVTDKDIEALVDENIAVPEIFVIDSFQINSGNKMISTSTVSVRKDEEIITEAATGDGPVDAAFNAVERATGVNAELVHYRIKAVTEGKDALGEVTVKISNNNSIFMGKGVSTDIIEASVKAYLNAINRSISEIGESIISQ

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus anthracis (strain A0248)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.375 kDa
Sequence
MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIYRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYALFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSMTLKEIKATSTLVSRLTGMVVSKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus anthracis (strain CDC 684 / NRRL 3495)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.375 kDa
Sequence
MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIYRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYALFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSMTLKEIKATSTLVSRLTGMVVSKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus thuringiensis (strain Al Hakam)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.417 kDa
Sequence
MKKILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIYRSVTLGKSLFPTVQFSAEDATRTSRDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus anthracis
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.375 kDa
Sequence
MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIYRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYALFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSMTLKEIKATSTLVSRLTGMVVSKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus cereus (strain AH820)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.385 kDa
Sequence
MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIYRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYALFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus cereus (strain ATCC 10987 / NRS 248)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.464 kDa
Sequence
MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIHRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYQAEPSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPELVGESQNLFVLGKHSGRHAFTEKMKELGYEFTTEERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGTHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus cereus (strain 03BB102)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.401 kDa
Sequence
MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIYRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.544 kDa
Sequence
MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLEKLGIDVMEAGFAAASEGDFQSVKRIAESIQNASVMSLARAKESDIRKAYEAVKRAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIHRSVILGKSLFPTVQFSAEDATRTAQPFLAEAVEVAIRAGADVINIPDTVGYTHPEEYYSLFQYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAIEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDHYKTQSSIILKEIKATSTLVSRLTGMMIPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIAPELIGESQNLFVLGKHSGRHAFTERMKELGYELTQKERDAAFEAFKALADRKKEITDEDLRALMLGEAALLTQQYNIKQLQVHFVSNHIQCATVVLQDGKGNKYEDAATGAGSIEAIYHAIQRILEMECKLVDYRIQSITQGQDALAHVHVELKEGPHQVSGFGVAQDVLEASARAYVHAAGKLKALLTLVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus cereus (strain Q1)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.464 kDa
Sequence
MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIHRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYQAEPSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPELVGESQNLFVLGKHSGRHAFTEKMKELGYEFTTEERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGTHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus cereus (strain ZK / E33L)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.401 kDa
Sequence
MKKILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIYRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.371 kDa
Sequence
MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIHRSVTLGKSLFPTVQFSAEDATRTARDFLAEAIEVAIRAGANVINIPDTVGYTNPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSITLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Methylacidiphilum infernorum (isolate V4)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.078 kDa
Sequence
MEMTANRLIVFDTTLRDGEQCPGASMTSRQKLEVAKQLARLGVDVIEAGFPVISQGDFESVSEIAAQVKGPKICGLARCLPKDIEAAAEALKAAADAARIHVFLATSQIHRRFKLAKDEEEIVRIAVEGVRLAKRYVQDVEFSAEDASRTEPEFLAKIIQKVIEAGATTVNIPDTVGYAVPEEFASLIRYLFDHVQDIDKVVVSVHCHNDLGLAVSNSLAAIKAGARQVEGTINGIGERAGNAALEEIIMALHTRPDAFGKIETGIQLKEILRTSRLVSRMSGLAVQRNKAVVGENAFAHAAGIHQDGILKKRETYEIIDPKIIGWEQSELPLTKHSGRAALENRLKILGFELEKEEIDNIFSQFKQIGDKKKFIYDDDLVSLVEGQISRIKETYELEYVAVTVCSGGIPMATIKLRHGEEVLVDASTGDGAVDAAMKAVDRITGQHGHLVEYEVKSVTEGKDAIGEVTVKVNFDSKKLVTAKAASTDVIEASIKAYLNAVNKALL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Bacillus weihenstephanensis (strain KBAB4)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.397 kDa
Sequence
MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGINVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIHRSVTLGKSLFPTVQFSAEDATRTSRAFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYEAESSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPSLIGESQNLFVLGKHSGRHAFTEKMKELGYEFTKEERDVVFEAFKNLADRKKEITEEDLRALMLGEAAFAAQQYSITQLQVHFVSNSTQCATVVLKDEEGNMYEDAATGSGSIEAIYNAIQRILGLECDLADYRIQSITQGQDALAHVHVELKEGTHQVSGFGVAQDVLEASARAYVHAAGKLKSFITLVK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter fetus subsp. fetus (strain 82-40)
Length
506 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
54.896 kDa
Sequence
MDNNKIIVFDTTLRDGEQSPGASMNTEEKIQIALQLERLGVDVMEAGFAAASPGDFDAINQIAKQIHSIRIASLARALEKDIKAAGEAISPAKNRRIHTFIATSPIHMEHKLKMTPDEVIKRAVEAVKYAKTFVDDVEFSCEDAGRSDIVFLKEICAAVVEAGARTLNLPDTVGFRMPDEIYNMVKSMVDFIGDRAIISVHNHNDLGLAVANTLASIKAGARQVECTINGLGERAGNAALEEIVMTIRTRSDEFAPLYTDIVTKEIYATSRLVASITGIEPQPNKAIVGKNAFAHESGIHQDGMLKCAQTYEIIKAEDIGAEKNSLVLGKHSGRHAFKDKLINLGFDLDDNEINEAFIKFKELCDKKKEIFDDDIRALVSHEIIKIPEIYSIQTLSTSSCNAGHSSAAVSIKFSDNIISDAALGNGTADAIFKVIDRISGISGELKDYKVNAVSQGKDALAKITVKVVFEGSSCATIGHGLDIDTMMASAKAYVSALNSYLSMKNR

Gene
leuA
Protein
Probable 2-isopropylmalate synthase
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
505 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
54.674 kDa
Sequence
MYIEEVKGEMNLPENVRIFDTTLRDGEQTPGVALTVEEKTGIARKLDALGVDTIEAGFPAASPGEMNSIRRIVELGLEANICGLARVLREDIDAAIDCGVDYIHTFIGTSPLHREYKLKMSPDEIIDRAVFGVEYAAEHGLKVEFSAEDATRTEFDYLVEVYRAAEDAGAEIINVPDTVGVMIPRAMNHLVSRLKEELRVPISVHCHNDFGLAVANSLAAVEAGASQVHATVNGLGERAGNAALEEVVMALITRYDLPVDIRTVELVNISEFVSKITGVRMPPNKAIVGENAFAHEAGIHVHGVLEKAETYEPITPEMVGHKRRIVLGKHTGANALRSKLQEYGIEMKEEQFCTLYEQVKRLGDKGKRITDADLRAMAVTILGKASREIVKLEGIAVMTGESVMPTATVKLRIGDEVKTTSMTGVGPVDAAINAIQSLVSETADIELDEYNIEAITGGTNALAEVFVVMSDGEGNKATGRSTREDIVMASVEAVLDAINKILSLK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
Length
505 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.085 kDa
Sequence
MSQRVYIFDTTLRDGEQSPGVSLNVGEKVQIARQLAKLGVDIIEAGFPITSPGDFKAVSEIARQVKGVTVAALARANFQDIDRAWEAVRHAEQPRIHTFIATSDIHLKYKLRMSREEVLDAAVAAVKRARAYTGDVEFSAEDASRSDLDFLCRVLAAAIEAGATVINIPDTVGYAVPEEWGKFINTIYHKVPGIEKVIVSVHCHNDLGMAVANSLAAVMNGARQVEGAINGIGERAGNAAIEEMVMALYTRKDQYNLYTNIKTEEIYRTSKLVSALTGMKVQPNKAVVGKNAFAHEAGIHQDGVLKERTTYEIMNPAMVGISKSNLVLGKHSGRHAFRHRLEEMGYNLSDEELNSAFERFKKLADKKMEITDEDLEAIIEEEMRLVPHTYTLEYLHISSGTTVVPTATVGLKRDGQLMEEAACGNGPVDAICKAIDKITGLNCTMTSWGINAVTAGKDALGDVSLKVTADGEKVYVGRGISTDVLEASAKAYVNAVNKLIWDSQK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
Length
505 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.085 kDa
Sequence
MSQRVYIFDTTLRDGEQSPGVSLNVGEKVQIARQLAKLGVDIIEAGFPITSPGDFKAVSEIARQVKGVTVAALARANFQDIDRAWEAVRHAEQPRIHTFIATSDIHLKYKLRMSREEVLDAAVAAVKRARAYTGDVEFSAEDASRSDLDFLCRVLAAAIEAGATVINIPDTVGYAVPEEWGKFINTIYHKVPGIEKVIVSVHCHNDLGMAVANSLAAVMNGARQVEGAINGIGERAGNAAIEEMVMALYTRKDQYNLYTNIKTEEIYRTSKLVSALTGMKVQPNKAVVGKNAFAHEAGIHQDGVLKERTTYEIMNPAMVGISKSNLVLGKHSGRHAFRHRLEEMGYNLSDEELNSAFERFKKLADKKMEITDEDLEAIIEEEMRLVPHTYTLEYLHISSGTTVVPTATVGLKRDGQLMEEAACGNGPVDAICKAIDKITGLNCTMTSWGINAVTAGKDALGDVSLKVTADGEKVYVGRGISTDVLEASAKAYVNAVNKLIWDSQK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Desulfotomaculum reducens (strain MI-1)
Length
505 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.19 kDa
Sequence
MNNRVHIFDTTLRDGEQSPGVSLNLNEKLQIARQLARLGVDIIEAGFPITSPGDFAAVQAVAREVRGVTVAGLARANFKDIDVAWDAIKEAEQARIHTFIATSDIHLKYKLRKDREQVIEAAVAAVKHARKYTSDVEFSAEDASRSDIDYLCRIFQEVIKAGATVINVPDTVGYTTPGEYAQFIRDILEKTPGMEKIVLSVHCHDDLGLAVANSLAAVGAGARQVEGAINGIGERAGNAALEEVVMGLYTRKDYYGLMTGINTPEIYRTSRLVSSLTGMPVQPNKSVVGKNAFAHESGIHQDGVLKERTTYEIMNPEQVGITANNLVLGKHSGRHAFRDRLEELGYHLNEEELNLAFSRFKVLADKKKEITDHDLQAMVEDEIKHIPDTYVLKYLHISTGTAVVPTATLGLQMGDELKEEAACGDGPVDAIYKTVDKITGISCTLVNYAINAITGGKDALGDVTVKIRCEEKEKVYIGRGVSTDILEASAKAYVNAINKLIHDMQ

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Sediminispirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228)
Length
505 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.377 kDa
Sequence
MPRRIKIFDTTLRDGEQSPGASMSLEQKIKMASALERLGVDRIEAGFPVSSPVQFEAVQRVSATVKKAEVVGLARCVQRDIDAAYDALRDAAHPMLHIFIATSPLHREYKLKKSKEEILDTVRECLNYGGKGFSRMEFSPEDASRTEPDYLVEVVKTAIECGATSINIPDTVGYAVPKEFGQLISFLVEQVPQFSDGSVDLSVHCHNDLGLALANSLAAVRSGASQVEVTLNGIGERAGNCPMEELIMSLDVRKDMFDVETGIHTEYLYPTGKLLQSITGLLIPRNKPIFGDNVFVHESGIHQHGVLNKRETYEIMKPERIGRSSETIIMGRHSGKHALEDKLSQYNIKLTRQQFEDVFARFTAIADKKKEVYDEDLFSIVGTVLGGVVKGFSLLYFHTFTGNSLIPGATVKVRSEAGEKVASATGDGPVDAVFNAIDECVGINARLKEYIIHAIGSGKDAQGEVKLEVEIEGATYGGKASSTDIIEASAMAYLNAVNRFELRKR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter concisus (strain 13826)
Length
504 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
54.341 kDa
Sequence
MDKNKIIIFDTTLRDGEQSPGASMNTAEKLQIALQLERLGVDVMEAGFAAASPGDFDAVNQIAKQASNITVCSLARAVERDIKAAGEALAPAKNKRIHTFIATSPIHMQYKLKMSPDEVIRCAVEAVQYSKTFCDDVEFSCEDACRSEMSFLKEICEAAINAGAKTINIPDTVGYLYPEEITARISEIVKFIGDRAVVSVHNHNDLGMATANSLAAIKAGARQVEGTINGIGERAGNAALEEIVMAIKTRQDVFAPLYTGIISKEIYPTSRLIASITGIEPQPNKAIVGKNAFAHESGIHQDGVLKHKETYEIISAESIGLEKNSLVLGKHSGRHAFKDKLASLGFDLDSDALNKAFEKFKDLADKKKEIFDDDIRALVAEEITKIPQAYEITDLLQSSGGSLASASMSIRHNDEIVSDSALGNGTADAIFKVVDRISGINGTLKDYKVTAVSQGKDALAKVDVKVEFEGKTAVMGHGLDIDTMMASAKAYVGALNSYLRIHKN

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Length
504 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
54.802 kDa
Sequence
MNKNKIIVFDTTLRDGEQSPGASMNTAEKVELAIQLEKLGVDVIEAGFAAASPGDFDAIERICGAVSKIRVCSLARAIEKDIKAAGESIKSAKFKRIHTFIATSPIHMEYKLKLSPDDVIKKAINSIKYAKTFCDDVEFSCEDAGRSEISFIKEIVEAAINAGATTINLPDTVGYRLPSEMSYMIGELVKFVGDRAVISSHCHDDLGMSVANTIACIKAGARQIECTINGLGERAGNTALEEVVMAIKTRSDVFAPLYTDINFKEIYHSSRLVATITGIEPQPNKAIVGKNAFAHESGIHQDGVLKHKETYEIMRAEDIGLEKNSIVLGKHSGSHAFRDKLVSLGYNLSEDELANVFEKFKILADAKKEIFDDDLRELMTDELVKIPCAFEIIALSSSECNKGHASAALTLKHNDEILKDSALGNGVVDAIFKTIDRISGIKGNLKDYQVRAVSQGKDAQAKVTVKVLFENSSTIIGHGLDTDTLMATAKAYIGALNSYISMKQ

Gene
leuA
Protein
Probable 2-isopropylmalate synthase
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
503 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
55.212 kDa
Sequence
MSAVMTTIRVFDTTLRDGEQMPGVSLPLEYKIRIAKQLDKLGVDVIEAGFPSATKGEFESVKEISSLSLNAEICGLARIVKEDIDAAINANVDMVHIFVPTSRIQIEHTVKMSKEEIIEKSVECVEYIKSHGVKCMFSAMDATRTEVEYLKQIFKAVENAKVDIVNVPDTVGVATPFKFYELIKQLREHLKVPIDVHCHNDFGLAVANTYAAVMAGANEVQVTVNGIGERAGNADLAQVVMILHAIEGIKTNIKTEHLFETSKLVERLTGVKMPPNHPIVGENAFSHESGIHAHGVLKEYSTFEPGVVTPEMVGHKRRIVIGKHAGRYQIKKILEEAGYHLDDEKLNQIFEKVKEMGDKGKRVTDLDLFAIAEVVIGELKREEKAILVDEVTVLTGNKITPTAVLNAEVFGHRKVTSAIGVGPVDASLKAVTSLVGESIRITEFRMDAITGGSDALAEVYVTVEDDEGHSFTSRGAAQDIVMASIDAVINAVNYLLRMKRRKS

Gene
leuA
Protein
Probable 2-isopropylmalate synthase
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
503 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
55.212 kDa
Sequence
MSAVMTTIRVFDTTLRDGEQMPGVSLPLEYKIRIAKQLDKLGVDVIEAGFPSATKGEFESVKEISSLSLNAEICGLARIVKEDIDAAINANVDMVHIFVPTSRIQIEHTVKMSKEEIIEKSVECVEYIKSHGVKCMFSAMDATRTEVEYLKQIFKAVENAKVDIVNVPDTVGVATPFKFYELIKQLREHLKVPIDVHCHNDFGLAVANTYAAVMAGANEVQVTVNGIGERAGNADLAQVVMILHAIEGIKTNIKTEHLFETSKLVERLTGVKMPPNHPIVGENAFSHESGIHAHGVLKEYSTFEPGVVTPEMVGHKRRIVIGKHAGRYQIKKILEEAGYHLDDEKLNQIFEKVKEMGDKGKRVTDLDLFAIAEVVIGELKREEKAILVDEVTVLTGNKITPTAVLNAEVFGHRKVTSAIGVGPVDASLKAVTSLVGESIRITEFRMDAITGGSDALAEVYVTVEDDEGHSFTSRGAAQDIVMASIDAVINAVNYLLRMKRRKS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Uroleucon erigeronensis
Length
503 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
56.023 kDa
Fragment
single
Sequence
DGEQALQASLSVEEKLXIALCLEKTGVDIMEVGFPISSPGDFKSVQTISKKIKNSQICSLARCIEKDIDIAGEAMSVCDFFRIHIFLATSRLHMKSKLRKNFDEIIDMAIFSVKRALRYTDDVQFSCEDASRTTIDNLCRIVEKLINSGVKTINIPDTVGYSIPNELSFIIKNLFQRVPNIDKAVISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVREKNLGVYTNINHKEIYRTSQMISRICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNRENYEIIDPVSIGLKNVQLNLTSRSGRAAVKYYMNEMGYKDSDYNIDELYSDFLKLADKKGQVFDYDLESLAFISKQQDELEYFCLKFFSVQSISNGLSTASVKLLCGKKVYTESSTTSNGPVDAIYQALNRITHFPITLQKFQLIAKGKGKDALGQVDILVEYKKRKFHGVGLATDIIESSAKAMINVLNNIWKAKQVNKKLKILKKK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Uroleucon ambrosiae
Length
503 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.717 kDa
Fragment
single
Sequence
DGEQALQASLSVKEKLQIALCLEKSGVDIMEVGFPISSPGDFKSVQTISQKIKNSRVCSLARCIEKDIDVAGEAMSASNSFRIHIFLATSTLHMESKLRKNFNEIIDMAIFSVKRALRYTDDIEFSCEDASRTTIDNLCRIVEKLISCGVKTINIPDTVGYTIPNELSFIIKNLFEKVPNIHKSTISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVREDILGVSTNINHKEIYRTSQIVSSICNMPIPSNKAIVGSNAFAHSSGIHQDGVLKNRENYEIIDPISIGLKKVKLNLTSRSGRAAVKHYMNEMGYKENDYNIDELYTDFLKLADKKGQVFDYDLEALAFINKQQDESEYFSLKFFSVQSISNNLSTASVTLLCGKKIYTEASTTSNGPVDAIYQALNRITHFPIVLQKFQLVAKGKGKDALGQVDILVEYKKRKFHGVGLATDIMESSAKAMVNVLNNIWKAKQVNKNLKNLKKQ

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)
Length
503 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.081 kDa
Sequence
MTKLYIFDTTLRDGEQTPGVNLNKEEKLEIAKQLAKLNVDIIEAGFPIASPGEFEAVKTIAENVKGPVIAALARAIPMDIDRAWEAIKYSESPRIHTFIATSDIHIEKKLKKTRDEVLEQAVSAVKYAKRYCSDVEFSAEDAVRSDFNFLVKIFEAVIDAGATVINIPDTVGYALPWEFGDLIRRLKENIKNIDKAIVSVHCHNDLGLATANSLSAIVNGAEQVECTINGLGERAGNAAMEEIVMAIKVRRLPFEVGIKTEEIYKTSKLVSNLTGIVIQPNKAIVGENAFAHESGIHQHGVIQDPSTYEIIDPKMIGIPESKIVLGKHSGKHAFEKRLQELGYSLPPEQLEEAFKKFKELADKKKEITDKDIEALVSNQIKLVPEYYRLVHLQVVSGIGIVPTATIIISEDGEEIKTVEIGNGPVDAVYKAIAKAIKIPHSLEDFSLKSVTGGTDALGEAMVKLSDKDGNIYVGRATSTDIVEASALAYLRALNQLVMLKGKG

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Dictyoglomus turgidum (strain Z-1310 / DSM 6724)
Length
503 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.32 kDa
Sequence
MGKLYIFDTTLRDGEQTPGVNLNKEEKLEIAKQLAKLNVDIIEAGFPIASPGEFEAVKNIAEKVKGPIIAALARAIPMDIDRAWEAIKYSESPRIHTFIATSDIHIEKKLKKTRDEVLEQAVSAVKYAKRYCSDVEFSAEDAVRSDFNFLVKIFEAVIEAGATVINVPDTVGYALPWEFGELIRRLKENIRNIDKARVSVHCHNDLGLATANSLSAIVNGAEQVECTVNGLGERAGNAAMEEIVMAIKVRRLPFEVSIKTEEIYKTSKLVSNLTGIPIQPNKAIVGENAFAHESGIHQHGVIQDPSTYEIIDPKTIGIPESKIVLGKHSGKHAFEKRLQELGYSLPPDQLEEAFRRFKELADKKKEITDKDIEALVSNQIRIIPEYYKLRHLQVVSGIGIVPTATIIISENGEEIKTVEIGNGPVDAVYKAITKAVKVPHSLEDFSLKSVTGGTDALGEAMVKLSDKDGNIYVGRATSTDVIEASALAYLRALNQLVMLKGKD

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Macrosiphoniella ludovicianae
Length
502 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.911 kDa
Fragment
single
Sequence
DGEQALQASLSVKEKLQIALCLEKIGVDIMEIGFPISSPGDFKSVQIISKNIKNSRICSLARCVEKDIDAAGEAMSASNSFRIHIFLATSTLHMEYKLKKNFHEIIDMAIFAVKRALRYTDDIEFSCEDASRTTIDNLCRIVEKLIYHGVKTINIPDTVGYTVPNELSYIIKNLLERVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVREDILGVSTNINYKEIYHTSKIISRICNMPIPPNKAIVGSNAFSHSSGIHQDGVLKNRKNYEIIDPSSIGFKKLKLNLTSRSGRAAVKYYMSEMGYKDTDYNIDELYADFLKLADKKGQVFDYDLESLAFISKHPEELEHFCLKFFSVQSISNGLSTASIKLLCGQKLYIESSTTSNGPVDAIYQALNKITNFPIILQKFQLIAKGKGKDALGQVNILIEYKKRKFHGIGLATDFIESSAKAMVNVLNNIWQAEQVNKKLQELKK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Uroleucon sonchi
Length
502 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
55.842 kDa
Fragment
single
Sequence
DGEQALQASLSVKEKLQIALCLEKAGVDIMEVGFPISSPGDFKSVQTISQNIKNSRICSLARCIEKDIDTAGEAMSHCDFFRIHVFLATSTLHMESKLRKNFDEIIDMAIFSVKRALRYTDDVEFSCEDASRTTMDNLCRIVEKLISCGVKTINIPDTVGYTIPNELSLIIKNLFERVPNIHKSTISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVREDILGLSTNINHKEIYRTSQVISRICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNRENYEIMDPSSIGLKKVKLNLTSRSGRAAVKYYMNEMGYKDSDYNIDELYVDFLKLADKKGQVFDYDLEALAFINKKQDELEHFCLKFFSVQSISNNLSTASVTLLCGDKIYTESSTTSNGPVXAIYQALNRITHFPIILQKFQLIAKGQGKDALGQVDILVKYKKRQFHGVGLATDIIESSAQAMINVLNNIWKVKQVNKNLKNLKK

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Length
501 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
54.744 kDa
Sequence
MDLKDYVRIFDTTLRDGEQCPGAAMTENEKLEIASQLATMKVDIIEAGFPVSSPVQFQAVERIARETEGPMIAALARAMKADIEAASKALQPAKKRRIHTFIASSPIHMKYKLGKEPKEVLKMAVEAVTLCRQFVDDVEFSPEDATRSEPEFLRELCEAVIAAGATTINIPDTVGYTTPAEYGGLFKFLLSNVRGAEKIIFSAHCHNDLGLATANSLAAVQNGARQIECTINGIGERAGNTAMEEVVMAMRTRKDTFGIQTQIKTEEIARASYLVKTITGMLVQPNKAIVGANAFAHESGIHQDGVIKHRETYEIMKPETVGLSSNRMVLGRHSGRAGFKDRIVKLGFSPQVEELEAAYQRFLEIADRKKEIYDEDIRALFSEEARKSTGDRFQLEGFTVSTGTKSTPTAGVRILIDGHVREESATGDGPVDAIYKAIQKTTGMDPEVSRLVISPVTEGQDAMAEASVTLEYKGDRVVGKGSSTDIIEACSRAYISALNRL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Length
501 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
54.744 kDa
Sequence
MDLKDYVRIFDTTLRDGEQCPGAAMTENEKLEIASQLATMKVDIIEAGFPVSSPVQFQAVERIARETEGPMIAALARAMKADIEAASKALQPAKKRRIHTFIASSPIHMKYKLGKEPKEVLKMAVEAVTLCRQFVDDVEFSPEDATRSEPEFLRELCEAVIAAGATTINIPDTVGYTTPAEYGGLFKFLLSNVRGAEKIIFSAHCHNDLGLATANSLAAVQNGARQIECTINGIGERAGNTAMEEVVMAMRTRKDTFGIQTQIKTEEIARASYLVKTITGMLVQPNKAIVGANAFAHESGIHQDGVIKHRETYEIMKPETVGLSSNRMVLGRHSGRAGFKDRIVKLGFSPQVEELEAAYQRFLEIADRKKEIYDEDIRALFSEEARKSTGDRFQLEGFTVSTGTKSTPTAGVRILIDGHVREESATGDGPVDAIYKAIQKTTGMDPEVSRLVISPVTEGQDAMAEASVTLEYKGDRVVGKGSSTDIIEACSRAYISALNRL

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)
Length
500 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
54.632 kDa
Sequence
MSDRLFIFDTTLRDGEQVPGCQLNTVEKIQVAKALEQLGVDVIEAGFPVSSPGDFKSVVEISKAVTWPTICALTRAVEKDIDVAAEALRFAKRGRIHTGIGTSDSHIKYKFNSTREEIIERAIAATKYAKKYVEDVEFYCEDAGRTDNEYLARVVEAVIKAGATVVNIPDTTGYCLPDEYGAKIKYLMEHVDGVHNAILSTHCHNDLGMATANTVQGVLNGARQVEVTINGIGERAGNTSLEEVAMVFKSHKERDIITNITTNKIYSTSRMVSSLMNMPVQPNKAIVGRNAFAHSSGIHQDGVLKNAQTYEIIDPKDVGIDDNAIVLTARSGRAALKHRLHVLGVDLEQEKLDKVYDEFLKLADRKKDINDDDVLMLVGKDRTATHRIKLEYLQVTSGVGVQSVASICLNLSGVRRYEAAAGNGPVDAGIKAVKKAISNSDMTIQEFLIQAINKGSDDTGKVHMQVEYNGATYYGFSANTDIIAASVEAFVDAINKFIVD

Gene
leuA
Protein
Probable 2-isopropylmalate synthase
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Length
499 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
54.339 kDa
Sequence
MPDRVRIFDTTLRDGEQTPGVSLTVEEKVEIARKLDEFGVDTIEAGFPVASEGEFEAVRAIAGEELDAEICGLARCVKGDIDAAIDADVDCVHVFIATSDIHLRYKLEMSREEALERAIEGVEYASDHGVTVEFSAEDATRTDRDYLLEVYKATVEAGADRVNVPDTVGVMTPPEMYRLTAEVVDAVDVPVSVHCHNDFGMAVANSLAAVEAGAEQVHVTVNGIGERAGNASLEQVVMALKALYDIELDVRTEMLVELSRLVERLTGVVVPPNTPIVGENAFAHESGIHSHGVIKKAETYEPIRPEDVGHRRRIVLGKHAGRHAIKKKLEEMGIEVTEEQLDEIVRRVKELGDKGKRVTEDDLEAIARDVVGEVPESEAAVKLEEIAVMTGNKFTPTASVRVYLDGEEHEAASTGVGSVDAAIRALREAIEELGMDVELKEYRLEAITGGTDALAEVTVRLEDEDGNVTTARGAAEDIVMASVKAFVRGVNRLARRRRD

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Length
499 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
54.718 kDa
Sequence
MARKIKIFDTTLRDGEQTPGVSLTVEEKIEIAKQLARLNVDVIEAGFPISSPGEFEAVKRIAREVRGPTIAALARAVKKDIDAAGEALKDAESKRIHTFIATSLIHMKYKLRKTPEEVKKMAVEAVEYATKYTDDIEFSAEDATRSDWNFLVEVYEAVIDAGATTINVPDTVGYTTPEEFYELIRYLKRNITNLNGVTISVHCHNDLGLAVANSLSAVRAGADQVEVTVNGIGERAGNAALEEVVVALDVRKDFYNVETGINLGEIARTSKLVARLTGIEVPPNKAVVGANAFAHESGIHQDGVLKERTTYEIIDPRKLGFSGSKIVLGKHSGRHAFRKKLEEMGYRLSEEEINRLFAKFKEIADRKKGLTELDIEAIVQEELGKGKGKYSVEVLHVISGKISTATVRVQGDGIDKIESAWSSNGPIDALFAAINRALGIDCKLKEYRVSSVTSGRDALGEVLVRVEYNGEIYVGRGLSTDIIEASAQAYLSALNRIRR

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas oryzae pv. oryzae (strain PXO99A)
Length
491 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
53.169 kDa
Sequence
MTPQQKLVMARALDELGVDIIETGFPASSHSDREAVAMMGRELRRPTLAVLSRCLQADIETSAKALETAANPRLHVFLSTSPLHREHKLRMSREQVLESVHRHVTLARGYIDDVEFSAEDATRTEEDFLAEVTRVAVAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVERRLRALGYLLEEEEVKLMFEQFKALCEKQRLVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPEGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVIAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Xanthomonas oryzae pv. oryzae (strain PXO99A)
Length
491 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
53.169 kDa
Sequence
MTPQQKLVMARALDELGVDIIETGFPASSHSDREAVAMMGRELRRPTLAVLSRCLQADIETSAKALETAANPRLHVFLSTSPLHREHKLRMSREQVLESVHRHVTLARGYIDDVEFSAEDATRTEEDFLAEVTRVAVAAGATTINLPDTVGFTTPEEIRGMFSRLIASVEGADKVIFSAHCHNDLGLAVANSLAAIEGGARQVECTINGIGERAGNCALEEITMALKVRGAFYNIDSAINTPRIVSTSQLLQRLVGMPVQRNKAVVGGNAFAHESGIHQHGMLRHRGTYEIMRPEDVGWESSQMVLGRHSGRAAVERRLRALGYLLEEEEVKLMFEQFKALCEKQRLVTDADLQALMQDATVQEGYRLASMTISDVGSRANALVELSDPEGNRVAETAQGNGPVDALFGALASATGVKLELDSYQVHSVGIGADARGEASLSVRHDGVEYEGTGTSKDIIEASALAWLDVANRLLRQRERGVIAGKTAAVA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Length
486 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
53.768 kDa
Sequence
MRKVYIFDTTLRDGEQTPGVSLTVEEKVEIAKQLAKLNVDVIEAGFPIASEGEFKAVKKIATEVEDPTIAALARAVEKDIDRAGEALRNAEKNRIHTFIATSPIHMKYKLRKEPEEVKKLAVKAVEHATKYTEDVEFSAEDATRSDWDFLVEVYEAVIDAGATVINVPDTVGYATPEEFYELVRYLRRNISNIKGVQISVHCHDDLGLAVANSLSAIRAGADQVEVTVNGIGERAGNAALEEVIVALDVRRDFYKVKTDVNLKEIARTSKLVSHLTGIEVPPNKAIVGGNAFAHESGIHQDGVLKERTTYEIIDPKKLGFSGSKIVLGKHSGRHAFRKKLEELGYSLTEEHLERAFKKFKDIADRKRWITDTDIEAIIQEELTKSNGKLKVEIIHVTSGKVSTATVRISMNGEERIEVAWFKNGPIDALFSAINKALGEEFKLREYRVSSVTSGKDSLGEVLVRVEVNGEIFVGRGLSTDIIEASA

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Uroleucon rurale
Length
437 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
48.673 kDa
Fragment
single
Sequence
EKLQIALSLEKIGVDIMEVGFPISSPGDFKSVQTISKNIKNSRICSLARCLEKDIDAAGEAMSVCDNFRIHIFLATSTLHIESKLRKNFNEIIEMAIFSVKKALRYTNDVEFSCEDASRTNIDNLCRIVEKLIKSGVKTINIPDTVGYSTPDELTFIIKNLFERVPNIHKSIISVHCHDDLGMAVGNSIAAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVRKNILGVSTNINHKEIYRTSQMISRICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNRENYEIMDPRSIGLKKVKLNLTSRSGRAAVKYYMSEMGYKDSDYNIDELYTDFLKLADKKGQVFDYDLESLAFINKQQDELEYFRLQFFSVQSISNNLSTASVKLLCGNKTYTESSTTSNGPVDAIYQALNRITHFPIILQKFQLIAKGKGKDALG

Gene
leuA
Protein
Probable 2-isopropylmalate synthase
Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Length
399 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
43.687 kDa
Sequence
MLIVEGVRIAEELENLPKEVRIFDTTLRDGEQTPGISFTKEQKLMIARQLAKLGVASIEAGFPAVSQGEFEAVKAIAREGLGPEIVALARANKRDIDKALDADVDAIHVFIAASDIHLKYKLRMTREEALRRAVEAVEYAKSHGVTVEFSPEDGTRADLNYLYTMVEAVVDAGADRVDIPDTVGVMTPTRMKYLIKFILPAAKGRIVSVHCHNDFGLAVANSIAGIEAGARQAHVTVNGIGERAGNAALEEVVAALEFLLNVRTGVNTKLLYETSLLVSKITGIPIPPNKPIVGENVFSHESGIHVHGVINNPFTYEPIQPEMVGQRRRIVLGKHSGRHGVEYALKTLGYPTDPDVVLRVLDEVKRLGDMGIRVTEDKLREIVEKVLEERERAKEAATS

Gene
leuA
Protein
Putative 2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Length
390 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
43.227 kDa
Sequence
MTQKIIIFDTTLRDGEQSLKMSLSVKKKLKIAFALEKLGVDVIEAGFPISSPGDFESVKKISERIKDAKICSLARCIDGDIDIAAKAMKKANSFRIHIFLGTSALHVQSKLKKTFDQIIDMMVSSVKRAQKYTDDVEFSCEDAGRTSLDDLCRIIELAIDLGVKTINIPDTVGYTIPYEFSNIISSIYKKVPNIDKAIISVHCHDDLGMAVANSISAIQVGARQIEGTITGVGERAGNAALEEILMAIKIRKDILNFKTNIKYQEIYSTCRVISSICNIPVPVNKAIIGSNAFSHSSGIHQDGILKDKKTYEIIVPESIGFVSQPLNLTSRSGRAAVKYRMKKIGYKDSDYNIDILYSRFLKLADKKGRVSDSDLKQLVCFNNKLKNLKD

Gene
leuA
Protein
Probable 2-isopropylmalate synthase
Organism
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Length
386 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
42.433 kDa
Sequence
MGCQFSVNSKKVRIFDTTLRDGEQAPGIDLTVEQKVKIARKLAELGVDVIEAGFPAASEGEFIATKKILEEVGDQVEVIGLSRANKQDIDKTIDTGISSIHVFIATSDIHLKYKLKMTREQVLDKIYESVRYAKDHGLIVEYSPEDATRTDKDFLLKAVSTAIEAGADRINIPDTVGVMHPFKFHDLIKDVVSVTKDKIVSVHCHNDFGLATANSIAGVMAGARQVHVTVNGIGERAGNASLEEVVMALKKLLGYEVNIKTYKLYETSRLVSELTGVPVPYFKAIVGENAFGHEAGIHVHGVIENPLTYEPISPEEVGNFRRLALGKHSGIHGLKKLLEEQGIYLNDQELREVLNEIKKLAENGEKVNVDVAKEIAIKVSSKKIKV

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Buchnera aphidicola subsp. Thelaxes suberi
Length
375 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
41.208 kDa
Fragment
single
Sequence
GRTSIDNLCRIVESAIKAGATTINIPDTVGYTIPSQFKTIIKNLFNKVPNINNAIISAHCHDDLGLAVGNAIASIEAGVRQIEGTISGIGERAGNTALEEVILTIKLKEELLNVFTNIKHNELYRTSQLISQLCNTPIPANKSIIGSNAFAHSSGIHQDGILKNRANYEIIDPKTIGVKAVQLNLTSRSGRAAVKHHMHEMGYQDDDYDLNQLYVNFLKLADKKGQVFDYDLEALAFISNQEDKDQEHFQLKYFSIHSGSTGVSTASVKLLCGNKILNEIITTRNGPINSIYQALNNIAGLPIVLEKFHLVGKGEGRDALGQVDIVVKYNNRKFHGIGLATDIIESSIKAMLNVLNNIWLSNKIKSKIKNIKNKK

Gene
leuA
Protein
Probable 2-isopropylmalate synthase
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Length
364 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
39.819 kDa
Sequence
MPGVALSISEKLEIAMALDDAGVDMIEAGFAAVSDDEKEAIKLISKEVSRAKVVSLARMTKSDVDAAAEADVDMIHLFIATSDIHLKYKLGITREEALRRIEEVVSYAKSYGVEILFSAEDATRSDLEFLAKAYKTAIEAGADEINVPDTVGVMTPSRMAYLIKYLRERLPPIPMHVHCHDDFGMAVANTVTAIENGADVAQVVVNNFGERAGNAALEEVVAAVHYLLGLRTNIKLEKLYSLSQLVSKLFGVPVPPNKAVVGENAFSHEAGIHVHGVLNNPFTYEPMRPEDVGNRRRIVLGKHSGRHSVIWALKNLGVEPSEDLVNYVLDAVKKLAVKKVKVDEAVLREIVNRYNKGLSMSYAV

Gene
leuA
Protein
Probable 2-isopropylmalate synthase
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Length
347 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family.
Mass
38.401 kDa
Sequence
MIARKLADLGVDVIEAGFPASSEGEFIATRKIFEEIGDQVEVIGLSRSNKNDIDKTISTGISSIHLFIATSELHMKYKLKMTKEEVLNKIYESVKYAKDHGMIVEFSPEDATRTEEDFLFTAIRTAIEAGADRINIPDTVGTMHPFKYYDMIKKIVNFVGERIIVSVHCHNDFGLATANSLAGVYAGARQAHVTVNGIGERAGNASLEEVVMGIKKLLNYETNVKTWKLYEVSRFVAEMTGVPVPYFKAIVGDNAFGHESGIHVHGVIENPFTYEPISPEEVGNFRRLALGKHSGIHGLRKLLEEQGIYLSDDKLKIVLAEIKKLAESGNKVTVEDAKNIALKLMNS

Gene
leuA
Protein
2-isopropylmalate synthase
Organism
Thermus thermophilus
Length
331 amino acids
Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Similarity
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Mass
36.083 kDa
Fragment
single
Sequence
RDEVVRGRDVVISTHTHDDLGMATANALAGVENGAGQIECTINGIGERAGNCALEEVVMALYVRRDWYKAYTRINTREIYRVSRLVERYTGMPVPPNKAIVGDNAFAHESGIHQDGVIKHRATYEIMDAELIGRRPAVLVLGKHSGRAAFKKALEDLGYKDLSEEEVKKLFARFKEIAEKKGPLSAEELQALVESEREPTSHFFQLEHVQFFSGSGLLPTATVKVKTPDGERLATHTGDGPVDAVYKAIQEAIGLRPELELYRVEAITGSTEALGQVTVRLRLGELQAVGVGVSPDIIEASALAFLDAAGKLASGRATRHPPSIEEVHRGV