Protein
Small toxic polypeptide LdrA
Organism
Escherichia coli (strain K12)
Function
Toxic component of a type I toxin-antitoxin (TA) system. Inhibits ATP synthesis possibly due to its insertion in the cell inner membrane, ATP levels drop over 50% 2 minutes after induction (PubMed:24513967). Overexpression is toxic leading to cell death, it inhibits cell growth within 30 minutes; C-terminally tagged versions of the protein are toxic while N-terminally tagged versions are not (PubMed:24513967).
Similarity
Belongs to the Ldr toxic peptide family.
Sequence
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK