Protein
Leucine dehydrogenase
Organism
Thermoactinomyces intermedius
Function
Catalyzes the reversible deamination of L-leucine to 4-methyl-2-oxopentanoate. Exhibits the highest activity with L-leucine as substrate, but can also use other L-amino acids such as L-isoleucine, L-valine and L-2-aminovaleric acid. All of the oxo analogs of the amino acid substrates serve as good substrates for the reverse reaction.
Similarity
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Sequence
MKIFDYMEKYDYEQLVMCQDKESGLKAIICIHVTTLGPALGGMRMWTYASEEEAIEDALRLGRGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEAMFRALGRFIQGLNGRYITAEDVGTTVEDMDIIHEETRYVTGVSPAFGSSGNPSPVTAYGVYRGMKAAAKEAFGDDSLEGKVVAVQGVGHVAYELCKHLHNEGAKLIVTDINKENADRAVQEFGAEFVHPDKIYDVECDIFAPCALGAIINDETIERLKCKVVAGSANNQLKEERHGKMLEEKGIVYAPDYVINAGGVINVADELLGYNRERAMKKVEGIYDKILKVFEIAKRDGIPSYLAADRMAEERIEMMRKTRSTFLQDQRNLINFNNK