Protein
Nucleotidyltransferase lcsQ
Organism
Purpureocillium lilacinum
Function
Nucleotidyltransferase; part of the gene cluster that mediates the biosynthesis of the lipopeptide antibiotics leucinostatins that show extensive biological activities, including antimalarial, antiviral, antibacterial, antifungal, and antitumor activities, as well as phytotoxic (PubMed:27416025). The function of lcsQ within the leucinostatins biosynthesis has not been identified yet (Probable).
Similarity
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
Sequence
MLLRLSPSRMALKRKLDSFLRNVHSQSAPPAAMAHARTVRLSAREEQLRALLLDVCRSIDAAGDVTQPIILRWAGGWVRDKLLGIESHDIDVAINAMTGVHFAQRMCDFCTLPDAIKRHGIGPRDVGNLHNVARNPDKSKHLETAMVKIFGLDLDFVNLRRETYADDSRNPAMEFGSAEEDALRRDATINALFFNLHTGCVEDFTGGLPDMAARMIRTPLDPLQTFTDDPLRVLRLVRFASRLQFYIDPATQRVMDHPTVLQALRVKISRERVGVELEKMLKGTCPPQVEVHFWAQPTRRALELLDELHLYHAIFTDPAREPTERPDLRRWHVAYECLGWLLGNRSPGSIGTLLAQSEEAVYVAWNLAAVSPWMPVEEPPGVKKKANALPPVAVIAREGFRAPNKLTDVMAASHRHRKEILQLKEAVCHGEPWTRQRDRCGMAIRRWDSQGGFWTLQVLSTLLVDAMEQVDSWPIVAHPGKPSQPADVPETPLSSGASKSKNLDPSIAKRDDFITGWQKFLDHVVELNVYNAPTMKRLLDGRALAQALGVKPGKWTGKALDVCMAWQLRNPDETDPSKAIEEVRMRRDELGIPLDG