Protein
ABC multidrug transporter lscH
Organism
Purpureocillium lilacinum
Function
ABC multidrug transporter; part of the gene cluster that mediates the biosynthesis of the lipopeptide antibiotics leucinostatins that show extensive biological activities, including antimalarial, antiviral, antibacterial, antifungal, and antitumor activities, as well as phytotoxic (PubMed:27416025). May be involved in the efflux of leucinostatins (Probable).
Similarity
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Sequence
MSAEAACSDDSFGPWAGATCRGGFDFTLLFEETILSILPSVLVIVVAPIPIIRLAREPPKVRASALDWFKKISSICFITLSAALVGLWARNSTITQTRASTPSAVLTFVLSLVYVLLSTIEHRLSLRPSSVLSFYLGLSVLFDIARTRTLFMLEDATHSAIPPVFASSLALRVVMLLLESTEKRSLLLAKYDNAAPESVGGPYNLGVFYWLSTLFFTGYRKILEIGDLYPLDDELRSTGLAKKMSDAWRKVPDKAAPNVLFATWLKTFSKAMFMPVVPRLFQIGFTYAQPFLITAAIELAATPQTQPYNNNGYGLIGAYILVYSGIAVSVGQYEWRNYRAATMMRGSIIPLVYEKSLILDSCSSATFHPTAALTLVSTDIETITSGLVQIHETWSNLVEIGLAIYLLERQLGAACVMSVGFAIVVMVGTVFLARPTGTHLAAWIQASQVRVIETSKALASIKWLKISGLTDVAFSVIQKLRKQELVVSEKFRYLLGLSLILSICTPILGPLLTFAVFAGIAAHGGSTLTIAKVFTAFSIIVLLNSPLAKIVQALPQISGSIASFQRIQDHLNAEERHDPRSTTTGTSPESNNGSQQTLSDKQATADGDTMISISGKFSWRSETPAPGTGITLVTGSDEGHLADTTPDANGDSRDAPVIDISPRLDIPRGALTLILGPVGCGKSTLLKALLGELSSFDGVIEAKYSGAVTYCDQNPWLPNETVRDIIRGRSATDTSDADSSEKADHDEDWYRVVVSACELQRDMQIWPRGDRTPVGSKGISMSGGQKQRLSIARAVYARRALVILDDVFSGLDANTEDVVFENLLGNSGILRKANMTVVLASSDVRRVPFADKIVLLNQHGQVQHTGTPGDLKQVAELGWADRDLDAQQEKPGKDELNHEHGEYSESAPEKLRRSQTNHGADNNAAVQEVLQAVESQADTARQMGDSAVYKFYVKSAGWLTITIFVIAICVYAFCDSFPSVWLKWWAEANEKNPNSDLGKWLGVYAVLGVGAVAACLIGTWQLFIITINRSGLYFHNLLVETVSRAPMMFHSTTDTGITVNRFSQDLQLIDMELPSAALGVVMALSFGIAQFILVCVSSRYMAALLPFLLAVLYAIQHFYLRTARQLRLLDIEYKAPLYTQLMETISGVVTIRAFRWETQSTEKAIRILDTSQKPSYLLFCVQRWITFAVNMVIMMLAVILIVLTTTLREAIGPGYVGIALSNILAFSATMQATITSWVTLEIALGAVARIRSFSMQVRSEDDEARDGLAKAGLDARLVQPTPETVGERWPSQGRIELDNVTASYPSSGRVLHNITMIIEPGQKVAICGRTGSGKSSLFLSLLGLIAQDSGSITIDSVDLATLPREYLRSQIVAVPQEAYILDGTVRLNADPYHNKETLGSTDPPDSRDEQIIDVLKRVGLWEKIATRGGLDMVIDDKFLSQGQAQLMVLARAMLRRDESRVLLLDEATSSLDEATTTLIDEIVSTWFKDWTVLAIAHKLDAILDYDRVAVLDAGRLVEYDQPRELLQRPTSIFKELYLLSTNQASLSSPDSN