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let-502

Gene
let-502
Protein
Rho-associated protein kinase let-502
Organism
Caenorhabditis briggsae
Length
1194 amino acids
Function
Negatively regulates mel-11 to relieve the inhibition of mlc-4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization (By similarity).
Similarity
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Mass
138.925 kDa
Sequence
MEQDELLHQLVDPKSPINIESLLDTITALVNDCKIPVLMRMKSVDNFISRYERIVESVAALRMKATDFRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYEVSEKWTRFYTAEIVEALAALHNMGYIHRDVKPDNMLISRSGHIKLADFGTCVKMNSNGVVRCSTAVGTPDYISPEVLRNQGKDSEFGKEVDWWSVGVFIYEMLVGETPFYAEALVSTYANIMNHQTSLRFPDEPLISTQAKDIIKKFLSAAPERLGKNNVDEIRNHKFFKNDEWTFETLKDATPPIVPSLKSDDDTTHFEEIETRDRDNASDFQLPKTFNGNQLPFIGFTYSNEYSPVKKLLNGASSNGVQNGVENKPVVVQQPLTNGHSTGIPEEQYEEVVIELDSKKRELESLKDSISRTEIRAKLIETEKNSLSSKINDLERELKDNKERLRLGADSDTKVNELSVELRMSKEYNGEMENELSKFRDKCEQLKEDLRKKSGELAQEKNETQRVLQQKKNAEEAFAEIKRDHEMLQTREAEKSLQLKKALDERKENGAYQQSVAKATDAEWERKMQYYEKQLEQATDDRKREEQKRTAAEFDQSRVARKLAGIEANYELLQNDYTNMKEARKDLERDLQDVIAEKRRLEIRVEQLMDSRNTDERVLNLCQEELLESQEEAKYKEDGLRGKIDGIRNELENEKMKSQTLEENLIVADKERGMLKMEVQELMQRHKWEMANKEQNLKHIENQLEELKEHSRIESTEQESNDKKTIADLNKKLELEKAHKKAVINKLEEEMAKRQPLKKGDKGITKSALIKKEREIVGFKKCRTGRILMSLQQENQHLQQKMTEMYMDSEKQGEHFSYQMQEMSQLIETLRDELKEYKDEYPQRHSVNRYEDKRSLDSREGIPTSISHQNIQIDGWLSLRDMTKKSRKPKVVFKKKSDHQLTLFFQWTNYFVILNEYAFTIYTDEKHLNSVVLTIEAGAMAHVRHVTSADLRNVDDNQLPKIFHIMYDDTSSNSSRHASNSDLSICEPREEGWKRHDFQELSYHTRTYCDDCGKKLSDFIRPTPAFECKNCHYKTHKEHIAQGTITMCRYTGLSRELVLMGTHKEVCNQWVSQLRRFIEASRPANVSVSRVSSRRHVGGPGSSA

Gene
let-502
Protein
Rho-associated protein kinase let-502
Organism
Caenorhabditis elegans
Length
1173 amino acids
Function
Negatively regulates mel-11 to relieve the inhibition of mlc-4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization.
Similarity
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Mass
135.774 kDa
Sequence
MEQDELRDQLVDPKSPINIESLLDTITALVNDCKIPVLMRMKSVDNFISRYERVVESLAALRMKAADFRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYEVSEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFGTCVKMNANGVVRCSTAVGTPDYISPEVLRNQGQDAEFGKEVDWWSVGVFIYEMLVGETPFYAEALVSTYTNIMNHKTSLKFPDEPLISTQAKDIIKKFLSAAPDRLGRNSVDDIRNHKFFVNDEWTFATLREASPPVIPSLKSDDDTTHFEEIETRDRDNAGDFQLPKTFNGNQLPFIGFTYSNEYSPVKNLLKGHGAGSKQNGIEQHKPQTVVEQPLTNGHASGVPEEKYEAVKMELDSKNREFELLKDSIARNEIRAKMIENEKNSLSTKISDLERELKDNKDKLRHGADSDAKVNELAVELRMSKEYNSEMESELSKFRDKCEQLKEDLRKKSGELAQEKNETQRVFQQKKDADEAFAEIKRDYELLQTRENEKSVQLKKALDERKENGAYQQSVAKATDAEWERKMQFYEKQLEHANDERKREEQKRTAAEFDQSRVARKLAGIEANYELLQNDYKSMKEARKDLERDLQDVITEKRRLEIRVEQLMDSRNTDERVLSLCQDELVESQEEAKYKEDGLRGKIDGFKHELENEKMKTQTLEENLLVADKERGMLKMEVQELMQRHKWEITNKDQTLKHLETQLDEIKQQSKIESSEQESNDKQTIADLRKKLDLEKAHKKAVINKLEEEMAKRQPLKKGEKGVTKSALIKKEREIMALEQERDTMSKRIAALFYENDKQAEHFNIAIQDMQTTQDALRDELKECKEELANRNVNTRYEDKRSLDSREGIPSSLSNQHIQMEGWLSLRDNTKKSRKPKWTNCFVALNEYSFTIYVDEKAVSVILLIEAGAMAHVRHVTAADLRNVDDSQLPKIFHIMYDDASCNSSRHASNSDLSMIESFREESWKRHDFQELSYHIRTFCDVCNKKLSDIIRPTPAFECKNCHFKTHKDHVAQGSLPMCRYNTGLSRELVLMAPQTDNCNKWVSQLRRFIESSRSAAVSVSRVSSRRHAPGSSNSSTIYQ